TW202123962A - 一種預防和治療腎纖維化的方法 - Google Patents

一種預防和治療腎纖維化的方法 Download PDF

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Publication number
TW202123962A
TW202123962A TW110102361A TW110102361A TW202123962A TW 202123962 A TW202123962 A TW 202123962A TW 110102361 A TW110102361 A TW 110102361A TW 110102361 A TW110102361 A TW 110102361A TW 202123962 A TW202123962 A TW 202123962A
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Taiwan
Prior art keywords
plasminogen
fibrosis
renal
mice
group
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TW110102361A
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English (en)
Chinese (zh)
Inventor
李季男
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大陸商深圳瑞健生命科學研究院有限公司
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Publication of TW202123962A publication Critical patent/TW202123962A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW110102361A 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法 TW202123962A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2016110174 2016-12-15
WOPCT/CN2016/110174 2016-12-15
WOPCT/CN2016/110169 2016-12-15
CN2016110169 2016-12-15

Publications (1)

Publication Number Publication Date
TW202123962A true TW202123962A (zh) 2021-07-01

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Application Number Title Priority Date Filing Date
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Family Applications After (3)

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TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Country Status (7)

Country Link
US (2) US20190328848A1 (enExample)
EP (2) EP3556386A4 (enExample)
JP (2) JP7182793B2 (enExample)
CN (2) CN110366427A (enExample)
CA (2) CA3047171A1 (enExample)
TW (4) TW202123962A (enExample)
WO (3) WO2018107700A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110114080A (zh) 2016-12-15 2019-08-09 泰伦基国际有限公司 一种预防和治疗皮肤纤维化的方法
TWI714862B (zh) 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
MX9800684A (es) 1995-07-27 1998-04-30 Genentech Inc Formulacion de proteinas liofilizadas isotonicas estables.
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
EP1472346A2 (de) * 2002-02-06 2004-11-03 N-Zyme BioTec GmbH Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
JP2006507297A (ja) * 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
ATE331708T1 (de) * 2002-12-10 2006-07-15 Wyeth Corp Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
CA2577782A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as pai-1 inhibitors
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
EP2056864B1 (en) * 2006-08-28 2013-12-11 Omnio Healer AB Candidates against infection
CA2763496A1 (en) * 2009-05-26 2010-12-02 Yaremi Quiros Luis Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure
EP2451835A1 (en) * 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
ES2583082T3 (es) * 2011-01-05 2016-09-19 Thrombogenics N.V. Variantes de plasminógeno y plasmina
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
CN107496899A (zh) * 2011-09-29 2017-12-22 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
US9845363B2 (en) * 2013-08-13 2017-12-19 Sanofi Antibodies to plasminogen activator inhibitor-1 (PAI-1) and uses thereof
JP6512213B2 (ja) * 2014-02-21 2019-05-15 アステラス製薬株式会社 新規抗ヒトpai−1抗体

Also Published As

Publication number Publication date
EP3556386A4 (en) 2020-07-08
TW201822793A (zh) 2018-07-01
WO2018107700A1 (zh) 2018-06-21
EP3556388A4 (en) 2020-07-08
JP7182793B2 (ja) 2022-12-05
CA3047171A1 (en) 2018-06-21
EP3556388A1 (en) 2019-10-23
US20190328848A1 (en) 2019-10-31
JP7242057B2 (ja) 2023-03-20
CN110366427A (zh) 2019-10-22
WO2018107699A1 (zh) 2018-06-21
TW201822797A (zh) 2018-07-01
JP2020502135A (ja) 2020-01-23
CN110167582A (zh) 2019-08-23
TWI661838B (zh) 2019-06-11
TW201822794A (zh) 2018-07-01
CA3047170A1 (en) 2018-06-21
JP2020502134A (ja) 2020-01-23
TWI642441B (zh) 2018-12-01
WO2018107695A1 (zh) 2018-06-21
US20190343930A1 (en) 2019-11-14
EP3556386A1 (en) 2019-10-23

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