WO2021124496A1

WO2021124496A1 - Spray preparation for skin cleaning

Info

Publication number: WO2021124496A1
Application number: PCT/JP2019/049706
Authority: WO
Inventors: 航平山本
Original assignee: 小林製薬株式会社
Priority date: 2019-12-18
Filing date: 2019-12-18
Publication date: 2021-06-24

Abstract

[Problem] To provide a skin cleaner composition which is to be used by a method differing from conventional ones. [Solution] A spray preparation for skin cleaning including (A) a surfactant and (B) an amphipathic ester and held in a spray vessel. This skin cleaner composition shows reduced skin irritativeness but can exhibit excellent detergency. With this skin cleaner composition, it is possible to provide a new usage in which, when applied to the skin, the skin cleaner composition is sprayed directly to the skin instead of being foamed in advance as in conventional usage.

Description

Skin cleansing spray

The present invention relates to a skin cleansing spray agent used by directly spraying it on the skin.

Various skin cleansing compositions such as facial cleansers, body soaps, and shampoos are provided as products aimed at cleaning the skin and keeping the skin clean. In the mechanism by which the skin cleansing composition cleans the skin, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and the mechanical force due to friction also causes the dirt to float in the water. In order for such a cleaning mechanism to work effectively, it is necessary to add a surfactant at a critical micelle concentration or higher.

On the other hand, the detergency of the surfactant is too strong, which causes skin irritation, and as a result, it causes skin troubles such as dry skin. For this reason, various formulations have been proposed in which the combination of cleansing ingredients, the blending amount, and the like are devised for the purpose of mildly acting on the skin. Above all, since it is recognized that the foam formed during washing reduces the friction generated by direct contact between the skin and fingers, a formulation that improves foam quality such as foaming power and foam holding power is applied to the skin. It is common knowledge that it is excellent as a prescription that makes the action mild.

For this reason, in recent years, various pump former type skin cleansers have been proposed, and attention is being paid not only to the ease with which high-quality foam can be easily obtained, but also to the gentleness to the skin. Specifically, in Patent Document 1, a liquid skin cleansing product comprising a former container and a liquid skin cleansing composition filled in the former container, wherein the liquid skin cleansing composition is (1). A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, and (B) a specific dimethyldialyl ammonium chloride and acrylic acid and / or acrylamide. Liquid skin containing the copolymer of (C) and (C) sugar alcohol, and the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) is 20 to 250. Detergent products are disclosed. Further, Patent Document 2 describes (a) 2 to 9% by mass of a fatty acid salt, (b) 0.5 to 4% by mass of betaine lauryldimethylaminoacetate, and (c) one or more divalent alcohols. 1 to 10% by mass, and the sum (a) + (b) of the blending amount (mass%) of the component (a) and the component (b) is 3 to 10% by mass, and the blending amount ratio (b) A skin cleansing composition is disclosed, which comprises filling a former container with a cleanser having a / (a) of 0.1 to 0.5. Further, Patent Document 3 describes a former container containing (a) betaine lauryldimethylaminoacetate and (b) 4 to 15% by mass of a higher fatty acid soap having a specific composition and formed from a fatty acid having 5 to 25 carbon atoms. The cleaning agent composition discharged in the above is disclosed.

International Publication No. 2014/003114 Japanese Unexamined Patent Publication No. 2016-098182 International Publication No. 2017/081897

The pumpformer-type skin cleansing composition contains a relatively small amount of surfactant, and in that respect, irritation to the skin is reduced as compared with the solid or semi-solid skin cleansing composition. It is thought that there is a tendency to be. On the other hand, since it is a major premise that the pump former type skin cleansing composition is discharged in the form of foam, the minimum amount of surfactant necessary for exerting the foaming force is blended. That is inevitable due to its composition.

In recent years, awareness of skin-friendly facial cleansing has been increasing. At the same time, attention has been focused on time-saving skin care, and skin cleaning agents that are gentle on sensitive skin and can be washed quickly are expected.

Various skin cleansing agents have been created for the purpose of removing body fluids such as sebum and sweat and dirt, except for skin cleansing agents for the purpose of removing makeup (cleansing), but all skin cleansing agents are no exception for the skin. It is premised on whipping before applying to the skin, and it is also common knowledge that whipping well before washing is preferable in terms of reducing friction on the skin. Foam can relieve physical friction by intervening between the skin and the hand, but since the foam itself is rubbed against the skin, it itself causes physical friction and is irritating to the skin. There is no change in being. As described above, there is a limit to the reduction of the burden on the skin of the skin cleansing agent by the same usage method as before.

