CN112449589A

CN112449589A - Spray for cleaning skin

Info

Publication number: CN112449589A
Application number: CN202080003360.0A
Authority: CN
Inventors: 山本航平; 久保嘉一
Original assignee: Kobayashi Pharmaceutical Co Ltd
Current assignee: Kobayashi Pharmaceutical Co Ltd
Priority date: 2019-06-26
Filing date: 2020-06-17
Publication date: 2021-03-05
Also published as: JP2021004201A; WO2020262155A1

Abstract

The purpose of the present invention is to provide a skin cleanser composition used in a method different from the conventional method. A spray for skin cleansing which contains (A) a surfactant and (B) an amphiphilic ester, has a pH of 3-8, and is stored in a spray container, and which can exhibit excellent cleansing power while reducing skin irritation of a skin cleanser composition, and therefore can provide a new use in which a skin cleanser composition is directly sprayed onto the skin, unlike conventional uses in which the composition is previously foamed when applied to the skin.

Description

Spray for cleaning skin

Technical Field

The present invention relates to a spray for skin cleansing which is used by spraying directly on the skin.

Background

Various skin cleansing compositions such as facial cleanser, body soap, and shampoo are provided as products for the purpose of cleansing the skin and keeping the skin clean. In the mechanism of skin cleansing by the skin cleanser composition, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and mechanical force due to friction also interacts with each other to float the dirt in water. In order to effectively exert such a cleaning mechanism, it is necessary to incorporate a surfactant at a critical micelle concentration or higher.

On the other hand, the cleansing power by the surfactant is too strong and causes skin irritation, and as a result, there is a current situation in which a skin problem typified by dry skin is caused. Therefore, various formulations for studying combinations of cleansing components, blending amounts, and the like have been proposed for the purpose of moderating the action on the skin. Among them, it is common knowledge that a formulation for improving the quality of foam such as foaming power and foam retention is excellent as a formulation for moderating the action on the skin because the foam formed during washing can reduce the friction caused by direct contact between the skin and fingers.

Therefore, in recent years, various pump foamer type skin cleansers have been proposed, which not only can easily obtain good quality foam, but also attract attention to the softness of the skin. Specifically, patent document 1 discloses a liquid skin cleansing composition comprising a foam container (Japanese original: フォーマー container) and a liquid skin cleansing composition filled in the foam container, wherein the liquid skin cleansing composition comprises (A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, (B) a copolymer of a specific dimethyldiallylammonium chloride and acrylic acid and/or acrylamide, and (C) a sugar alcohol, and the mass ratio (A)/(B) of the content of component (A) to the content of component (B) is 20 to 250. Patent document 2 discloses a skin cleansing composition comprising a cleansing agent filled in a foam container, wherein the cleansing agent comprises 2 to 9 mass% of a fatty acid salt (a), 0.5 to 4 mass% of lauryl dimethyl glycine betaine (b), and 1 to 10 mass% of one or more glycols (c), wherein the sum of the amounts (mass%) of a component (a) and a component (b) is 3 to 10 mass%, and the ratio (b)/(a) is 0.1 to 0.5. Further, patent document 3 discloses a detergent composition containing 4 to 15 mass% of a higher fatty acid soap (a) composed of lauryl dimethyl glycine betaine and (b) a fatty acid having 5 to 25 carbon atoms and having a specific composition, and being discharged from a foamer container.

[ Prior art documents ]

[ patent document ]

Patent document 1: international publication No. 2014/003114

Patent document 2: japanese patent laid-open publication No. 2016-098182

Patent document 3: international publication No. 2017/081897

Disclosure of Invention

Problems to be solved by the invention

In view of the fact that the amount of the surfactant to be added is relatively small, the pump-foamer type skin cleanser composition tends to cause less irritation to the skin than the solid or semisolid skin cleanser composition. On the other hand, since it is a big premise that the pump foamer type skin cleanser composition is discharged in a state of foam, it is inevitable to add a minimum amount of surfactant necessary for exerting foaming power to the composition.

