WO2021124497A1 - Liquid composition for skin cleansing - Google Patents
Liquid composition for skin cleansing Download PDFInfo
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- WO2021124497A1 WO2021124497A1 PCT/JP2019/049707 JP2019049707W WO2021124497A1 WO 2021124497 A1 WO2021124497 A1 WO 2021124497A1 JP 2019049707 W JP2019049707 W JP 2019049707W WO 2021124497 A1 WO2021124497 A1 WO 2021124497A1
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- skin
- liquid composition
- acid
- cleansing
- surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Definitions
- the present invention relates to a liquid composition for skin cleansing that can be washed without applying physical friction to the skin.
- Various skin cleansing compositions such as facial cleansers, body soaps, and shampoos are provided as products aimed at cleaning the skin and keeping the skin clean.
- the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and the mechanical force due to friction also causes the dirt to float in the water.
- it is necessary to add a surfactant at a critical micelle concentration or higher.
- the detergency of the surfactant is too strong, which causes skin irritation, and as a result, it causes skin troubles such as dry skin.
- various formulations have been proposed in which the combination of cleansing ingredients, the blending amount, and the like are devised for the purpose of mildly acting on the skin.
- foam formed during washing reduces the friction generated by direct contact between the skin and fingers
- a formulation that improves foam quality such as foaming power and foam holding power is applied to the skin. It is common knowledge that it is excellent as a prescription that makes the action mild.
- a liquid skin cleansing product comprising a former container and a liquid skin cleansing composition filled in the former container, wherein the liquid skin cleansing composition is (1).
- Liquid skin containing the copolymer of (C) and (C) sugar alcohol, and the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) is 20 to 250.
- Detergent products are disclosed. Further, Patent Document 2 describes (a) 2 to 9% by mass of a fatty acid salt, (b) 0.5 to 4% by mass of betaine lauryldimethylaminoacetate, and (c) one or more divalent alcohols.
- a skin cleansing composition which comprises filling a former container with a cleanser having a / (a) of 0.1 to 0.5.
- Patent Document 3 describes a former container containing (a) betaine lauryldimethylaminoacetate and (b) 4 to 15% by mass of a higher fatty acid soap having a specific composition and formed from a fatty acid having 5 to 25 carbon atoms. The cleaning agent composition discharged in the above is disclosed.
- the pumpformer-type skin cleansing composition contains a relatively small amount of surfactant, and in that respect, irritation to the skin is reduced as compared with the solid or semi-solid skin cleansing composition. It is thought that there is a tendency to be. On the other hand, since it is a major premise that the pump former type skin cleansing composition is discharged in the form of foam, the minimum amount of surfactant necessary for exerting the foaming force is blended. That is inevitable due to its composition.
- an object of the present invention is to provide a liquid composition for skin cleansing that can be washed without applying physical friction to the skin.
- the present inventor directly applies the skin cleansing liquid composition to the skin without foaming in advance when applying it to the skin, and cleanses without giving physical friction to the skin.
- the present invention has been completed by further studies based on this finding.
- Item 1 A liquid composition for skin cleansing containing (A) a surfactant and (B) an amphipathic ester, which is used for washing without giving physical friction to the skin.
- Item 2. Item 2. The liquid composition for skin cleaning according to Item 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10.
- Item 3. Item 2.
- the liquid composition for skin cleaning according to Item 2 wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
- Item 4. Item 2. The liquid composition for skin cleansing according to any one of Items 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.
- Item 5. Item 2. The liquid composition for skin cleansing according to Item 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.
- a skin cleaning method comprising applying a skin cleaning liquid composition containing (A) a surfactant and (B) an amphipathic ester to the skin without applying physical friction to the skin.
- liquid composition for skin cleansing of the present invention it is possible to exert excellent cleansing power while reducing skin irritation, so that physical friction is given to the skin without foaming in advance when applied to the skin. It can be washed without. Since it can be washed without giving physical friction to the skin, the amount of the surfactant compounded in the liquid composition for skin cleaning should be significantly reduced from the amount contained in the conventional liquid composition for skin cleaning. It is also possible to further reduce skin irritation.
- the liquid composition for skin cleansing of the present invention includes (A) a surfactant (hereinafter, may be referred to as (A) component) and (B) an amphipathic ester (hereinafter, (B). ) Is sometimes referred to as a component).
- A a surfactant
- B an amphipathic ester
- the liquid composition for skin cleansing of the present invention contains a surfactant as a component (A).
- the surfactant is not particularly limited, but from the viewpoint of suppressing irritation to the skin, preferably an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned.
- an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned.
- the surfactant one of anionic surfactant, nonionic surfactant, amphoteric surfactant, and natural surfactant may be used alone, or two or more thereof may be arbitrarily combined. May be used.
- anionic surfactant used in the present invention examples include carboxylic acid type, sulfonic acid type, sulfate ester type, and phosphoric acid ester type surfactants.
- carboxylic acid type surfactant examples include saturated or unsaturated amino acids having 6 to 22 carbon atoms such as octanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, and stearic acid; octanoyl groups and decanoyles.
- Examples include N-acyl amino acids (carboxylic acid-type amino acid-based anionic surfactants) having saturated or unsaturated N-acyl groups having 8 to 24 carbon atoms such as groups, lauroyl groups, myristic groups, palmitoyl groups, and cocoyl groups. Be done.
- N-acyl amino acid in the carboxylic acid type amino acid-based anionic surfactant examples include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, lauroylmethyl- ⁇ -alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroyl sarcosine, N-lauroyl aspartic acid, cocoyl glutamic acid, and lauroyl methyl- ⁇ -alanine sodium.
- sulfonic acid type surfactant examples include an ester of a fatty acid having 6 to 22 carbon atoms such as cocoyl ISEthionic acid and an acetylonic acid; hexane sulfonic acid, octane sulfonic acid, decane sulfonic acid, dodecane sulfonic acid and the like.
- sulfuric acid ester-type surfactant examples include esters of saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate and sulfuric acid.
- phosphoric acid ester-type surfactant examples include esters of saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphoric acid and phosphoric acid.
- anionic surfactants may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. it can.
- alkali metal salts such as sodium salt and potassium salt
- TAA triethanolamine
- ammonium salt and the like it can.
- carboxylic acid type surfactants and sulfonic acid type surfactants are preferable, and more preferably, from the viewpoint of obtaining better skin irritation reducing property and detergency.
- Lauric acid, N-lauroyl aspartic acid, cocoyl glutamate, cocoyl methyl taurine and salts thereof are mentioned, and more preferably, sodium laurate, sodium N-lauroyl aspartate, cocoyl glutamate triethanolamine, sodium cocoyl methyl taurine are mentioned. Be done.
- These salts are mentioned, more preferably cocoyl glutamate, cocoyl methyl taurine and salts thereof, further preferably cocoyl glutamate triethanolamine, cocoyl methyl taurine sodium, and even better detergency.
- N-acylaspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms is preferably mentioned, more preferably N-lauroyl aspartic acid is mentioned, and further preferably sodium N-lauroyl aspartate is mentioned. Can be mentioned.
- anionic surfactants may be used alone or in combination of two or more.
- nonionic surfactant used in the present invention examples include ester-type, ether-type, ester-ether-type, alkanolamide-type, alkylglycoside-type, and alcohol-type surfactants.
- ester-type surfactant examples include glycols dilaurate, glycol monostearate, glycol distearate, glyceryl monolaurate, glyceryl dilaurate, glyceryl monostearate, and glyceryl distearate, which have 8 to 20 carbon atoms.
- ether-type surfactant examples include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, and polyoxyethylene polyoxypropylene glycol.
- ester-ether type surfactant examples include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitan fatty acid ester, and sorbitan fatty acid ester polyethylene glycol.
- alkanolamide type surfactant examples include coconut DEA (coconut oil fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide and the like.
- alkyl glucoside type surfactant examples include octyl glucoside, decyl glucoside, and lauryl glucoside.
- alcohol-type surfactants examples include cetanol, stearyl alcohol, and oleyl alcohol.
- ester ether type surfactants and alkanolamide type surfactants are preferable from the viewpoint of obtaining better skin irritation reducing property and detergency.
- Preferred are polyoxyethylene hydrogenated castor oil and cocamide DEA, and more preferably polyoxyethylene hydrogenated castor oil.
- nonionic surfactants may be used alone or in combination of two or more.
- amphoteric surfactants used in the present invention include alkyl betaine type, fatty acid amide propyl betaine type, amine oxide type and other surfactants.
- alkyl betaine type surfactant examples include lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, octadecylaminomethyldimethylsulfopropyl betaine and the like.
- fatty acid amide propyl betaine type amphoteric tenside agent examples include amide betaine (amino acid-based amphoteric tenside agent) such as cocamidopropyl betaine, and sulfobetaine such as cocamidopropyl hydroxysultaine.
- amine oxide type amphoteric surfactant examples include lauryldimethylamine N-oxide and oleyldimethylamine N-oxide.
- amphoteric tenside agents may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. ..
- amphoteric surfactants fatty acid amide propyl betaine type surfactants are preferable, and amide betaines such as cocamidopropyl betaine are more preferable, from the viewpoint of obtaining better skin irritation reduction property and detergency.
- Amino acid-based amphoteric surfactant more preferably cocamidopropyl betaine.
- amphoteric surfactants may be used alone or in combination of two or more.
- Natural surfactants used in the present invention include lecithin and lysolecithin; saponins such as Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azuxaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin. And so on.
- saponins such as Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azuxaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin.
- Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol with components such as triglycerides, fatty acids, and carbohydrates from vegetable oils, and is a known component in pharmaceuticals, quasi-drugs, and cosmetics. is there.
- the lecithin may be natural lecithin derived from animals and plants (for example, soybean lecithin, egg yolk lecithin, etc.) itself, a chemically treated product of natural lecithin, or a purified product of natural lecithin. ..
- the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation treatment (for example, fully hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation treatment.
- the purified product of natural lecithin include lecithin in which the content of phosphatidylcholine is increased by a solvent such as acetone.
- lysolecithin examples include lyso-forms of the above-mentioned lecithin (natural lecithin, chemically treated natural lecithin, purified natural lecithin). Lysolecithin has a structure in which the fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin by an enzyme such as phospholipase A2.
- lecithin and lysolecithin and saponin are preferable, lecithin and lysolecithin are more preferable, and lysolecithin is more preferable, from the viewpoint of obtaining better skin irritation reducing property and detergency. Can be mentioned.
- These natural surfactants may be used alone or in combination of two or more.
- the content of the component (A) in the liquid composition of the skin cleansing agent of the present invention is not particularly limited, and can be appropriately determined according to the cleansing power to be imparted. Since the skin cleansing liquid composition of the present invention can be washed without applying physical friction to the skin, the blending amount of the surfactant in the skin cleansing liquid composition can be adjusted to the conventional skin cleansing liquid. It can be significantly reduced compared to the blending amount contained in the composition, and even a small amount of surfactant that originally cannot exert effective detergency can effectively exert detergency. it can. From this point of view, the content of the component (A) in the liquid composition of the skin detergent of the present invention is preferably 0.025 to 2% by weight, more preferably 0.025 to 1.5% by weight or less.
- the lower limit of the range of the content of the component (A) is preferably 0.1% by weight or more, and preferably 0.5% by weight or more. More preferred.
- the liquid composition for skin cleansing of the present invention contains an amphipathic ester as a component (B). Although the component (B) does not show a cleansing action by itself, by coexisting with the component (A), the cleansing power of the liquid composition for skin cleansing can be improved while maintaining low irritation.
- the amphipathic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 ⁇ s / m by 2% by mass or more at room temperature by the method specified in the Japanese Pharmacopoeia General Test Method.
- Isotridecyl isononanoate manufactured by Nisshin Oillio Group, Saracos 913
- which is an oil agent also dissolves in 10% by mass or more at room temperature (25 ° C.)
- ester-based surfactants are excluded.
- the amphoteric ester is not particularly limited, but from the viewpoint of reducing skin irritation and obtaining better detergency, a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 are used. It is preferably selected from the group consisting of.
- a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diic acid / tetradecane diic acid) polyglyceryl-10 may be used alone, or both may be combined. You may use it.
- the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is more preferable from the viewpoint of obtaining better skin irritation reducing property and detergency.
- the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether.
- Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, and the like.
- Examples thereof include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like.
- Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Be done.
- dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters a diester of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether is preferable from the viewpoint of obtaining better skin irritation reduction property and detergency.
- cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol examples include, for example, "Neosolue-Aquilio (trade name)” manufactured by Nippon Fine Chemical Co., Ltd.
- Specific examples of the bisethoxydiglycol succinate include "High Aquos Star DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.
- dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.
- the polyglyceryl-10 (eicosane diic acid / tetradecane diic acid) used in the present invention is not particularly limited, but for example, "Neosolue-Aqua (trade name)" and “Neosolue-AquaS” manufactured by Nippon Fine Chemical Co., Ltd. Product name) ”and the like.
- the content of the component (B) in the liquid composition for skin washing of the present invention is not particularly limited, and examples thereof include 0.1% by weight or more. From the viewpoint of obtaining better detergency, the content of the component (B) is preferably 0.5% by weight or more.
- the upper limit of the content of the component (B) is not particularly limited, but from the viewpoint of stability of the liquid composition for skin washing, for example, 5% by weight or less, preferably 3% by weight or less, more preferably 2% by weight. The following can be mentioned.
- the ratio of the component (A) to the component (B) is not particularly limited and is determined by each of the above-mentioned contents, but the skin irritation reducing property and the detergency can be obtained better.
- the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, and more preferably 0.5 to 5 parts by weight with respect to 1 part by weight of the component (A). ..
- the liquid composition for skin cleansing of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. You may.
