CN115087652B - 作为血浆激肽释放酶抑制剂的杂芳族甲酰胺衍生物 - Google Patents

作为血浆激肽释放酶抑制剂的杂芳族甲酰胺衍生物 Download PDF

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Publication number
CN115087652B
CN115087652B CN202180014104.6A CN202180014104A CN115087652B CN 115087652 B CN115087652 B CN 115087652B CN 202180014104 A CN202180014104 A CN 202180014104A CN 115087652 B CN115087652 B CN 115087652B
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methyl
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compound
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CN115087652A (zh
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M·埃克哈特
M·吉鲁
C·迈尔
H·瓦格纳
D·威登迈尔
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Boehringer Ingelheim International GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180014104.6A 2020-02-13 2021-02-11 作为血浆激肽释放酶抑制剂的杂芳族甲酰胺衍生物 Active CN115087652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20157257 2020-02-13
EP20157257.5 2020-02-13
PCT/EP2021/053284 WO2021160716A1 (en) 2020-02-13 2021-02-11 Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors

Publications (2)

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CN115087652A CN115087652A (zh) 2022-09-20
CN115087652B true CN115087652B (zh) 2024-05-07

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CN202180014104.6A Active CN115087652B (zh) 2020-02-13 2021-02-11 作为血浆激肽释放酶抑制剂的杂芳族甲酰胺衍生物

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US (1) US11851418B2 (https=)
EP (1) EP4103561A1 (https=)
JP (1) JP7686002B2 (https=)
CN (1) CN115087652B (https=)
AR (1) AR121340A1 (https=)
TW (1) TW202144331A (https=)
WO (1) WO2021160716A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112839711A (zh) 2018-10-10 2021-05-25 勃林格殷格翰国际有限公司 作为血浆激肽释放酶抑制剂的苯基四唑衍生物
TWI873290B (zh) 2020-02-13 2025-02-21 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
TW202144331A (zh) 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106257976A (zh) * 2014-03-07 2016-12-28 拜奥克里斯特制药公司 人类血浆激肽释放酶抑制剂
WO2017072021A1 (en) * 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
CN107108576A (zh) * 2014-11-27 2017-08-29 卡尔维斯塔制药有限公司 作为血浆激肽释放酶抑制剂的n‑((杂)芳基甲基)‑杂芳基‑甲酰胺化合物
CN108289893A (zh) * 2015-10-01 2018-07-17 拜奥克里斯特制药公司 人类血浆激肽释放酶抑制剂
WO2018192866A1 (en) * 2017-04-21 2018-10-25 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
WO2020035540A1 (en) * 2018-08-16 2020-02-20 Boehringer Ingelheim International Gmbh Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors

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TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
JP2005089362A (ja) 2003-09-17 2005-04-07 Sumitomo Chemical Co Ltd アリールピラゾリン化合物及びその用途
EP2259679A4 (en) 2008-01-31 2011-09-14 Joslin Diabetes Ct METHODS OF TREATING KALLIKREIN RELATED DISORDERS
EP2807156A1 (en) 2012-01-27 2014-12-03 Novartis AG Aminopyridine derivatives as plasma kallikrein inhibitors
US20140378474A1 (en) 2012-01-27 2014-12-25 Novartis Ag 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
EP2999697B1 (en) 2013-05-23 2017-04-19 Kalvista Pharmaceuticals Limited Heterocyclic derivates
WO2017072020A1 (en) 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
DK3464271T3 (da) 2016-05-31 2020-06-15 Kalvista Pharmaceuticals Ltd Pyrazolderivater som plasma-kallikreininhibitorer
CN110022875A (zh) 2016-07-11 2019-07-16 莱福斯希医药公司 治疗性抑制化合物
DK4031547T3 (da) * 2019-09-18 2024-09-09 Takeda Pharmaceuticals Co Plasmakallikreininhibitorer og anvendelser deraf
TW202144331A (zh) 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
TWI873290B (zh) 2020-02-13 2025-02-21 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106257976A (zh) * 2014-03-07 2016-12-28 拜奥克里斯特制药公司 人类血浆激肽释放酶抑制剂
CN107108576A (zh) * 2014-11-27 2017-08-29 卡尔维斯塔制药有限公司 作为血浆激肽释放酶抑制剂的n‑((杂)芳基甲基)‑杂芳基‑甲酰胺化合物
CN108289893A (zh) * 2015-10-01 2018-07-17 拜奥克里斯特制药公司 人类血浆激肽释放酶抑制剂
WO2017072021A1 (en) * 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
WO2018192866A1 (en) * 2017-04-21 2018-10-25 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
CN110546146A (zh) * 2017-04-21 2019-12-06 勃林格殷格翰国际有限公司 作为血浆激肽释放酶抑制剂的杂芳基羧酰胺衍生物
WO2020035540A1 (en) * 2018-08-16 2020-02-20 Boehringer Ingelheim International Gmbh Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors

Also Published As

Publication number Publication date
AR121340A1 (es) 2022-05-11
EP4103561A1 (en) 2022-12-21
CN115087652A (zh) 2022-09-20
US20210276976A1 (en) 2021-09-09
JP2023513906A (ja) 2023-04-04
TW202144331A (zh) 2021-12-01
WO2021160716A1 (en) 2021-08-19
JP7686002B2 (ja) 2025-05-30
US11851418B2 (en) 2023-12-26

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