In addition to skin cleansing materials intended for cleansing (cleansing), various skin cleansing materials intended for removing body fluids such as sebum and sweat, dirt, and the like have been created, but it is common knowledge that any skin cleansing material is not exceptional, and foaming is performed before application to the skin, and further, foaming is preferably performed well before cleansing from the viewpoint of moderating friction against the skin. Although the foam can alleviate physical friction by being interposed between the skin and the hand, the foam itself generates physical friction by rubbing against the skin, and causes irritation to the skin, which is not changed. In particular, irritation may still occur with respect to skin that is sensitive to irritation.

In this way, in the same use method as in the conventional art, the reduction of the burden on the skin by the skin cleansing material is limited. Therefore, in order to be applied to skin sensitive to irritation, it is considered that the skin cleansing composition needs to reduce irritation to the skin more than ever before.

Accordingly, an object of the present invention is to provide a skin cleanser composition used in a method different from the conventional methods.

Means for solving the problems

The present inventors have conceived a novel use in which a skin cleansing composition is directly sprayed on the skin without causing a preliminary lathering when applied to the skin in order to further reduce the irritation to the skin. Further, it has been found that by allowing an amphiphilic ester to coexist with a surfactant and adjusting the pH to 3 to 8, a cleaning power can be effectively obtained even without pre-foaming. The present invention has been completed through further repeated studies based on this finding.

That is, the present invention provides the inventions of the embodiments disclosed below.

Item 1. A spray for skin cleansing, which contains (A) a surfactant and (B) an amphiphilic ester,

the pH of the spray for skin cleansing is 3 to 8, and the spray for skin cleansing is contained in a spray container.

The spray for skin cleansing according to item 1, wherein the spray container is a pump spray container.

The spray according to item 1, item 3, wherein the spray container is an aerosol spray container.

Item 4 the spray for skin cleansing according to any one of items 1 to 3, wherein the component (B) is selected from the group consisting of bis (polyoxyalkylene alkyl ether) dicarboxylate, dialkoxyalkyl dicarboxylate, and polyglycerol-10 eicosadipate/tetradecadipate.

The spray for skin cleansing according to any one of claims 1 to 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate.

The spray for skin cleansing according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.

The spray for skin cleansing according to any one of claims 1 to 6, wherein the spray for skin cleansing is applied to sensitive skin.

Effects of the invention

According to the present invention, since the skin cleanser composition can exhibit excellent cleansing power while reducing skin irritation, a new use can be provided in which the skin cleanser composition is directly sprayed on the skin, unlike a conventional use in which the skin cleanser composition is previously foamed when applied to the skin. Since the cleansing can be performed without foaming in advance, the amount of the surfactant to be added to the liquid composition for cleansing skin can be significantly reduced as compared with the amount to be added to a conventional liquid composition for cleansing skin, and thus the skin irritation can be further reduced. Therefore, the spray for skin cleansing can be suitably used for cleansing skin sensitive to irritation.

Detailed Description

The spray for skin cleansing of the present invention contains (a) a surfactant (hereinafter, sometimes referred to as component (a)) and (B) an amphipathic ester (hereinafter, sometimes referred to as component (B)), is adjusted to a predetermined pH, and is stored in a spray container. The skin cleansing spray of the present invention will be described in detail below.

(A) Surface active agent

The spray for skin cleansing of the present invention contains a surfactant as the component (a). The surfactant is not particularly limited, and from the viewpoint of suppressing irritation to the skin, preferable examples thereof include anionic surfactants, nonionic surfactants, amphoteric surfactants, natural surfactants, and the like. As the surfactant, one of an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, and a natural surfactant may be used alone, and two or more kinds may be used in any combination.

Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate type, and phosphate type surfactants.

Specific examples of the carboxylic acid type surfactant include saturated or unsaturated fatty acids having 6 to 22 carbon atoms such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and the like; and an N-acylamino acid (carboxylic acid type amino acid type anionic surfactant) having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, and a cocoyl group.

