WO2020262155A1

WO2020262155A1 - Spray agent for skin cleansing

Info

Publication number: WO2020262155A1
Application number: PCT/JP2020/023782
Authority: WO
Inventors: 航平山本; 嘉一久保
Original assignee: 小林製薬株式会社
Priority date: 2019-06-26
Filing date: 2020-06-17
Publication date: 2020-12-30
Also published as: CN112449589A; JP2021004201A

Abstract

[Problem] The purpose of the present invention is to provide a skin cleanser composition that is used in a non-conventional method. [Solution] A spray agent for skin cleansing according to the present invention, which contains (A) a surfactant and (B) an amphiphilic ester and has a pH of from 3 to 8, while being contained in a spray container, is capable of exhibiting excellent cleansing power, while being reduced in the skin irritancy of a skin cleanser composition, and is able to provide a novel use that is different from conventional uses wherein a skin cleanser composition is foamed before application to the skin, said novel use being direct spraying of a skin cleanser composition onto the skin.

Description

Skin cleansing spray

The present invention relates to a skin cleansing spray agent used by directly spraying it on the skin.

Various skin cleansing compositions such as facial cleansers, body soaps, and shampoos are provided as products aimed at cleaning the skin and keeping the skin clean. In the mechanism by which the skin cleansing composition cleans the skin, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and the mechanical force due to friction causes the dirt to float in the water. In order for such a cleaning mechanism to work effectively, it is necessary to add a surfactant at a critical micelle concentration or higher.

On the other hand, the detergency of the surfactant is too strong, which causes skin irritation, and as a result, skin troubles such as dry skin are caused. For this reason, various formulations have been proposed in which the combination of cleansing ingredients and the blending amount are devised for the purpose of mildly acting on the skin. Above all, since it is recognized that the foam formed during washing reduces the friction generated by direct contact between the skin and fingers, a formulation that improves foam quality such as foaming power and foam holding power is applied to the skin. It is common knowledge that it is excellent as a prescription that makes the action mild.

For this reason, in recent years, various pump former type skin cleansers have been proposed, and attention is being paid not only to the ease with which high-quality foam can be easily obtained, but also to the gentleness to the skin. Specifically, Patent Document 1 describes a liquid skin cleaning agent product comprising a former container and a liquid skin cleaning agent composition filled in the former container, wherein the liquid skin cleaning agent composition is (1). A) Specific fatty acid salts having a linear or branched monohydric hydrocarbon group having 7 to 21 carbon atoms in an amount of 3 to 10% by mass, and (B) Specific dimethyldialyl ammonium chloride and acrylic acid and / or acrylamide. Liquid skin containing the copolymer of (C) and (C) sugar alcohol, and the mass ratio (A) / (B) of the content of the component (A) to the content of the component (B) is 20 to 250. Cleaning agent products are disclosed. Further, Patent Document 2 states that (a) fatty acid salt is 2 to 9% by mass, (b) betaine lauryldimethylaminoacetate is 0.5 to 4% by mass, and (c) one or more dihydric alcohols. 1 to 10% by mass, and the sum (a) + (b) of the blending amount (mass%) of the component (a) and the component (b) is 3 to 10% by mass, and the blending amount ratio (b) A skin cleaning agent composition is disclosed, which comprises filling a former container with a cleaning agent having a / (a) of 0.1 to 0.5. Further, Patent Document 3 describes a former container containing (a) betaine lauryldimethylaminoacetate and (b) 4 to 15% by mass of a higher fatty acid soap having a specific composition and formed from a fatty acid having 5 to 25 carbon atoms. The cleaning agent composition discharged in the above is disclosed.

International Publication No. 2014/003114 Japanese Unexamined Patent Publication No. 2016-098182 International Publication No. 2017/081897

The pumpformer-type skin cleansing composition contains a relatively small amount of surfactant, and in that respect, irritation to the skin is reduced as compared with the solid or semi-solid skin cleansing composition. It is thought that there is a tendency to be. On the other hand, since it is a major premise that the pump former type skin cleansing composition is discharged in the form of foam, the minimum amount of surfactant necessary for exerting the foaming force is blended. That is inevitable due to its composition.

In addition, various skin cleansing agents have been created for the purpose of removing body fluids such as sebum and sweat and dirt, except for skin cleansing agents for the purpose of removing makeup (cleansing), but all skin cleansing agents are without exception. It is premised on whipping before applying to the skin, and it is also common knowledge that whipping well before washing is preferable in terms of relieving friction on the skin. Foam can relieve physical friction by intervening between the skin and the hand, but since the foam itself is rubbed against the skin, it itself causes physical friction and is irritating to the skin. There is no change in being. In particular, irritation is still a concern for skin that is sensitive to irritation.

In this way, there is a limit to reducing the burden on the skin of the skin cleanser with the same usage as before. Therefore, it is considered necessary for the skin cleanser to reduce the irritation to the skin more than ever so that it can be applied to the skin sensitive to irritation.

Therefore, an object of the present invention is to provide a skin cleansing composition used by a method different from the conventional method.

