TW201822797A - 一種預防和治療腎纖維化的方法 - Google Patents

一種預防和治療腎纖維化的方法 Download PDF

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Publication number
TW201822797A
TW201822797A TW106120455A TW106120455A TW201822797A TW 201822797 A TW201822797 A TW 201822797A TW 106120455 A TW106120455 A TW 106120455A TW 106120455 A TW106120455 A TW 106120455A TW 201822797 A TW201822797 A TW 201822797A
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TW
Taiwan
Prior art keywords
plasminogen
pro
gly
fibrosis
glu
Prior art date
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TW106120455A
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English (en)
Chinese (zh)
Inventor
李季男
Original Assignee
深圳瑞健生命科學研究院有限公司
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Publication of TW201822797A publication Critical patent/TW201822797A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW106120455A 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法 TW201822797A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
??PCT/CN2016/110169 2016-12-15
??PCT/CN2016/110174 2016-12-15
CN2016110169 2016-12-15
CN2016110174 2016-12-15

Publications (1)

Publication Number Publication Date
TW201822797A true TW201822797A (zh) 2018-07-01

Family

ID=62557856

Family Applications (4)

Application Number Title Priority Date Filing Date
TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Country Status (7)

Country Link
US (2) US20190343930A1 (enExample)
EP (2) EP3556388A4 (enExample)
JP (2) JP7182793B2 (enExample)
CN (2) CN110366427A (enExample)
CA (2) CA3047170A1 (enExample)
TW (4) TW201822797A (enExample)
WO (3) WO2018107699A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201822790A (zh) 2016-12-15 2018-07-01 大陸商深圳瑞健生命科學研究院有限公司 一種預防和治療皮膚纖維化的方法
DK3643321T3 (da) 2017-06-19 2025-08-18 Talengen Int Ltd Plasminogen til anvendelse i behandling af parkinsons og alzheimers sygdom
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

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CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
SI1516628T1 (sl) 1995-07-27 2013-10-30 Genentech, Inc. Stabilna izotonična liofilizirana proteinska formulacija
US7202066B2 (en) 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
CN1768138A (zh) * 2002-02-06 2006-05-03 N-酶生物技术有限公司 在微生物中生产重组蛋白质的方法
CN1668312A (zh) * 2002-05-13 2005-09-14 洛杉矶儿童医院 疤痕疙瘩和其它的皮肤或内部的创伤或损伤中异常疤痕形成的处理和抑制
ATE331708T1 (de) * 2002-12-10 2006-07-15 Wyeth Corp Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
AU2005277137A1 (en) * 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as PAI-1 inhibitors
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
DK2056864T3 (en) * 2006-08-28 2014-03-10 Omnio Healer Ab CANDIDATES AGAINST INFECTION
US20120129721A1 (en) * 2009-05-26 2012-05-24 Universidad De Salamanca Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure
WO2011004011A1 (en) * 2009-07-10 2011-01-13 Thrombogenics Nv Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
JP6085568B2 (ja) * 2011-01-05 2017-02-22 スロンボジェニックス・ナムローゼ・フェンノートシャップThromboGenics NV プラスミノーゲンおよびプラスミンの変異体
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
CN103987397A (zh) * 2011-09-29 2014-08-13 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
KR20160035077A (ko) 2013-08-13 2016-03-30 사노피 플라스미노겐 활성인자 저해제-1(pai-1)에 대한 항체 및 그의 용도
JP6512213B2 (ja) * 2014-02-21 2019-05-15 アステラス製薬株式会社 新規抗ヒトpai−1抗体

Also Published As

Publication number Publication date
EP3556386A1 (en) 2019-10-23
EP3556388A1 (en) 2019-10-23
JP7182793B2 (ja) 2022-12-05
US20190343930A1 (en) 2019-11-14
JP2020502135A (ja) 2020-01-23
CN110366427A (zh) 2019-10-22
EP3556388A4 (en) 2020-07-08
TWI642441B (zh) 2018-12-01
WO2018107695A1 (zh) 2018-06-21
JP2020502134A (ja) 2020-01-23
CN110167582A (zh) 2019-08-23
TWI661838B (zh) 2019-06-11
US20190328848A1 (en) 2019-10-31
EP3556386A4 (en) 2020-07-08
CA3047171A1 (en) 2018-06-21
WO2018107699A1 (zh) 2018-06-21
JP7242057B2 (ja) 2023-03-20
WO2018107700A1 (zh) 2018-06-21
TW202123962A (zh) 2021-07-01
CA3047170A1 (en) 2018-06-21
TW201822793A (zh) 2018-07-01
TW201822794A (zh) 2018-07-01

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