Therefore, an object of the present invention is to provide a skin cleansing composition used in a method different from the conventional method.

The present inventor has come up with the idea of a novel application in which the skin cleansing composition is directly sprayed onto the skin without foaming in advance when applied to the skin in order to further reduce irritation to the skin. .. Furthermore, it has been found that by coexisting an amphipathic ester with a surfactant, detergency can be effectively obtained without foaming in advance. The present invention has been completed by further studies based on this finding.

That is, the present invention provides the inventions of the following aspects.
Item 1. A skin cleansing spray agent containing (A) a surfactant and (B) an amphipathic ester and contained in a spray container.
Item 2. Item 2. The spray agent for skin cleaning according to Item 1, wherein the spray container is a pump type spray container.
Item 3. Item 2. The spray agent for skin cleaning according to Item 1, wherein the spray container is an aerosol spray container.
Item 4. Item 2. The skin washing according to any one of Items 1 to 3, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. Spray agent for.
Item 5. Item 4. The skin cleaning spray agent according to Item 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 6. The skin cleansing spray agent according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.
Item 7. Item 2. The skin cleansing spray agent according to any one of Items 1 to 6, wherein the content of the component (A) is 0.025 to 0.9% by weight.

According to the present invention, since the skin cleansing composition can exhibit excellent cleansing power while reducing the skin irritation, it is different from the conventional use of foaming in advance when applied to the skin, and directly on the skin. It is possible to provide a new application of spraying and applying a cleansing composition onto the skin. Since it can be washed without foaming in advance, the blending amount of the surfactant in the skin cleansing liquid composition can be significantly reduced as compared with the blending amount contained in the conventional skin cleansing liquid composition. It is also possible to further reduce skin irritation.

The skin cleansing spray agent of the present invention may be referred to as (A) surfactant (hereinafter, may be referred to as (A) component) and (B) amphipathic ester (hereinafter, may be referred to as (B) component). It is characterized in that it contains (there is) and is contained in a spray-type container. Hereinafter, the skin cleansing spray agent of the present invention will be described in detail.

(A) Surfactant The skin cleansing spray agent of the present invention contains a surfactant as the component (A). The surfactant is not particularly limited, but from the viewpoint of suppressing irritation to the skin, preferably an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned. As the surfactant, one of anionic surfactant, nonionic surfactant, amphoteric surfactant, and natural surfactant may be used alone, or two or more thereof may be arbitrarily combined. May be used.

Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate ester type, and phosphoric acid ester type surfactants.

Specific examples of the carboxylic acid type surfactant include saturated or unsaturated amino acids having 6 to 22 carbon atoms such as octanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, and stearic acid; octanoyl groups and decanoyles. Examples include N-acyl amino acids (carboxylic acid-type amino acid-based anionic surfactants) having saturated or unsaturated N-acyl groups having 8 to 24 carbon atoms such as groups, lauroyl groups, myristic groups, palmitoyl groups, and cocoyl groups. Be done. Examples of the N-acyl amino acid in the carboxylic acid type amino acid-based anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, lauroylmethyl-β-alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroyl sarcosine, N-lauroyl aspartic acid, cocoyl glutamic acid, and lauroyl methyl-β-alanine sodium.

Specific examples of the sulfonic acid type surfactant include an ester of a fatty acid having 6 to 22 carbon atoms such as cocoyl ISEthionic acid and an acetylonic acid; hexane sulfonic acid, octane sulfonic acid, decane sulfonic acid, dodecane sulfonic acid and the like. Alkyl sulfonic acid having 6 to 22 carbon atoms; Alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as alkylbenzene sulfonic acid; Examples thereof include N-acyl-N-methyltaurin (sulfonic acid type amino acid-based anionic surfactant) having a saturated or unsaturated N-acyl group of No. 8 to 24. More specific sulfonic acid-type amino acid-based anionic surfactants include N-myristoyl-N-methyltaurine, N-lauroylmethyltaurine, cocoylmethyltaurine and the like.

Specific examples of the sulfuric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate and sulfuric acid. Specific examples of the phosphoric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphoric acid and phosphoric acid.