Examples of the carboxylic acid type amino acid anionic surfactant include N-acylamino acids having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, and a cocoyl group. Examples of the N-acylamino acid in the carboxylic acid type amino acid type anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, and N-acyl-N-methyl-. beta. -alanine. More specific examples of the carboxylic acid type amino acid type anionic surfactant include N-lauroyl sarcosine, cocoyl sarcosine, N-lauroyl aspartic acid, cocoyl aspartic acid, N-lauroyl glutamic acid, cocoyl glutamic acid, N-lauroyl-N-methyl- β -alanine, and cocoyl methyl alanine.

Specific examples of the sulfonic acid type surfactant include esters of fatty acids having 6 to 22 carbon atoms such as cocoyl isethionic acid and isethionic acid; alkyl sulfonic acids having 6 to 22 carbon atoms such as hexane sulfonic acid, octane sulfonic acid, decane sulfonic acid, dodecane sulfonic acid and the like; alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as alkyl benzene sulfonic acid; N-acyl-N-methyltaurine (sulfonic acid-type amino acid-based anionic surfactant) having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as octanoyl group, decanoyl group, lauroyl group, myristoyl group, palmitoyl group, and cocoyl group.

Examples of the sulfonic acid-type amino acid-based anionic surfactant include N-acyl-N-methyltaurine having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, and a cocoyl group. More specific examples of the sulfonic acid-type amino acid-based anionic surfactant include N-myristoyl-N-methyltaurine, N-lauroyl-N-methyltaurine, and cocoyl methyltaurine.

Specific examples of the sulfate-type surfactant include esters of sulfuric acid with saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate. Specific examples of the phosphate ester type surfactant include esters of phosphoric acid with saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphate.

These anionic surfactants may be in the form of salts, and for example, alkali metal salts such as sodium salts and potassium salts; triethanolamine (TEA) salts; ammonium salts, and the like.

Among these anionic surfactants, from the viewpoint of more favorably obtaining skin irritation reducing properties and cleansing power, preferable examples thereof include carboxylic acid type surfactants and sulfonic acid type surfactants, and more preferable examples thereof include carboxylic acid type amino acid type anionic surfactants and sulfonic acid type amino acid type anionic surfactants. When the pH of the spray for skin cleansing of the present invention is, for example, 3 to 6, it is preferable to use a carboxylic acid type amino acid type anionic surfactant and a sulfonic acid type amino acid type anionic surfactant from the viewpoint of suppressing a tight feeling due to insufficient moisture retention, or suppressing a tight feeling due to insufficient moisture retention and cleansing power. More specifically, the carboxylic acid type amino acid anionic surfactant and the sulfonic acid type amino acid anionic surfactant are preferably used from the viewpoint of suppressing the tight feeling due to insufficient moisture retention when the pH of the spray for skin cleansing of the present invention is, for example, 3 to 4, and are preferably used from the viewpoint of suppressing the tight feeling due to insufficient moisture retention and cleansing power when the pH is, for example, 5 to 6.

Further, among these, from the viewpoint of detergency and/or reduction of skin irritation, preferable examples include N-acyl glutamic acid and N-acyl aspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms, and fatty acid amide sulfonic acid having 8 to 22 carbon atoms and salts thereof, more preferable examples include cocoyl glutamic acid, N-lauroyl aspartic acid, cocoyl methyl taurine and salts thereof, and further preferable examples include triethanolamine cocoyl glutamate, sodium N-lauroyl aspartate, and sodium cocoyl methyl taurate.

These anionic surfactants may be used alone or in combination of two or more.

Examples of the nonionic surfactant used in the present invention include ester-type, ether-type, ester/ether-type, alkanolamide-type, alkylglycoside-type, and alcohol-type surfactants.

When the pH of the spray for skin cleansing of the present invention is, for example, 5 to 8, preferably 5 to 6, a nonionic surfactant is preferably used from the viewpoint of cleansing power and skin irritation reducing property. Specific examples of the ester-type surfactant include monoesters or diesters of saturated or unsaturated fatty acids having 8 to 20 carbon atoms and glycerin, such as ethylene glycol dilaurate, ethylene glycol monostearate, ethylene glycol distearate, glycerol monolaurate, glycerol dilaurate, glycerol monostearate, and glycerol distearate; sorbitan fatty acid esters; sucrose fatty acid esters, and the like.

Specific examples of the ether-type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, and polyoxyethylene polyoxypropylene glycol.