The present inventor has come up with the idea of a novel application in which the skin cleansing composition is directly sprayed onto the skin without foaming in advance when applied to the skin in order to further reduce irritation to the skin. .. It was also found that by coexisting an amphipathic ester with a surfactant and adjusting the pH to 3 to 8, detergency can be effectively obtained without foaming in advance. The present invention has been completed by further studies based on this finding.

That is, the present invention provides the inventions of the following aspects.
Item 1. A skin cleansing spray agent containing (A) a surfactant and (B) an amphipathic ester, having a pH of 3 to 8, and contained in a spray container.
Item 2. Item 2. The spray agent for skin cleaning according to Item 1, wherein the spray container is a pump type spray container.
Item 3. Item 2. The spray agent for skin cleaning according to Item 1, wherein the spray container is an aerosol spray container.
Item 4. Item 1 to 3 in which the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. The skin cleaning spray agent according to any one of.
Item 5. Item 2. The skin cleaning spray agent according to any one of Items 1 to 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 6. The skin cleansing spray agent according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.
Item 7. Item 2. The skin cleansing spray agent according to any one of Items 1 to 6, which is applied to sensitive skin.

According to the present invention, since the skin cleansing composition can exhibit excellent cleansing power while reducing the skin irritation, it is different from the conventional use of foaming in advance when applied to the skin, and directly on the skin. It is possible to provide a new application of spraying and applying a cleansing composition onto the skin. Since it can be washed without foaming in advance, the blending amount of the surfactant in the skin cleansing liquid composition can be significantly reduced as compared with the blending amount contained in the conventional skin cleansing liquid composition. It is also possible to further reduce skin irritation. Therefore, the skin cleansing spray can be suitably used for cleaning the skin that is sensitive to irritation.

The skin cleansing spray agent of the present invention may be referred to as (A) surfactant (hereinafter, may be referred to as (A) component) and (B) amphipathic ester (hereinafter, may be referred to as (B) component). It is characterized in that it contains (is), is adjusted to a predetermined pH, and is housed in a spray container. Hereinafter, the skin cleansing spray agent of the present invention will be described in detail.

(A) Surfactant The skin cleansing spray agent of the present invention contains a surfactant as the component (A). The surfactant is not particularly limited, but preferably an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, a natural surfactant and the like can be mentioned from the viewpoint of suppressing irritation to the skin. As the surfactant, one of anionic surfactant, nonionic surfactant, amphoteric surfactant, and natural surfactant may be used alone, or two or more thereof may be arbitrarily combined. May be used.

Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate ester type, and phosphoric acid ester type surfactants.

Specific examples of the carboxylic acid type surfactant include saturated or unsaturated amino acids having 6 to 22 carbon atoms such as octanoic acid, decanoic acid, lauric acid, myristic acid, palmitic acid, and stearic acid; octanoyl groups and decanoyles. Examples include N-acylamino acids (carboxylic acid type amino acid-based anionic surfactants) having saturated or unsaturated N-acyl groups having 8 to 24 carbon atoms such as groups, lauroyl groups, myristic groups, palmitoyl groups, and cocoyl groups. Be done.

Examples of the carboxylic acid-type amino acid-based anionic surfactant include N having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyyl group, a lauroyl group, a myritoyl group, a palmitoyl group, and a cocoyl group. -Acyl amino acids can be mentioned. Examples of the N-acyl amino acid in the carboxylic acid type amino acid-based anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, N-acyl-N-methyl-β-alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroyl sarcosine, cocoyl sarcosine, N-lauroyl aspartic acid, cocoyl aspartic acid, N-lauroyl glutamic acid, cocoyl glutamic acid, and N-lauroyl-N-methyl. -Β-alanine, cocoylmethylalanine and the like can be mentioned.

Specific examples of the sulfonic acid type surfactant include an ester of a fatty acid having 6 to 22 carbon atoms such as cocoyl isethionic acid and isethionic acid; hexanesulfonic acid, octanesulfonic acid, decanesulfonic acid, dodecanesulfonic acid and the like. Alkyl sulfonic acid having 6 to 22 carbon atoms; Alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as alkylbenzene sulfonic acid; Carbon such as octanoyl group, decanoyle group, lauroyl group, myristoyl group, palmitoyl group, cocoyl group and the like. Examples thereof include N-acyl-N-methyltaurin (sulfonic acid type amino acid-based anionic surfactant) having a saturated or unsaturated N-acyl group of No. 8 to 24.

Examples of the sulfonic acid-type amino acid-based anionic surfactant include N having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyyl group, a lauroyl group, a myritoyl group, a palmitoyl group, and a cocoyl group. -Acyl-N-methyltaurine can be mentioned. More specific sulfonic acid-type amino acid-based anionic surfactants include N-myristoyl-N-methyltaurine, N-lauroyl-N-methyltaurine, cocoylmethyltaurine and the like.

Specific examples of the sulfuric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate and sulfuric acid. Specific examples of the phosphoric acid ester-type surfactant include esters of saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphate and phosphoric acid.

These anionic surfactants may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. it can.