These anionic surfactants may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. it can.

Among these anionic surfactants, carboxylic acid type surfactants and sulfonic acid type surfactants are preferable, and more preferably, from the viewpoint of obtaining better skin irritation reducing property and detergency. Lauric acid, N-lauroyl aspartic acid, cocoyl glutamate, cocoyl methyl taurine and salts thereof are mentioned, and more preferably, sodium laurate, sodium N-lauroyl aspartate, cocoyl glutamate triethanolamine, sodium cocoyl methyl taurine are mentioned. Be done. Further, among these, from the viewpoint of obtaining better skin irritation reducing property, preferably N-aspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms, fatty acid amide sulfonic acid having 8 to 22 carbon atoms, and the like. These salts are mentioned, more preferably cocoyl glutamate, cocoyl methyl taurine and salts thereof, further preferably cocoyl glutamate triethanolamine, cocoyl methyl taurine sodium, and even better detergency. From the viewpoint, N-acylaspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms is preferably mentioned, more preferably N-lauroyl aspartic acid is mentioned, and further preferably sodium N-lauroyl aspartate is mentioned. Can be mentioned.

These anionic surfactants may be used alone or in combination of two or more.

Examples of the nonionic surfactant used in the present invention include ester-type, ether-type, ester-ether-type, alkanolamide-type, alkylglycoside-type, and alcohol-type surfactants.

Specific examples of the ester-type surfactant include glycols dilaurate, glycol monostearate, glycol distearate, glyceryl monolaurate, glyceryl dilaurate, glyceryl monostearate, and glyceryl distearate, which have 8 to 20 carbon atoms. Saturated or unsaturated fatty acids and glycerin mono- or diesters; sorbitan fatty acid esters; sucrose fatty acid esters and the like.

Specific examples of the ether-type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, and polyoxyethylene polyoxypropylene glycol.

Examples of the ester-ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitan fatty acid ester, and sorbitan fatty acid ester polyethylene glycol.

Specific examples of the alkanolamide type surfactant include coconut DEA (coconut oil fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide and the like.

Specific examples of the alkyl glucoside type surfactant include octyl glucoside, decyl glucoside, and lauryl glucoside.

Examples of alcohol-type surfactants include cetanol, stearyl alcohol, and oleyl alcohol.

Among these nonionic surfactants, ester ether type surfactants and alkanolamide type surfactants are preferable from the viewpoint of obtaining better skin irritation reducing property and detergency. Preferred are polyoxyethylene hydrogenated castor oil and cocamide DEA, and more preferably polyoxyethylene hydrogenated castor oil.

These nonionic surfactants may be used alone or in combination of two or more.

Examples of amphoteric surfactants used in the present invention include alkyl betaine type, fatty acid amide propyl betaine type, amine oxide type and other surfactants.

Specific examples of the alkyl betaine type surfactant include lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, octadecylaminomethyldimethylsulfopropyl betaine and the like.

Specific examples of the fatty acid amide propyl betaine type amphoteric tenside agent include amide betaine (amino acid-based amphoteric tenside agent) such as cocamidopropyl betaine, and sulfobetaine such as cocamidopropyl hydroxysultaine.

Specific examples of the amine oxide type amphoteric surfactant include lauryldimethylamine N-oxide and oleyldimethylamine N-oxide.

These amphoteric tenside agents may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. ..

Among these amphoteric surfactants, fatty acid amide propyl betaine type surfactants are preferable, and amide betaines such as cocamidopropyl betaine are more preferable, from the viewpoint of obtaining better skin irritation reduction property and detergency. Amino acid-based amphoteric surfactant), more preferably cocamidopropyl betaine.

These amphoteric surfactants may be used alone or in combination of two or more.

Natural surfactants used in the present invention include lecithin and lysolecithin; saponins such as Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azuxaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin. And so on.

Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol with components such as triglycerides, fatty acids, and carbohydrates from vegetable oils, and is a known component in pharmaceuticals, quasi-drugs, and cosmetics. is there.

The lecithin may be natural lecithin derived from animals and plants (for example, soybean lecithin, egg yolk lecithin, etc.) itself, a chemically treated product of natural lecithin, or a purified product of natural lecithin. .. Examples of the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation treatment (for example, fully hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation treatment. Examples of the purified product of natural lecithin include lecithin in which the content of phosphatidylcholine is increased by a solvent such as acetone.

