TW202114619A - Skin-cleansing spray - Google Patents

Abstract

The purpose of the present invention is to provide a skin-cleansing composition that is used via a different method than in the prior art. A skin-cleansing spray that is housed in a sprayer container and contains (A) a natural surfactant and (B) an amphipathic ester, the (A) content thereof being 0.025-2% by weight, wherein the skin-cleansing composition is capable of exerting superior cleansing power while having reduced skin irritancy, thus making it possible to provide a novel method of use wherein the skin-cleansing composition is applied by being sprayed directly onto the skin, unlike in the prior art in which foaming is performed before application to the skin.

Description

Spray for skin cleansing

The present invention relates to a spray for skin cleansing used by spraying directly on the skin.

As products for the purpose of cleansing and keeping the skin clean, various skin cleansing compositions such as facial cleanser, body soap, and shampoo are provided. In the mechanism of skin cleansing composition to clean the skin, the surfactant adsorbs on the dirt to reduce the surface tension between the dirt and water, and also cooperates with the mechanical force generated by friction to float the dirt in the water. In order for this cleaning mechanism to work effectively, it is necessary to formulate a surfactant above the critical micelle concentration.

On the other hand, the cleansing power by the surfactant is too strong to cause skin irritation, and as a result, there is also the current status of causing skin problems such as dry skin. Therefore, for the purpose of making the effect on the skin mild, various formulations such as combinations or blending amounts of designed cleansing ingredients have been proposed. Among them, it is understood that the foam formed during cleansing reduces friction caused by direct contact between the skin and the fingers. Therefore, formulas that improve foam quality such as bubble strength and foam retention are generally excellent as formulas that mildly affect the skin.

Therefore, in recent years, various pump foamer-type skin cleansing materials have been proposed, which not only can easily obtain high-quality foam, but also the gentleness of the skin has attracted much attention. Specifically, Patent Document 1 discloses a liquid skin cleansing agent product, which includes a bubbler container and a liquid skin cleansing composition filled in the bubbler container, and the liquid skin cleansing agent The composition contains: (A) 3%-10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group with 7 to 21 carbon atoms, and (B) a specific dimethyl diallyl chloride The mass ratio (A)/(B) of the copolymer of ammonium, acrylic acid and/or acrylamide, and (C) sugar alcohol, the content of (A) component and the content of (B) component is 20-250. In addition, Patent Document 2 discloses a skin cleansing composition characterized in that a cleansing agent is filled in a bubbler container, and the cleansing agent contains: (a) 2% to 9% by mass of fatty acid salt, ( b) 0.5% to 4% by mass of lauryl dimethyl amino betaine, and (c) 1% to 10% by mass of one or more diols, and (a) component and (b) The sum (a)+(b) of the blending amounts (mass%) of the components is 3% by mass to 10% by mass, and the blending amount ratio (b)/(a) is 0.1 to 0.5. Furthermore, Patent Document 3 discloses a cleaning material composition which is sprayed from a bubbler container and contains (a) lauryl dimethyl amino acetic acid betaine and (b) a fatty acid composed of 5 to 25 carbon atoms. A higher fatty acid soap of a specific composition is formed from 4% to 15% by mass.

On the other hand, there is also known a cleaning agent composition that uses a biodegradable natural surfactant in consideration of environmental load. For example, Patent Document 4 discloses a cleaning agent composition, wherein natural surfactant 11 parts by weight to 45 parts by weight, mirabilite 25 parts by weight to 35 parts by weight, hard water softener 10 parts by weight to 40 parts by weight, chelating agent 0.1 Parts by weight to 5 parts by weight and remaining additional cleaning agent raw materials total 100 parts by weight. [Prior Art Literature] [Patent Literature]

[Patent Document 1] International Publication No. 2014/003114 [Patent Document 2] Japanese Patent Laid-Open No. 2016-098182 [Patent Document 3] International Publication No. 2017/081897 [Patent Document 4] Japanese Patent Laid-Open No. 2014-051544

[The problem to be solved by the invention] The blending amount of the surfactant in the pump-type foamer type skin cleansing composition is relatively small. In terms of the above-mentioned aspect, it is considered that compared with the solid or semi-solid skin cleansing composition, it is more effective on the skin. Tendency to decrease stimulus. On the other hand, the pump foamer type skin cleansing composition is based on the premise that it is sprayed in a foamed state, so it is inevitable in its composition to formulate the minimum surfactant required to exert the foaming power. .

In addition, in addition to skin cleansing materials for the purpose of removing makeup (cleansing), various skin cleansing materials for the purpose of removing body fluids such as sebum or sweat or dirt are created, but include pump-type aerator-type skin cleansing Any skin cleansing materials including natural surfactants and skin cleansing materials are no exception. They will foam before being applied to the skin. In addition, it is better to reduce friction on the skin. It has become common sense to foam sufficiently before washing. Although the foam can relax the physical friction between the skin and the hand, the foam itself will rub the skin, so it will still produce physical friction and cause irritation to the skin. In this way, the same method of use as in the past has a limit in reducing the burden of the skin cleanser on the skin.

