TW201822797A - 一種預防和治療腎纖維化的方法 - Google Patents

一種預防和治療腎纖維化的方法 Download PDF

Info

Publication number
TW201822797A
TW201822797A TW106120455A TW106120455A TW201822797A TW 201822797 A TW201822797 A TW 201822797A TW 106120455 A TW106120455 A TW 106120455A TW 106120455 A TW106120455 A TW 106120455A TW 201822797 A TW201822797 A TW 201822797A
Authority
TW
Taiwan
Prior art keywords
plasminogen
pro
gly
fibrosis
glu
Prior art date
Application number
TW106120455A
Other languages
English (en)
Chinese (zh)
Inventor
李季男
Original Assignee
深圳瑞健生命科學研究院有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳瑞健生命科學研究院有限公司 filed Critical 深圳瑞健生命科學研究院有限公司
Publication of TW201822797A publication Critical patent/TW201822797A/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW106120455A 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法 TW201822797A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2016110174 2016-12-15
??PCT/CN2016/110174 2016-12-15
CN2016110169 2016-12-15
??PCT/CN2016/110169 2016-12-15

Publications (1)

Publication Number Publication Date
TW201822797A true TW201822797A (zh) 2018-07-01

Family

ID=62557856

Family Applications (4)

Application Number Title Priority Date Filing Date
TW106120455A TW201822797A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
TW110102361A TW202123962A (zh) 2016-12-15 2017-06-19 一種預防和治療腎纖維化的方法
TW106120523A TWI661838B (zh) 2016-12-15 2017-06-20 一種預防和治療病理性腎組織損傷的方法
TW106120521A TWI642441B (zh) 2016-12-15 2017-06-20 一種預防和治療藥物性腎損傷的方法

Country Status (7)

Country Link
US (2) US20190343930A1 (enExample)
EP (2) EP3556386A4 (enExample)
JP (2) JP7182793B2 (enExample)
CN (2) CN110167582A (enExample)
CA (2) CA3047171A1 (enExample)
TW (4) TW201822797A (enExample)
WO (3) WO2018107699A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11219669B2 (en) 2016-12-15 2022-01-11 Talengen International Limited Method for preventing and treating liver fibrosis
US11938172B2 (en) 2017-06-19 2024-03-26 Talengen International Limited Method for regulating and controlling GLP-1/GLP-1R and drug
TWI868051B (zh) * 2017-06-23 2025-01-01 美商波麥堤克生物治療股份有限公司 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療
CN113456579B (zh) * 2021-07-12 2023-04-25 南开大学 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
CN87104683A (zh) * 1986-05-15 1988-12-21 埃默里大学 改善血纤维蛋白溶解作用的组合物
CA2226575C (en) 1995-07-27 2011-10-18 Genentech, Inc. Stabile isotonic lyophilized protein formulation
US7202066B2 (en) * 2002-01-29 2007-04-10 Carrington Laboratories, Inc. Combination of a growth factor and a protease enzyme
JP2005525798A (ja) * 2002-02-06 2005-09-02 トロムスドルフ ゲーエムベーハー ウント コー.カーゲー アルツナイミッテル 微生物内での組み換えタンパク質の生産方法
WO2004041155A2 (en) * 2002-05-13 2004-05-21 Children's Hospital Los Angeles Treatment and prevention of abnormal scar formation in keloids and other cutaneous or internal wounds or lesions
DK1569899T3 (da) * 2002-12-10 2006-10-23 Wyeth Corp Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1)
US20050250694A1 (en) * 2003-10-10 2005-11-10 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
JP2008510814A (ja) * 2004-08-23 2008-04-10 ワイス Pai−1阻害剤としてのピロロ−ナフチル酸
US8741260B2 (en) 2005-10-07 2014-06-03 Armagen Technologies, Inc. Fusion proteins for delivery of GDNF to the CNS
WO2008026999A2 (en) * 2006-08-28 2008-03-06 Omnio Healer Ab Candidates against infection
US20120129721A1 (en) * 2009-05-26 2012-05-24 Universidad De Salamanca Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure
EP2451835A1 (en) * 2009-07-10 2012-05-16 ThromboGenics N.V. Variants of plasminogen and plasmin
CN102121023B (zh) * 2010-12-22 2012-07-04 中山大学 突变型人纤溶酶原kringle5及其制备方法及应用
RU2604807C2 (ru) * 2011-01-05 2016-12-10 ТромбоДженикс НВ Варианты плазминогена и плазмина
CN102154253A (zh) 2011-01-06 2011-08-17 郑州大学 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途
WO2013049697A1 (en) * 2011-09-29 2013-04-04 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
EA033403B1 (ru) * 2013-08-13 2019-10-31 Sanofi Sa Антитела к ингибитору активатора плазминогена 1 (pai-1) и пути их применения
CA2939897A1 (en) * 2014-02-21 2015-08-27 Astellas Pharma Inc. New anti-human pai-1 antibody

Also Published As

Publication number Publication date
WO2018107699A1 (zh) 2018-06-21
WO2018107695A1 (zh) 2018-06-21
US20190343930A1 (en) 2019-11-14
EP3556388A1 (en) 2019-10-23
EP3556388A4 (en) 2020-07-08
TWI642441B (zh) 2018-12-01
WO2018107700A1 (zh) 2018-06-21
TW201822794A (zh) 2018-07-01
JP2020502134A (ja) 2020-01-23
JP7242057B2 (ja) 2023-03-20
CA3047171A1 (en) 2018-06-21
JP7182793B2 (ja) 2022-12-05
US20190328848A1 (en) 2019-10-31
CN110366427A (zh) 2019-10-22
TW202123962A (zh) 2021-07-01
TW201822793A (zh) 2018-07-01
CA3047170A1 (en) 2018-06-21
CN110167582A (zh) 2019-08-23
TWI661838B (zh) 2019-06-11
EP3556386A4 (en) 2020-07-08
JP2020502135A (ja) 2020-01-23
EP3556386A1 (en) 2019-10-23

Similar Documents

Publication Publication Date Title
TWI670075B (zh) 一種預防和治療肝纖維化的方法
HK1257585A1 (zh) 预防和治疗皮肤纤维化的药物及其用途
TW202123962A (zh) 一種預防和治療腎纖維化的方法
HK1257586A1 (zh) 预防和治疗肾纤维化的药物及其用途