Examples of lysolecithin include lyso-forms of the above-mentioned lecithin (natural lecithin, chemically treated natural lecithin, purified natural lecithin). Lysolecithin has a structure in which the fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin by an enzyme such as phospholipase A2.

Among these natural surfactants, lecithin and lysolecithin and saponin are preferable, lecithin and lysolecithin are more preferable, and lysolecithin is more preferable, from the viewpoint of obtaining better skin irritation reducing property and detergency. Can be mentioned.

These natural surfactants may be used alone or in combination of two or more.

The content of the component (A) in the skin cleansing spray agent of the present invention is not particularly limited and can be appropriately determined according to the cleansing power to be imparted. Since the skin cleansing spray agent of the present invention can be washed without applying physical friction to the skin, the blending amount of the surfactant in the skin cleansing spray agent can be adjusted to the conventional liquid composition for skin cleansing. It is possible to significantly reduce the amount of the compounding amount contained in the above, and it is possible to effectively exert the detergency even with a small amount of the surfactant which originally cannot exert the effective detergency. From this point of view, the content of the component (A) in the skin cleansing spray agent of the present invention is preferably 0.025 to 2% by weight, more preferably 0.025 to 1.5% by weight or less, and further. It is preferably 0.025 to 1% by weight or less, and particularly preferably 0.025 to 0.9% by weight or less. Since the amount of the surfactant is small as described above, the skin irritation can be significantly reduced. Further, from the viewpoint of obtaining more excellent detergency, the lower limit of the range of the content of the component (A) is preferably 0.1% by weight or more, and preferably 0.5% by weight or more. More preferred.

(B) Amphiphilic ester The skin cleansing spray agent of the present invention contains an amphipathic ester as a component (B). The component (B) does not show a cleansing action by itself, but by coexisting with the component (A), the cleansing power of the skin cleansing spray can be improved while maintaining low irritation.

In the present invention, the amphipathic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 μs / m by 2% by mass or more at room temperature by the method specified in the Japanese Pharmacopoeia General Test Method. , Isotridecyl isononanoate (manufactured by Nisshin Oillio Group, Saracos 913), which is an oil agent, also dissolves in 10% by mass or more at room temperature (25 ° C.), and ester-based surfactants are excluded.

The amphoteric ester is not particularly limited, but from the viewpoint of reducing skin irritation and obtaining better detergency, a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 are used. It is preferably selected from the group consisting of. As the amphipathic ester, either one of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diic acid / tetradecane diic acid) polyglyceryl-10 may be used alone, or both may be combined. You may use it. Among these amphipathic esters, the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is more preferable from the viewpoint of obtaining better skin irritation reducing property and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, and the like. Examples thereof include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Be done.

Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, a diester of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether is preferable from the viewpoint of obtaining better skin irritation reduction property and detergency. Compound, specifically, INCI name (International Cosmetic Ingredient Dicarboxylic Acid Handbook, 13th Edition, Volume 1, CTFA, 2010, p.331): BIS-ETHOXYDIGLYCOLCYCOLTECYCYCLOHEXANE 1,4-D A compound called hexethoxy-1,4-dicarboxylic acid bisethoxydiglycol, and a diester compound of succinic acid and diethylene glycol monoethyl ether, specifically, INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th edition). , Volume 1, CTFA, 2010, p.331-332): BIS-ETHOXYDIGLYCOL SUCCINATE, a compound called bisethoxydiglycol succinate, more preferably cyclohexane-1. , 4-Dicarboxylic acid bisethoxydiglycol.

Further, in the present invention, specific examples of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol include, for example, "Neosolue-Aquilio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd. Specific examples of the bisethoxydiglycol succinate include "High Aquos Star DCS (trade name)" manufactured by Higher Alcohol Industry Co., Ltd.

These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.

The polyglyceryl-10 (eicosane diic acid / tetradecane diic acid) used in the present invention is not particularly limited, but for example, "Neosolue-Aqua (trade name)" and "Neosolue-AquaS" manufactured by Nippon Fine Chemical Co., Ltd. Product name) ”and the like.