Examples of the ester/ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitol anhydride fatty acid ester, sorbitan fatty acid ester polyethylene glycol, and the like.

Specific examples of the alkanolamide type surfactant include cocamide DEA (coconut fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide, and the like.

Specific examples of the alkyl glycoside type surfactant include octyl glucoside, decyl glucoside, and lauryl glucoside.

Examples of the alcohol-type surfactant include cetyl alcohol, stearyl alcohol, and oleyl alcohol.

Among these nonionic surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are ester-ether type surfactants and alkanolamide type surfactants, more preferred are polyoxyethylene hydrogenated castor oil and cocamide DEA, and still more preferred is polyoxyethylene hydrogenated castor oil.

These nonionic surfactants may be used singly or in combination of two or more.

Examples of the amphoteric surfactant used in the present invention include alkyl betaine type surfactants, fatty acid amide propyl betaine type surfactants, amine oxide type surfactants, and the like.

Specific examples of the alkyl betaine type surfactant include lauryl dimethyl glycine betaine, stearyl dimethyl glycine betaine, and stearyl amino methyl dimethyl sulfopropyl betaine.

Specific examples of the fatty acid amide propyl betaine amphoteric surfactant include an amide betaine (amino acid amphoteric surfactant) such as cocamidopropyl betaine, and a sulfobetaine such as cocamidopropyl hydroxysulfobetaine.

Specific examples of the amine oxide type amphoteric surfactant include lauryl dimethyl amine oxide and oleyl dimethyl amine oxide.

In addition, these amphoteric surfactants may be in the form of salts, and for example, alkali metal salts such as sodium salts and potassium salts; triethanolamine (TEA) salts; ammonium salts, and the like.

Among these amphoteric surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, a fatty acid amide propyl betaine type surfactant is preferably included, an amido betaine (amino acid type amphoteric surfactant) such as cocamidopropyl betaine is more preferably included, and cocamidopropyl betaine is further preferably included.

These amphoteric surfactants may be used singly or in combination of two or more.

Examples of the natural surfactant used in the present invention include lecithin and lysolecithin; saponins such as Quillaja Saponaria Molina saponin, soyasaponin, yucca saponin, Sophora Japonica Saponin, beet saponin, semen Phaseoli saponin, ginsenoside, tea saponin, fructus Luffae saponin, and asiaticoside.

Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol and components such as triglycerides, fatty acids, and carbohydrates derived from vegetable oils, and is a known component in pharmaceuticals, quasi drugs, and cosmetics.

The lecithin may be natural lecithin derived from animals and plants (e.g., soybean lecithin, egg yolk lecithin, etc.), or a chemically treated product of natural lecithin, or a purified product of natural lecithin. Examples of the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation (e.g., fully hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation. The purified product of natural lecithin may be lecithin in which the content of phosphatidylcholine has been increased by a solvent such as acetone.

Examples of the lysolecithin include lysosomes of the above-mentioned lecithins (natural lecithins, chemically treated products of natural lecithins, purified products of natural lecithins). Lysolecithin has a structure in which a fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin with an enzyme such as phospholipase a 2.

Among these natural surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are lecithin, lysolecithin and saponin, more preferred are lecithin and lysolecithin, and still more preferred is lysolecithin.

These natural surfactants may be used alone or in combination of two or more.

The content of the component (a) in the skin cleansing spray of the present invention is not particularly limited, and can be appropriately determined according to the cleansing power to be imparted. Since the spray for skin cleansing of the present invention can cleanse the skin without physically rubbing the skin, the amount of surfactant to be added in the spray for skin cleansing can be significantly reduced from that contained in a conventional liquid composition for skin cleansing, and even a small amount of surfactant that cannot exert an effective cleansing power originally can exert an effective cleansing power effectively. From such a viewpoint, the content of the component (a) in the skin cleansing spray of the present invention is preferably 0.025 to 2 wt%. Further, from the viewpoint of further suppressing the tight feeling due to skin irritation and insufficient moisture retention, the upper limit of the range of the content of the component (a) may be 1.5% by weight or less, preferably 1% by weight or less, more preferably 0.9% by weight or less, further preferably 0.6% by weight or less, and still further preferably 0.2% by weight or less. On the other hand, from the viewpoint of obtaining more excellent detergency, the lower limit of the range of the content of the component (a) is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, further preferably 1.5% by weight or more, and particularly preferably 1.8% by weight or more.