- Such additives are not particularly limited as long as they are pharmaceutically acceptable, but are, for example, aqueous bases such as water, lower alcohols having 1 to 5 carbon atoms, and polyhydric alcohols; preservatives, coloring agents, etc.
- Additives such as agents, thickeners, pH regulators, wetting agents, stabilizers, antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, solubilizers, preservatives, etc. Be done.
- These base materials and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.
- the liquid composition for skin cleansing of the present invention may contain, if necessary, other pharmacological components in addition to the above-mentioned components as long as the effects of the present invention are not impaired.
- pharmacological components include vitamins, antihistamines, local anesthetics, anti-inflammatory agents, skin protectants, blood circulation promoting components, refreshing agents, mucopolysaccharides and the like.
- These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological component to be used, the expected effect, and the like.
- the form of the liquid composition for skin cleansing of the present invention is liquid or gel at room temperature.
- the viscosity of the liquid composition for skin washing of the present invention is 10,000 mPa ⁇ s or less, preferably 5000 mPa ⁇ s or less at 20 ° C.
- the viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).
- the container for accommodating the liquid composition for skin cleaning of the present invention is not particularly limited as long as the liquid composition for skin cleaning can be directly applied to the skin from inside the container, for example, a spray-type container.
- the spray container in the present invention discharges the contents in a mist state, and is different from the pump former container in which the liquid composition for skin washing is discharged in a foam state.
- the spray type container include a pump type spray container which is a non-aerosol type spray container and an aerosol type spray container.
- the diameter (nozzle inner diameter) of the spray container include 0.01 to 3 mm ⁇ , preferably 0.1 to 1 mm ⁇ .
- the liquid composition for skin cleansing of the present invention is used for removing body fluids such as oils and fats and sweat on the skin, stains, etc., and is not used as a makeup remover (cleansing).
- the liquid composition for skin cleansing of the present invention is used for facial cleansing in beauty salons and beauty salons.
- the liquid composition for skin cleansing of the present invention is used by applying it to the skin as it is without foaming without diluting with water.
- the amount used at one time depends on the concentration of the surfactant, the degree of stain, etc., but for example, when used for face washing, 0.5 to 3 g, preferably 1 to 2 g can be mentioned.
- the liquid composition for skin cleansing can be directly applied to the site to be cleaned from a spray-type container, a pouring or dropping-type container (particularly a washing bottle) without picking it up.
- the skin cleansing liquid composition directly to the cleansing site, the friction generated between the skin and the hand of the cleansing site and the friction generated between the skin and air bubbles of the cleansing site. It is possible to wash by simply using the mechanical force of the liquid flow without giving any physical friction such as.
- the liquid composition for skin cleansing of the present invention is a formulation having excellent cleansing power, it is possible to cleanse the skin at the time of washing by using the mechanical force of the liquid flow without giving physical friction in this way.
- the burden on the skin is remarkably reduced, and an extremely gentle cleaning method becomes possible.
- Such a non-foaming cleaning method enables quick cleaning, and it is easy to realize that it is gentle on the skin with less surfactant, and it is easy to obtain satisfaction of consumers who are highly conscious of pursuing skin-friendly cleaning.
- the site to be cleaned of the liquid composition for skin cleaning of the present invention is not particularly limited because it can clean any body part, and examples thereof include hands, hair, scalp, body, and face. Further, since the liquid composition for skin cleansing of the present invention can exert excellent cleansing power without giving physical friction to the skin, it is suitable for use on a face sensitive to irritation.
- the liquid composition for skin washing can be washed away with water. Even when rinsing with water, wash it off using the mechanical force of the water stream so as not to give physical friction by hand.
- the water used for rinsing is also contained in a spray container, a pouring or dropping container (particularly a washing bottle), preferably a pouring or dropping container (particularly a washing bottle), and is to be washed in the same manner as the liquid composition for skin washing. It can be applied to the site.
- the liquid composition for skin washing of the present invention can make the concentration of the surfactant extremely low, in this case, it is not necessary to wash off after washing. Therefore, the liquid composition for skin cleansing of the present invention is also suitable for cleaning in hospitals, skin cleansing treatments such as face washing in beauty salons and beauty salons, and disaster supplies. If it is not washed away, a water-absorbent base material such as a towel or tissue may be used to absorb and remove the liquid composition for skin washing remaining on the washing site without rubbing.
- a water-absorbent base material such as a towel or tissue may be used to absorb and remove the liquid composition for skin washing remaining on the washing site without rubbing.
- the liquid composition for skin cleansing of the present invention is prepared into a predetermined form by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary. Manufactured.
- the amphipathic ester can improve the cleansing power in the skin cleansing composition containing a surfactant without giving physical friction to the skin. Therefore, the present invention further provides a liquid composition for skin cleaning containing a surfactant as a component (A) and an amphipathic ester as a component (B) without giving physical friction to the skin.
- the skin cleaning method of the present invention can be carried out as a cleaning treatment performed at an esthetic salon or a beauty salon.
- the types and amounts of ingredients used in the skin cleansing method, the form of the skin cleansing composition, etc. are as shown in the column of "1. Liquid composition for skin cleansing".
- Liquid compositions for skin cleansing having the compositions shown in Tables 1 to 4 were prepared. Details of each component shown in Tables 1 to 4 are as follows.
- the skin cleansing liquid compositions shown in Tables 1 to 4 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all liquid. It was in the range of 5000 mPa ⁇ s or less.
- ⁇ Sodium laurate NOF CORPORATION "Nonsar LN-1 (trade name)"
- Cocoyl glutamic acid TEA (Ajinomoto Co., Inc.
- Amisoft CT-12S (trade name)" ⁇ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION) -N-Lauroyl aspartate sodium solution (20% by weight) (“Aminoformer FLDS-L (trade name)” manufactured by Asahi Kasei Fine Chemicals Co., Ltd.) -Polyoxyethylene lauryl ether acetic acid (“Kao Akipo RLM-45 (trade name)” manufactured by Kao Corporation) ⁇ Cocamide DEA (“Amisol CDE-G (trade name)” manufactured by Kawaken Fine Chemicals Co., Ltd.) -PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; "NIKKOL HCO-60 (trade name)” manufactured by Nikko Chemicals Co., Ltd.) -Polyoxyethylene sorbitan monostearate (Kao Corporation Leodor TW-S120V) -Glycerin mono-2-ethylhexy
- each skin cleansing liquid composition is contained in a pump-type spray container (“Z-155-C110 (trade name)” manufactured by Takemoto Yohki Co., Ltd., the injection amount per push is 0.15 g), and 1 It was applied by spraying 5.5 g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. After holding the face with a towel and absorbing water, the feeling of dirt removal on the skin was scored by sensory evaluation based on the following indexes.
- each skin cleansing liquid composition is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g). It was applied by spraying 1.5g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. The feeling was scored by sensory evaluation based on the following indexes.
- ⁇ Cultured epidermal skin irritation test (in vitro evaluation of skin irritation)> The prepared liquid composition for skin washing was subjected to a cultured epidermal skin irritation test as follows. 1. 1. Preparation of Cultured Epidermis Model LabCite EPI-MODEL24 The assay medium was warmed and 0.5 mL each was added to a 24-well assay plate. Cultured epidermis model LabCite EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to a 24-well assay plate supplemented with assay medium. After confirming that there were no air bubbles on the bottom of the culture cup, the cells were placed in a CO 2 incubator and allowed to stand for 1 hour or more until exposure to the test substance.
- test substance Twelve of the 24 epidermis models were used (the rest were pre-cultured until this test). A 24-well assay plate was removed from the CO 2 incubator. The assay medium was warmed and 1.0 mL each was added to the third row of the 24-well assay plate. 25 ⁇ L of the test substance (each skin cleansing liquid composition) was added dropwise to the culture epidermis of the culture cup without using a pump-type spray container, and the whole was exposed. After 1 minute, 5 minutes and 10 minutes after exposure, the test substance was aspirated off, the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of the 24-well assay plate.
- PBS phosphate buffer
- MTT test occurs when MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltrazolium bromide] taken up into cells is reduced by intracellular mitochondrial dehydrogenase. This is a method of measuring the viable cell ratio by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.
- MTT medium 10 mL was prepared at a final concentration of 0.5 mg / mL.
- the MTT medium was warmed and 0.5 mL each was added to row 4 of the 24-well assay plate.
- the cultured epidermis model was transferred to row 4 of the 24-well assay plate and placed in a CO2 incubator for 3 hours MTT reaction. After completion of the MTT reaction, the cultured skin was picked up with tweezers and taken out, and transferred to a 1.5 mL microtube. 300 ⁇ L of isopropanol was placed in a microtube and the cultured epidermis model was completely immersed. After that, it was allowed to stand for 2 hours, and the microtube was vortexed to extract the pigment.
- Extract 200 mL was placed in each well of a 96-well plate.
- the viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3-4. ⁇ : 90% or more ⁇ : 75% or more and less than 90% ⁇ : 65% or more and less than 75% ⁇ : 50% or more and less than 65% ⁇ ⁇ : less than 50%
- a liquid composition for skin cleansing containing more than 2% by weight of a surfactant alone can also obtain excellent cleansing power simply by applying it directly to the skin by spraying.
- the surfactant concentration shown in Reference Examples 1 to 3 when the surfactant concentration is 2% by weight or less as shown in Examples 9 to 20, not only the detergency but also the detergency is excellent.
- Hypoallergenicity was also played. That is, by setting the surfactant concentration of the liquid composition for skin cleaning applied to the cleaning method applied directly to the skin by spraying to 0.025 to 2% by weight, it is physically and chemically gentle on the skin. It was shown that cleaning is possible.
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Abstract
[Problem] To provide a liquid composition for skin cleansing that is to be used in a different way from conventional products. [Solution] A liquid composition for skin cleansing that comprises (A) a surfactant and (B) an amphiphilic ester and is to be used for cleansing the skin with no physical friction. This liquid composition for skin cleansing is capable of cleansing the skin with no physical friction and, therefore, can further reduce skin irritation.
Description
本発明は、物理的摩擦を皮膚に与えなくても洗浄可能な皮膚洗浄用液体組成物に関する。
The present invention relates to a liquid composition for skin cleansing that can be washed without applying physical friction to the skin.
皮膚を洗浄し、肌を清潔に保つことを目的とした製品として、洗顔料、ボディソープ、シャンプー等の様々な皮膚洗浄料組成物が提供されている。皮膚洗浄料組成物が皮膚を洗浄する機構においては、界面活性剤が汚れに吸着して汚れと水との間の表面張力を小さくし、摩擦による機械力も相まって、汚れを水中に浮き上がらせる。このような洗浄機構を有効に作用させるには、界面活性剤を臨界ミセル濃度以上で配合することが必要である。
Various skin cleansing compositions such as facial cleansers, body soaps, and shampoos are provided as products aimed at cleaning the skin and keeping the skin clean. In the mechanism by which the skin cleansing composition cleans the skin, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and the mechanical force due to friction also causes the dirt to float in the water. In order for such a cleaning mechanism to work effectively, it is necessary to add a surfactant at a critical micelle concentration or higher.
一方で、界面活性剤による洗浄力が強すぎることで皮膚刺激の原因となり、その結果、乾燥肌とはじめとする肌トラブルが引き起こされているといった現状もある。このため、肌への作用をマイルドにすることを目的として、洗浄成分の組み合わせや配合量等を工夫する処方が種々提案されている。中でも、洗浄時に形成される泡が、肌と指とが直接触れて発生する摩擦を軽減すると認識されていることから、気泡力、泡持ち力等の泡質を向上させる処方は、肌への作用をマイルドにする処方として優れているというのが一般常識となっている。
On the other hand, the detergency of the surfactant is too strong, which causes skin irritation, and as a result, it causes skin troubles such as dry skin. For this reason, various formulations have been proposed in which the combination of cleansing ingredients, the blending amount, and the like are devised for the purpose of mildly acting on the skin. Above all, since it is recognized that the foam formed during washing reduces the friction generated by direct contact between the skin and fingers, a formulation that improves foam quality such as foaming power and foam holding power is applied to the skin. It is common knowledge that it is excellent as a prescription that makes the action mild.
このため、近年では、ポンプフォーマータイプの皮膚洗浄料が種々提案されており、簡単に良質な泡が得られる手軽さだけでなく、肌への優しさも注目されている。具体的には、特許文献1に、フォーマー容器と、このフォーマー容器に充填されてなる液体皮膚洗浄剤組成物とからなる液体皮膚洗浄剤製品であって、上記液体皮膚洗浄剤組成物が、(A)炭素数7~21の直鎖又は分岐鎖の一価炭化水素基を有する特定の脂肪酸塩を3~10質量%と、(B)特定の塩化ジメチルジアリルアンモニウムとアクリル酸及び/又はアクリルアミドとの共重合体と、(C)糖アルコールとを含有し、(A)成分の含有量と(B)成分の含有量との質量比(A)/(B)が20~250である液体皮膚洗浄剤製品が開示されている。また、特許文献2には、(a)脂肪酸塩を2~9質量%、(b)ラウリルジメチルアミノ酢酸ベタインを0.5~4質量%、(c)2価アルコールの1種類または2種類以上を1~10質量%を含有し、かつ、(a)成分と(b)成分の配合量(質量%)の和(a)+(b)が3~10質量%、配合量比(b)/(a)が0.1~0.5である洗浄剤をフォーマー容器に充填したことを特徴とする皮膚洗浄剤組成物が開示されている。さらに、特許文献3には、(a)ラウリルジメチルアミノ酢酸ベタインと、(b)炭素数5~25の脂肪酸から形成され且つ特定組成の高級脂肪酸石鹸4~15質量%と、を含有するフォーマー容器で吐出される洗浄料組成物が開示されている。
For this reason, in recent years, various pump former type skin cleansers have been proposed, and attention is being paid not only to the ease with which high-quality foam can be easily obtained, but also to the gentleness to the skin. Specifically, in Patent Document 1, a liquid skin cleansing product comprising a former container and a liquid skin cleansing composition filled in the former container, wherein the liquid skin cleansing composition is (1). A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, and (B) a specific dimethyldialyl ammonium chloride and acrylic acid and / or acrylamide. Liquid skin containing the copolymer of (C) and (C) sugar alcohol, and the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) is 20 to 250. Detergent products are disclosed. Further, Patent Document 2 describes (a) 2 to 9% by mass of a fatty acid salt, (b) 0.5 to 4% by mass of betaine lauryldimethylaminoacetate, and (c) one or more divalent alcohols. 1 to 10% by mass, and the sum (a) + (b) of the blending amount (mass%) of the component (a) and the component (b) is 3 to 10% by mass, and the blending amount ratio (b) A skin cleansing composition is disclosed, which comprises filling a former container with a cleanser having a / (a) of 0.1 to 0.5. Further, Patent Document 3 describes a former container containing (a) betaine lauryldimethylaminoacetate and (b) 4 to 15% by mass of a higher fatty acid soap having a specific composition and formed from a fatty acid having 5 to 25 carbon atoms. The cleaning agent composition discharged in the above is disclosed.