Therefore, the object of the present invention is to provide a skin cleansing composition used in different existing methods. [Means to solve the problem]

In order to further reduce the irritation to the skin, the inventors thought of a new application, namely, to directly spray the skin cleanser composition and apply it to the skin, instead of pre-foaming when applied to the skin. In addition, in order to further reduce the irritation to the skin, natural-derived surfactants are blended, and the blending amount is significantly reduced compared to the blending amount contained in the conventional skin cleansing composition. Regarding such a skin cleansing composition containing only a very small amount of surfactant, it has been found that the cleansing power cannot be obtained in order to reduce the irritation to the skin. However, the coexistence of amphiphilic esters makes it effective even without pre-foaming. Obtain cleaning power. The present invention is based on the above-mentioned knowledge and completed by further repeated research.

That is, the present invention provides inventions in the aspects disclosed below. Item 1. A spray for skin cleansing, comprising (A) a natural-derived surfactant and (B) an amphiphilic ester, the content of (A) is 0.025% by weight to 2% by weight, and the skin The cleaning spray is contained in a spray container. Item 2. The spray for skin cleansing according to Item 1, wherein the spray container is a pump spray container. Item 3. The spray for skin cleansing according to Item 1, wherein the spray container is an aerosol spray container. Item 4. The skin cleansing spray according to any one of items 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins, and lipopeptides. Item 5. The spray for skin cleansing according to Item 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin. Item 6. The spray for skin cleansing according to Item 4, wherein the lipopeptide is selected from the group consisting of surfactin and its salt. Item 7. The spray for skin cleansing according to any one of items 1 to 6, wherein the component (B) is selected from dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, dicarboxylic acid Dialkoxy alkyl esters, and (eicosandioic acid/tetradecanedioic acid) polyglycerol-10 esters. Item 8. The spray for skin cleansing according to Item 7, wherein the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydi Glycol esters. [Effects of the invention]

According to the present invention, it is possible to reduce the skin irritation of the skin cleansing material composition while exhibiting excellent cleansing power. Therefore, unlike the existing application of pre-foaming when applied to the skin, the skin cleansing material composition can be sprayed and sprayed directly. Suitable for new uses on the skin. Since it can be cleaned beforehand without foaming, it is possible to greatly reduce the blending amount of the surfactant in the skin cleansing liquid composition compared with the blending amount contained in the conventional skin cleansing liquid composition, thereby also Can further reduce skin irritation.

The spray for skin cleansing of the present invention is characterized by containing a predetermined amount of (A) a natural-derived surfactant (hereinafter, sometimes expressed as (A) component) and (B) an amphiphilic ester (hereinafter, there are It is expressed as (B) component) and stored in a spray container. Hereinafter, the spray for skin cleansing of the present invention will be described in detail.

(A) Surfactant of natural origin The spray for skin cleansing of the present invention contains a natural-derived surfactant as the (A) component. Natural-derived surfactants are substances that are biologically originated and have interfacial activity.

The natural-derived surfactant used in the present invention is not particularly limited. Examples include: natural products extracted and refined from animals, plants, or microorganisms; these natural products are cultivated and synthesized in a microbiological manner. Those who are successful, those who are synthesized by genetic engineering, and those who are chemically synthesized; those who have undergone treatments such as hydrogenation treatment, hydrogenation treatment, and hydrolysis treatment, etc.

Examples of natural-derived surfactants used in the present invention include phospholipids, saponins, lipopeptides, cholesterol, bile acids, and the like. These natural-derived surfactants can be used alone or in combination of two or more. Among these natural-derived surfactants, preferably phospholipids, saponins, and lipopeptides can be cited.

Examples of the phospholipid include glycerophospholipid, sphingomyelin, and the like. The glycerophospholipid is a substance having a glycerophosphoric acid skeleton and having fatty acid esters, long-chain alkyl ethers, vinyl ethers, and the like as lipophilic groups. Specific examples of glycerophospholipids include: phospholipid choline (lecithin), phospholipid ethanolamine, phospholipid serine, phospholipid inositol, phospholipid inositol polyphosphate, diphospholipid glycerol (cardiolipin ( cardiolipin)), phosphatidic acid, and these hydrogenated products, hydrogenated products, and hydrolyzed products. Sphingosine-phospholipids are phosphoric acid or phosphonic acid derivatives of long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine. Specific examples of sphingomyelin include ceramide 1-phosphoric acid derivatives (sphingomyelin, etc.) and ceramide 1-phosphonic acid derivatives (sphingomyelin, etc.). One kind of these phospholipids may be used alone, or two or more kinds may be used in combination.

Among these phospholipids, glycerophospholipids are preferred, lecithin (soy lecithin, egg yolk lecithin), hydrogenated lecithin, hydroxide lecithin, and lysolecithin are more preferred, and lecithin is more preferred. Examples include lecithin (soy lecithin, egg yolk lecithin, etc.), hydrogenated lecithin, and lysolecithin. In addition, from the viewpoint of obtaining more excellent cleaning power, it is preferable to include lecithin (soy lecithin, egg yolk lecithin, etc.) and lysolecithin to further suppress skin irritation and tightness caused by insufficient moisture retention. From the viewpoint of sensation, preferably, hydrogenated lecithin is used.