Among these anionic surfactants, carboxylic acid type surfactants and sulfonic acid type surfactants are preferable, and more preferably, from the viewpoint of obtaining better skin irritation reducing property and detergency. Examples thereof include carboxylic acid-type amino acid-based anionic surfactants and sulfonic acid-type amino acid-based anionic surfactants. The carboxylic acid-type amino acid-based anionic surfactant and the sulfonic acid-type amino acid-based anionic surfactant have a viewpoint of suppressing a feeling of tension due to insufficient moisturization when the pH of the skin cleaning spray agent of the present invention is, for example, 3 to 6. Or, it is preferably used from the viewpoint of suppressing the feeling of tension due to insufficient moisturizing and detergency. More specifically, the carboxylic acid-type amino acid-based anionic surfactant and the sulfonic acid-type amino acid-based anionic surfactant lack moisturizing when the pH of the skin cleaning spray agent of the present invention is, for example, 3 to 4. It is preferably used from the viewpoint of suppressing the feeling of tension due to insufficient moisturization and detergency when the pH is, for example, 5 to 6.

Further, among these, N-acylglutamic acid and N-acylaspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms, and N-acylaspartic acid, and the number of carbon atoms are preferable from the viewpoint of detergency and / or skin irritation reduction property. 8 to 22 fatty acid amide sulfonic acids and salts thereof, more preferably cocoyl glutamic acid, N-lauroyl aspartic acid, cocoyl methyl taurine and salts thereof, still more preferably cocoyl glutamic acid triethanolamine, N- Examples thereof include sodium lauroyl aspartate and sodium cocoyl methyl taurine.

These anionic surfactants may be used alone or in combination of two or more.

Examples of the nonionic surfactant used in the present invention include ester-type, ether-type, ester-ether-type, alkanolamide-type, alkylglycoside-type, and alcohol-type surfactants.

The nonionic surfactant is preferably used from the viewpoint of detergency and skin irritation reduction when the pH of the skin cleansing spray agent of the present invention is, for example, 5 to 8, preferably 5 to 6. Specific examples of the ester-type surfactant include glycols dilaurate, glycol monostearate, glycol distearate, glyceryl monolaurate, glyceryl dilaurate, glyceryl monostearate, and glyceryl distearate, which have 8 to 20 carbon atoms. Saturated or unsaturated fatty acids and glycerin mono- or diesters; sorbitan fatty acid esters; sucrose fatty acid esters and the like.

Specific examples of the ether-type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, and polyoxyethylene polyoxypropylene glycol.

Examples of the ester-ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitan fatty acid ester, and sorbitan fatty acid ester polyethylene glycol.

Specific examples of the alkanolamide type surfactant include cocamide DEA (coconut oil fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide and the like.

Specific examples of the alkyl glucoside type surfactant include octyl glucoside, decyl glucoside, and lauryl glucoside.

Examples of alcohol-type surfactants include cetanol, stearyl alcohol, and oleyl alcohol.

Among these nonionic surfactants, ester-ether type surfactants and alkanolamide type surfactants are preferable from the viewpoint of obtaining better skin irritation reducing property and detergency. Preferred are polyoxyethylene cured castor oil and cocamide DEA, and more preferably polyoxyethylene cured castor oil.

These nonionic surfactants may be used alone or in combination of two or more.

Examples of the amphoteric surfactant used in the present invention include alkyl betaine type, fatty acid amide propyl betaine type, amine oxide type and other surfactants.

Specific examples of the alkyl betaine type surfactant include lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, octadecylaminomethyldimethylsulfopropyl betaine and the like.

Specific examples of the fatty acid amide propyl betaine type amphoteric tenside agent include amide betaine (amino acid-based amphoteric tenside agent) such as cocamidopropyl betaine, and sulfobetaine such as cocamidopropyl hydroxysultaine.

Specific examples of the amine oxide type amphoteric surfactant include lauryldimethylamine N-oxide and oleyldimethylamine N-oxide.

These amphoteric tenside agents may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. ..

Among these amphoteric surfactants, fatty acid amide propyl betaine type surfactants are preferable, and amide betaines such as cocamidopropyl betaine are more preferable, from the viewpoint of obtaining better skin irritation reduction property and detergency. Amino acid-based amphoteric surfactant), and more preferably cocamidopropyl betaine.

These amphoteric surfactants may be used alone or in combination of two or more.

Natural surfactants used in the present invention include lecithin and lysolecithin; saponins such as Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azuxaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin. And so on.

Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol with components such as triglycerides, fatty acids, and carbohydrates from vegetable oils, and is a known component in pharmaceuticals, quasi-drugs, and cosmetics. is there.

The lecithin may be natural lecithin derived from animals and plants (for example, soybean lecithin, egg yolk lecithin, etc.) itself, a chemically treated product of natural lecithin, or a purified product of natural lecithin. .. Examples of the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation treatment (for example, fully hydrogenated lecithin and partially hydrogenated lecithin), hydroxylated lecithin obtained by hydroxylation treatment, and the like. Examples of the purified product of natural lecithin include lecithin in which the content of phosphatidylcholine is increased by a solvent such as acetone.