ポンプフォーマータイプの皮膚洗浄料組成物は、界面活性剤の配合量が比較的少なく、その点で、固形状や半固形状の皮膚洗浄料組成物に比べて皮膚への刺激は低減されている傾向にあると考えられる。一方で、ポンプフォーマータイプの皮膚洗浄料組成物は、泡の状態で吐出されることが大前提となっているため、気泡力を発揮させるために必要な最低限の界面活性剤を配合することがその構成上不可避となっている。
The pumpformer-type skin cleansing composition contains a relatively small amount of surfactant, and in that respect, irritation to the skin is reduced as compared with the solid or semi-solid skin cleansing composition. It is thought that there is a tendency to be. On the other hand, since it is a major premise that the pump former type skin cleansing composition is discharged in the form of foam, the minimum amount of surfactant necessary for exerting the foaming force is blended. That is inevitable due to its composition.
近年、肌に優しい洗顔への意識はますます高まってきている。それと共に、時短スキンケアにも注目が集まり、敏感肌にも優しく、且つ素早く洗浄可能な皮膚洗浄料が期待されている。
In recent years, awareness of skin-friendly facial cleansing has been increasing. At the same time, attention has been focused on time-saving skin care, and skin cleaning agents that are gentle on sensitive skin and can be washed quickly are expected.
メイク落とし(クレンジング)を目的とした皮膚洗浄料を除く、皮脂や汗等の体液や汚れ等の除去を目的とした皮膚洗浄料は様々創出されているが、どの皮膚洗浄料も例外なく、肌へ適用する前に泡立てることを前提としており、また、洗浄前によく泡立てることは、肌への摩擦を和らげる点で好ましいということも常識化している。泡は、肌と手との間に介在することで物理的摩擦を和らげることができるものの、泡自体が肌にこすりつけられるため、それ自体が物理的摩擦を生じさせ、肌への刺激になっていることには変わりない。特に、エステサロンや美容院では、顔等の洗浄施術が行われることがあり、サービスの質の向上のため、より肌に優しい洗浄施術が望まれる。
Various skin cleansing agents have been created for the purpose of removing body fluids such as sebum and sweat and dirt, except for skin cleansing agents for the purpose of removing makeup (cleansing), but all skin cleansing agents are no exception for the skin. It is premised on whipping before applying to the skin, and it is also common knowledge that whipping well before washing is preferable in terms of reducing friction on the skin. Foam can relieve physical friction by intervening between the skin and the hand, but since the foam itself is rubbed against the skin, it itself causes physical friction and is irritating to the skin. There is no change in being. In particular, in beauty salons and beauty salons, facial cleansing treatments may be performed, and in order to improve the quality of service, more skin-friendly cleansing treatments are desired.
そこで本発明は、物理的摩擦を皮膚に与えなくても洗浄可能な皮膚洗浄用液体組成物を提供することを目的とする。
Therefore, an object of the present invention is to provide a liquid composition for skin cleansing that can be washed without applying physical friction to the skin.
本発明者は、肌への刺激をより軽減させるため、肌への適用に際して予め泡立てることなく、直接的に皮膚洗浄用液体組成物を肌へ適用し、物理的摩擦を皮膚に与えることなく洗浄するという斬新な用途の着想に至った。さらに、界面活性剤に両親媒性エステルを共存させることによって、物理的摩擦を皮膚に与えなくとも効果的に洗浄力が得られることを見出した。本発明は、この知見に基づいてさらに検討を重ねることにより完成したものである。
In order to further reduce irritation to the skin, the present inventor directly applies the skin cleansing liquid composition to the skin without foaming in advance when applying it to the skin, and cleanses without giving physical friction to the skin. I came up with the idea of a novel use of doing. Furthermore, it has been found that by coexisting an amphoteric ester with a surfactant, detergency can be effectively obtained without applying physical friction to the skin. The present invention has been completed by further studies based on this finding.
即ち、本発明は、下記に掲げる態様の発明を提供する。
項1. (A)界面活性剤と(B)両親媒性エステルとを含有し、物理的摩擦を皮膚に与えることなく洗浄するために用いられる、皮膚洗浄用液体組成物。
項2. 前記(B)成分が、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルおよび(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10よりなる群から選ばれる、項1に記載の皮膚洗浄用液体組成物。
項3. 前記ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルが、シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコールである、項2に記載の皮膚洗浄用液体組成物。
項4. 前記(A)成分の含有量が0.025~2重量%である、項1~3のいずれかに記載の皮膚洗浄用液体組成物。
項5. 前記(A)成分の含有量が0.025~0.9重量%である、項4に記載の皮膚洗浄用液体組成物。
項6. (A)界面活性剤と(B)両親媒性エステルとを含有する皮膚洗浄用液体組成物を、物理的摩擦を皮膚に与えることなく皮膚に適用することを含む、皮膚洗浄方法。 That is, the present invention provides the inventions of the following aspects.
Item 1. A liquid composition for skin cleansing containing (A) a surfactant and (B) an amphipathic ester, which is used for washing without giving physical friction to the skin.
Item 2. Item 2. The liquid composition for skin cleaning according to Item 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10.
Item 3. Item 2. The liquid composition for skin cleaning according to Item 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 4. Item 2. The liquid composition for skin cleansing according to any one of Items 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.
Item 5. Item 2. The liquid composition for skin cleansing according to Item 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.
Item 6. A skin cleaning method comprising applying a skin cleaning liquid composition containing (A) a surfactant and (B) an amphipathic ester to the skin without applying physical friction to the skin.
項1. (A)界面活性剤と(B)両親媒性エステルとを含有し、物理的摩擦を皮膚に与えることなく洗浄するために用いられる、皮膚洗浄用液体組成物。
項2. 前記(B)成分が、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルおよび(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10よりなる群から選ばれる、項1に記載の皮膚洗浄用液体組成物。
項3. 前記ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルが、シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコールである、項2に記載の皮膚洗浄用液体組成物。
項4. 前記(A)成分の含有量が0.025~2重量%である、項1~3のいずれかに記載の皮膚洗浄用液体組成物。
項5. 前記(A)成分の含有量が0.025~0.9重量%である、項4に記載の皮膚洗浄用液体組成物。
項6. (A)界面活性剤と(B)両親媒性エステルとを含有する皮膚洗浄用液体組成物を、物理的摩擦を皮膚に与えることなく皮膚に適用することを含む、皮膚洗浄方法。 That is, the present invention provides the inventions of the following aspects.
Item 1. A liquid composition for skin cleansing containing (A) a surfactant and (B) an amphipathic ester, which is used for washing without giving physical friction to the skin.
Item 2. Item 2. The liquid composition for skin cleaning according to Item 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10.
Item 3. Item 2. The liquid composition for skin cleaning according to Item 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 4. Item 2. The liquid composition for skin cleansing according to any one of Items 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.
Item 5. Item 2. The liquid composition for skin cleansing according to Item 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.
Item 6. A skin cleaning method comprising applying a skin cleaning liquid composition containing (A) a surfactant and (B) an amphipathic ester to the skin without applying physical friction to the skin.
本発明の皮膚洗浄用液体組成物によれば、皮膚刺激性が低減されつつも優れた洗浄力を発揮することができるため、肌への適用に際して予め泡立てることなく、物理的摩擦を皮膚に与えずに洗浄可能となる。物理的摩擦を皮膚に与えずに洗浄可能であるため、皮膚洗浄用液体組成物における界面活性剤の配合量を、従前の皮膚洗浄用液体組成物に含まれる配合量よりも大幅に低減させることができ、これによってより一層皮膚刺激性を低減させることも可能である。
According to the liquid composition for skin cleansing of the present invention, it is possible to exert excellent cleansing power while reducing skin irritation, so that physical friction is given to the skin without foaming in advance when applied to the skin. It can be washed without. Since it can be washed without giving physical friction to the skin, the amount of the surfactant compounded in the liquid composition for skin cleaning should be significantly reduced from the amount contained in the conventional liquid composition for skin cleaning. It is also possible to further reduce skin irritation.
1.皮膚洗浄用液体組成物
本発明の皮膚洗浄用液体組成物は、(A)界面活性剤(以下、(A)成分と表記することがある)と(B)両親媒性エステル(以下、(B)成分と表記することがある)とを含有することを特徴とする。以下、本発明の皮膚洗浄用液体組成物について詳述する。 1. 1. Liquid composition for skin cleansing The liquid composition for skin cleansing of the present invention includes (A) a surfactant (hereinafter, may be referred to as (A) component) and (B) an amphipathic ester (hereinafter, (B). ) Is sometimes referred to as a component). Hereinafter, the liquid composition for skin cleansing of the present invention will be described in detail.
本発明の皮膚洗浄用液体組成物は、(A)界面活性剤(以下、(A)成分と表記することがある)と(B)両親媒性エステル(以下、(B)成分と表記することがある)とを含有することを特徴とする。以下、本発明の皮膚洗浄用液体組成物について詳述する。 1. 1. Liquid composition for skin cleansing The liquid composition for skin cleansing of the present invention includes (A) a surfactant (hereinafter, may be referred to as (A) component) and (B) an amphipathic ester (hereinafter, (B). ) Is sometimes referred to as a component). Hereinafter, the liquid composition for skin cleansing of the present invention will be described in detail.
(A)界面活性剤
本発明の皮膚洗浄用液体組成物は、(A)成分として界面活性剤を含有する。界面活性剤としては特に限定されないが、皮膚への刺激を抑制する観点から、好ましくはアニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤、天然界面活性剤等が挙げられる。界面活性剤としては、アニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤、天然界面活性剤の中から1種を単独で使用してもよく、また2種以上を任意に組み合わせて使用してもよい。 (A) Surfactant The liquid composition for skin cleansing of the present invention contains a surfactant as a component (A). The surfactant is not particularly limited, but from the viewpoint of suppressing irritation to the skin, preferably an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned. As the surfactant, one of anionic surfactant, nonionic surfactant, amphoteric surfactant, and natural surfactant may be used alone, or two or more thereof may be arbitrarily combined. May be used.
本発明の皮膚洗浄用液体組成物は、(A)成分として界面活性剤を含有する。界面活性剤としては特に限定されないが、皮膚への刺激を抑制する観点から、好ましくはアニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤、天然界面活性剤等が挙げられる。界面活性剤としては、アニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤、天然界面活性剤の中から1種を単独で使用してもよく、また2種以上を任意に組み合わせて使用してもよい。 (A) Surfactant The liquid composition for skin cleansing of the present invention contains a surfactant as a component (A). The surfactant is not particularly limited, but from the viewpoint of suppressing irritation to the skin, preferably an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned. As the surfactant, one of anionic surfactant, nonionic surfactant, amphoteric surfactant, and natural surfactant may be used alone, or two or more thereof may be arbitrarily combined. May be used.
本発明に使用されるアニオン性界面活性剤としては、例えば、カルボン酸型、スルホン酸型、硫酸エステル型、リン酸エステル型等の界面活性剤が挙げられる。
Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate ester type, and phosphoric acid ester type surfactants.
カルボン酸型の界面活性剤としては、具体的には、オクタン酸、デカン酸、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸等の炭素数6~22の飽和又は不飽和脂肪酸;オクタノイル基、デカノイル基、ラウロイル基、ミリストイル基、パルミトイル基、ココイル基等の炭素数8~24の飽和又は不飽和のN-アシル基を有するN-アシルアミノ酸(カルボン酸型アミノ酸系アニオン性界面活性剤)が挙げられる。カルボン酸型アミノ酸系アニオン性界面活性剤におけるN-アシルアミノ酸としては、N-アシルサルコシン、N-アシルアスパラギン酸、N-アシルグルタミン酸、ラウロイルメチル-β-アラニン等が挙げられる。より具体的なカルボン酸型アミノ酸系アニオン性界面活性剤としては、N-ラウロイルサルコシン、N-ラウロイルアスパラギン酸、ココイルグルタミン酸、ラウロイルメチル-β-アラニンナトリウム等が挙げられる。
Specific examples of the carboxylic acid type surfactant include saturated or unsaturated amino acids having 6 to 22 carbon atoms such as octanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, and stearic acid; octanoyl groups and decanoyles. Examples include N-acyl amino acids (carboxylic acid-type amino acid-based anionic surfactants) having saturated or unsaturated N-acyl groups having 8 to 24 carbon atoms such as groups, lauroyl groups, myristic groups, palmitoyl groups, and cocoyl groups. Be done. Examples of the N-acyl amino acid in the carboxylic acid type amino acid-based anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, lauroylmethyl-β-alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroyl sarcosine, N-lauroyl aspartic acid, cocoyl glutamic acid, and lauroyl methyl-β-alanine sodium.