Saponins are glycosides containing sapogenins and sugars, and specific examples include triterpene glycosides and steroid glycosides. Specific examples of the saponins include Quercus saponins, soybean saponins, yucca saponins, sophora saponins, beets saponins, red bean saponins, carrot saponins, tea saponins, loofah saponins, and asiatic saponins. These saponins may be used individually by 1 type, and may be used in combination of 2 or more types.

Lipopeptides are lipidated peptides, and specific examples include surfactin, arthrofactin, iturin, and salts of these. One kind of these lipopeptides may be used alone, or two or more kinds may be used in combination.

Among these lipopeptides, surfactants and their salts are preferred, and surfactants are more preferred. The salt of surfactant is a compound represented by the following formula (I).

[化1]

In the formula (I), X represents an amino acid residue selected from leucine, isoleucine and valine, R represents a C _9-18 alkyl group, and M ⁺ represents an alkali metal ion or a quaternary ammonium ion. It does not specifically limit as an alkali metal ion, A lithium ion, a sodium ion, a potassium ion, etc. are mentioned, Preferably, a sodium ion is mentioned. Examples of the substituent of the quaternary ammonium ion include alkyl groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, and tertiary butyl; benzyl, methylbenzyl, phenylethyl Aralkyl groups such as phenyl groups; organic groups such as aryl groups such as phenyl, tolyl and xylyl groups. These surfactants or their salts may be used alone or in combination of two or more kinds.

The content of the (A) component in the spray for skin cleansing of the present invention is 0.025% by weight to 2% by weight. By such a small amount of the interface active dose, the skin irritation can be reduced in each section. In the present invention, by coexisting with the component (B), excellent cleaning power can be exhibited. Therefore, even a small amount of surfactant dose that cannot exhibit effective cleaning power can effectively exhibit cleaning power.

As a preferable content of the component (A), for example, from the viewpoint of obtaining a more excellent cleaning power, 0.5% by weight to 2% by weight, more preferably 1% by weight to 2% by weight, are further suppressed by moisturizing. From the viewpoint of the tightness caused by insufficient, 0.025% by weight to 1.5% by weight, and more preferably 0.025% by weight to 1% by weight. Furthermore, when the component (A) is lecithin or lysolecithin, from the viewpoint of obtaining more excellent cleaning power, 0.5% to 2% by weight can be cited, which further suppresses the tightness caused by insufficient moisture retention From the viewpoint of sensation, 0.025% by weight to 1% by weight is exemplified, and from the viewpoint of further suppressing skin irritation, 0.025% by weight to 1.5% by weight is exemplified. When the (A) component is a saponin, from the viewpoint of obtaining more excellent cleaning power, 1% by weight to 2% by weight can be cited.

(B) Amphiphilic ester The spray for skin cleansing of the present invention contains an amphiphilic ester as the (B) component. Although component (B) alone does not exhibit a cleansing effect, coexistence with 0.025% to 2% by weight of component (A) can improve the cleansing power of the spray for skin cleansing while maintaining low irritation.

In the present invention, the amphiphilic ester is measured by the method specified in the General Test Method of the Japanese Pharmacopoeia, and dissolved in an ion exchange with a conductivity of 70 μs/m to 110 μs/m at room temperature at a level of 2% by mass or more. In water and in isononanoic acid isotridecanyl ester (manufactured by Nisshin OilliO Group, Salacos 913) as an oil agent, also at room temperature (25°C) Dissolves more than 10% by mass, except for ester-based surfactants.

The amphiphilic ester is not particularly limited, but from the viewpoint of obtaining better skin irritation reduction and cleansing power, it is preferably selected from dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters, Dialkoxyalkyl dicarboxylic acid esters, and (eicosandioic acid/tetradecanedioic acid) polyglycerol-10 esters. As the amphiphilic ester, bis(polyoxyalkylene alkyl ether) dicarboxylic acid, dialkoxyalkyl dicarboxylic acid, and (eicosanedioic acid/tetradecanedioic acid) can be used alone. ) Any one of polyglycerol-10 esters, or two or more of them can be used in combination. Among these amphiphilic esters, from the viewpoint of further suppressing the tightness caused by insufficient moisture retention, dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is more preferable.

The dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of dicarboxylic acid and polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester include, for example, oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, and glutaric acid. Diacid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetone dicarboxylic acid, phthalic acid, cyclohexane-1,4 -Dicarboxylic acids and the like. In addition, as the polyoxyalkylene alkyl ether constituting the diester compound, for example, polyoxyethylene monoalkyl ether and the like can be cited. More specifically, for example, diethylene glycol monoethyl ether and triethylene glycol can be cited. Monoethyl ether and so on.