Examples of lysolecithin include lyso-forms of the above-mentioned lecithin (natural lecithin, chemically treated natural lecithin, purified natural lecithin). Lysolecithin has a structure in which the fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin by an enzyme such as phospholipase A2.

Among these natural surfactants, lecithin, lysolecithin and saponin are preferably mentioned, more preferably lecithin and lysolecithin, and further preferably lysolecithin, from the viewpoint of obtaining better skin irritation reducing property and detergency. Can be mentioned.

These natural surfactants may be used alone or in combination of two or more.

The content of the component (A) in the skin cleansing spray agent of the present invention is not particularly limited and can be appropriately determined according to the cleansing power to be imparted. Since the skin cleansing spray agent of the present invention can be washed without applying physical friction to the skin, the blending amount of the surfactant in the skin cleansing spray agent can be adjusted to the conventional liquid composition for skin cleansing. It is possible to significantly reduce the amount of the compounding amount contained in the above, and it is possible to effectively exert the detergency even with a small amount of the surfactant which originally cannot exert the effective detergency. From this point of view, the content of the component (A) in the skin cleansing spray agent of the present invention is preferably 0.025 to 2% by weight. Further, from the viewpoint of further suppressing the feeling of tension due to skin irritation and lack of moisturizing, the upper limit of the range of the content of the component (A) is 1.5% by weight or less, preferably 1% by weight or less, more preferably. It may be 0.9% by weight or less, more preferably 0.6% by weight or less, still more preferably 0.2% by weight or less. On the other hand, from the viewpoint of obtaining more excellent detergency, the lower limit of the range of the content of the component (A) is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, still more preferably. Is 1.5% by weight or more, particularly preferably 1.8% by weight or more.

(B) Amphiphilic ester The skin cleansing spray agent of the present invention contains an amphipathic ester as a component (B). The component (B) does not show a cleansing action by itself, but by coexisting with the component (A), the cleansing power of the skin cleansing spray can be improved while maintaining low irritation.

In the present invention, the amphipathic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 μs / m in an amount of 2% by mass or more at room temperature by the method specified in the General Test Method of the Japanese Pharmacopoeia. , Isotridecyl isononanoate (manufactured by Nisshin Oillio Group, Saracos 913), which is an oil agent, also dissolves in 10% by mass or more at room temperature (25 ° C.), and ester-based surfactants are excluded.

The amphoteric ester is not particularly limited, but from the viewpoint of obtaining better skin irritation reduction property and detergency, a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and (eicosandic acid) are used. / Tetradecanedioic acid) It is preferable that it is selected from the group consisting of polyglyceryl-10. As the amphoteric ester, any one of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 is used alone. Also, two or more kinds may be used in combination. Among these amphipathic esters, the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is more preferable from the viewpoint of obtaining better skin irritation reducing property and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, and the like. Examples thereof include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Be done.

Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, a diester of cyclohexane-1,4-dicarboxylic acid and diethylene glycol monoethyl ether is preferable from the viewpoint of obtaining better skin irritation reduction property and detergency. Compound, specifically, INCI name (International Cosmetic DiGLYCOL AND Handbook, 13th edition, Vol. 1, CTFA, 2010, p.331): BIS-ETHOXYDIGLYCOLCYCOLTECYCYCLOHEXASE 1,4-D A compound called hexethoxy-1,4-dicarboxylic acid bisethoxydiglycol, and a diester compound of succinic acid and diethylene glycol monoethyl ether, specifically, INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th edition). , Vol. 1, CTFA, 2010, p.331-332): A compound called bisethoxydiglycol succinate, which is represented by BIS-ETHOXYDIGLYCOL SUCCINATE, is more preferable, cyclohexane-1. , 4-Dicarboxylic acid bisethoxydiglycol.

Further, in the present invention, specific examples of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol include, for example, "Neosolue-Aqulio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd. Further, specific examples of the bisethoxydiglycol succinate include "High Aquos Star DCS (trade name)" manufactured by Higher Alcohol Industry Co., Ltd.

These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.

The dicarboxylic acid dialkoxyalkyl ester used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid dialkoxyalkyl include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, suberic acid, and azelaic acid. Examples thereof include sebacic acid, aspartic acid, glutamic acid, acetone dicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol and 2-ethoxyethanol.

Among these dicarboxylic acid dialkoxyalkyl esters, a diester compound of succinic acid and 2-ethoxyethanol is preferable, and specifically, diethoxyethyl succinate is mentioned from the viewpoint of obtaining the effect of the present invention better. ..

These dicarboxylic acid dialkoxyalkyl esters may be used alone or in combination of two or more.

The polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) used in the present invention is not particularly limited, but for example, "Neosolue-Aqua (trade name)" and "Neosolue-AquaS" manufactured by Nippon Seika Co., Ltd. Product name) ”and the like.

