JP7182793B2 - 病理学的腎組織損傷を予防及び治療するための方法 - Google Patents

病理学的腎組織損傷を予防及び治療するための方法 Download PDF

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JP7182793B2
JP7182793B2 JP2019531809A JP2019531809A JP7182793B2 JP 7182793 B2 JP7182793 B2 JP 7182793B2 JP 2019531809 A JP2019531809 A JP 2019531809A JP 2019531809 A JP2019531809 A JP 2019531809A JP 7182793 B2 JP7182793 B2 JP 7182793B2
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plasminogen
renal
administered
mice
pbs
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JP2020502134A (ja
JP2020502134A5 (enExample
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季男 李
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Talengen International Ltd
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Talengen International Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019531809A 2016-12-15 2017-06-19 病理学的腎組織損傷を予防及び治療するための方法 Active JP7182793B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CNPCT/CN2016/110169 2016-12-15
CN2016110169 2016-12-15
CNPCT/CN2016/110174 2016-12-15
CN2016110174 2016-12-15
PCT/CN2017/089060 WO2018107700A1 (zh) 2016-12-15 2017-06-19 一种预防和治疗病理性肾组织损伤的方法

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JP2020502134A JP2020502134A (ja) 2020-01-23
JP2020502134A5 JP2020502134A5 (enExample) 2020-07-30
JP7182793B2 true JP7182793B2 (ja) 2022-12-05

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JP2019531809A Active JP7182793B2 (ja) 2016-12-15 2017-06-19 病理学的腎組織損傷を予防及び治療するための方法
JP2019531812A Active JP7242057B2 (ja) 2016-12-15 2017-06-19 薬物性腎損傷を予防及び治療するための方法

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US (2) US20190328848A1 (enExample)
EP (2) EP3556388A4 (enExample)
JP (2) JP7182793B2 (enExample)
CN (2) CN110167582A (enExample)
CA (2) CA3047170A1 (enExample)
TW (4) TW201822797A (enExample)
WO (3) WO2018107699A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7213552B2 (ja) 2016-12-15 2023-01-27 タレンゲン インターナショナル リミテッド 肝の繊維化を予防及び治療するための方法
CA3067890A1 (en) 2017-06-19 2018-12-27 Talengen International Limited Method for regulating and controling glp-1/glp-1r and drug
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250694A1 (en) 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2010502600A (ja) 2006-08-28 2010-01-28 オムニオ・ヒーラー・アクチボラゲット 感染症に対する候補薬
JP2014530212A (ja) 2011-09-29 2014-11-17 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
MXPA04007585A (es) * 2002-02-06 2005-09-20 N Zyme Biotec Gmbh Metodo para la produccion de proteinas recombinantes en microorganismos.
JP2006507297A (ja) * 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
EP1569899B1 (en) * 2002-12-10 2006-06-28 Wyeth Substituted 3-alkyl- and 3-arylalkyl-1h-indol-1-yl-acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
WO2006023864A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as pai-1 inhibitors
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
ES2516717T3 (es) * 2009-05-26 2014-10-31 Universidad De Salamanca Proteína activadora de GM2 en orina como marcador de fallo renal agudo o de riesgo de desarrollar fallo renal agudo
NZ597452A (en) * 2009-07-10 2013-10-25 Thrombogenics Nv Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
CA2823491A1 (en) * 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
BR112016002753A2 (pt) * 2013-08-13 2017-11-21 Sanofi Sa anticorpos contra o inibidor-1 de ativador de plasminogênio (pai-1) e usos dos mesmos
MX2016010852A (es) * 2014-02-21 2016-10-26 Astellas Pharma Inc Anticuerpo anti-inhibidor de activador de plasminogeno 1 (pai-1) humano novedoso.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050250694A1 (en) 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2010502600A (ja) 2006-08-28 2010-01-28 オムニオ・ヒーラー・アクチボラゲット 感染症に対する候補薬
JP2014530212A (ja) 2011-09-29 2014-11-17 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Heamostasis，1988年，Vol.18, Suppl.1，p.165-175
J. Am. Soc. Nephrol. (2010) vol.21, issue 12, p.2169-2179
J. Exp. Med. (1997) vol.185, no.5, p.963-968
血管と脈管，1981年，第１２巻、第４号，第４９３頁－第５０１頁

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JP2020502134A (ja) 2020-01-23
EP3556386A1 (en) 2019-10-23
CN110366427A (zh) 2019-10-22
US20190328848A1 (en) 2019-10-31
JP7242057B2 (ja) 2023-03-20
TWI642441B (zh) 2018-12-01
TW201822794A (zh) 2018-07-01
US20190343930A1 (en) 2019-11-14
WO2018107695A1 (zh) 2018-06-21
TW201822797A (zh) 2018-07-01
WO2018107699A1 (zh) 2018-06-21
TW202123962A (zh) 2021-07-01
TWI661838B (zh) 2019-06-11
JP2020502135A (ja) 2020-01-23
EP3556388A1 (en) 2019-10-23
CA3047170A1 (en) 2018-06-21
WO2018107700A1 (zh) 2018-06-21
EP3556386A4 (en) 2020-07-08
EP3556388A4 (en) 2020-07-08
CA3047171A1 (en) 2018-06-21
CN110167582A (zh) 2019-08-23
TW201822793A (zh) 2018-07-01

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