スルホン酸型の界面活性剤としては、具体的には、ココイルイセチオン酸等の炭素数6~22の脂肪酸とイセチオン酸のエステル;ヘキサンスルホン酸、オクタンスルホン酸、デカンスルホン酸、ドデカンスルホン酸等の炭素数6~22のアルキルスルホン酸;アルキルベンゼンスルホン酸等の炭素数10~16のアルキル基を有するアルキルベンゼンスルホン酸;オクタノイル基、デカノイル基、ラウロイル基、ミリストイル基、パルミトイル基、ココイル基等の炭素数8~24の飽和又は不飽和のN-アシル基を有するN-アシル-N-メチルタウリン(スルホン酸型アミノ酸系アニオン性界面活性剤)が挙げられる。より具体的なスルホン酸型アミノ酸系アニオン性界面活性剤としては、N-ミリストイル-N-メチルタウリン、N-ラウロイルメチルタウリン、ココイルメチルタウリン等が挙げられる。
Specific examples of the sulfonic acid type surfactant include an ester of a fatty acid having 6 to 22 carbon atoms such as cocoyl ISEthionic acid and an acetylonic acid; hexane sulfonic acid, octane sulfonic acid, decane sulfonic acid, dodecane sulfonic acid and the like. Alkyl sulfonic acid having 6 to 22 carbon atoms; Alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as alkylbenzene sulfonic acid; Examples thereof include N-acyl-N-methyltaurin (sulfonic acid type amino acid-based anionic surfactant) having a saturated or unsaturated N-acyl group of No. 8 to 24. More specific sulfonic acid-type amino acid-based anionic surfactants include N-myristoyl-N-methyltaurine, N-lauroylmethyltaurine, cocoylmethyltaurine and the like.
硫酸エステル型の界面活性剤としては、具体的には、ラウリル硫酸、ミリスチル硫酸等の炭素数10~22の飽和又は不飽和脂肪酸と硫酸のエステル等が挙げられる。リン酸エステル型の界面活性剤としては、具体的には、ラウリルリン酸等の炭素数8~24の飽和又は不飽和脂肪酸とリン酸のエステル等が挙げられる。
Specific examples of the sulfuric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate and sulfuric acid. Specific examples of the phosphoric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphoric acid and phosphoric acid.
なお、これらのアニオン性界面活性剤は、塩の形態であってもよく、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩;トリエタノールアミン(TEA)塩;アンモニウム塩等の形態をとることができる。
These anionic surfactants may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. it can.
これらのアニオン性界面活性剤の中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、好ましくはカルボン酸型の界面活性剤及びスルホン酸型の界面活性剤が挙げられ、より好ましくは、ラウリン酸、N-ラウロイルアスパラギン酸、ココイルグルタミン酸、ココイルメチルタウリン及びこれらの塩が挙げられ、さらに好ましくは、ラウリン酸ナトリウム、N-ラウロイルアスパラギン酸ナトリウム、ココイルグルタミン酸トリエタノールアミン、ココイルメチルタウリンナトリウムが挙げられる。さらにこれらの中でも、皮膚刺激低減性を一層良好に得る観点から、好ましくは炭素数8~24の飽和又は不飽和のアシル基を有するN-アシルグルタミン酸及び炭素数8~22の脂肪酸アミドスルホン酸及びこれらの塩が挙げられ、より好ましくはココイルグルタミン酸、ココイルメチルタウリン及びこれらの塩が挙げられ、さらに好ましくはココイルグルタミン酸トリエタノールアミン、ココイルメチルタウリンナトリウムが挙げられ、また、洗浄力を一層良好に得る観点から、好ましくは炭素数8~24の飽和又は不飽和のアシル基を有するN-アシルアスパラギン酸が挙げられ、より好ましくはN-ラウロイルアスパラギン酸が挙げられ、さらに好ましくはN-ラウロイルアスパラギン酸ナトリウムが挙げられる。
Among these anionic surfactants, carboxylic acid type surfactants and sulfonic acid type surfactants are preferable, and more preferably, from the viewpoint of obtaining better skin irritation reducing property and detergency. Lauric acid, N-lauroyl aspartic acid, cocoyl glutamate, cocoyl methyl taurine and salts thereof are mentioned, and more preferably, sodium laurate, sodium N-lauroyl aspartate, cocoyl glutamate triethanolamine, sodium cocoyl methyl taurine are mentioned. Be done. Further, among these, from the viewpoint of obtaining better skin irritation reducing property, preferably N-aspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms, fatty acid amide sulfonic acid having 8 to 22 carbon atoms, and the like. These salts are mentioned, more preferably cocoyl glutamate, cocoyl methyl taurine and salts thereof, further preferably cocoyl glutamate triethanolamine, cocoyl methyl taurine sodium, and even better detergency. From the viewpoint, N-acylaspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms is preferably mentioned, more preferably N-lauroyl aspartic acid is mentioned, and further preferably sodium N-lauroyl aspartate is mentioned. Can be mentioned.
これらのアニオン性界面活性剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
These anionic surfactants may be used alone or in combination of two or more.
本発明に使用される非イオン性界面活性剤としては、例えば、エステル型、エーテル型、エステル・エーテル型、アルカノールアミド型、アルキルグリコシド型、アルコール型等の界面活性剤が挙げられる。
Examples of the nonionic surfactant used in the present invention include ester-type, ether-type, ester-ether-type, alkanolamide-type, alkylglycoside-type, and alcohol-type surfactants.
エステル型の界面活性剤としては、具体的には、ジラウリン酸グリコール、モノステアリン酸グリコール、ジステアリン酸グリコール、モノラウリン酸グリセリル、ジラウリン酸グリセリル、モノステアリン酸グリセリル、ジステアリン酸グリセリル等の炭素数8~20の飽和又は不飽和脂肪酸とグリセリンのモノ又はジエステル;ソルビタン脂肪酸エステル;ショ糖脂肪酸エステル等が挙げられる。
Specific examples of the ester-type surfactant include glycols dilaurate, glycol monostearate, glycol distearate, glyceryl monolaurate, glyceryl dilaurate, glyceryl monostearate, and glyceryl distearate, which have 8 to 20 carbon atoms. Saturated or unsaturated fatty acids and glycerin mono- or diesters; sorbitan fatty acid esters; sucrose fatty acid esters and the like.
エーテル型の界面活性剤としては、具体的には、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンポリオキシプロピレングリコール等が挙げられる。
Specific examples of the ether-type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, and polyoxyethylene polyoxypropylene glycol.
エステル・エーテル型の界面活性剤としては、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンヘキシタン脂肪酸エステル、ソルビタン脂肪酸エステルポリエチレングリコール等が挙げられる。
Examples of the ester-ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitan fatty acid ester, and sorbitan fatty acid ester polyethylene glycol.
アルカノールアミド型の界面活性剤としては、具体的には、コカミドDEA(ヤシ油脂肪酸ジエタノールアミド)、ラウリン酸ジエタノールアミド、オレイン酸ジエタノールアミド、ステアリン酸ジエタノールアミド等が挙げられる。
Specific examples of the alkanolamide type surfactant include coconut DEA (coconut oil fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide and the like.
アルキルグリコシド型界面活性剤としては、具体的には、オクチルグルコシド、デシルグルコシド、ラウリルグルコシド等が挙げられる。
Specific examples of the alkyl glucoside type surfactant include octyl glucoside, decyl glucoside, and lauryl glucoside.
アルコール型の界面活性剤としては、セタノール、ステアリルアルコール、オレイルアルコール等が挙げられる。
Examples of alcohol-type surfactants include cetanol, stearyl alcohol, and oleyl alcohol.
これらの非イオン性界面活性剤の中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、好ましくは、エステル・エーテル型の界面活性剤及びアルカノールアミド型の界面活性剤が挙げられ、より好ましくは、ポリオキシエチレン硬化ヒマシ油及びコカミドDEAが挙げられ、さらに好ましくはポリオキシエチレン硬化ヒマシ油が挙げられる。
Among these nonionic surfactants, ester ether type surfactants and alkanolamide type surfactants are preferable from the viewpoint of obtaining better skin irritation reducing property and detergency. Preferred are polyoxyethylene hydrogenated castor oil and cocamide DEA, and more preferably polyoxyethylene hydrogenated castor oil.
これらの非イオン性界面活性剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
These nonionic surfactants may be used alone or in combination of two or more.
本発明に使用される両性界面活性剤としては、例えば、アルキルベタイン型、脂肪酸アミドプロピルベタイン型、アミンオキシド型等の界面活性剤が例示される。
Examples of amphoteric surfactants used in the present invention include alkyl betaine type, fatty acid amide propyl betaine type, amine oxide type and other surfactants.
アルキルベタイン型の界面活性剤としては、具体的には、ラウリルジメチルアミノ酢酸ベタイン、ステアリルジメチルアミノ酢酸ベタイン、オクタデシルアミノメチルジメチルスルホプロピルベタイン等が挙げられる。
Specific examples of the alkyl betaine type surfactant include lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, octadecylaminomethyldimethylsulfopropyl betaine and the like.
脂肪酸アミドプロピルベタイン型両性界面活性剤としては、具体的には、コカミドプロピルベタイン等のアミドベタイン(アミノ酸系両性界面活性剤)、コカミドプロピルヒドロキシスルタイン等のスルホベタイン等が挙げられる。
Specific examples of the fatty acid amide propyl betaine type amphoteric tenside agent include amide betaine (amino acid-based amphoteric tenside agent) such as cocamidopropyl betaine, and sulfobetaine such as cocamidopropyl hydroxysultaine.
アミンオキシド型両性界面活性剤としては、具体的には、ラウリルジメチルアミンN‐オキシド、オレイルジメチルアミンN‐オキシド等が挙げられる。
Specific examples of the amine oxide type amphoteric surfactant include lauryldimethylamine N-oxide and oleyldimethylamine N-oxide.
なお、これらの両性界面活性剤は、塩の形態であってもよく、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩;トリエタノールアミン(TEA)塩;アンモニウム塩等の形態をとることができる。
These amphoteric tenside agents may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. ..
これらの両性界面活性剤の中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、好ましくは脂肪酸アミドプロピルベタイン型界面活性剤が挙げられ、より好ましくはコカミドプロピルベタイン等のアミドベタイン(アミノ酸系両性界面活性剤)が挙げられ、さらに好ましくはコカミドプロピルベタインが挙げられる。
Among these amphoteric surfactants, fatty acid amide propyl betaine type surfactants are preferable, and amide betaines such as cocamidopropyl betaine are more preferable, from the viewpoint of obtaining better skin irritation reduction property and detergency. Amino acid-based amphoteric surfactant), more preferably cocamidopropyl betaine.
これらの両性界面活性剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
These amphoteric surfactants may be used alone or in combination of two or more.
本発明に使用される天然界面活性剤としては、レシチン及びリゾレシチン;キラヤサポニン、ダイズサポニン、ユッカサポニン、エンジュサポニン、ビートサポニン、アズキサポニン、ニンジンサポニン、茶種サポニン、ヘチマサポニン、ツボクササポニンなどのサポニン等が挙げられる。
Natural surfactants used in the present invention include lecithin and lysolecithin; saponins such as Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azuxaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin. And so on.
レシチンは、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルセリン、ホスファチジルイノシトールなどのリン脂質と、トリグリセリド、脂肪酸、植物油からの炭水化物などの成分との混合物であり、医薬品、医薬部外品、化粧品において公知の成分である。
Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol with components such as triglycerides, fatty acids, and carbohydrates from vegetable oils, and is a known component in pharmaceuticals, quasi-drugs, and cosmetics. is there.
レシチンとしては、動植物由来の天然レシチン(例えば、大豆レシチン、卵黄レシチン等)そのものであってもよいし、天然レシチンの化学処理物であってもよいし、天然レシチンの精製物であってもよい。天然レシチンの化学処理物としては、水素添加処理により得られた水素添加レシチン(例えば、完全水素添加レシチンや部分水素添加レシチン)、水酸化処理により得られた水酸化レシチン等が挙げられる。天然レシチンの精製物としては、アセトン等の溶剤によりホスファチジルコリンの含有量を高めたレシチンが挙げられる。
The lecithin may be natural lecithin derived from animals and plants (for example, soybean lecithin, egg yolk lecithin, etc.) itself, a chemically treated product of natural lecithin, or a purified product of natural lecithin. .. Examples of the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation treatment (for example, fully hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation treatment. Examples of the purified product of natural lecithin include lecithin in which the content of phosphatidylcholine is increased by a solvent such as acetone.
リゾレシチンとしては、上記のレシチン(天然レシチン、天然レシチンの化学処理物、天然レシチンの精製物)のリゾ体が挙げられる。リゾレシチンは、レシチンをホスホリパーゼA2などの酵素による加水分解(溶解)でホスファチジルコリンの2位の脂肪酸が除去された構造を有する。
Examples of lysolecithin include lyso-forms of the above-mentioned lecithin (natural lecithin, chemically treated natural lecithin, purified natural lecithin). Lysolecithin has a structure in which the fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin by an enzyme such as phospholipase A2.
これらの天然界面活性剤の中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、好ましくはレシチン及びリゾレシチン並びにサポニンが挙げられ、より好ましくはレシチン及びリゾレシチンが挙げられ、さらに好ましくはリゾレシチンが挙げられる。
Among these natural surfactants, lecithin and lysolecithin and saponin are preferable, lecithin and lysolecithin are more preferable, and lysolecithin is more preferable, from the viewpoint of obtaining better skin irritation reducing property and detergency. Can be mentioned.
これらの天然界面活性剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
These natural surfactants may be used alone or in combination of two or more.