The content of the component (B) in the skin cleansing spray agent of the present invention is not particularly limited, and examples thereof include 0.1% by weight or more. From the viewpoint of obtaining better detergency and / or further reducing the feeling of tension due to insufficient moisturizing, the content of the component (B) is preferably 0.5% by weight or more, more preferably 1. 5% by weight or more, more preferably 2% by weight or more. The upper limit of the content of the component (B) is not particularly limited, but from the viewpoint of the stability of the skin cleansing spray, for example, 5% by weight or less, preferably 4% by weight or less, more preferably 3% by weight or less. Can be mentioned.

In the skin cleaning spray agent of the present invention, the ratio of the component (A) to the component (B) is not particularly limited and is determined by each of the above contents, but from the viewpoint of obtaining better skin irritation reducing property and detergency. Therefore, for 1 part by weight of the component (A), the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, more preferably 0.5 to 5 parts by weight, still more preferably. Examples include 1 to 5 parts by weight.

Other Ingredients In addition to the above ingredients, the skin cleansing spray agent of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. May be good. Such additives are not particularly limited as long as they are pharmaceutically acceptable, but for example, water, lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, etc.), and polyhydric alcohols (ethylene glycol, Aqueous bases such as 1,3-butylene glycol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin, etc.; preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, etc.) , Sodium citrate, sorbic acid, etc.), flavoring agents (citral, 1,8-cineole, citroneral, farnesol, etc.), colorants (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.) ), Cacao pigment, chlorophyll, aluminum oxide, etc.), viscous agent (hydroxypropyl cellulose, hydroxyethyl cellulose, crosslinked acrylic acid polymer, carboxyvinyl polymer, hypromerose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, Carrageenan, etc.), pH adjusters (phosphate, hydrochloric acid, formic acid, acetic acid, citrate, glycolic acid, glucuronic acid, chloroacetic acid, succinic acid, fumaric acid, tartaric acid, maleic acid, malonic acid, malic acid, lactic acid, benzoic acid , Potassium phosphate, dipotassium phosphate, disodium phosphate, trisodium phosphate, ammonium phosphate, pentasodium triphosphate, potassium citrate, sodium citrate (trisodium citrate), calcium citrate, glycolic acid Sodium, sodium citrate, sodium succinate, trisodium sulfosuccinate, sodium fumarate, potassium tartrate, disodium tartrate, tetrapotassium pyrophosphate, disodium pyrophosphate, tetrasodium pyrophosphate, sodium borate, potassium sulfate, hydrogen sulfate Examples thereof include sodium, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine and the like, preferably citrate and potassium hydroxide.), Wetting agents (sodium dl-pyrrolidone carboxylate solution, D-sorbitol). Liquid, macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium citrate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, erythrium Sodium sorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, UV absorbers, chelating agents, adhesives, buffers, solubilizers, solubilizers , Additives such as preservatives. These substrates and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.

The skin cleansing spray agent of the present invention may contain, if necessary, other pharmacological components in addition to the above-mentioned components as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, niacin). Kind, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procine, tetrakine, bupivakine, mepivacaine, chloroprocine, proparakine, meprilcaine or salts thereof, orthokine, oxesazein, oxypolyentoxy Decane, funnel extract, percamine pase, tesitdecitin, etc.), anti-inflammatory agents (indomethasin, fervinac, diclofenac sodium, loxoprofen sodium, etc.), skin protectants (corodione, sunflower oil, etc.) , Capsaicin, capsicum extract, etc.), refreshing agents (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, hyaluronic acid, cationized hyaluronic acid (dihydroxypropyltrimonium hyaluronate) Etc.) etc.) etc. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological component used, the expected effect, and the like.

pH
The pH of the skin cleansing spray agent of the present invention is adjusted to 3 to 8 from the viewpoint of obtaining skin irritation reducing property and cleansing power. The preferable pH of the skin cleaning spray agent of the present invention may differ depending on the type of the component (A) and the like. For example, as the component (A), a carboxylic acid type amino acid-based anionic surfactant and / or a sulfonic acid type amino acid When an anionic surfactant is used, it is preferably 3 to 6, more preferably 3 to 5, from the viewpoint of suppressing the feeling of tension due to insufficient moisturizing, or suppressing the feeling of tension and detergency due to insufficient moisturizing. From the viewpoint of suppressing the feeling of tension due to insufficient moisturizing, 3 to 4 are more preferably mentioned, and from the viewpoint of suppressing the feeling of tension due to insufficient moisturizing and detergency, 5 to 6 are more preferably mentioned; as the component (A), a nonionic surfactant is mentioned. When an activator is used, it is preferably 5 to 8, more preferably 5 to 6, from the viewpoint of detergency and skin irritation reduction property. In the present invention, the pH means the pH at 25 ° C.

Form The form of the skin cleansing spray agent of the present invention is liquid or gel at room temperature. The viscosity of the skin cleansing spray agent of the present invention is 10,000 mPa · s or less, preferably 5000 mPa · s or less at 20 ° C. The viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).

Container The container for accommodating the skin cleansing spray agent of the present invention is not particularly limited as long as it is a spray type container. The spray container in the present invention discharges the contents in a mist state, and is different from the pump former container that discharges the skin cleansing composition in a foam state.