Among these dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters, from the viewpoint of obtaining better skin irritation reduction and cleansing power, preferably cyclohexane-1,4-di A diester compound of carboxylic acid and diethylene glycol monoethyl ether, specifically INCI name (International Cosmetic Ingredient Dictionary and Handbook), 13th Edition, Volume 1, CTFA, 2010, p. 331): Bis-ethoxydiethylene glycol cyclohexane 1,4-dicarboxylate (BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATE) is called cyclohexane-1,4-dicarboxylic acid bis Ethoxydiglycol ester compounds, and succinic acid and diethylene glycol monoethyl ether diester compounds, specifically, INCI name (International Cosmetic Ingredient Dictionary and Handbook), 13th edition , Volume 1, CTFA, 2010, p.331-332): Bis-ethoxydiglycol succinate (BIS-ETHOXYDIGLYCOL SUCCINATE) is called bisethoxydiglycol succinate Compound.

In addition, in the present invention, as a specific example of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol ester, for example, "Neosolue-Aqulio (commercial product) manufactured by Nippon Seika Co., Ltd. Name)” and so on. In addition, as a specific example of the succinic acid bisethoxydiglycol ester, for example, "Haiaqueouster DCS (trade name)" manufactured by Advanced Alcohol Industry Co., Ltd. can be cited.

These dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more kinds.

Among these dicarboxylic acid bis(polyoxyalkylene alkyl ether) esters, especially when hydrogenated lecithin or lipopeptide is used as component (A), the tightness caused by insufficient moisture retention is further suppressed From the viewpoint of, it is preferable to use cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol ester.

The dialkoxyalkyl dicarboxylic acid used in the present invention is a diester compound of dicarboxylic acid and alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound of the dialkoxyalkyl dicarboxylic acid include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, and adipic acid. Acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetone dicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid, etc. . Moreover, as an alkoxy alcohol which comprises a diester compound, 2-methoxyethanol, 2-ethoxyethanol, etc. are mentioned, for example.

Among these dialkoxyalkyl dicarboxylic acid esters, from the viewpoint of obtaining better skin irritation reduction and cleansing power, a diester compound of succinic acid and 2-ethoxyethanol is preferred Specific examples include diethoxyethyl succinate.

These dialkoxyalkyl dicarboxylic acid esters may be used individually by 1 type, and may be used in combination of 2 or more types.

The (eicosanedioic acid/tetradecanedioic acid) polyglycerol-10 ester used in the present invention is not particularly limited. For example, "Neosolue-Aqua (trade name) manufactured by Nippon Seiki Co., Ltd." ", "Neosolue-AquaS (trade name)", etc.

The content of the component (B) in the spray for skin cleansing of the present invention is not particularly limited, and for example, it can be 0.1% by weight or more. From the viewpoint of obtaining a better cleaning power and/or the viewpoint of further reducing the tightness caused by insufficient moisture retention, the content of the component (B) is preferably 0.5% by weight or more, and more preferably 1.5 % By weight or more, more preferably 2% by weight or more. (B) The upper limit of the content range of the component is not particularly limited. From the viewpoint of the stability of the spray for skin cleansing, for example, 5 wt% or less, preferably 4 wt% or less, more preferably 3 wt% the following.

In the skin cleansing spray of the present invention, the ratio of the (A) component to the (B) component is not particularly limited, and is determined by the respective contents, but from the viewpoint of obtaining better skin irritation reduction and cleansing power In other words, the amount of (B) component is, for example, 0.1 part by weight to 100 parts by weight, and preferably 1 part by weight to 80 parts by weight with respect to 1 part by weight of (A) component. In addition, from the viewpoint of obtaining more excellent cleaning power, the following can be cited: 1 part by weight to 4 parts by weight of component (B), and more preferably 1 part by weight to 2 parts by weight relative to 1 part by weight of component (A) From the viewpoint of further suppressing the tightness caused by insufficient moisture retention, 1.2 parts by weight to 80 parts by weight, more preferably 2 parts by weight to 80 parts by weight. Furthermore, when the component (A) is lecithin or lysolecithin, from the viewpoint of obtaining a more excellent cleaning power, the component (B) is 1 part by weight relative to 1 part by weight of the component (A). ~4 parts by weight, from the viewpoint of further suppressing the tightness caused by insufficient moisturizing, it can be mentioned that relative to 1 part by weight of (A) component and 2 parts by weight to 80 parts by weight of (B) component, the skin is further suppressed From the viewpoint of irritation, the (B) component is 1.2 parts by weight to 80 parts by weight with respect to 1 part by weight of the (A) component. When the (A) component is a saponin, from the viewpoint of obtaining more excellent cleaning power, the (B) component is 1 part by weight to 2 parts by weight with respect to 1 part by weight of the (A) component.