(B) Amphiphilic esters

The spray for skin cleansing of the present invention contains an amphiphilic ester as the component (B). (B) The component (A) does not exhibit a cleansing action when used alone, and can improve the cleansing power of the spray for cleansing the skin while maintaining low irritation by allowing the component (A) to coexist.

In the present invention, the amphiphilic ester is dissolved in ion-exchanged water having an electric conductivity adjusted to 70 to 110 μ s/m at room temperature by 2 mass% or more, and also dissolved in isotridecyl isononanoate (SALACOS 913, manufactured by riqing oitici corporation) as an oil agent at room temperature (25 ℃) by 10 mass% or more, and does not include an ester-based surfactant, in the measurement according to the method defined in the general test method of japanese pharmacopoeia.

The amphiphilic ester is not particularly limited, and is preferably an amphiphilic ester selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate, from the viewpoint of more satisfactory skin irritation reducing property and detergency. As the amphiphilic ester, any of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate may be used alone, or two or more thereof may be used in combination. Among these amphiphilic esters, dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters are more preferable from the viewpoint of more satisfactory skin irritation reducing properties and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound such as the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether.

Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are diester compounds of cyclohexane-1, 4-dicarboxylic acid and diethylene glycol monoethyl ether, specifically under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331): the compounds known as BIS-diethoxydibycol CYCLOHEXANE 1,4-DICARBOXYLATE and the diester compounds of succinic acid and diethylene glycol monoethyl ether described by BIS-ETHOXYDIGLYCOL cyclonexane 1,4-DICARBOXYLATE, in particular under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331-332): the compound called BIS-ETHOXYDIGLYCOL SUCCINATE described in BIS-ETHOXYDIGLYCOL SUCCINATE is more preferably BIS-diethoxydiol cyclohexane 1, 4-dicarboxylate.

In the present invention, specific examples of the bis-diethoxydiol cyclohexane 1,4-dicarboxylate include "neosolve-Aqulio (trade name)" manufactured by japan koku corporation. Specific examples of the bis-ethoxydiglycol succinate include "haiaqeosister DCS (trade name)" manufactured by higher alcohol industries.

These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used singly or in combination of two or more.

The dialkoxyalkyl dicarboxylate used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound such as dialkoxyalkyl dicarboxylate include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol and 2-ethoxyethanol.

Among these dialkoxyalkyl dicarboxylates, a diester compound of succinic acid and 2-ethoxyethanol is preferable from the viewpoint of more favorably obtaining the effects of the present invention, and specifically diethoxyethyl succinate is exemplified.

These dialkoxyalkyl dicarboxylates may be used singly or in combination of two or more kinds.

The polyglycerol-10 eicosadioate/tetradecadioate used in the present invention is not particularly limited, and examples thereof include "neosolve-Aqua (trade name)" and "neosolve-Aqua (trade name)" manufactured by japan koku corporation.

The content of component (B) in the skin cleansing spray of the present invention is not particularly limited, and may be, for example, 0.1 wt% or more. From the viewpoint of more satisfactory detergency and/or from the viewpoint of further reducing a tight feeling due to insufficient moisture retention, the content of the component (B) is preferably 0.5% by weight or more, more preferably 1.5% by weight or more, and still more preferably 2% by weight or more. (B) The upper limit of the range of the content of the component is not particularly limited, and from the viewpoint of stability of the spray for skin cleansing, for example, it is 5% by weight or less, preferably 4% by weight or less, and more preferably 3% by weight or less.

In the skin cleansing spray of the present invention, the ratio of the component (a) to the component (B) is not particularly limited, and is determined by the above-mentioned contents, but from the viewpoint of obtaining more favorable skin irritation reducing properties and cleansing power, for example, the component (B) is 0.1 to 100 parts by weight, preferably 0.1 to 10 parts by weight, more preferably 0.5 to 5 parts by weight, and still more preferably 1 to 5 parts by weight, relative to 1 part by weight of the component (a).