In the present invention, by housing the skin cleansing spray agent in the spray container in this way, the skin cleansing spray agent is directly applied to the skin by spraying without foaming before application to the skin. .. Therefore, it is easy to apply to the skin, and physical friction by hands or the like at the time of application can be avoided. Examples of the spray type container include a pump type spray container which is a non-aerosol type spray container and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include 0.01 to 3 mmφ, preferably 0.1 to 1 mmφ. When the spray type container is a pump type spray container, the injection amount per push is, for example, 0.05 to 1.2 g, preferably 0.1 to 0.3 g.

Applications The skin cleansing spray of the present invention is used to remove body fluids such as oils and sweats on the skin, stains, etc., and is not used as a makeup remover (cleansing). The skin cleansing spray agent of the present invention is used by applying it to the skin as it is without foaming without diluting with water. The amount used at one time depends on the concentration of the surfactant, the degree of stain, etc., but for example, when used for face washing, 0.5 to 3 g, preferably 1 to 2 g can be mentioned.

More specifically, it can be applied directly to the area to be cleaned by spraying from a spray container without picking up the skin cleansing spray agent. In this way, by applying the skin cleansing spray directly to the cleansing area, the friction generated between the skin and hands of the cleansing area and the friction generated between the skin and air bubbles in the cleansing area are physical. Cleaning can be performed simply by using the mechanical force of the liquid flow without giving any physical friction. Since the spray agent for skin cleansing of the present invention is a formulation having excellent cleansing power, it is possible to cleanse the skin by using the mechanical force of the liquid flow without giving physical friction in this way. The burden is significantly reduced and an extremely gentle cleaning method becomes possible. Such a non-foaming cleaning method enables quick cleaning, and it is easy to realize that it is gentle on the skin with less surfactant, and it is easy to obtain satisfaction of consumers who are highly conscious of pursuing skin-friendly cleaning. The skin cleansing spray agent of the present invention is particularly suitable for the above-mentioned cleaning method that does not give physical friction to the skin, but after applying the skin cleansing spray agent to the site to be cleaned, a hand or the like is used. It does not exclude the usage of scrubbing.

The site to be cleaned of the skin cleansing spray agent of the present invention is not particularly limited because it can clean any body part, and examples thereof include hands, hair, scalp, body, and face. Since the spray agent for skin cleaning of the present invention is applied to the site to be cleaned by spraying, it is suitable for use on hair, scalp, and body from the viewpoint of ease of application. In addition, the skin cleansing spray agent of the present invention can exert excellent cleansing power without foaming in advance, and is therefore suitable for use on the face sensitive to irritation. Further, since the skin cleaning spray agent of the present invention is mild and has excellent detergency, it is particularly preferable to use it for sensitive skin. Sensitive skin refers to skin that reacts chronically or temporarily to specific components of external preparations (for example, surfactants, preservatives, fragrances, etc.), ultraviolet rays, and the like. An example of a preferable sensitive skin to which the skin cleaning spray of the present invention is applied is when a skin cleaning spray containing (A) component and (B) component is not applied chronically or temporarily. Skin that has become irritatingly sensitive can be mentioned, especially chronically or temporarily, for example, containing 0.025 to 2% by weight of component (A) and not containing component (B), at pH 3 to 8. Examples of skins are sensitive enough to be irritating when a conditioned skin cleansing spray is applied.

After washing, the skin cleansing spray can be washed away with water. When rinsing with water, it may be performed in the same manner as a normal face wash, but from the viewpoint of reducing the burden on the skin, it is preferable to wash off using the mechanical force of the water stream so as not to give friction by hand.

Further, since the spray agent for skin cleaning of the present invention can extremely reduce the concentration of the surfactant, in this case, it is not necessary to wash it off after washing. Therefore, the skin cleansing spray agent of the present invention is also suitable for cleaning in hospitals, skin cleansing treatments such as face washing in beauty salons and beauty salons, and disaster supplies. If it is not washed away, a water-absorbent base material such as a towel or tissue may be used to absorb and remove the skin-cleaning spray agent remaining on the washed area.

Production Method The skin cleansing spray agent of the present invention is prepared by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary, so as to have a predetermined form and pH. After being prepared, it is manufactured by being housed in a spray container. When it is housed in an aerosol spray container as a spray container, it is manufactured by being housed together with a spray agent such as gas.

The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto.