Other ingredients In the spray for skin cleansing of the present invention, in addition to the above-mentioned components, other bases or additives required for formulation and the like may be contained within a range that does not impair the effects of the present invention. There are no particular restrictions on such additives as long as they are pharmaceutically acceptable. Examples include water, lower alcohols with 1 to 5 carbon atoms (ethanol, isopropanol, etc.), and polyhydric alcohols (ethylene glycol, 1, 3-Butanediol (BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin, etc.) and other aqueous bases; preservatives (phenoxyethanol, methyl paraben Ester, propyl p-hydroxybenzoate, benzoic acid, sodium benzoate, sorbic acid, etc.), flavoring agents (citral, 1,8-cineole, citronellal, bacteriochloroenol ( farnesol), coloring agents (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.), cocoa pigments, chlorophyll, alumina, etc.), thickeners (hydroxypropyl cellulose, hydroxyl Ethyl cellulose, cross-linked acrylic polymer, carboxyvinyl polymer, hypromellose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, sodium carboxymethyl cellulose , Sanxian gum, carrageenan, etc.), pH adjusters (phosphoric acid, hydrochloric acid, citric acid, sodium citrate (trisodium citrate), succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropyl Alcoholamine, etc.), wetting agent (dl-pyrrolidone carboxylate sodium solution, D-sorbitol solution, polyethylene glycol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, Sodium edetic acid, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite , Sulfur dioxide, chlorogenic acid, catechins, rosemary extract, etc.), antioxidants, ultraviolet absorbers, chelating agents, adhesives, buffers, dissolution aids, solubilizers, preservatives, etc. additive. One kind of these base materials or additives may be used alone, or two or more kinds may be used in combination. The content of these base materials or additives can be appropriately set according to the form of the formulation and the like.

In the spray for skin cleansing of the present invention, in addition to the above-mentioned ingredients, other pharmacological ingredients may be contained as needed within a range that does not impair the effects of the present invention. Examples of such pharmacological ingredients include vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, tobacco Alkali acids, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, etc.) Tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, meprylcaine or these salts, O-Caine, oxethazaine, oxidized polyethoxydecane, scopolia extract, percaminpase, polyoxyethylene lauryl ether (Thesit Desitin, etc.), anti- Inflammatory agents (indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protectants (collodion, castor oil, etc.), blood circulation promoters (pelargonic acid) Vanillamide, benzyl nicotinate, capsaicin, pepper extract, etc.), cooling agents (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, etc.) Hyaluronic acid, cationized hyaluronic acid (hyaluronic acid dihydroxypropyl triammonium etc.) etc.). These pharmacological ingredients may be used alone or in combination of two or more. When these pharmacological ingredients are contained, the content thereof may be appropriately set according to the type of pharmacological ingredient used, the expected effect, and the like.

form The form of the spray for skin cleansing of the present invention is liquid or gel at normal temperature. In addition, as the viscosity of the spray for skin cleansing of the present invention, it is 10,000 mPa·s or less at 20°C, preferably 5,000 mPa·s or less. In addition, the viscosity is a value measured with a BL viscometer (rotor No. 3, 6 rpm, 20°C).

container There are no particular limitations on the container containing the spray for skin cleansing of the present invention as long as it is a spray-type container. Furthermore, the spray-type container in the present invention sprays the contents in a mist state, and is different from a pump-type foamer container in which the skin cleansing composition is sprayed in a foam state.

In the present invention, by storing the spray for skin cleansing in a spray-type container in the manner described above, the spray for skin cleansing is directly applied to the skin by the spray instead of being applied to the skin before foaming. Therefore, application to the skin is simple, and physical friction caused by hands etc. during application can be avoided. As the spray type container, a pump type spray container which is a non-aerosol type spray container, and an aerosol type spray container are mentioned. As the diameter of the spray container (the inner diameter of the nozzle), for example, 0.01 mmϕ to 3 mmϕ, preferably 0.1 mmϕ to 1 mmϕ. As the spray amount per press when the spray container is a pump spray container, for example, 0.05 g to 1.2 g, preferably 0.1 g to 0.3 g.

use The spray for skin cleansing of the present invention is used to remove body fluids such as oils, sweat, or dirt from the skin, and is not used for makeup removal (cleansing). The spray for skin cleansing of the present invention can be directly applied to the skin for use when it is unfavorable to be diluted with water and does not foam. Although the amount used per time depends on the concentration of the surfactant and the degree of soiling, for example, in the case of washing the face, it can be 0.5 g to 3 g, preferably 1 g to 2 g.

More specifically, the spray for skin cleansing can be applied directly from a spray-type container to the area to be cleaned by spraying without holding the spray for skin cleansing by hand. By directly applying the spray for skin cleansing to the cleansing target area in the manner described above, it is possible to avoid friction between the skin and hands of the cleansing area or the skin and air bubbles at the cleansing area. In the case of physical friction such as friction, only the mechanical force of the liquid flow is used for cleaning. The spray for skin cleansing of the present invention is a formula with excellent cleansing power. Therefore, by using the mechanical force of the liquid flow to cleanse without causing physical friction in the manner described above, the burden on the skin is significantly reduced during cleansing, and it can be realized An extremely excellent cleaning method. The non-foaming cleaning method can realize quick cleaning, has less surfactants, and is easy to experience softness to the skin, and consumers who are highly conscious of pursuing gentle cleansing of the skin can easily obtain a sense of satisfaction. In addition, the spray for skin cleansing of the present invention is particularly suitable for the above-mentioned cleansing method that does not cause physical friction on the skin, but it does not rule out that the spray for skin cleansing is applied to the area to be cleaned and then rubbed with hands. Instructions.

