AR121340A1 - Derivados de carboxamida heteroaromáticos como inhibidores de calicreína plasmática - Google Patents
Derivados de carboxamida heteroaromáticos como inhibidores de calicreína plasmáticaInfo
- Publication number
- AR121340A1 AR121340A1 ARP210100384A ARP210100384A AR121340A1 AR 121340 A1 AR121340 A1 AR 121340A1 AR P210100384 A ARP210100384 A AR P210100384A AR P210100384 A ARP210100384 A AR P210100384A AR 121340 A1 AR121340 A1 AR 121340A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- plasma
- kallicerein
- inhibitors
- carboxamide derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Las carboxamidas heteroaromáticas de la fórmula (1), en donde R, R¹, A¹, A², L¹, y L² son como se definen en la descripción y las reivindicaciones, y sus sales farmacéuticamente aceptables se pueden usar en los métodos para el tratamiento de enfermedades que pueden estar influenciadas por la inhibición de la calicreína plasmática. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde R se selecciona del grupo R-G¹ que consiste en los compuestos del grupo de fórmulas (2); R¹ se selecciona del grupo R¹-G¹ que consiste en H y F; el resto =A¹-CR=A²- se selecciona del grupo A-G¹ que consiste en =N-CR=N-, =N-CR=CH- y =CH-CR=N-; y el resto -L¹=L²- se selecciona del grupo L-G¹ que consiste en -N=N-, -N=CH- y -CH=N-; y/o sus tautómeros o una de sus sales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20157257 | 2020-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR121340A1 true AR121340A1 (es) | 2022-05-11 |
Family
ID=69591570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210100384A AR121340A1 (es) | 2020-02-13 | 2021-02-12 | Derivados de carboxamida heteroaromáticos como inhibidores de calicreína plasmática |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11851418B2 (es) |
| EP (1) | EP4103561A1 (es) |
| JP (1) | JP2023513906A (es) |
| CN (1) | CN115087652B (es) |
| AR (1) | AR121340A1 (es) |
| TW (1) | TW202144331A (es) |
| WO (1) | WO2021160716A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3863713B1 (en) | 2018-10-10 | 2023-01-25 | Boehringer Ingelheim International GmbH | Phenyltetrazole derivatives as plasma kallikrein inhibitors |
| TW202144330A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TW202144331A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| JP2005089362A (ja) | 2003-09-17 | 2005-04-07 | Sumitomo Chemical Co Ltd | アリールピラゾリン化合物及びその用途 |
| US8658685B2 (en) | 2008-01-31 | 2014-02-25 | Activesite Pharmaceuticals, Inc. | Methods for treatment of kallikrein-related disorders |
| WO2013111108A1 (en) | 2012-01-27 | 2013-08-01 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| EP2807156A1 (en) | 2012-01-27 | 2014-12-03 | Novartis AG | Aminopyridine derivatives as plasma kallikrein inhibitors |
| CA2912285C (en) | 2013-05-23 | 2021-07-13 | Kalvista Pharmaceuticals Limited | Fused 6,5 or 6,6-heteroaromatic bicyclic amide derivatives and pharmaceutical compositions thereof useful as plasma kallikrein inhibitor |
| EP3828173B1 (en) * | 2014-03-07 | 2022-08-31 | BioCryst Pharmaceuticals, Inc. | Substituted pyrazoles as human plasma kallikrein inhibitors |
| GB201421083D0 (en) * | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| SI3355890T1 (sl) * | 2015-10-01 | 2022-04-29 | Biocryst Pharmaceuticals, Inc. | Inhibitorji kalikreina človeške plazme |
| EP3368524B1 (en) | 2015-10-27 | 2021-08-18 | Boehringer Ingelheim International GmbH | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| EP3368529B1 (en) | 2015-10-27 | 2022-04-06 | Boehringer Ingelheim International GmbH | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| US11180484B2 (en) | 2016-05-31 | 2021-11-23 | Kalvista Pharmaceuticals Limited | Pyrazole derivatives as plasma kallikrein inhibitors |
| WO2018011628A1 (en) | 2016-07-11 | 2018-01-18 | Lifesci Pharmaceuticals, Inc. | Therapeutic inhibitory compounds |
| CN110546146B (zh) * | 2017-04-21 | 2023-02-21 | 勃林格殷格翰国际有限公司 | 作为血浆激肽释放酶抑制剂的杂芳基羧酰胺衍生物 |
| EP3837252A1 (en) | 2018-08-16 | 2021-06-23 | Boehringer Ingelheim International GmbH | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors |
| TW202144331A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TW202144330A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
-
2021
- 2021-02-09 TW TW110104876A patent/TW202144331A/zh unknown
- 2021-02-11 CN CN202180014104.6A patent/CN115087652B/zh active Active
- 2021-02-11 JP JP2022548997A patent/JP2023513906A/ja active Pending
- 2021-02-11 WO PCT/EP2021/053284 patent/WO2021160716A1/en unknown
- 2021-02-11 EP EP21704539.2A patent/EP4103561A1/en active Pending
- 2021-02-11 US US17/173,212 patent/US11851418B2/en active Active
- 2021-02-12 AR ARP210100384A patent/AR121340A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021160716A1 (en) | 2021-08-19 |
| EP4103561A1 (en) | 2022-12-21 |
| US20210276976A1 (en) | 2021-09-09 |
| CN115087652A (zh) | 2022-09-20 |
| TW202144331A (zh) | 2021-12-01 |
| JP2023513906A (ja) | 2023-04-04 |
| CN115087652B (zh) | 2024-05-07 |
| US11851418B2 (en) | 2023-12-26 |
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