本発明の皮膚洗浄剤液体組成物における(A)成分の含有量は特に限定されず、付与すべき洗浄力に応じて適宜決定することができる。本発明の皮膚洗浄剤液体組成物は、物理的摩擦を皮膚に与えることなく洗浄することが可能であるため、皮膚洗浄用液体組成物における界面活性剤の配合量を、従前の皮膚洗浄用液体組成物に含まれる配合量よりも大幅に低減させることができ、本来的には有効な洗浄力を発揮できないような少量の界面活性剤量であっても効果的に洗浄力を発揮することができる。このような観点から、本発明の皮膚洗浄剤液体組成物における(A)成分の含有量としては、好ましくは0.025~2重量%、より好ましくは0.025~1.5重量%以下、さらに好ましくは0.025~1重量%以下、特に好ましくは0.025~0.9重量%以下が挙げられる。このように界面活性剤量が少量であることより、皮膚刺激性を各段に低減することができる。また、より優れた洗浄力を得る観点からは、(A)成分の上記含有量の範囲の下限としては、0.1重量%以上であることが好ましく、0.5重量%以上であることがより好ましい。
The content of the component (A) in the liquid composition of the skin cleansing agent of the present invention is not particularly limited, and can be appropriately determined according to the cleansing power to be imparted. Since the skin cleansing liquid composition of the present invention can be washed without applying physical friction to the skin, the blending amount of the surfactant in the skin cleansing liquid composition can be adjusted to the conventional skin cleansing liquid. It can be significantly reduced compared to the blending amount contained in the composition, and even a small amount of surfactant that originally cannot exert effective detergency can effectively exert detergency. it can. From this point of view, the content of the component (A) in the liquid composition of the skin detergent of the present invention is preferably 0.025 to 2% by weight, more preferably 0.025 to 1.5% by weight or less. More preferably, it is 0.025 to 1% by weight or less, and particularly preferably 0.025 to 0.9% by weight or less. Since the amount of the surfactant is small as described above, the skin irritation can be significantly reduced. Further, from the viewpoint of obtaining more excellent detergency, the lower limit of the range of the content of the component (A) is preferably 0.1% by weight or more, and preferably 0.5% by weight or more. More preferred.
(B)両親媒性エステル
本発明の皮膚洗浄用液体組成物は、(B)成分として両親媒性エステルを含有する。(B)成分は単独で洗浄作用を示さないが、(A)成分と共存させることによって、低刺激性を維持しながら皮膚洗浄用液体組成物の洗浄力を向上させることができる。 (B) Amphiphilic ester The liquid composition for skin cleansing of the present invention contains an amphipathic ester as a component (B). Although the component (B) does not show a cleansing action by itself, by coexisting with the component (A), the cleansing power of the liquid composition for skin cleansing can be improved while maintaining low irritation.
本発明の皮膚洗浄用液体組成物は、(B)成分として両親媒性エステルを含有する。(B)成分は単独で洗浄作用を示さないが、(A)成分と共存させることによって、低刺激性を維持しながら皮膚洗浄用液体組成物の洗浄力を向上させることができる。 (B) Amphiphilic ester The liquid composition for skin cleansing of the present invention contains an amphipathic ester as a component (B). Although the component (B) does not show a cleansing action by itself, by coexisting with the component (A), the cleansing power of the liquid composition for skin cleansing can be improved while maintaining low irritation.
本発明において、両親媒性エステルは、日本薬局方一般試験法に定められた方法による測定で、導電率70~110μs/mに調整されたイオン交換水に常温で2質量%以上溶解し、かつ、油剤であるイソノナン酸イソトリデシル(日清オイリオグループ社製、サラコス913)にも常温(25℃)で10質量%以上溶解するものであり、エステル系界面活性剤は除かれる。
In the present invention, the amphipathic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 μs / m by 2% by mass or more at room temperature by the method specified in the Japanese Pharmacopoeia General Test Method. , Isotridecyl isononanoate (manufactured by Nisshin Oillio Group, Saracos 913), which is an oil agent, also dissolves in 10% by mass or more at room temperature (25 ° C.), and ester-based surfactants are excluded.
両親媒性エステルとしては特に限定されないが、皮膚刺激低減性及び洗浄力をより良好に得る観点から、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステル及び(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10よりなる群から選ばれるものであることが好ましい。両親媒性エステルとしては、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステル及び(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10の中からいずれかを単独で使用してもよく、また両方を組み合わせて使用してもよい。これらの両親媒性エステルの中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルがより好ましい。
The amphoteric ester is not particularly limited, but from the viewpoint of reducing skin irritation and obtaining better detergency, a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 are used. It is preferably selected from the group consisting of. As the amphipathic ester, either one of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and (eicosane diic acid / tetradecane diic acid) polyglyceryl-10 may be used alone, or both may be combined. You may use it. Among these amphipathic esters, the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is more preferable from the viewpoint of obtaining better skin irritation reducing property and detergency.
本発明に使用されるジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルは、ジカルボン酸とポリオキシアルキレンアルキルエーテルとのジエステル化合物である。ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルのジエステル化合物を構成するジカルボン酸の具体例としては、例えば、シュウ酸、マロン酸、コハク酸、酒石酸、リンゴ酸、グルタル酸、アジピン酸、ペメリン酸、スベリン酸、アゼライン酸、セバシン酸、アスパラギン酸、グルタミン酸、アセトンジカルボン酸、フタル酸、シクロヘキサン-1,4-ジカルボン酸などが挙げられる。また、ジエステル化合物を構成するポリオキシアルキレンアルキルエーテルとしては、例えば、ポリオキシエチレンモノアルキルエーテルなどが挙げられ、より具体的には、例えば、ジエチレングリコールモノエチルエーテル、トリエチレングリコールモノエチルエーテルなどが挙げられる。
The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, and the like. Examples thereof include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Be done.
これらのジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルの中でも、皮膚刺激低減性及び洗浄力をより良好に得る観点から、好ましくは、シクロヘキサン-1,4-ジカルボン酸とジエチレングリコールモノエチルエーテルとのジエステル化合物、具体的には、INCI名(International Cosmetic Ingredient Dictionary and Handbook,第13版,第1巻,CTFA,2010年,p.331):BIS-ETHOXYDIGLYCOL CYCLOHEXANE 1,4-DICARBOXYLATEで表記される、シクロへキサン-1,4-ジカルボン酸ビスエトキシジグリコールと称される化合物、及びコハク酸とジエチレングリコールモノエチルエーテルとのジエステル化合物、具体的には、INCI名(International Cosmetic Ingredient Dictionary and Handbook,第13版,第1巻,CTFA,2010年,p.331-332):BIS-ETHOXYDIGLYCOL SUCCINATEで表記される、コハク酸ビスエトキシジグリコールと称される化合物が挙げられ、より好ましくは、シクロへキサン-1,4-ジカルボン酸ビスエトキシジグリコールが挙げられる。
Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, a diester of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether is preferable from the viewpoint of obtaining better skin irritation reduction property and detergency. Compound, specifically, INCI name (International Cosmetic Ingredient Dicarboxylic Acid Handbook, 13th Edition, Volume 1, CTFA, 2010, p.331): BIS-ETHOXYDIGLYCOLCYCOLTECYCYCLOHEXANE 1,4-D A compound called hexethoxy-1,4-dicarboxylic acid bisethoxydiglycol, and a diester compound of succinic acid and diethylene glycol monoethyl ether, specifically, INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th edition). , Volume 1, CTFA, 2010, p.331-332): BIS-ETHOXYDIGLYCOL SUCCINATE, a compound called bisethoxydiglycol succinate, more preferably cyclohexane-1. , 4-Dicarboxylic acid bisethoxydiglycol.
また、本発明において、前記シクロへキサン-1,4-ジカルボン酸ビスエトキシジグリコールの具体例としては、例えば、日本精化株式会社製の「Neosolue-Aqulio(商品名)」等が挙げられる。また、前記コハク酸ビスエトキシジグリコールの具体例としては、例えば、高級アルコール工業株式会社製の「ハイアクオスター DCS(商品名)」等が挙げられる。
Further, in the present invention, specific examples of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol include, for example, "Neosolue-Aquilio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd. Specific examples of the bisethoxydiglycol succinate include "High Aquos Star DCS (trade name)" manufactured by Higher Alcohol Industry Co., Ltd.
これらのジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.
本発明に使用される(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10としては、特に限定されないが、例えば、日本精化株式会社製の「Neosolue-Aqua(商品名)」、「Neosolue-AquaS(商品名)」等が挙げられる。
The polyglyceryl-10 (eicosane diic acid / tetradecane diic acid) used in the present invention is not particularly limited, but for example, "Neosolue-Aqua (trade name)" and "Neosolue-AquaS" manufactured by Nippon Fine Chemical Co., Ltd. Product name) ”and the like.
本発明の皮膚洗浄用液体組成物における(B)成分の含有量としては特に限定されないが、例えば0.1重量%以上が挙げられる。洗浄力をより良好に得る観点から、(B)成分の含有量としては好ましくは0.5重量%以上が挙げられる。(B)成分の含有量の範囲の上限は特に限定されないが、皮膚洗浄用液体組成物の安定性等の観点から、例えば5重量%以下、好ましくは3重量%以下、より好ましくは2重量%以下が挙げられる。
The content of the component (B) in the liquid composition for skin washing of the present invention is not particularly limited, and examples thereof include 0.1% by weight or more. From the viewpoint of obtaining better detergency, the content of the component (B) is preferably 0.5% by weight or more. The upper limit of the content of the component (B) is not particularly limited, but from the viewpoint of stability of the liquid composition for skin washing, for example, 5% by weight or less, preferably 3% by weight or less, more preferably 2% by weight. The following can be mentioned.
本発明の皮膚洗浄用液体組成物において、(A)成分と(B)成分との比率は特に限定されず、上記の各含有量により定まるが、皮膚刺激低減性及び洗浄力をより良好に得る観点から、(A)成分1重量部に対して(B)成分が例えば0.1~100重量部、好ましくは0.1~10重量部、より好ましくは0.5~5重量部が挙げられる。
In the liquid composition for skin cleaning of the present invention, the ratio of the component (A) to the component (B) is not particularly limited and is determined by each of the above-mentioned contents, but the skin irritation reducing property and the detergency can be obtained better. From the viewpoint, the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, and more preferably 0.5 to 5 parts by weight with respect to 1 part by weight of the component (A). ..
他の成分
本発明の皮膚洗浄用液体組成物には、前記成分の他に、本発明の効果を損なわない範囲で、製剤化等に必要とされる他の基剤や添加剤が含まれていてもよい。このような添加剤については、薬学的に許容されることを限度として特に制限されないが、例えば、水、炭素数1~5の低級アルコール、及び多価アルコール等の水性基剤;防腐剤、着色剤、粘稠剤、pH調整剤、湿潤剤、安定化剤、酸化防止剤、紫外線吸収剤、キレート剤、粘着剤、緩衝剤、溶解補助剤、可溶化剤、保存剤等の添加剤が挙げられる。これらの基材や添加剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。これらの基材や添加剤の含有量は、製剤形態等に応じて適宜設定することができる。 Other Ingredients In addition to the above ingredients, the liquid composition for skin cleansing of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. You may. Such additives are not particularly limited as long as they are pharmaceutically acceptable, but are, for example, aqueous bases such as water, lower alcohols having 1 to 5 carbon atoms, and polyhydric alcohols; preservatives, coloring agents, etc. Additives such as agents, thickeners, pH regulators, wetting agents, stabilizers, antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, solubilizers, preservatives, etc. Be done. These base materials and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.
本発明の皮膚洗浄用液体組成物には、前記成分の他に、本発明の効果を損なわない範囲で、製剤化等に必要とされる他の基剤や添加剤が含まれていてもよい。このような添加剤については、薬学的に許容されることを限度として特に制限されないが、例えば、水、炭素数1~5の低級アルコール、及び多価アルコール等の水性基剤;防腐剤、着色剤、粘稠剤、pH調整剤、湿潤剤、安定化剤、酸化防止剤、紫外線吸収剤、キレート剤、粘着剤、緩衝剤、溶解補助剤、可溶化剤、保存剤等の添加剤が挙げられる。これらの基材や添加剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。これらの基材や添加剤の含有量は、製剤形態等に応じて適宜設定することができる。 Other Ingredients In addition to the above ingredients, the liquid composition for skin cleansing of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. You may. Such additives are not particularly limited as long as they are pharmaceutically acceptable, but are, for example, aqueous bases such as water, lower alcohols having 1 to 5 carbon atoms, and polyhydric alcohols; preservatives, coloring agents, etc. Additives such as agents, thickeners, pH regulators, wetting agents, stabilizers, antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, solubilizers, preservatives, etc. Be done. These base materials and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.
本発明の皮膚洗浄用液体組成物には、前記成分の他に、本発明の効果を損なわない範囲で、必要に応じて他の薬理成分を含有していてもよい。このような薬理成分としては、例えば、ビタミン類、抗ヒスタミン剤、局所麻酔剤、抗炎症剤、皮膚保護剤、血行促進成分、清涼化剤、ムコ多糖類等が挙げられる。これらの薬理成分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。これらの薬理成分を含有させる場合、その含有量については、使用する薬理成分の種類、期待する効果等に応じて適宜設定すればよい。
The liquid composition for skin cleansing of the present invention may contain, if necessary, other pharmacological components in addition to the above-mentioned components as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins, antihistamines, local anesthetics, anti-inflammatory agents, skin protectants, blood circulation promoting components, refreshing agents, mucopolysaccharides and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological component to be used, the expected effect, and the like.