The cleansing target part of the spray for skin cleansing of the present invention is not particularly limited because it can clean all body parts, and examples thereof include hands, hair, scalp, body, and face. Since the spray for skin cleansing of the present invention is sprayed onto the area to be cleaned, it is suitable for hair, scalp, and body from the viewpoint of ease of application. In addition, the spray for skin cleansing of the present invention can exhibit excellent cleansing power without foaming in advance, so it is suitable for use on faces that are sensitive to irritation.

After cleansing, the spray for skin cleansing can be rinsed with water. In the case of washing with water, it is sufficient to perform the same as a normal face washing. However, from the viewpoint of reducing the burden on the skin, it is preferable to use the mechanical force of the water stream to wash so as not to cause friction by the hands.

In addition, the spray for skin cleansing of the present invention can make the concentration of the surfactant extremely low, and therefore, in the above-mentioned case, it may not be rinsed after cleansing. Therefore, the spray for skin cleansing of the present invention is also suitable for cleansing applications in hospitals, facial cleansing operations such as facial cleansing in beauty salons and beauty salons, and disaster supplies. Without rinsing, you can also use absorbent substrates such as towels or paper towels to absorb and remove the residual skin cleansing spray on the cleaned area.

Production method The spray for skin cleansing of the present invention is manufactured by mixing the above-mentioned (A) component and (B) component, and other components if necessary, and preparing it into a predetermined form, and storing it in a spray container. . When it is stored in an aerosol spray container which is a spray container, it is stored and manufactured together with aerosol such as gas. [Example]

Examples are shown below to explain the present invention more specifically, but the present invention is not limited to these.

Test example The spray for skin cleansing having the composition shown in Table 1 to Table 4 was prepared. The details of each component shown in Table 1 to Table 4 are as follows. In addition, the skin cleansing sprays shown in Tables 1 to 4 are in liquid form, and the viscosity at 20°C (using BL viscometer (B type viscometer manufactured by Brookfield) rotor No. 3, 6 rpm Measurement) are in the range of 5000 mPa·s or less. · Lysolecithin: Lysolecithin Concord (manufactured by Concord Fermentation) Lecithin: Basis LP-20 (manufactured by Nisshin OilliO) ·Hydrogenated Lecithin: Basis LP-20H (manufactured by Nisshin OilliO) ·Saponins: Soap fruit extract powder (manufactured by Ichimaru pharcos) (saponins content 20% by weight) · Surfactin sodium: Kaneka Surfactin (manufactured by Kaneka) ·Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol ester ("Neosolue-Aqulio (trade name)" manufactured by Nippon Seiki Co., Ltd.) ·Diethylene glycol succinate (“Haiaqueouster DCS (trade name)” manufactured by Advanced Alcohol Industry Co., Ltd.)

＜Evaluation of cleaning power＞ With respect to the prepared spray for skin cleansing, 10 panelists specialized in cosmetic evaluation evaluated cleansing power. Specifically, each skin cleansing spray is stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by Takemoto Container Co., Ltd.) (the spray volume per press is 0.15 g), Apply by spraying 1.5 g directly onto the face. Leave it for about 5 seconds, and then rinse with water to prevent your hands from touching your face. After pressing the face with a towel to absorb water, sensory evaluation of the skin's feeling of falling off dirt was scored based on the following indicators.

5 points: Really feel the dirt coming off 4 points: Feeling of dirt falling off 3 points: none of the above 2 points: I don't feel that the dirt comes off 1 point: no dirt peeling off at all

A total of 10 sensory inspectors obtained points, and the degree of cleaning power was evaluated by the following classification. The results are shown in Tables 1 to 4. ◎: 45 points or more ○: 40 points or more but less than 45 points △: 35 points or more but less than 40 points ×: less than 35 points

＜Tightness evaluation＞ The skin cleansing spray prepared was evaluated for tightness by 10 panelists specialized in cosmetic evaluation. Specifically, each skin cleansing spray is stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by Takemoto Container Co., Ltd.) (the spray volume per press is 0.15 g), Apply by spraying 1.5 g directly onto the face. Leave it for about 5 seconds, and then rinse with water to prevent your hands from touching your face. After pressing the face with a towel to absorb water, sensory evaluation of tightness was performed based on the following indicators to score. The stronger the tightness, the less moisturizing.

