TW202134436A - 用於神經保護之方法及組成物 - Google Patents

用於神經保護之方法及組成物 Download PDF

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TW202134436A
TW202134436A TW109141403A TW109141403A TW202134436A TW 202134436 A TW202134436 A TW 202134436A TW 109141403 A TW109141403 A TW 109141403A TW 109141403 A TW109141403 A TW 109141403A TW 202134436 A TW202134436 A TW 202134436A
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Taiwan
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disease
disorder
antisense oligonucleotide
injury
subject
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TW109141403A
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Chinese (zh)
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麗莎 利文撒爾
湯瑪斯 安格柏
羅爾 愛德華多 克羅斯
拉杰什 德芙拉吉
羅伯特 歐文 修斯
陶德 波薩納克
蘇迪爾 阿格拉沃爾
馬可 A 帕西尼
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美商達薩瑪治療公司
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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TW109141403A 2019-11-26 2020-11-25 用於神經保護之方法及組成物 TW202134436A (zh)

Applications Claiming Priority (2)

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US201962940437P 2019-11-26 2019-11-26
US62/940,437 2019-11-26

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US (1) US12595481B2 (enExample)
EP (1) EP4065714A1 (enExample)
JP (2) JP7528212B2 (enExample)
KR (1) KR20220119366A (enExample)
CN (1) CN115176002A (enExample)
AU (1) AU2020391206A1 (enExample)
BR (1) BR112022009772A2 (enExample)
IL (1) IL293123A (enExample)
MX (1) MX2022006146A (enExample)
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Publication number Priority date Publication date Assignee Title
JP7528212B2 (ja) * 2019-11-26 2024-08-05 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物
PE20242222A1 (es) * 2022-03-14 2024-11-19 Lilly Co Eli Agentes de interferencia de arn de sarm1
CN116059367B (zh) * 2022-07-15 2025-02-18 浙江乘时佳生物科技有限公司 一种治疗阿尔茨海默症的sarm1抑制剂
US20240102018A1 (en) * 2022-07-21 2024-03-28 Amylyx Pharmaceuticals, Inc. Oligonucleotide compositions and methods thereof
TW202547525A (zh) 2024-02-02 2025-12-16 美商美國禮來大藥廠 SARM1 RNAi藥劑
GB202408068D0 (en) 2024-06-06 2024-07-24 Univ London Treatment of cancer of the central nervous system
WO2025261431A1 (zh) * 2024-06-19 2025-12-26 上海拓界生物医药科技有限公司 靶向SARM1的RNAi剂及其医药用途

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US20040096830A1 (en) 2002-11-16 2004-05-20 Isis Pharmaceuticals Inc. Modulation of protein kinase D2 expression
US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20050244851A1 (en) * 2004-01-13 2005-11-03 Affymetrix, Inc. Methods of analysis of alternative splicing in human
JP5697297B2 (ja) * 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロｎａｓおよびその使用
US7901882B2 (en) * 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
JP2013003911A (ja) * 2011-06-17 2013-01-07 Sony Corp 電子機器、電子機器の制御方法およびプログラム
WO2012178022A2 (en) * 2011-06-24 2012-12-27 University Of Massachusetts Therapeutic applications targeting sarm1
CN107921148A (zh) 2015-05-08 2018-04-17 哈佛学院校长同事会 通用供体干细胞和相关方法
JP7198489B2 (ja) 2016-03-23 2023-01-04 国立大学法人 岡山大学 リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
JP7044789B2 (ja) 2016-09-24 2022-03-30 ワシントン・ユニバーシティ Ｓａｒｍ１ ｎａｄアーゼ活性の阻害剤およびその使用
WO2018154413A1 (en) * 2017-02-22 2018-08-30 Crispr Therapeutics Ag Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
EP3697401B1 (en) 2017-10-18 2025-12-03 Washington University Dominant negative sarm1 molecules as a therapeutic strategy for neurodegenerative diseases or disorders
CN112839648B (zh) 2018-06-07 2025-04-04 达萨玛治疗公司 Sarm1抑制剂
CN112839647B (zh) 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
CA3108669A1 (en) 2018-06-07 2019-12-12 Disarm Therapeutics, Inc. Inhibitors of sarm1
JP7528212B2 (ja) 2019-11-26 2024-08-05 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物

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CN115176002A (zh) 2022-10-11
US20230242909A1 (en) 2023-08-03
WO2021108602A1 (en) 2021-06-03
BR112022009772A2 (pt) 2022-08-16
CA3159374A1 (en) 2021-06-03
KR20220119366A (ko) 2022-08-29
AU2020391206A1 (en) 2022-05-19
IL293123A (en) 2022-07-01
JP2023503994A (ja) 2023-02-01
JP2024112834A (ja) 2024-08-21
JP7796797B2 (ja) 2026-01-09
JP7528212B2 (ja) 2024-08-05
US12595481B2 (en) 2026-04-07
EP4065714A1 (en) 2022-10-05
MX2022006146A (es) 2022-10-18

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