形態
本発明の皮膚洗浄用液体組成物の形態は、常温で液状又はジェル状である。また、本発明の皮膚洗浄用液体組成物の粘度としては、20℃において10000mPa・s以下、好ましくは5000mPa・s以下が挙げられる。なお、粘度は、BL粘度計(ロ-ターNo3、6rpm、20℃)によって測定される値である。 Form The form of the liquid composition for skin cleansing of the present invention is liquid or gel at room temperature. The viscosity of the liquid composition for skin washing of the present invention is 10,000 mPa · s or less, preferably 5000 mPa · s or less at 20 ° C. The viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).
本発明の皮膚洗浄用液体組成物の形態は、常温で液状又はジェル状である。また、本発明の皮膚洗浄用液体組成物の粘度としては、20℃において10000mPa・s以下、好ましくは5000mPa・s以下が挙げられる。なお、粘度は、BL粘度計(ロ-ターNo3、6rpm、20℃)によって測定される値である。 Form The form of the liquid composition for skin cleansing of the present invention is liquid or gel at room temperature. The viscosity of the liquid composition for skin washing of the present invention is 10,000 mPa · s or less, preferably 5000 mPa · s or less at 20 ° C. The viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).
容器
本発明の皮膚洗浄用液体組成物を収容する容器については、容器内から皮膚洗浄用液体組成物を直接肌に適用することが可能なものであれば特に限定されず、例えば、噴霧式容器、注下又は滴下式容器(特に洗浄瓶)が挙げられ、エステサロンや美容院における施術容易性の観点からは、好ましくは注下又は滴下式容器(特に洗浄瓶)が挙げられる。なお、本発明における噴霧式容器は、内容物をミスト状態で吐出するものであり、いずれも、皮膚洗浄用液体組成物を泡状態で吐出するポンプフォーマー容器とは異なる。 Container The container for accommodating the liquid composition for skin cleaning of the present invention is not particularly limited as long as the liquid composition for skin cleaning can be directly applied to the skin from inside the container, for example, a spray-type container. , A pouring or dropping type container (particularly a washing bottle), and preferably a pouring or dropping type container (particularly a washing bottle) from the viewpoint of ease of treatment in an esthetic salon or a beauty salon. The spray container in the present invention discharges the contents in a mist state, and is different from the pump former container in which the liquid composition for skin washing is discharged in a foam state.
本発明の皮膚洗浄用液体組成物を収容する容器については、容器内から皮膚洗浄用液体組成物を直接肌に適用することが可能なものであれば特に限定されず、例えば、噴霧式容器、注下又は滴下式容器(特に洗浄瓶)が挙げられ、エステサロンや美容院における施術容易性の観点からは、好ましくは注下又は滴下式容器(特に洗浄瓶)が挙げられる。なお、本発明における噴霧式容器は、内容物をミスト状態で吐出するものであり、いずれも、皮膚洗浄用液体組成物を泡状態で吐出するポンプフォーマー容器とは異なる。 Container The container for accommodating the liquid composition for skin cleaning of the present invention is not particularly limited as long as the liquid composition for skin cleaning can be directly applied to the skin from inside the container, for example, a spray-type container. , A pouring or dropping type container (particularly a washing bottle), and preferably a pouring or dropping type container (particularly a washing bottle) from the viewpoint of ease of treatment in an esthetic salon or a beauty salon. The spray container in the present invention discharges the contents in a mist state, and is different from the pump former container in which the liquid composition for skin washing is discharged in a foam state.
本発明においては、このように皮膚洗浄用液体組成物を噴霧式容器、注下又は滴下式容器(特に洗浄瓶)に収容することにより、肌への適用の前に泡立てることなく、皮膚洗浄用液体組成物が直接的に肌に塗布される。従って、肌への塗布が手軽であり且つ塗布時における手等による物理摩擦及び/又は洗浄時の泡による物理摩擦を回避することができる。噴霧式容器としては、非エアゾール式スプレー容器であるポンプ式スプレー容器、及び、エアゾール式スプレー容器が挙げられる。噴霧式容器の口径(ノズル内径)としては、例えば0.01~3mmφ、好ましくは0.1~1mmφが挙げられる。噴霧式容器がポンプ式スプレー容器である場合の1プッシュあたりの噴射量としては、例えば0.05~1.2g、好ましくは0.1~0.3gが挙げられる。
In the present invention, by containing the liquid composition for skin washing in a spray container, a pouring or dropping container (particularly a washing bottle) in this way, for skin washing without foaming before application to the skin. The liquid composition is applied directly to the skin. Therefore, it is easy to apply to the skin, and physical friction due to hands or the like at the time of application and / or physical friction due to bubbles during washing can be avoided. Examples of the spray type container include a pump type spray container which is a non-aerosol type spray container and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include 0.01 to 3 mmφ, preferably 0.1 to 1 mmφ. When the spray type container is a pump type spray container, the injection amount per push is, for example, 0.05 to 1.2 g, preferably 0.1 to 0.3 g.
用途
本発明の皮膚洗浄用液体組成物は、皮膚の油脂、汗などの体液や汚れ等を除去するために用いられるものであり、化粧落とし(クレンジング)として用いられるものではない。本発明の皮膚洗浄用液体組成物は、エステサロンや美容院における洗顔施術用途に用いられる。本発明の皮膚洗浄用液体組成物は、水で薄めることなく、泡立てずにそのまま皮膚に塗布することで使用する。1回当たりの使用量としては、界面活性剤の濃度及び汚れの程度等にもよるが、例えば洗顔に用いる場合0.5~3g、好ましくは1~2gが挙げられる。 Uses The liquid composition for skin cleansing of the present invention is used for removing body fluids such as oils and fats and sweat on the skin, stains, etc., and is not used as a makeup remover (cleansing). The liquid composition for skin cleansing of the present invention is used for facial cleansing in beauty salons and beauty salons. The liquid composition for skin cleansing of the present invention is used by applying it to the skin as it is without foaming without diluting with water. The amount used at one time depends on the concentration of the surfactant, the degree of stain, etc., but for example, when used for face washing, 0.5 to 3 g, preferably 1 to 2 g can be mentioned.
本発明の皮膚洗浄用液体組成物は、皮膚の油脂、汗などの体液や汚れ等を除去するために用いられるものであり、化粧落とし(クレンジング)として用いられるものではない。本発明の皮膚洗浄用液体組成物は、エステサロンや美容院における洗顔施術用途に用いられる。本発明の皮膚洗浄用液体組成物は、水で薄めることなく、泡立てずにそのまま皮膚に塗布することで使用する。1回当たりの使用量としては、界面活性剤の濃度及び汚れの程度等にもよるが、例えば洗顔に用いる場合0.5~3g、好ましくは1~2gが挙げられる。 Uses The liquid composition for skin cleansing of the present invention is used for removing body fluids such as oils and fats and sweat on the skin, stains, etc., and is not used as a makeup remover (cleansing). The liquid composition for skin cleansing of the present invention is used for facial cleansing in beauty salons and beauty salons. The liquid composition for skin cleansing of the present invention is used by applying it to the skin as it is without foaming without diluting with water. The amount used at one time depends on the concentration of the surfactant, the degree of stain, etc., but for example, when used for face washing, 0.5 to 3 g, preferably 1 to 2 g can be mentioned.
より具体的には、皮膚洗浄用液体組成物を手に取ることなく、直接的に噴霧式容器、注下又は滴下式容器(特に洗浄瓶)から洗浄対象部位に塗布することができる。このように、皮膚洗浄用液体組成物を直接的に洗浄対象部位に塗布することで、洗浄対象部位の皮膚と手との間に生じる摩擦や、洗浄部位の皮膚と気泡との間に生じる摩擦といった物理的摩擦を一切与えることなく、液流の機械力を利用するだけで洗浄することが可能になる。本発明の皮膚洗浄用液体組成物は、洗浄力に優れた処方であるため、このように物理的摩擦を与えずに液流の機械力を利用して洗浄することで、洗浄時における肌への負担が顕著に軽減され極めて優しい洗浄方法が可能となる。このように泡立てない洗浄方法は、素早い洗浄を可能とし、界面活性剤が少なく肌に優しいことも実感しやすく、肌に優しい洗浄を追及する意識が高い消費者の満足感も得られやすくなる。
More specifically, the liquid composition for skin cleansing can be directly applied to the site to be cleaned from a spray-type container, a pouring or dropping-type container (particularly a washing bottle) without picking it up. In this way, by applying the skin cleansing liquid composition directly to the cleansing site, the friction generated between the skin and the hand of the cleansing site and the friction generated between the skin and air bubbles of the cleansing site. It is possible to wash by simply using the mechanical force of the liquid flow without giving any physical friction such as. Since the liquid composition for skin cleansing of the present invention is a formulation having excellent cleansing power, it is possible to cleanse the skin at the time of washing by using the mechanical force of the liquid flow without giving physical friction in this way. The burden on the skin is remarkably reduced, and an extremely gentle cleaning method becomes possible. Such a non-foaming cleaning method enables quick cleaning, and it is easy to realize that it is gentle on the skin with less surfactant, and it is easy to obtain satisfaction of consumers who are highly conscious of pursuing skin-friendly cleaning.
本発明の皮膚洗浄用液体組成物の洗浄対象部位としては、あらゆる身体部位の洗浄が可能であるため特に制限されず、例えば、手、髪、頭皮、体、顔等が挙げられる。また、本発明の皮膚洗浄用液体組成物が物理的摩擦を皮膚に与えることなく優れた洗浄力を発揮することができるため、刺激に対して敏感な顔への使用において好適である。
The site to be cleaned of the liquid composition for skin cleaning of the present invention is not particularly limited because it can clean any body part, and examples thereof include hands, hair, scalp, body, and face. Further, since the liquid composition for skin cleansing of the present invention can exert excellent cleansing power without giving physical friction to the skin, it is suitable for use on a face sensitive to irritation.
洗浄後、皮膚洗浄用液体組成物は、水で洗い流すことができる。水で洗い流す場合も、手による物理的摩擦を与えないように水流の機械力を利用して洗い流す。洗い流しに用いる水も、噴霧式容器、注下又は滴下式容器(特に洗浄瓶)、好ましくは注下又は滴下式容器(特に洗浄瓶)に収容し、皮膚洗浄用液体組成物と同様に洗浄対象部位に適用することができる。
After washing, the liquid composition for skin washing can be washed away with water. Even when rinsing with water, wash it off using the mechanical force of the water stream so as not to give physical friction by hand. The water used for rinsing is also contained in a spray container, a pouring or dropping container (particularly a washing bottle), preferably a pouring or dropping container (particularly a washing bottle), and is to be washed in the same manner as the liquid composition for skin washing. It can be applied to the site.
また、本発明の皮膚洗浄用液体組成物は、界面活性剤濃度を極端に低くすることができるため、この場合、洗浄後に洗い流さなくてもよい。このため、本発明の皮膚洗浄用液体組成物は、病院における清拭用途、エステサロンや美容院における洗顔等皮膚洗浄施術用途、及び災害用品用途等でも好適である。洗い流さない場合、タオルやティッシュ等の吸水性基材を用いてこすらないように洗浄部位に残存した皮膚洗浄用液体組成物を吸い取って除去してもよい。
Further, since the liquid composition for skin washing of the present invention can make the concentration of the surfactant extremely low, in this case, it is not necessary to wash off after washing. Therefore, the liquid composition for skin cleansing of the present invention is also suitable for cleaning in hospitals, skin cleansing treatments such as face washing in beauty salons and beauty salons, and disaster supplies. If it is not washed away, a water-absorbent base material such as a towel or tissue may be used to absorb and remove the liquid composition for skin washing remaining on the washing site without rubbing.
製造方法
本発明の皮膚洗浄用液体組成物は、前述する(A)成分及び(B)成分、並びに必要に応じて配合される他の成分等を混合して、所定の形態に調製することによって製造される。 Production Method The liquid composition for skin cleansing of the present invention is prepared into a predetermined form by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary. Manufactured.
本発明の皮膚洗浄用液体組成物は、前述する(A)成分及び(B)成分、並びに必要に応じて配合される他の成分等を混合して、所定の形態に調製することによって製造される。 Production Method The liquid composition for skin cleansing of the present invention is prepared into a predetermined form by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary. Manufactured.
2.皮膚洗浄方法
前述するように、両親媒性エステルは、界面活性剤を含む皮膚洗浄料組成物において、物理的摩擦を皮膚に与えることなく、洗浄力を向上させることができる。従って、本発明は、更に、(A)成分である界面活性剤と共に、(B)成分である両親媒性エステルを含有する皮膚洗浄用液体組成物を、物理的摩擦を皮膚に与えることなく皮膚に適用することを含む皮膚洗浄方法を提供する。本発明の皮膚洗浄方法は、エステサロンや美容院で行われる洗浄施術として実施することができる。 2. Skin Cleansing Method As described above, the amphipathic ester can improve the cleansing power in the skin cleansing composition containing a surfactant without giving physical friction to the skin. Therefore, the present invention further provides a liquid composition for skin cleaning containing a surfactant as a component (A) and an amphipathic ester as a component (B) without giving physical friction to the skin. Provide skin cleaning methods, including applying to. The skin cleaning method of the present invention can be carried out as a cleaning treatment performed at an esthetic salon or a beauty salon.
前述するように、両親媒性エステルは、界面活性剤を含む皮膚洗浄料組成物において、物理的摩擦を皮膚に与えることなく、洗浄力を向上させることができる。従って、本発明は、更に、(A)成分である界面活性剤と共に、(B)成分である両親媒性エステルを含有する皮膚洗浄用液体組成物を、物理的摩擦を皮膚に与えることなく皮膚に適用することを含む皮膚洗浄方法を提供する。本発明の皮膚洗浄方法は、エステサロンや美容院で行われる洗浄施術として実施することができる。 2. Skin Cleansing Method As described above, the amphipathic ester can improve the cleansing power in the skin cleansing composition containing a surfactant without giving physical friction to the skin. Therefore, the present invention further provides a liquid composition for skin cleaning containing a surfactant as a component (A) and an amphipathic ester as a component (B) without giving physical friction to the skin. Provide skin cleaning methods, including applying to. The skin cleaning method of the present invention can be carried out as a cleaning treatment performed at an esthetic salon or a beauty salon.