Other ingredients

The spray for skin cleansing of the present invention may contain other base agents and additives necessary for formulation and the like, in addition to the above components, within a range not impairing the effects of the present invention. Such additives are not particularly limited as long as they are pharmaceutically acceptable, and examples thereof include water, aqueous base agents such as lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, and the like) and polyhydric alcohols (ethylene glycol, 1, 3-butanediol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, and glycerin); preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), perfuming agents (citral, 1, 8-cineole, citronellal, farnesol, etc.), coloring agents (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.), cacao pigments, chlorophyll, alumina, etc.), thickening agents (hydroxypropyl cellulose, hydroxyethyl cellulose, crosslinked acrylic polymer, carboxyvinyl polymer, hydroxypropyl methyl cellulose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, carboxymethylcellulose sodium, xanthan gum, carrageenan, etc.), pH adjusters (phosphoric acid, hydrochloric acid, formic acid, acetic acid, citric acid, glycolic acid, glucuronic acid, chloroacetic acid, succinic acid, fumaric acid, tartaric acid, maleic acid, etc.), pH adjusters (phosphoric acid, hydrochloric acid, formic acid, acetic acid, citric acid, glycolic acid, glucuronic acid, chloroacetic acid, succinic acid, fumaric acid, tartaric acid, maleic acid, etc.), pH adjusting agents (citric acid, citric, Malonic acid, malic acid, lactic acid, benzoic acid, potassium phosphate, dipotassium phosphate, disodium phosphate, trisodium phosphate, ammonium phosphate, pentasodium triphosphate, potassium citrate, sodium citrate (trisodium citrate), calcium citrate, sodium glycolate, sodium silicate, sodium succinate, trisodium sulfosuccinate, sodium fumarate, potassium tartrate, disodium tartrate, tetrapotassium pyrophosphate, disodium pyrophosphate, tetrasodium pyrophosphate, sodium borate, potassium sulfate, sodium hydrogen sulfate, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc., preferably, citric acid, potassium hydroxide, wetting agents (dl-pyrrolidone carboxylic acid sodium solution, D-sorbitol solution, polyethylene glycol (MACROGOL), etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, ethylenediaminetetraacetic acid, sodium metaphosphate, L-arginine, L-aspartic acid, etc.), DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidant, ultraviolet absorbent, chelating agent, binder, buffer, dissolution assistant, solubilizer, preservative, etc. These base materials and additives may be used singly or in combination of two or more. The contents of these base materials and additives may be appropriately set according to the form of the preparation.

The spray for skin cleansing of the present invention may contain other pharmacological components as needed, in addition to the above components, within a range not impairing the effects of the present invention. Examples of such pharmacological components include vitamins (e.g., vitamin a, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, nicotinic acid, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, mepivacaine or salts thereof, oxolocaine, oxicaine, oxypolyethoxydecane (oxyphenoxydecane) (japanese manuscript: オキシポリエントキシデカン), hyoscyamine, dibucaine powder (japanese manuscript: ペルカミンパーゼ), polyoxyethylene lauryl ether (japanese manuscript: テシットデシチン), anti-inflammatory agents (indomethacin, etc.) Felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protecting agents (collodion, castor oil, etc.), blood circulation promoting components (vanillylnonanoate, benzyl nicotinate, capsaicin, capsicum extract, etc.), algefacients (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (chondroitin sulfate sodium, glucosamine, hyaluronic acid, cationized hyaluronic acid (dihydroxypropyltrimethylammonium chloride hyaluronic acid (japanese original: ヒアルロン acid ジヒドロキシプロピルトリモニウム, etc.)) and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the kind of the pharmacological component to be used, the desired effect, and the like.