The content of the component (B) in the skin cleansing spray agent of the present invention is not particularly limited, and examples thereof include 0.1% by weight or more. From the viewpoint of obtaining better detergency, the content of the component (B) is preferably 0.5% by weight or more. The upper limit of the content of the component (B) is not particularly limited, but from the viewpoint of the stability of the skin cleansing spray, for example, 5% by weight or less, preferably 3% by weight or less, more preferably 2% by weight or less. Can be mentioned.

In the skin cleaning spray agent of the present invention, the ratio of the component (A) to the component (B) is not particularly limited and is determined by each of the above contents, but from the viewpoint of obtaining better skin irritation reducing property and detergency. Therefore, the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, and more preferably 0.5 to 5 parts by weight with respect to 1 part by weight of the component (A).

Other Ingredients In addition to the above ingredients, the skin cleansing spray agent of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. May be good. Such additives are not particularly limited as long as they are pharmaceutically acceptable, but are, for example, aqueous bases such as water, lower alcohols having 1 to 5 carbon atoms, and polyhydric alcohols; preservatives, coating agents, etc. Fragrances, colorants, thickeners, pH regulators, wetting agents, stabilizers, antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, solubilizers, preservatives, etc. Additives can be mentioned. These base materials and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.

The skin cleansing spray agent of the present invention may contain, if necessary, other pharmacological components in addition to the above-mentioned components as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins, antihistamines, local anesthetics, anti-inflammatory agents, skin protectants, blood circulation promoting components, refreshing agents, mucopolysaccharides and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological component to be used, the expected effect, and the like.

Form The form of the skin cleansing spray agent of the present invention is liquid or gel at room temperature. The viscosity of the skin cleansing spray agent of the present invention is 10,000 mPa · s or less, preferably 5000 mPa · s or less at 20 ° C. The viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).

Container The container for accommodating the skin cleansing spray agent of the present invention is not particularly limited as long as it is a spray type container. The spray container in the present invention discharges the contents in a mist state, and is different from the pump former container that discharges the skin cleansing composition in a foam state.

In the present invention, by housing the skin cleansing spray agent in the spray container in this way, the skin cleansing spray agent is directly applied to the skin by spraying without foaming before application to the skin. .. Therefore, it is easy to apply to the skin, and physical friction by hands or the like at the time of application can be avoided. Examples of the spray type container include a pump type spray container which is a non-aerosol type spray container and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include 0.01 to 3 mmφ, preferably 0.1 to 1 mmφ. When the spray type container is a pump type spray container, the injection amount per push is, for example, 0.05 to 1.2 g, preferably 0.1 to 0.3 g.

Applications The skin cleansing spray of the present invention is used to remove body fluids such as oils and sweats on the skin, stains, etc., and is not used as a makeup remover (cleansing). The skin cleansing spray agent of the present invention is used by applying it to the skin as it is without foaming without diluting with water. The amount used at one time depends on the concentration of the surfactant, the degree of stain, etc., but for example, when used for face washing, 0.5 to 3 g, preferably 1 to 2 g can be mentioned.

More specifically, it can be applied directly to the area to be cleaned by spraying from a spray container without picking up the skin cleansing spray agent. In this way, by applying the skin cleansing spray directly to the cleansing site, friction generated between the skin and hands of the cleansing site and friction generated between the skin and air bubbles of the cleansing site can be described. Cleaning can be performed simply by using the mechanical force of the liquid flow without giving any physical friction. Since the spray agent for skin cleansing of the present invention is a formulation having excellent cleansing power, it is possible to cleanse the skin by using the mechanical force of the liquid flow without giving physical friction in this way. The burden is significantly reduced and an extremely gentle cleaning method becomes possible. Such a non-foaming cleaning method enables quick cleaning, and it is easy to realize that it is gentle on the skin with less surfactant, and it is easy to obtain satisfaction of consumers who are highly conscious of pursuing skin-friendly cleaning. The skin cleansing spray agent of the present invention is particularly suitable for the above-mentioned cleaning method that does not give physical friction to the skin, but after applying the skin cleansing spray agent to the site to be cleaned, a hand or the like is used. It does not exclude the usage of scrubbing.

The site to be cleaned of the skin cleansing spray agent of the present invention is not particularly limited because it can clean any body part, and examples thereof include hands, hair, scalp, body, and face. Since the spray agent for skin cleaning of the present invention is applied to the site to be cleaned by spraying, it is suitable for use on hair, scalp, and body from the viewpoint of ease of application. In addition, the skin cleansing spray agent of the present invention can exert excellent cleansing power without foaming in advance, and is therefore suitable for use on the face sensitive to irritation.