5 points: no tightness at all 4 points: almost no tightness 3 points: Only a little tightness is felt 2 points: I feel tightness 1 point: strong feeling of tightness

A total of the scores obtained by 10 sensory examiners are evaluated by the following classifications to evaluate the degree of tightness. The results are shown in Tables 3 to 4. ◎: 45 points or more ○: 40 points or more but less than 45 points △: 35 points or more but less than 40 points ×: less than 35 points

<Cultivated epidermal skin irritation test (in vitro evaluation of skin irritation)> The prepared skin cleansing spray was subjected to a cultured epidermal skin irritation test as follows. 1. Preparation of the culture epidermal model LabCyte EPI-MODEL24. Heat the analysis medium and add 0.5 mL each to the 24-well analysis plate. Transfer the cultured epidermal model LabCyte EPI-MODEL24 (batch number: LCE24-180226-A) to a 24-well analysis plate supplemented with analysis medium. Confirm that there are no bubbles on the bottom of the culture cup, and place it in a CO ₂ incubator for more than 1 hour until the tested substance is exposed.

2. Application and cleaning of the tested substance 12 of the 24 epidermal models were used (the rest were cultured until the formal test). Take out the 24-well analysis plate from the CO _{2 incubator.} Heat the analysis medium, and add 1.0 mL each to the third column of the 24-well analysis plate. Without using a pump spray container, drop 25 μL of the test substance (spray for each skin cleansing) into the culture epidermis of the culture cup to spread the whole and expose it. After 1 minute, 5 minutes, and 10 minutes after exposure, aspirate and remove the tested substance, wash the cultured epidermal model in the cup with phosphate buffer saline (PBS), and move it to the third column of the 24-well analysis plate .

3.MTT test The MTT test is the following method: For MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (3-(4,5) taken into the cell -dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)] The formazan pigment produced by the reduction of mitochondrial dehydrogenase in the cell is extracted with an organic solvent and the absorbance at 570 nm is measured. To measure the rate of viable cells.

Prepare 10 mL of MTT medium at a final concentration of 0.5 mg/mL. Heat the MTT medium and add 0.5 mL each to the fourth column of the 24-well analysis plate. Move the cultured epidermal model to the fourth column of the 24-well analysis plate and put it in the CO ₂ incubator for 3 hours of MTT reaction. After the MTT reaction is over, the cultured skin is clamped with tweezers and taken out, and transferred to a 1.5 mL microtube. Put 300 μL of isopropanol into the microtube and completely immerse and culture the epidermal model. Then let it stand for 2 hours, place the microtube in a vortex, and extract the pigment. Put the extract (200 mL) into each well of a 96-well plate. In addition, as a blank (negative control), put 200 μL of isopropanol in A1. A microplate reader was used to measure the absorbance at 570 nm and 650 nm. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell rate of the test substance was calculated according to the following formula.

[Numerical formula 1]

The viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3 to 4. ◎: more than 90% ○: 75% or more but less than 90% △: more than 65% and less than 75% ×: 50% or more but less than 65% ××: Less than 50%

As shown in Tables 1 to 4, skin cleansing sprays (Comparative Examples 13 to 16) containing surfactants at a concentration exceeding 2% by weight showed skin irritation at a concentration of 0.025% to 2% by weight No cleansing power was observed in the spray for skin cleansing (Comparative Example 1 to Comparative Example 10) containing a natural-derived surfactant. In contrast, with respect to a spray for skin cleansing (implementation) containing an amphiphilic ester (Comparative Example 11 to Comparative Example 12) that alone does not exhibit cleansing power together with 0.025% by weight to 2% by weight of natural-derived surfactants Example 1 to Example 21), by spraying directly onto the skin only from a spray container, it is possible to obtain excellent cleaning power by using only the mechanical force of the liquid flow without causing physical friction at all. That is, it means that gentle cleansing of the skin can be achieved. Furthermore, as shown in Example 4 to Example 7, Example 9, Example 11, Example 15, and Example 17 to Example 21, the skin cleansing spray of the present invention is shown to suppress skin irritation. In addition to the tightness caused by insufficient moisture retention, the cleaning power is improved. That is, it is shown that the concentration of the natural-derived surfactant of the spray for skin cleansing applied directly on the skin by spraying is set to 0.025% by weight to 2% by weight, and it is possible to achieve a physical and chemical softness to the skin. Clean.

[Table 1] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Example 17 A Lysolecithin 0.025 0.050 0.100 0.5 1 1.5 2 - - - - - - - - - - Lecithin - - - - - - - 0.20 2 - - - - - - - - Hydrogenated Lecithin - - - - - - - - - 0.20 2 - - - - - - Soap fruit extract powder (saponins 20%) - - - - - - - - - - - 1 (0.2) 3 (0.6) 6 (1.2) 10 (2) - - Surfactin Sodium - - - - - - - - - - - - - - - 0.20 2 B Cyclohexane-1,4-dicarboxylic acid bisethoxy diethylene glycol ester 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 Diethylene glycol succinate - - - - - - - - - - - - - - - - - 1,3-BG 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 water The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest total 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Cleaning power ○ ○ ○ ◎ ◎ ◎ ◎ ○ ◎ ○ ○ ○ ○ ◎ ◎ ○ ○ In the table, the unit of the numerical value showing the blending amount of each component is wt%. In addition, the values in parentheses indicate the saponin content.

