CN115176002A - 用于神经保护的方法和组合物 - Google Patents

用于神经保护的方法和组合物 Download PDF

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Publication number
CN115176002A
CN115176002A CN202080082124.2A CN202080082124A CN115176002A CN 115176002 A CN115176002 A CN 115176002A CN 202080082124 A CN202080082124 A CN 202080082124A CN 115176002 A CN115176002 A CN 115176002A
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disease
disorder
antisense oligonucleotide
injury
subject
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Chinese (zh)
Inventor
L·莱文塔尔
T·恩伯
R·E·克劳斯
R·德夫拉
R·O·休斯
T·波萨纳奇
S·阿拉瓦尔
M·A·帕西尼
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Disarm Therapeutics Inc
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Disarm Therapeutics Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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CN202080082124.2A 2019-11-26 2020-11-25 用于神经保护的方法和组合物 Pending CN115176002A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962940437P 2019-11-26 2019-11-26
US62/940437 2019-11-26
PCT/US2020/062289 WO2021108602A1 (en) 2019-11-26 2020-11-25 Methods and compositions for neuroprotection

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CN115176002A true CN115176002A (zh) 2022-10-11

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US (1) US12595481B2 (enExample)
EP (1) EP4065714A1 (enExample)
JP (2) JP7528212B2 (enExample)
KR (1) KR20220119366A (enExample)
CN (1) CN115176002A (enExample)
AU (1) AU2020391206A1 (enExample)
BR (1) BR112022009772A2 (enExample)
IL (1) IL293123A (enExample)
MX (1) MX2022006146A (enExample)
TW (1) TW202134436A (enExample)
WO (1) WO2021108602A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025261431A1 (zh) * 2024-06-19 2025-12-26 上海拓界生物医药科技有限公司 靶向SARM1的RNAi剂及其医药用途

Families Citing this family (6)

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JP7528212B2 (ja) * 2019-11-26 2024-08-05 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物
PE20242222A1 (es) * 2022-03-14 2024-11-19 Lilly Co Eli Agentes de interferencia de arn de sarm1
CN116059367B (zh) * 2022-07-15 2025-02-18 浙江乘时佳生物科技有限公司 一种治疗阿尔茨海默症的sarm1抑制剂
US20240102018A1 (en) * 2022-07-21 2024-03-28 Amylyx Pharmaceuticals, Inc. Oligonucleotide compositions and methods thereof
TW202547525A (zh) 2024-02-02 2025-12-16 美商美國禮來大藥廠 SARM1 RNAi藥劑
GB202408068D0 (en) 2024-06-06 2024-07-24 Univ London Treatment of cancer of the central nervous system

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US7250496B2 (en) * 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20050244851A1 (en) * 2004-01-13 2005-11-03 Affymetrix, Inc. Methods of analysis of alternative splicing in human
JP5697297B2 (ja) * 2004-05-14 2015-04-08 ロゼッタ ジノミクス リミテッド マイクロｎａｓおよびその使用
US7901882B2 (en) * 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
JP2013003911A (ja) * 2011-06-17 2013-01-07 Sony Corp 電子機器、電子機器の制御方法およびプログラム
WO2012178022A2 (en) * 2011-06-24 2012-12-27 University Of Massachusetts Therapeutic applications targeting sarm1
CN107921148A (zh) 2015-05-08 2018-04-17 哈佛学院校长同事会 通用供体干细胞和相关方法
JP7198489B2 (ja) 2016-03-23 2023-01-04 国立大学法人 岡山大学 リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用
CN109843914B (zh) 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
JP7044789B2 (ja) 2016-09-24 2022-03-30 ワシントン・ユニバーシティ Ｓａｒｍ１ ｎａｄアーゼ活性の阻害剤およびその使用
WO2018154413A1 (en) * 2017-02-22 2018-08-30 Crispr Therapeutics Ag Materials and methods for treatment of dystrophic epidermolysis bullosa (deb) and other collagen type vii alpha 1 chain (col7a1) gene related conditions or disorders
EP3697401B1 (en) 2017-10-18 2025-12-03 Washington University Dominant negative sarm1 molecules as a therapeutic strategy for neurodegenerative diseases or disorders
CN112839648B (zh) 2018-06-07 2025-04-04 达萨玛治疗公司 Sarm1抑制剂
CN112839647B (zh) 2018-06-07 2025-09-23 达萨玛治疗公司 Sarm1抑制剂
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JP7528212B2 (ja) 2019-11-26 2024-08-05 ディスアーム セラピューティクス， インコーポレイテッド 神経保護のための方法および組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025261431A1 (zh) * 2024-06-19 2025-12-26 上海拓界生物医药科技有限公司 靶向SARM1的RNAi剂及其医药用途

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US20230242909A1 (en) 2023-08-03
TW202134436A (zh) 2021-09-16
WO2021108602A1 (en) 2021-06-03
BR112022009772A2 (pt) 2022-08-16
CA3159374A1 (en) 2021-06-03
KR20220119366A (ko) 2022-08-29
AU2020391206A1 (en) 2022-05-19
IL293123A (en) 2022-07-01
JP2023503994A (ja) 2023-02-01
JP2024112834A (ja) 2024-08-21
JP7796797B2 (ja) 2026-01-09
JP7528212B2 (ja) 2024-08-05
US12595481B2 (en) 2026-04-07
EP4065714A1 (en) 2022-10-05
MX2022006146A (es) 2022-10-18

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