[Reference test example]
A skin cleansing spray having the compositions shown in Tables 1 to 4 was prepared. Details of each component shown in Tables 1 to 4 are as follows. The skin cleaning sprays shown in Tables 1 to 4 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all 5000 mPa. The pH was in the range of s or less, and the pH at 25 ° C was in the range of 3 to 8, except for Reference Example 1 (pH at 25 ° C was about 10).
・ Sodium laurate (NOF CORPORATION "Non-Sal LN-1" (trade name))
・ Cocoyl glutamic acid TEA (Ajinomoto Co., Inc. "Amisoft CT-12S (trade name)")
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION)
-N-Lauroyl aspartate sodium solution (20% by weight) ("Aminoformer FLDS-L (trade name)" manufactured by Asahi Kasei Fine Chemicals Co., Ltd.)
-Polyoxyethylene lauryl ether acetic acid ("Kao Akipo RLM-45 (trade name)" manufactured by Kao Corporation)
・ Cocamide DEA ("Amisol CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
-PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; Nikko Chemicals Co., Ltd. "NIKKOL HCO-60 (trade name)")
-Polyoxyethylene sorbitan monostearate (Kao Corporation "Leodor TW-S120V (trade name)")
-Glycerin mono-2-ethylhexyl ether (SEPPIC "sensivaSC 50 JP (trade name)")
・ Cocamidopropyl betaine ("Softazoline CPB (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
-Lauryl hydroxysulfobetaine solution (30% by weight) (Kao Corporation "Anhitor 20HD (trade name)")
・ Lysolecithin (“Resolecithin Kyowa (trade name)” manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceuticals Co., Ltd., saponin content 5% by weight)
-Cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol ("Neosolue-Aqulio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd.)
・ Bisethoxydiglycol succinate (“High Aquos Star DCS (trade name)” manufactured by Higher Alcohol Industry Co., Ltd.)

<Detergency evaluation>
Ten panelists specializing in cosmetics evaluation evaluated the cleansing power of the prepared skin cleansing spray. Specifically, each skin cleansing spray agent is contained in a pump-type spray container (injection amount per push of "Z-155-C110 (trade name)" manufactured by Takemoto Yohki Co., Ltd. is 0.15 g). It was applied by spraying 5 g directly onto the face. It was left for about 5 seconds, and then rinsed with water so that the hands did not touch the face. After holding the face with a towel and absorbing water, the feeling of dirt removal on the skin was scored by sensory evaluation based on the following indexes.

5 points: Dirt removal was felt firmly 4 points: Dirt removal was felt 3 points: Neither 2 points: Dirt removal was not felt so much 1 point: Dirt removal was not felt at all

The scores obtained by the 10 panelists were totaled, and the degree of detergency was evaluated according to the following classification. The results are shown in Tables 1 to 4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points

<Evaluation of tension>
Ten panelists specializing in cosmetics evaluation evaluated the prepared skin cleansing spray agent for a feeling of tension. Specifically, each skin cleansing spray agent is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g), and 1 .5 g was applied by spraying directly on the face. Leave it for about 5 seconds, then rinse with water so that the hands do not touch the face. Hold the face with a towel to absorb the water, and immediately after washing. The feeling of tension was scored by sensory evaluation based on the following indexes. The stronger the degree of tension, the insufficient moisturizing.

5 points: No feeling of tension 4 points: Almost no feeling of tension 3 points: Feeling little tension 2 points: Feeling tension 1 point: Feeling strong feeling of tension

The scores obtained by the 10 panelists were totaled, and the degree of tension was evaluated according to the following classification. The results are shown in Tables 3-4.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points

<Cultured epidermal skin irritation test (in vitro evaluation of skin irritation)>
The prepared skin cleansing spray was subjected to a cultured epidermal skin irritation test as follows.
1. 1. Preparation of Cultured Epidermis Model LabCite EPI-MODEL24 The assay medium was warmed and 0.5 mL each was added to a 24-well assay plate. Cultured epidermis model LabCite EPI-MODEL24 (lot number: LCE24-180226-A) was transferred to a 24-well assay plate supplemented with assay medium. After confirming that there were no bubbles on the bottom surface of the culture cup, the cells were placed in a CO ₂ incubator and allowed to stand for 1 hour or more until exposure to the test substance.

2. 2. Application and washing of test substance Twelve of the 24 epidermis models were used (the rest were pre-cultured until this test). A 24-well assay plate was removed from the CO ₂ incubator. The assay medium was warmed and 1.0 mL each was added to the third row of the 24-well assay plate. 25 μL of the test substance (spray agent for cleaning each skin) was added dropwise to the culture epidermis of the culture cup without using a pump-type spray container, and the whole was exposed. After 1 minute, 5 minutes and 10 minutes after exposure, the test substance was aspirated and removed, and the cultured epidermis model in the cup was washed with phosphate buffer (PBS) and transferred to the third row of the 24-well assay plate.

3. 3. MTT test The MTT test occurs when MTT [3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltrazolium bromide] taken up into cells is reduced by intracellular mitochondrial dehydrogenase. This is a method of measuring the viable cell ratio by extracting a formazan dye with an organic solvent and measuring the absorbance at 570 nm.

10 mL of MTT medium was prepared at a final concentration of 0.5 mg / mL. The MTT medium was warmed and 0.5 mL each was added to row 4 of the 24-well assay plate. The cultured epidermis model was transferred to row 4 of the 24-well assay plate and placed in a CO2 incubator for 3 hours MTT reaction. After completion of the MTT reaction, the cultured skin was picked up with tweezers and taken out, and transferred to a 1.5 mL microtube. 300 μL of isopropanol was placed in a microtube and the cultured epidermis model was completely immersed. After that, it was allowed to stand for 2 hours, and the microtube was vortexed to extract the pigment. Extract (200 mL) was placed in each well of a 96-well plate. Further, as a blank (negative control), 200 μL of isopropanol was added to A1. Absorbance at 570 nm and 650 nm was measured with a microplate reader. The value obtained by subtracting the absorbance at 650 nm from the absorbance at 570 nm was used as the measured value, and the viable cell ratio of the test substance was calculated from the following formula.