pH

The pH of the spray for skin cleansing of the present invention is adjusted to 3 to 8 from the viewpoint of obtaining skin irritation reducing properties and cleansing power. The preferred pH of the skin cleansing spray of the present invention may vary depending on the type of component (a), and for example, when a carboxylic acid type amino acid anionic surfactant and/or a sulfonic acid type amino acid anionic surfactant is used as component (a), from the viewpoint of suppressing a tight feeling due to insufficient moisture retention, or from the viewpoint of suppressing a tight feeling due to insufficient moisture retention, and cleansing power, there are preferably 3 to 6, more preferably 3 to 5, from the viewpoint of suppressing a tight feeling due to insufficient moisture retention, further preferably 3 to 4, and from the viewpoint of suppressing a tight feeling due to insufficient moisture retention, and cleansing power, further preferably 5 to 6; when a nonionic surfactant is used as component (a), from the viewpoint of detergency and skin irritation reducing properties, it is preferably 5 to 8, more preferably 5 to 6. In the present invention, the pH means a pH at 25 ℃.

Form of the composition

The spray for skin cleansing according to the present invention is in the form of a liquid or gel at room temperature. The viscosity of the skin cleansing spray of the present invention is 10000mPa · s or less, preferably 5000mPa · s or less at 20 ℃. The viscosity was measured by using a BL viscometer (rotor No3, 6rpm, 20 ℃).

Container with a lid

The container for containing the spray for skin cleansing according to the present invention is not particularly limited as long as it is a spray type container. The aerosol container of the present invention is different from a pump foamer container that ejects a skin cleanser composition in a foam state by ejecting the contents in a mist state.

In the present invention, by housing the spray for skin cleansing in the spray container in this manner, the spray for skin cleansing can be directly applied to the skin by spraying without causing a bubble before being applied to the skin. Therefore, application to the skin is simple and physical friction by hands or the like at the time of application can be avoided. Examples of the spray container include a pump type spray container which is a non-aerosol type spray container, and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include

Preference is given to

The amount of spray per 1-time pressing when the spray container is a pump spray container is, for example, 0.05 to 1.2g, preferably 0.1 to 0.3 g.

Use of

The spray for skin cleansing of the present invention is used for removing body fluids such as oil and fat, sweat, dirt, and the like from the skin, and is not used as a makeup remover (makeup remover cream). The spray for skin cleansing of the present invention is used by being applied directly to the skin without dilution with water or foaming. The amount of the surfactant used per 1 time depends on the concentration of the surfactant, the degree of dirt, and the like, and for example, in the case of washing face, the amount is 0.5 to 3g, preferably 1 to 2 g.

More specifically, the spray for skin cleansing can be applied directly to the site to be cleansed by spraying from the spray container without taking the spray for skin cleansing on the hand. As described above, by directly applying the skin cleansing spray to the site to be cleansed, it is possible to wash the skin by only the mechanical force of the liquid flow without applying any physical friction such as friction between the skin of the site to be cleansed and the hand and friction between the skin of the site to be cleansed and the air bubbles. Since the spray for skin cleansing of the present invention is a formulation having an excellent cleansing power, by cleansing with a mechanical force of a liquid flow without applying physical friction in this way, it is possible to realize an extremely excellent cleansing method capable of remarkably reducing the burden on the skin during cleansing. Such a non-foaming cleansing method enables rapid cleansing, and is also easy to feel that the skin is soft with a small amount of surfactant, and to obtain a satisfactory feeling for consumers who have high awareness of gently cleansing the skin. The spray for skin cleansing of the present invention is particularly suitable for a cleansing method in which physical friction is not applied to the skin as described above, but does not exclude a use method in which the spray for skin cleansing is applied to a site to be cleansed and then rubbed with the hand or the like.

The part to be cleaned with the spray for skin cleansing according to the present invention is not particularly limited since all body parts can be cleaned, and examples thereof include hands, hair, scalp, body, face, and the like. The spray for skin cleansing of the present invention is applied to the site to be cleansed by spraying, and therefore, is suitable for application to hair, scalp, and body from the viewpoint of ease of application. The spray for skin cleansing of the present invention can exhibit excellent cleansing power without foaming in advance, and is therefore suitable for use on a face sensitive to irritation. Furthermore, the spray for skin cleansing of the present invention is low in irritation and excellent in cleansing power, and therefore is particularly preferably used for sensitive skin. Sensitive skin refers to skin that has a chronic or temporary allergic reaction to a specific component (e.g., a surfactant, a preservative, a perfume, etc.) for external use, ultraviolet rays, etc. Examples of preferred sensitive skin to which the spray for skin cleansing of the present invention is applied include sensitive skin which is irritated to a degree of chronic or temporary irritation when a spray for skin cleansing containing component (a) and not containing component (B) is applied, and particularly, sensitive skin which is irritated to a degree of chronic or temporary irritation when a spray for skin cleansing adjusted to pH3 to 8 containing component (a) in an amount of 0.025 to 2 wt% and not containing component (B) is applied.