前記皮膚洗浄方法において、使用する成分の種類や使用量、皮膚洗浄料組成物の形態等については、前記「1.皮膚洗浄用液体組成物」の欄に示す通りである。
The types and amounts of ingredients used in the skin cleansing method, the form of the skin cleansing composition, etc. are as shown in the column of "1. Liquid composition for skin cleansing".
以下に実施例を示して本発明をより具体的に説明するが、本発明はこれらに限定されるものではない。
The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto.
表1~4に示す組成の皮膚洗浄用液体組成物を調製した。表1~4に示す各成分の詳細は以下の通りである。なお、表1~4に示す皮膚洗浄用液体組成物は液状であり、20℃における粘度(BL粘度計(ブルックフィールド社製B型粘度計)ロ-ターNo3、6rpmによって測定)は、いずれも5000mPa・s以下の範囲にあった。
・ラウリン酸ナトリウム(日油株式会社製「ノンサールLN-1(商品名)」)
・ココイルグルタミン酸TEA(味の素株式会社製「アミソフトCT-12S(商品名)」)
・ココイルメチルタウリンNa(日油株式会社製「ダイヤポンK-SF(商品名)」)
・N-ラウロイルアスパラギン酸ナトリウム液(20重量%)(旭化成ファインケミカル株式会社製「アミノフォーマー FLDS-L(商品名)」)
・ポリオキシエチレンラウリルエーテル酢酸(花王株式会社製「カオーアキポRLM-45(商品名)」)
・コカミドDEA(川研ファインケミカル株式会社製「アミゾールCDE-G(商品名)」)
・PEG-60水添ヒマシ油(ポリオキシエチレン硬化ヒマシ油;日光ケミカルズ株式会社製 「NIKKOL HCO-60(商品名)」)
・モノステアリン酸ポリオキシエチレンソルビタン(花王株式会社製 レオドールTW-S120V)
・グリセリンモノ-2-エチルヘキシルエーテル(SEPPIC社製「sensiva SC 50 JP(商品名)」)
・コカミドプロピルベタイン(川研ファインケミカル株式会社製「ソフタゾリンCPB(商品名)」)
・ラウリルヒドロキシスルホベタイン液(30重量%)(花王株式会社製「アンヒトール20HD(商品名)」)
・リゾレシチン(協和発酵バイオ株式会社製「リゾレシチン協和(商品名)」)
・キラヤエキス(丸善製薬株式会社製「キラヤ抽出液BG」、サポニン含量5重量%)
・シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコール(日本精化株式会社製「Neosolue-Aqulio(商品名)」)
・コハク酸ビスエトキシジグリコール(高級アルコール工業株式会社製「ハイアクオスター DCS(商品名)」) Liquid compositions for skin cleansing having the compositions shown in Tables 1 to 4 were prepared. Details of each component shown in Tables 1 to 4 are as follows. The skin cleansing liquid compositions shown in Tables 1 to 4 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all liquid. It was in the range of 5000 mPa · s or less.
・ Sodium laurate (NOF CORPORATION "Nonsar LN-1 (trade name)")
・ Cocoyl glutamic acid TEA (Ajinomoto Co., Inc. "Amisoft CT-12S (trade name)")
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION)
-N-Lauroyl aspartate sodium solution (20% by weight) ("Aminoformer FLDS-L (trade name)" manufactured by Asahi Kasei Fine Chemicals Co., Ltd.)
-Polyoxyethylene lauryl ether acetic acid ("Kao Akipo RLM-45 (trade name)" manufactured by Kao Corporation)
・ Cocamide DEA ("Amisol CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
-PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; "NIKKOL HCO-60 (trade name)" manufactured by Nikko Chemicals Co., Ltd.)
-Polyoxyethylene sorbitan monostearate (Kao Corporation Leodor TW-S120V)
-Glycerin mono-2-ethylhexyl ether (SEPPIC "sensiva SC 50 JP (trade name)")
・ Cocamidopropyl betaine (“Softazoline CPB (trade name)” manufactured by Kawaken Fine Chemicals Co., Ltd.)
-Lauryl hydroxysulfobetaine solution (30% by weight) (Kao Corporation "Anhitor 20HD (trade name)")
・ Lysolecithin (“Resolecithin Kyowa (trade name)” manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceuticals Co., Ltd., saponin content 5% by weight)
-Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Nippon Fine Chemical Co., Ltd. "Neosolue-Aquolio (trade name)")
・ Bisethoxydiglycol succinate (“High Aquos Star DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.)
・ラウリン酸ナトリウム(日油株式会社製「ノンサールLN-1(商品名)」)
・ココイルグルタミン酸TEA(味の素株式会社製「アミソフトCT-12S(商品名)」)
・ココイルメチルタウリンNa(日油株式会社製「ダイヤポンK-SF(商品名)」)
・N-ラウロイルアスパラギン酸ナトリウム液(20重量%)(旭化成ファインケミカル株式会社製「アミノフォーマー FLDS-L(商品名)」)
・ポリオキシエチレンラウリルエーテル酢酸(花王株式会社製「カオーアキポRLM-45(商品名)」)
・コカミドDEA(川研ファインケミカル株式会社製「アミゾールCDE-G(商品名)」)
・PEG-60水添ヒマシ油(ポリオキシエチレン硬化ヒマシ油;日光ケミカルズ株式会社製 「NIKKOL HCO-60(商品名)」)
・モノステアリン酸ポリオキシエチレンソルビタン(花王株式会社製 レオドールTW-S120V)
・グリセリンモノ-2-エチルヘキシルエーテル(SEPPIC社製「sensiva SC 50 JP(商品名)」)
・コカミドプロピルベタイン(川研ファインケミカル株式会社製「ソフタゾリンCPB(商品名)」)
・ラウリルヒドロキシスルホベタイン液(30重量%)(花王株式会社製「アンヒトール20HD(商品名)」)
・リゾレシチン(協和発酵バイオ株式会社製「リゾレシチン協和(商品名)」)
・キラヤエキス(丸善製薬株式会社製「キラヤ抽出液BG」、サポニン含量5重量%)
・シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコール(日本精化株式会社製「Neosolue-Aqulio(商品名)」)
・コハク酸ビスエトキシジグリコール(高級アルコール工業株式会社製「ハイアクオスター DCS(商品名)」) Liquid compositions for skin cleansing having the compositions shown in Tables 1 to 4 were prepared. Details of each component shown in Tables 1 to 4 are as follows. The skin cleansing liquid compositions shown in Tables 1 to 4 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all liquid. It was in the range of 5000 mPa · s or less.
・ Sodium laurate (NOF CORPORATION "Nonsar LN-1 (trade name)")
・ Cocoyl glutamic acid TEA (Ajinomoto Co., Inc. "Amisoft CT-12S (trade name)")
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION)
-N-Lauroyl aspartate sodium solution (20% by weight) ("Aminoformer FLDS-L (trade name)" manufactured by Asahi Kasei Fine Chemicals Co., Ltd.)
-Polyoxyethylene lauryl ether acetic acid ("Kao Akipo RLM-45 (trade name)" manufactured by Kao Corporation)
・ Cocamide DEA ("Amisol CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
-PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; "NIKKOL HCO-60 (trade name)" manufactured by Nikko Chemicals Co., Ltd.)
-Polyoxyethylene sorbitan monostearate (Kao Corporation Leodor TW-S120V)
-Glycerin mono-2-ethylhexyl ether (SEPPIC "sensiva SC 50 JP (trade name)")
・ Cocamidopropyl betaine (“Softazoline CPB (trade name)” manufactured by Kawaken Fine Chemicals Co., Ltd.)
-Lauryl hydroxysulfobetaine solution (30% by weight) (Kao Corporation "Anhitor 20HD (trade name)")
・ Lysolecithin (“Resolecithin Kyowa (trade name)” manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceuticals Co., Ltd., saponin content 5% by weight)
-Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol (Nippon Fine Chemical Co., Ltd. "Neosolue-Aquolio (trade name)")
・ Bisethoxydiglycol succinate (“High Aquos Star DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.)
<洗浄力評価>
調製した皮膚洗浄用液体組成物について、化粧品評価専門パネラー10名が洗浄力評価を行った。具体的には、各皮膚洗浄用液体組成物をポンプ式スプレー容器(竹本容器株式会社製「Z-155-C110(商品名)」1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、肌の汚れ落ち感を以下の指標に基づいて官能評価することで採点した。 <Detergency evaluation>
The prepared liquid composition for skin cleansing was evaluated for its cleansing power by 10 panelists specializing in cosmetics evaluation. Specifically, each skin cleansing liquid composition is contained in a pump-type spray container (“Z-155-C110 (trade name)” manufactured by Takemoto Yohki Co., Ltd., the injection amount per push is 0.15 g), and 1 It was applied by spraying 5.5 g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. After holding the face with a towel and absorbing water, the feeling of dirt removal on the skin was scored by sensory evaluation based on the following indexes.
調製した皮膚洗浄用液体組成物について、化粧品評価専門パネラー10名が洗浄力評価を行った。具体的には、各皮膚洗浄用液体組成物をポンプ式スプレー容器(竹本容器株式会社製「Z-155-C110(商品名)」1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、肌の汚れ落ち感を以下の指標に基づいて官能評価することで採点した。 <Detergency evaluation>
The prepared liquid composition for skin cleansing was evaluated for its cleansing power by 10 panelists specializing in cosmetics evaluation. Specifically, each skin cleansing liquid composition is contained in a pump-type spray container (“Z-155-C110 (trade name)” manufactured by Takemoto Yohki Co., Ltd., the injection amount per push is 0.15 g), and 1 It was applied by spraying 5.5 g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. After holding the face with a towel and absorbing water, the feeling of dirt removal on the skin was scored by sensory evaluation based on the following indexes.
5点:汚れ落ちがしっかり感じられた
4点:汚れ落ちが感じられた
3点:どちらでもない
2点:汚れ落ちがあまり感じられない
1点:汚れ落ちが全く感じられない 5 points: Dirt removal was felt firmly 4 points: Dirt removal was felt 3 points: Neither 2 points: Dirt removal was not felt so much 1 point: Dirt removal was not felt at all
4点:汚れ落ちが感じられた
3点:どちらでもない
2点:汚れ落ちがあまり感じられない
1点:汚れ落ちが全く感じられない 5 points: Dirt removal was felt firmly 4 points: Dirt removal was felt 3 points: Neither 2 points: Dirt removal was not felt so much 1 point: Dirt removal was not felt at all
パネラー10名の獲得スコアを合計し、以下の分類により洗浄力の程度を評価した。結果を表1~4に示す。
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満 The scores obtained by the 10 panelists were totaled, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満 The scores obtained by the 10 panelists were totaled, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points
<つっぱり感評価(肌刺激性の官能評価)>
調製した皮膚洗浄用液体組成物について、化粧品評価専門パネラー10名がつっぱり感評価を行った。具体的には、各皮膚洗浄用液体組成物をポンプ式スプレー容器(竹本容器株式会社製「Z-155-C110(商品名)」(1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、つっぱり感を以下の指標に基づいて官能評価することで採点した。 <Evaluation of tension (sensory evaluation of skin irritation)>
Ten panelists specializing in cosmetics evaluation evaluated the prepared liquid composition for skin cleansing for a feeling of tension. Specifically, each skin cleansing liquid composition is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g). It was applied by spraying 1.5g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. The feeling was scored by sensory evaluation based on the following indexes.
調製した皮膚洗浄用液体組成物について、化粧品評価専門パネラー10名がつっぱり感評価を行った。具体的には、各皮膚洗浄用液体組成物をポンプ式スプレー容器(竹本容器株式会社製「Z-155-C110(商品名)」(1プッシュあたりの噴射量は0.15g)に収容し、1.5gを顔に直接的に噴霧することで塗布した。5秒程度放置し、その後、手が顔に触れないように水で洗い流した。タオルで顔を抑えて水を吸い取った後、つっぱり感を以下の指標に基づいて官能評価することで採点した。 <Evaluation of tension (sensory evaluation of skin irritation)>
Ten panelists specializing in cosmetics evaluation evaluated the prepared liquid composition for skin cleansing for a feeling of tension. Specifically, each skin cleansing liquid composition is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g). It was applied by spraying 1.5g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. The feeling was scored by sensory evaluation based on the following indexes.
5点:つっぱり感を全く感じない
4点:つっぱり感をほとんど感じない
3点:つっぱり感をわずかしか感じない
2点:つっぱり感を感じる
1点:つっぱり感を強く感じる 5 points: No feeling of tension 4 points: Almost no feeling of tension 3 points: Feeling little feeling of tension 2 points: Feeling of tension 1 point: Feeling strong feeling of tension
4点:つっぱり感をほとんど感じない
3点:つっぱり感をわずかしか感じない
2点:つっぱり感を感じる
1点:つっぱり感を強く感じる 5 points: No feeling of tension 4 points: Almost no feeling of tension 3 points: Feeling little feeling of tension 2 points: Feeling of tension 1 point: Feeling strong feeling of tension
パネラー10名の獲得スコアを合計し、以下の分類によりつっぱり感の程度を評価した。結果を表3~4に示す。
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満 The scores obtained by the 10 panelists were totaled, and the degree of tension was evaluated according to the following classification. The results are shown in Tables 3-4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points
◎:45点以上
○:40点以上45点未満
△:35点以上40点未満
×:35点未満 The scores obtained by the 10 panelists were totaled, and the degree of tension was evaluated according to the following classification. The results are shown in Tables 3-4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points
<培養表皮皮膚刺激試験(肌刺激性のin vitro評価)>
調製した皮膚洗浄用液体組成物について、以下の通りに培養表皮皮膚刺激試験を行った。
1.培養表皮モデルLabCyte EPI-MODEL24の準備
アッセイ培地を温め、24ウェルアッセイプレートに0.5mLずつ添加した。培養表皮モデルLabCyte EPI-MODEL24(ロット番号:LCE24-180226-A)を、アッセイ培地を添加した24ウェルアッセイプレートに移した。培養カップ底面に気泡が無いことを確認し、CO2インキュベーターに入れ被験物質暴露まで1時間以上静置した。 <Cultured epidermal skin irritation test (in vitro evaluation of skin irritation)>
The prepared liquid composition for skin washing was subjected to a cultured epidermal skin irritation test as follows.