The viable cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in Tables 3-4.
⊚: 90% or more ○: 75% or more and less than 90% Δ: 65% or more and less than 75% ×: 50% or more and less than 65% × ×: less than 50%

As shown in Tables 1 to 4, no detergency was observed in the skin cleansing sprays (Reference Comparative Examples 1 to 10) containing the surfactant alone at a concentration of 0.025 to 2% by weight. On the other hand, a skin cleansing spray containing 0.025 to 2% by weight of a surfactant containing an amphipathic ester (Reference Comparative Examples 11 to 15) which does not show detergency by itself (Reference Examples 1 to 20). Then, by simply applying it directly to the skin by spraying from a spray-type container, excellent detergency was obtained only by using the mechanical force of the liquid flow without giving any physical friction. In other words, it was shown that skin-friendly cleansing is possible.

As shown in Reference Examples 1 to 3, a skin cleansing spray agent containing more than 2% by weight of a surfactant alone can also obtain excellent cleansing power simply by applying it directly to the skin by spraying. On the other hand, in consideration of skin irritation due to the surfactant concentration shown in Reference Examples 1 to 3, when the surfactant concentration is 2% by weight or less as shown in Reference Examples 9 to 20, not only the detergency but also the detergency is obtained. Excellent hypoallergenicity was also achieved. That is, by setting the surfactant concentration of the skin cleaning spray agent applied directly to the skin by spraying to 0.025 to 2% by weight, it is possible to perform cleaning that is physically and chemically gentle on the skin. Shown.

[Test example]
A skin cleansing spray having the compositions shown in Tables 5 to 6 was prepared. Details of each component shown in Tables 5 to 6 are as shown in the reference test example. The skin cleansing sprays shown in Tables 5 to 6 are expected to be d, and the viscosity at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) is also expected. It was in the range of 5000 mPa · s or less.

<pH measurement>
The pH of the prepared skin cleansing composition was measured at 25 ° C. using a tabletop pH meter (F-72) manufactured by HORIBA.

<Detergency evaluation>
The degree of detergency of the prepared skin cleansing composition was evaluated in the same manner as in the reference test example. The results are shown in Tables 5-6.

<Stimulation evaluation>
The prepared skin cleansing composition was evaluated for irritation by 10 panelists specializing in cosmetics evaluation. Specifically, each skin cleansing composition is contained in a pump-type spray container (Takemoto Yohki Co., Ltd. "Z-155-C110 (trade name)" (injection amount per push is 0.15 g), and 1 .5 g was applied by spraying directly on the whole body. Leave it for about 5 seconds, then rinse with water so that the hands do not touch the skin. Hold the skin with a towel to absorb the water, and then stimulate. The feeling was scored by sensory evaluation based on the following indexes.

5 points: I did not feel any stimulus 4 points: I did not feel much stimulus 3 points: I felt slight stimulus 2 points: I felt stimulus 1 point: I felt strong stimulus

The scores obtained by the 10 panelists were totaled, and the degree of stimulation was evaluated according to the following classification. The results are shown in Tables 5-6.
⊚: 45 points or more ○: 40 points or more and less than 45 points Δ: 35 points or more and less than 40 points ×: less than 35 points

<Evaluation of tension>
The degree of tautness was evaluated in the same manner as in the reference test example, except that the tautness was evaluated immediately after washing, 5 minutes after washing, and 10 minutes after washing. The results are shown in Tables 5-6.

As shown in Tables 5 to 6, in the skin cleaning sprays (Examples 1 to 15) in which the surfactant was 2% by weight, the amphipathic ester was blended, and the pH was adjusted to 3 to 8, the surfactant was used. It was found that even if the concentration of is low, excellent detergency can be obtained by simply applying it directly to the skin by spraying from a spray container, without giving any physical friction, and by using the mechanical force of the liquid flow. It was. Even if the surfactant is 2% by weight and the amphipathic ester is blended, the skin cleaning sprays (Comparative Examples 1 to 5) having a pH lower than 3 become more irritating and the surfactants. Depending on the type of skin cleaning agent, a decrease in detergency and an increase in the feeling of tension due to insufficient moisturizing are observed. Depending on the type of agent, increased irritation and decreased detergency were observed.

Claims

A skin cleansing spray agent containing (A) a surfactant and (B) an amphipathic ester, having a pH of 3 to 8, and contained in a spray container.
The skin cleansing spray agent according to claim 1, wherein the spray container is a pump type spray container.
The skin cleansing spray agent according to claim 1, wherein the spray container is an aerosol spray container.
Claims 1 to 1, wherein the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. The skin cleaning spray agent according to any one of 3.
The skin cleaning spray agent according to claim 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
The skin cleansing spray agent according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.
The skin cleansing spray agent according to any one of claims 1 to 6, which is applied to sensitive skin.