TW202116312A - （ｓ）—３—胺基—６—甲氧基—ｎ—（３，３，３—三氟—２—羥基—２—甲基丙基）—５—（三氟甲基）吡啶甲醯胺配製物 - Google Patents

（ｓ）—３—胺基—６—甲氧基—ｎ—（３，３，３—三氟—２—羥基—２—甲基丙基）—５—（三氟甲基）吡啶甲醯胺配製物 Download PDF

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TW202116312A
TW202116312A TW109123960A TW109123960A TW202116312A TW 202116312 A TW202116312 A TW 202116312A TW 109123960 A TW109123960 A TW 109123960A TW 109123960 A TW109123960 A TW 109123960A TW 202116312 A TW202116312 A TW 202116312A
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TW
Taiwan
Prior art keywords
pharmaceutical composition
trifluoro
compound
amino
methoxy
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TW109123960A
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English (en)
Chinese (zh)
Inventor
維維克 度貝
羅伊特 洛瓦雷克
保羅 桑托斯
忽柏特 湯瑪
賢斌 田
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瑞士商諾華公司
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Publication of TW202116312A publication Critical patent/TW202116312A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C—CHEMISTRY; METALLURGY
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
TW109123960A 2019-07-15 2020-07-15 （ｓ）—３—胺基—６—甲氧基—ｎ—（３，３，３—三氟—２—羥基—２—甲基丙基）—５—（三氟甲基）吡啶甲醯胺配製物 TW202116312A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201911028435 2019-07-15
IN201911028435 2019-07-15
IN202011023329 2020-06-03
IN202011023329 2020-06-03

Publications (1)

Publication Number Publication Date
TW202116312A true TW202116312A (zh) 2021-05-01

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TW109123960A TW202116312A (zh) 2019-07-15 2020-07-15 （ｓ）—３—胺基—６—甲氧基—ｎ—（３，３，３—三氟—２—羥基—２—甲基丙基）—５—（三氟甲基）吡啶甲醯胺配製物

Country Status (13)

Country Link
US (1) US11865109B2 (https=)
EP (1) EP3999063A1 (https=)
JP (1) JP2022541178A (https=)
KR (1) KR20220035421A (https=)
CN (1) CN114007616A (https=)
AU (1) AU2020313422A1 (https=)
BR (1) BR112022000507A2 (https=)
CA (1) CA3143431A1 (https=)
CL (1) CL2022000079A1 (https=)
IL (1) IL288577A (https=)
MX (1) MX2022000549A (https=)
TW (1) TW202116312A (https=)
WO (1) WO2021009695A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023109939A1 (zh) * 2021-12-17 2023-06-22 苏州晶云药物科技股份有限公司 吡啶类衍生物的晶型及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
EA029416B1 (ru) * 2010-06-21 2018-03-30 Заклады Фармацеутицне Польфарма Са Таблетка, содержащая иматиниб или его фармацевтически приемлемую соль, и способ ее получения
ES2952878T3 (es) * 2016-08-08 2023-11-06 Hetero Labs Ltd Una composición antirretroviral multiclase
AU2017362350B2 (en) 2016-11-18 2021-12-23 Cystic Fibrosis Foundation Pyrrolopyrimidines as CFTR potentiators
US10131670B2 (en) 2016-12-16 2018-11-20 Cystic Fibrosis Foundation Therapeutics, Inc. Bicyclic heteroaryl derivatives as CFTR potentiators
US10633341B2 (en) 2016-12-19 2020-04-28 Novartis Ag Picolinic acid derivatives and their use as intermediates

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WO2021009695A1 (en) 2021-01-21
JP2022541178A (ja) 2022-09-22
IL288577A (en) 2022-02-01
US20210015804A1 (en) 2021-01-21
BR112022000507A2 (pt) 2022-05-10
CA3143431A1 (en) 2021-01-21
AU2020313422A1 (en) 2022-01-27
US11865109B2 (en) 2024-01-09
MX2022000549A (es) 2022-02-10
KR20220035421A (ko) 2022-03-22
CL2022000079A1 (es) 2022-11-11
EP3999063A1 (en) 2022-05-25
CN114007616A (zh) 2022-02-01

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