After washing, the skin cleansing spray can be washed away with water. When rinsing with water, it may be performed in the same manner as normal face washing, but from the viewpoint of reducing the burden on the skin, it is preferable to wash off using the mechanical force of the water stream so as not to give friction by hand.

Further, since the skin cleaning spray agent of the present invention can extremely reduce the concentration of the surfactant, in this case, it is not necessary to wash it off after washing. Therefore, the skin cleansing spray agent of the present invention is also suitable for cleaning in hospitals, skin cleansing treatments such as face washing in beauty salons and beauty salons, and disaster supplies. If it is not washed away, a water-absorbent base material such as a towel or tissue may be used to absorb and remove the skin cleansing spray agent remaining on the cleansing site.

Production Method The skin cleansing spray agent of the present invention is prepared into a predetermined form by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary, and then prepared into a predetermined form. Manufactured by being housed in a spray container. When it is housed in an aerosol spray container as a spray container, it is manufactured by being housed together with a spray agent such as gas.

The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto.

Skin cleansing sprays having the compositions shown in Tables 1 to 4 were prepared. Details of each component shown in Tables 1 to 4 are as follows. The skin cleansing sprays shown in Tables 1 to 4 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all 5000 mPa.・ It was in the range of s or less.
・ Sodium laurate (NOF CORPORATION "Nonsar LN-1 (trade name)")
・ Cocoyl glutamic acid TEA (Ajinomoto Co., Inc. "Amisoft CT-12S (trade name)")
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION)
-N-Lauroyl aspartate sodium solution (20% by weight) ("Aminoformer FLDS-L (trade name)" manufactured by Asahi Kasei Fine Chemicals Co., Ltd.)
-Polyoxyethylene lauryl ether acetic acid ("Kao Akipo RLM-45 (trade name)" manufactured by Kao Corporation)
・ Cocamide DEA ("Amisol CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
-PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; "NIKKOL HCO-60 (trade name)" manufactured by Nikko Chemicals Co., Ltd.)
-Polyoxyethylene sorbitan monostearate (Kao Corporation Leodor TW-S120V)
-Glycerin mono-2-ethylhexyl ether (SEPPIC "sensiva SC 50 JP (trade name)")
・ Cocamidopropyl betaine (“Softazoline CPB (trade name)” manufactured by Kawaken Fine Chemicals Co., Ltd.)
-Lauryl hydroxysulfobetaine solution (30% by weight) (Kao Corporation "Anhitor 20HD (trade name)")
・ Lysolecithin (“Resolecithin Kyowa (trade name)” manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceuticals Co., Ltd., saponin content 5% by weight)
-Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Nippon Fine Chemical Co., Ltd. "Neosolue-Aquolio (trade name)")
・ Bisethoxydiglycol succinate (“High Aquos Star DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.)

<Detergency evaluation>
Ten panelists specializing in cosmetics evaluation evaluated the cleansing power of the prepared skin cleansing spray. Specifically, each skin cleansing spray agent is contained in a pump-type spray container (injection amount per push of "Z-155-C110 (trade name)" manufactured by Takemoto Yohki Co., Ltd. is 0.15 g). It was applied by spraying 5 g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. After holding the face with a towel and absorbing water, the feeling of dirt removal on the skin was scored by sensory evaluation based on the following indexes.

5 points: Dirt removal was felt firmly 4 points: Dirt removal was felt 3 points: Neither 2 points: Dirt removal was not felt so much 1 point: Dirt removal was not felt at all

The scores obtained by the 10 panelists were totaled, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points

<Evaluation of tension (sensory evaluation of skin irritation)>
Ten panelists specializing in cosmetics evaluation evaluated the prepared skin cleansing spray agent for a feeling of tension. Specifically, each skin cleansing spray agent is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g), and 1 .5 g was applied by spraying directly on the face. Leave it for about 5 seconds, then rinse with water so that the hands do not touch the face. Hold the face with a towel and absorb the water, then feel taut. Was scored by sensory evaluation based on the following indicators.