[Table 2] Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5 Comparative example 6 Comparative example 7 Comparative example 8 Comparative example 9 Comparative example 10 Comparative example 11 Comparative example 12 A Lysolecithin 0.025 0.050 0.100 - - - - - - - - - Lecithin - - - 0.20 - - - - - - - - Hydrogenated Lecithin - - - - 0.20 - - - - - - - Soap fruit extract powder (saponins 20%) - - - - - 1 (0.2) 3 (0.6) 6 (1.2) 10 (2) - - - Surfactin Sodium - - - - - - - - - 0.20 - - B Cyclohexane-1,4-dicarboxylic acid bisethoxy diethylene glycol ester - - - - - - - - - - 2 - Diethylene glycol succinate - - - - - - - - - - - 5 1,3-BG 20 20 20 20 20 20 20 20 20 20 20 20 water The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest total 100 100 100 100 100 100 100 100 100 100 100 100 Cleaning power X X X X X X X X X X X X In the table, the unit of the numerical value showing the blending amount of each component is wt%. In addition, the values in parentheses indicate the saponin content.

[table 3] Example 4 Example 5 Example 6 Example 7 Example 9 Example 11 Example 15 Example 17 Example 18 Example 19 Example 20 Example 21 Comparative example 9 Comparative example 13 A Lysolecithin 0.5 1 1.5 2 - - - - - - - - - 5 Lecithin - - - - 2 - - - 2 - - - - - Hydrogenated Lecithin - - - - - 2 - - - 2 - - - - Soap fruit extract powder (saponins 20%) - - - - - - 10 (2) - - - 10 (2) - 10 (2) - Surfactin Sodium - - - - - - - 2 - - - 2 - - B Cyclohexane-1,4-dicarboxylic acid bisethoxy diethylene glycol ester 2 2 2 2 2 2 2 2 - - - - - 2 Diethylene glycol succinate - - - - - - - - 2 2 2 2 - - 1,3-BG 20 20 20 20 20 20 20 20 20 20 20 20 20 20 water The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest The rest total 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Cleaning power ◎ ◎ ◎ ◎ ◎ ○ ◎ ○ ◎ ○ ◎ ○ X ◎ Tightness ◎ ◎ ○ ○ ○ ◎ ○ ◎ ○ ○ ○ ○ ○ X Evaluation test of cultured epidermal skin irritation ◎ ◎ ◎ ○ ○ ◎ ○ ○ ○ ◎ ○ ○ △ X In the table, the unit of the numerical value showing the blending amount of each component is wt%. In addition, the values in parentheses indicate the saponin content.

[Table 4] Comparative example 14 Comparative example 15 Comparative example 16 A Lauric acid 2 - - Myristic acid 1.3 - - Coconut oil amine DEA 2 - - Coconut Oil Glutamate TEA - 6 - Coconut Oil Methyl Taurine Na - 2.5 - N-Lauryl Aspartame Sodium Solution (20%) - - 25 (5) Lauryl Hydroxy Sulfobetaine Liquid (30%) - - 5 (1.5) Alkyl ether carboxylic acid - - 1 Polyoxyethylene sorbitan monostearate - - 2 Glycerol mono-2-ethylhexyl ether solution (90%) - - 0.5 B Cyclohexane-1,4-dicarboxylic acid bisethoxy diethylene glycol ester - - - Potassium hydroxide 1 - - 1,3-Butanediol (BG) - 10 - Propylene Glycol (PG) - - 5 glycerin 35 - 10.5 Malic acid (50%) - - 0.34 (0.17) EDTA-2Na-2H ₂ O 0.05 0.05 0.2 Methyl p-hydroxybenzoate - - 0.3 Phenoxyethanol 0.2 0.2 0.3 water The rest The rest The rest total 100 100 100 Cleaning power ◎ ○ ○ Tightness X △ ◎ Evaluation test of cultured epidermal skin irritation ×× X X In the table, the unit of the numerical value showing the blending amount of each component is wt%. In addition, the numerical values in parentheses indicate the amount of component conversion.

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Claims (8)

A spray for skin cleansing, comprising (A) component, a natural-derived surfactant; and (B) component, an amphiphilic ester, the content of the (A) component is 0.025% by weight to 2% by weight, and The spray for skin cleansing is contained in a spray container. The spray for skin cleansing according to claim 1, wherein the spray container is a pump spray container. The spray for skin cleansing according to claim 1, wherein the spray container is an aerosol spray container. The spray for skin cleansing according to any one of claims 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponin, and lipopeptides. The spray for skin cleansing according to claim 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin. The spray for skin cleansing according to claim 4, wherein the lipopeptide is selected from the group consisting of surfactant and its salt. The spray for skin cleansing according to any one of claims 1 to 6, wherein the component (B) is selected from dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester, dicarboxylic acid dicarboxylic acid Alkoxyalkyl esters, and (eicosanedioic acid/tetradecanedioic acid) polyglycerol-10 esters. The spray for skin cleansing according to claim 7, wherein the dicarboxylic acid bis(polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxy diethylene glycol ester.