1. 1. Preparation of Cultured Epidermis Model LabCite EPI-MODEL24 The assay medium was warmed and 0.5 mL each was added to a 24-well assay plate. Cultured epidermis model LabCite EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to a 24-well assay plate supplemented with assay medium. After confirming that there were no air bubbles on the bottom of the culture cup, the cells were placed in a CO 2 incubator and allowed to stand for 1 hour or more until exposure to the test substance.
調製した皮膚洗浄用液体組成物について、以下の通りに培養表皮皮膚刺激試験を行った。
1.培養表皮モデルLabCyte EPI-MODEL24の準備
アッセイ培地を温め、24ウェルアッセイプレートに0.5mLずつ添加した。培養表皮モデルLabCyte EPI-MODEL24(ロット番号:LCE24-180226-A)を、アッセイ培地を添加した24ウェルアッセイプレートに移した。培養カップ底面に気泡が無いことを確認し、CO2インキュベーターに入れ被験物質暴露まで1時間以上静置した。 <Cultured epidermal skin irritation test (in vitro evaluation of skin irritation)>
The prepared liquid composition for skin washing was subjected to a cultured epidermal skin irritation test as follows.
1. 1. Preparation of Cultured Epidermis Model LabCite EPI-MODEL24 The assay medium was warmed and 0.5 mL each was added to a 24-well assay plate. Cultured epidermis model LabCite EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to a 24-well assay plate supplemented with assay medium. After confirming that there were no air bubbles on the bottom of the culture cup, the cells were placed in a CO 2 incubator and allowed to stand for 1 hour or more until exposure to the test substance.
2.被験物質の適用及び洗浄
表皮モデル24個のうち、12個を使用した(残りは本試験まで前培養を続けた)。24ウェルアッセイプレートをCO2インキュベーターから取り出した。アッセイ培地を温め、24ウェルアッセイプレート第3行に1.0mLずつ添加した。被験物質(各皮膚洗浄用液体組成物)をポンプ式スプレー容器を用いずに培養カップの培養表皮に25μL滴下し、全体にいきわたらせて暴露した。暴露後1分、5分、10分経過時に被験物質を吸引除去し、カップ内の培養表皮モデルをリン酸緩衝液(PBS)で洗浄し、24ウェルアッセイプレート第3行に移した。 2. Application and washing of test substance Twelve of the 24 epidermis models were used (the rest were pre-cultured until this test). A 24-well assay plate was removed from the CO 2 incubator. The assay medium was warmed and 1.0 mL each was added to the third row of the 24-well assay plate. 25 μL of the test substance (each skin cleansing liquid composition) was added dropwise to the culture epidermis of the culture cup without using a pump-type spray container, and the whole was exposed. After 1 minute, 5 minutes and 10 minutes after exposure, the test substance was aspirated off, the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of the 24-well assay plate.
表皮モデル24個のうち、12個を使用した(残りは本試験まで前培養を続けた)。24ウェルアッセイプレートをCO2インキュベーターから取り出した。アッセイ培地を温め、24ウェルアッセイプレート第3行に1.0mLずつ添加した。被験物質(各皮膚洗浄用液体組成物)をポンプ式スプレー容器を用いずに培養カップの培養表皮に25μL滴下し、全体にいきわたらせて暴露した。暴露後1分、5分、10分経過時に被験物質を吸引除去し、カップ内の培養表皮モデルをリン酸緩衝液(PBS)で洗浄し、24ウェルアッセイプレート第3行に移した。 2. Application and washing of test substance Twelve of the 24 epidermis models were used (the rest were pre-cultured until this test). A 24-well assay plate was removed from the CO 2 incubator. The assay medium was warmed and 1.0 mL each was added to the third row of the 24-well assay plate. 25 μL of the test substance (each skin cleansing liquid composition) was added dropwise to the culture epidermis of the culture cup without using a pump-type spray container, and the whole was exposed. After 1 minute, 5 minutes and 10 minutes after exposure, the test substance was aspirated off, the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of the 24-well assay plate.
3.MTT試験
MTT試験は、細胞内に取り込まれたMTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]が細胞内にあるミトコンドリアの脱水素酵素によって還元されて生じるフォルマザン色素を、有機溶媒により抽出して570nmの吸光度を測定することで生細胞率を計測する方法である。 3. 3. MTT test The MTT test occurs when MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltrazolium bromide] taken up into cells is reduced by intracellular mitochondrial dehydrogenase. This is a method of measuring the viable cell ratio by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.
MTT試験は、細胞内に取り込まれたMTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]が細胞内にあるミトコンドリアの脱水素酵素によって還元されて生じるフォルマザン色素を、有機溶媒により抽出して570nmの吸光度を測定することで生細胞率を計測する方法である。 3. 3. MTT test The MTT test occurs when MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltrazolium bromide] taken up into cells is reduced by intracellular mitochondrial dehydrogenase. This is a method of measuring the viable cell ratio by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.
MTT培地を終濃度0.5mg/mLで10mL調製した。MTT培地を温め、24ウェルアッセイプレート第4行に0.5mLずつ添加した。培養表皮モデルを24ウェルアッセイプレート第4行に移し、CO2インキュベーターに入れて、3時間MTT反応を行った。MTT反応終了後、培養皮膚をピンセットでつまんで取り出し、1.5mLマイクロチューブに移した。マイクロチューブにイソプロパノール300μLを入れて培養表皮モデルを完全に浸漬した。その後2時間静置し、マイクロチューブをボルテックスにかけ、色素を抽出した。抽出液(200mL)を96ウェルプレートの各ウェルに入れた。また、ブランク(陰性対照)として、A1にイソプロパノール200μLを入れた。マイクロプレートリーダーで570nm、650nmの吸光度を測定した。570nmの吸光度から650nmの吸光度を差し引いた値を測定値とし、下記式より被験物質の生細胞率を計算した。
10 mL of MTT medium was prepared at a final concentration of 0.5 mg / mL. The MTT medium was warmed and 0.5 mL each was added to row 4 of the 24-well assay plate. The cultured epidermis model was transferred to row 4 of the 24-well assay plate and placed in a CO2 incubator for 3 hours MTT reaction. After completion of the MTT reaction, the cultured skin was picked up with tweezers and taken out, and transferred to a 1.5 mL microtube. 300 μL of isopropanol was placed in a microtube and the cultured epidermis model was completely immersed. After that, it was allowed to stand for 2 hours, and the microtube was vortexed to extract the pigment. Extract (200 mL) was placed in each well of a 96-well plate. In addition, 200 μL of isopropanol was added to A1 as a blank (negative control). Absorbance at 570 nm and 650 nm was measured with a microplate reader. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell ratio of the test substance was calculated from the following formula.
生細胞率を以下の基準に基づいて分類し、肌刺激性を評価した。結果を表3~4に示す。
◎:90%以上
○:75%以上90%未満
△:65%以上75%未満
×:50%以上65%未満
××:50%未満 The viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3-4.
⊚: 90% or more ○: 75% or more and less than 90% Δ: 65% or more and less than 75% ×: 50% or more and less than 65% × ×: less than 50%
◎:90%以上
○:75%以上90%未満
△:65%以上75%未満
×:50%以上65%未満
××:50%未満 The viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3-4.
⊚: 90% or more ○: 75% or more and less than 90% Δ: 65% or more and less than 75% ×: 50% or more and less than 65% × ×: less than 50%
表1~4に示すとおり、界面活性剤を単独で0.025~2重量%の濃度で含む皮膚洗浄用液体組成物(比較例1~10)では洗浄力が認められなかった。これに対し、単独では洗浄力を示さない両親媒性エステル(比較例11~15)を0.025~2重量%の界面活性剤とともに含む皮膚洗浄用液体組成物(実施例1~20)では、噴霧式容器から噴霧により直接肌に塗布するだけで、物理的摩擦を一切与えることなく、液流の機械力を利用するだけで優れた洗浄力が得られた。つまり、肌に優しい洗浄が可能であることが示された。
As shown in Tables 1 to 4, no detergency was observed in the skin cleansing liquid compositions (Comparative Examples 1 to 10) containing the surfactant alone at a concentration of 0.025 to 2% by weight. On the other hand, in the liquid composition for skin cleaning (Examples 1 to 20) containing an amphipathic ester (Comparative Examples 11 to 15) which does not show detergency by itself together with 0.025 to 2% by weight of a surfactant. By simply applying it directly to the skin by spraying from a spray-type container, excellent detergency was obtained simply by using the mechanical force of the liquid flow without giving any physical friction. In other words, it was shown that cleansing that is gentle on the skin is possible.
なお、参考例1~3に示すように界面活性剤を単独で2重量%超含む皮膚洗浄用液体組成物も、噴霧により直接肌に塗布するだけで優れた洗浄力が得られる。一方で、参考例1~3に示される界面活性剤濃度による皮膚刺激を考慮し、実施例9~20に示されるように界面活性剤濃度を2重量%以下にすると、洗浄力だけでなく優れた低刺激性も奏された。つまり、噴霧により直接肌に塗布する洗浄方法に適用される皮膚洗浄用液体組成物の界面活性剤濃度を0.025~2重量%とすることで、物理的にも化学的にも肌に優しい洗浄が可能となることが示された。
As shown in Reference Examples 1 to 3, a liquid composition for skin cleansing containing more than 2% by weight of a surfactant alone can also obtain excellent cleansing power simply by applying it directly to the skin by spraying. On the other hand, in consideration of skin irritation due to the surfactant concentration shown in Reference Examples 1 to 3, when the surfactant concentration is 2% by weight or less as shown in Examples 9 to 20, not only the detergency but also the detergency is excellent. Hypoallergenicity was also played. That is, by setting the surfactant concentration of the liquid composition for skin cleaning applied to the cleaning method applied directly to the skin by spraying to 0.025 to 2% by weight, it is physically and chemically gentle on the skin. It was shown that cleaning is possible.
Claims (6)
- (A)界面活性剤と(B)両親媒性エステルとを含有し、物理的摩擦を皮膚に与えることなく洗浄するために用いられる、皮膚洗浄用液体組成物。 A liquid composition for skin cleansing that contains (A) a surfactant and (B) an amphipathic ester and is used for cleaning without giving physical friction to the skin.
- 前記(B)成分が、ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルおよび(エイコサン二酸/テトラデカン二酸)ポリグリセリル-10よりなる群から選ばれる、請求項1に記載の皮膚洗浄用液体組成物。 The liquid composition for skin cleaning according to claim 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. ..
- 前記ジカルボン酸ビス(ポリオキシアルキレンアルキルエーテル)エステルが、シクロヘキサン-1,4-ジカルボン酸ビスエトキシジグリコールである、請求項2に記載の皮膚洗浄用液体組成物。 The liquid composition for skin cleaning according to claim 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
- 前記(A)成分の含有量が0.025~2重量%である、請求項1~3のいずれかに記載の皮膚洗浄用液体組成物。 The liquid composition for skin cleansing according to any one of claims 1 to 3, wherein the content of the component (A) is 0.025 to 2% by weight.
- 前記(A)成分の含有量が0.025~0.9重量%である、請求項4に記載の皮膚洗浄用液体組成物。 The liquid composition for skin cleansing according to claim 4, wherein the content of the component (A) is 0.025 to 0.9% by weight.
- (A)界面活性剤と(B)両親媒性エステルとを含有する皮膚洗浄用液体組成物を、物理的摩擦を皮膚に与えることなく皮膚に適用することを含む、皮膚洗浄方法。 A skin cleaning method comprising applying a skin cleaning liquid composition containing (A) a surfactant and (B) an amphipathic ester to the skin without applying physical friction to the skin.
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JP2014181206A (en) * | 2013-03-19 | 2014-09-29 | Mandom Corp | Aqueous cleansing cosmetic |
JP2015199684A (en) * | 2014-04-08 | 2015-11-12 | ホーユー株式会社 | Detergent composition and method for inhibiting skin irritation using the same |
JP2016044180A (en) * | 2014-08-20 | 2016-04-04 | ホシケミカルズ株式会社 | Cosmetic |
JP2019059679A (en) * | 2017-09-25 | 2019-04-18 | 株式会社コーセー | Aqueous cleansing cosmetic |
JP2020007305A (en) * | 2018-06-27 | 2020-01-16 | 小林製薬株式会社 | Skin cleansing liquid composition |
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JP2014181206A (en) * | 2013-03-19 | 2014-09-29 | Mandom Corp | Aqueous cleansing cosmetic |
JP2015199684A (en) * | 2014-04-08 | 2015-11-12 | ホーユー株式会社 | Detergent composition and method for inhibiting skin irritation using the same |
JP2016044180A (en) * | 2014-08-20 | 2016-04-04 | ホシケミカルズ株式会社 | Cosmetic |
JP2019059679A (en) * | 2017-09-25 | 2019-04-18 | 株式会社コーセー | Aqueous cleansing cosmetic |
JP2020007305A (en) * | 2018-06-27 | 2020-01-16 | 小林製薬株式会社 | Skin cleansing liquid composition |
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