5 points: No feeling of tension 4 points: Almost no feeling of tension 3 points: Feeling little feeling of tension 2 points: Feeling of tension 1 point: Feeling strong feeling of tension

The scores obtained by the 10 panelists were totaled, and the degree of tension was evaluated according to the following classification. The results are shown in Tables 3-4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points

<Cultured epidermal skin irritation test (in vitro evaluation of skin irritation)>
The prepared skin cleansing spray was subjected to a cultured epidermal skin irritation test as follows.
1. 1. Preparation of Cultured Epidermis Model LabCite EPI-MODEL24 The assay medium was warmed and 0.5 mL each was added to a 24-well assay plate. Cultured epidermis model LabCite EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to a 24-well assay plate supplemented with assay medium. After confirming that there were no air bubbles on the bottom of the culture cup, the cells were _{placed in a CO 2} incubator and allowed to stand for 1 hour or more until exposure to the test substance.

2. Application and washing of test substance Twelve of the 24 epidermis models were used (the rest were pre-cultured until this test). A 24-well assay plate was removed from the _{CO 2 incubator.} The assay medium was warmed and 1.0 mL each was added to the third row of the 24-well assay plate. 25 μL of the test substance (spray agent for cleaning each skin) was dropped onto the culture epidermis of the culture cup without using a pump-type spray container, and the whole was exposed. After 1 minute, 5 minutes and 10 minutes after exposure, the test substance was aspirated off, the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of the 24-well assay plate.

3. 3. MTT test The MTT test occurs when MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltrazolium bromide] taken up into cells is reduced by intracellular mitochondrial dehydrogenase. This is a method of measuring the viable cell ratio by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.

10 mL of MTT medium was prepared at a final concentration of 0.5 mg / mL. The MTT medium was warmed and 0.5 mL each was added to row 4 of the 24-well assay plate. The cultured epidermis model was transferred to row 4 of the 24-well assay plate and placed in a CO2 incubator for 3 hours MTT reaction. After completion of the MTT reaction, the cultured skin was picked up with tweezers and taken out, and transferred to a 1.5 mL microtube. 300 μL of isopropanol was placed in a microtube and the cultured epidermis model was completely immersed. After that, it was allowed to stand for 2 hours, and the microtube was vortexed to extract the pigment. Extract (200 mL) was placed in each well of a 96-well plate. In addition, 200 μL of isopropanol was added to A1 as a blank (negative control). Absorbance at 570 nm and 650 nm was measured with a microplate reader. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell ratio of the test substance was calculated from the following formula.

The viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3-4.
⊚: 90% or more ○: 75% or more and less than 90% Δ: 65% or more and less than 75% ×: 50% or more and less than 65% × ×: less than 50%

As shown in Tables 1 to 4, no detergency was observed in the skin cleansing sprays (Comparative Examples 1 to 10) containing the surfactant alone at a concentration of 0.025 to 2% by weight. On the other hand, the skin cleaning sprays (Examples 1 to 20) containing 0.025 to 2% by weight of a surfactant containing an amphoteric ester (Comparative Examples 11 to 15) which does not show detergency by itself By simply applying it directly to the skin by spraying from a spray-type container, excellent detergency was obtained simply by using the mechanical force of the liquid flow without giving any physical friction. In other words, it was shown that cleansing that is gentle on the skin is possible.

As shown in Reference Examples 1 to 3, a skin cleansing spray agent containing more than 2% by weight of a surfactant alone can also obtain excellent cleansing power simply by applying it directly to the skin by spraying. On the other hand, in consideration of skin irritation due to the surfactant concentration shown in Reference Examples 1 to 3, when the surfactant concentration is 2% by weight or less as shown in Examples 9 to 20, not only the detergency but also the detergency is excellent. Hypoallergenicity was also played. In other words, by setting the surfactant concentration of the skin cleansing spray that is applied directly to the skin by spraying to 0.025 to 2% by weight, it is possible to perform cleansing that is physically and chemically gentle on the skin. Shown.

Claims

A skin cleansing spray agent containing (A) a surfactant and (B) an amphipathic ester and contained in a spray container.
The skin cleansing spray agent according to claim 1, wherein the spray container is a pump type spray container.
The skin cleansing spray agent according to claim 1, wherein the spray container is an aerosol spray container.
The skin according to any one of claims 1 to 3, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. Cleaning spray agent.
The skin cleansing spray agent according to claim 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
The skin cleansing spray agent according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.
The skin cleansing spray agent according to any one of claims 1 to 6, wherein the content of the component (A) is 0.025 to 0.9% by weight.