JP7182793B2 - 病理学的腎組織損傷を予防及び治療するための方法 - Google Patents

病理学的腎組織損傷を予防及び治療するための方法 Download PDF

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JP7182793B2
JP7182793B2 JP2019531809A JP2019531809A JP7182793B2 JP 7182793 B2 JP7182793 B2 JP 7182793B2 JP 2019531809 A JP2019531809 A JP 2019531809A JP 2019531809 A JP2019531809 A JP 2019531809A JP 7182793 B2 JP7182793 B2 JP 7182793B2
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plasminogen
renal
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mice
pbs
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JP2020502134A (ja
JP2020502134A5 (enExample
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季男 李
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Talengen International Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/484—Plasmin (3.4.21.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019531809A 2016-12-15 2017-06-19 病理学的腎組織損傷を予防及び治療するための方法 Active JP7182793B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2016110174 2016-12-15
CNPCT/CN2016/110174 2016-12-15
CN2016110169 2016-12-15
CNPCT/CN2016/110169 2016-12-15
PCT/CN2017/089060 WO2018107700A1 (zh) 2016-12-15 2017-06-19 一种预防和治疗病理性肾组织损伤的方法

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JP2020502134A JP2020502134A (ja) 2020-01-23
JP2020502134A5 JP2020502134A5 (enExample) 2020-07-30
JP7182793B2 true JP7182793B2 (ja) 2022-12-05

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JP2019531809A Active JP7182793B2 (ja) 2016-12-15 2017-06-19 病理学的腎組織損傷を予防及び治療するための方法
JP2019531812A Active JP7242057B2 (ja) 2016-12-15 2017-06-19 薬物性腎損傷を予防及び治療するための方法

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US (2) US20190328848A1 (enExample)
EP (2) EP3556386A4 (enExample)
JP (2) JP7182793B2 (enExample)
CN (2) CN110366427A (enExample)
CA (2) CA3047171A1 (enExample)
TW (4) TW202123962A (enExample)
WO (3) WO2018107700A1 (enExample)

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CN110114080A (zh) 2016-12-15 2019-08-09 泰伦基国际有限公司 一种预防和治疗皮肤纤维化的方法
TWI714862B (zh) 2017-06-19 2021-01-01 大陸商深圳瑞健生命科學硏究院有限公司 一種調控glp-1/glp-1r的方法和藥物
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

Citations (3)

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US20050250694A1 (en) 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2010502600A (ja) 2006-08-28 2010-01-28 オムニオ・ヒーラー・アクチボラゲット 感染症に対する候補薬
JP2014530212A (ja) 2011-09-29 2014-11-17 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法

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US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
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CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
MX9800684A (es) 1995-07-27 1998-04-30 Genentech Inc Formulacion de proteinas liofilizadas isotonicas estables.
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
EP1472346A2 (de) * 2002-02-06 2004-11-03 N-Zyme BioTec GmbH Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
JP2006507297A (ja) * 2002-05-13 2006-03-02 チルドレンズ・ホスピタル・ロサンジェルス ケロイドおよび他の皮膚または内部創傷または病変における異常瘢痕形成の処置および予防
ATE331708T1 (de) * 2002-12-10 2006-07-15 Wyeth Corp Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren
CA2577782A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as pai-1 inhibitors
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
CA2763496A1 (en) * 2009-05-26 2010-12-02 Yaremi Quiros Luis Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure
EP2451835A1 (en) * 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
ES2583082T3 (es) * 2011-01-05 2016-09-19 Thrombogenics N.V. Variantes de plasminógeno y plasmina
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US20050250694A1 (en) 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2010502600A (ja) 2006-08-28 2010-01-28 オムニオ・ヒーラー・アクチボラゲット 感染症に対する候補薬
JP2014530212A (ja) 2011-09-29 2014-11-17 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法

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Publication number Publication date
EP3556386A4 (en) 2020-07-08
TW201822793A (zh) 2018-07-01
WO2018107700A1 (zh) 2018-06-21
EP3556388A4 (en) 2020-07-08
CA3047171A1 (en) 2018-06-21
EP3556388A1 (en) 2019-10-23
US20190328848A1 (en) 2019-10-31
JP7242057B2 (ja) 2023-03-20
CN110366427A (zh) 2019-10-22
WO2018107699A1 (zh) 2018-06-21
TW201822797A (zh) 2018-07-01
JP2020502135A (ja) 2020-01-23
CN110167582A (zh) 2019-08-23
TWI661838B (zh) 2019-06-11
TW201822794A (zh) 2018-07-01
CA3047170A1 (en) 2018-06-21
JP2020502134A (ja) 2020-01-23
TWI642441B (zh) 2018-12-01
WO2018107695A1 (zh) 2018-06-21
US20190343930A1 (en) 2019-11-14
TW202123962A (zh) 2021-07-01
EP3556386A1 (en) 2019-10-23

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