After washing, the skin-washing spray can be rinsed with water. In the case of rinsing with water, it is sufficient to perform rinsing in the same manner as normal face washing, but from the viewpoint of reducing the burden on the skin, it is preferable to rinse with a mechanical force of a water flow so as not to apply friction by the hand.

In addition, since the skin cleansing spray of the present invention can reduce the surfactant concentration to a very low level, in this case, rinsing after cleansing may not be necessary. Therefore, the spray for skin cleansing of the present invention is also suitable for wiping applications in hospitals, skin cleansing applications such as face washing in beauty salons and beauty parlors, disaster supplies, and the like. When the washing is not performed, the skin cleansing spray remaining on the cleansing area may be sucked and removed by using a water-absorbent base material such as a towel or a paper towel.

Manufacturing method

The spray for skin cleansing of the present invention is produced by mixing the above-described components (a) and (B), and other components and the like which are blended as necessary, preparing the mixture into a predetermined form and pH, and storing the mixture in a spray container. When the aerosol spray container is stored as a spray container, the aerosol spray container is stored together with a gas or other aerosol and manufactured.

Examples

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

[ reference test example ]

Skin cleansing sprays having compositions shown in tables 1 to 4 were prepared. The details of each component shown in tables 1 to 4 are as follows. The skin cleansing sprays shown in tables 1 to 4 were liquid, had viscosities at 20 ℃ (measured by BL viscometer (B type viscometer, B model viscometer, Brookfield) spindle No3, 6 rpm) of 5000mPa · s or less, and had pH values at 25 ℃ in the range of 3 to 8, except for reference example 1 (pH at 25 ℃ is about 10).

Sodium laurate (Nonsoul LN-1 (trade name) manufactured by Nichikoku Co., Ltd.)

Cocoylglutamic acid TEA (product name of Aomoto Co., Ltd. "Amisoft CT-12S")

Sodium cocoyl methyl taurate ("DIAPON K-SF (trade name)" manufactured by Nichikoku Co., Ltd.)

N-sodium lauroyl aspartate solution (20% by weight) ("Amino former FLDS-L (trade name)" manufactured by Asahi Kasei chemical Co., Ltd.)

Polyoxyethylene lauryl ether acetic acid ("KAOAKYPO RLM-45 (trade name)" made by Kao corporation)

Cocoamide DEA ("AMISOL CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)

PEG-60 hydrogenated Castor oil (polyoxyethylene hydrogenated Castor oil; Nikko Chemicals "NIKKOLHCO-60 (trade name)")

Polyoxyethylene sorbitan monostearate ("RHEODOL TW-S120V (trade name)" made by Kao corporation)

Glycerol mono-2-ethylhexyl ether ("sendivaSC 50JP (trade name)" manufactured by SEPPIC corporation)

Cocoamidopropyl betaine (product name of "SOFTAZOLINE CPB" manufactured by Kawaken Fine Chemicals)

Lauryl hydroxysulfobetaine solution (30% by weight) ("AMPHITOL 20HD (trade name)" manufactured by Kao corporation)

Lysolecithin ("Lysolecithin KYOWA (Pyraca, Co., Ltd.) (trade name)", product of Kyowa fermentation Co., Ltd.)

Quillaja bark extract (bark extract BG, manufactured by Wanshan pharmaceuticals Co., Ltd., saponin content 5% by weight)

Bis-diethoxydiol cyclohexane 1,4-dicarboxylate ("Neosolve-Aqulio (trade name)" made by Nippon Kogyo Co., Ltd.)

Bisethoxydiglycol succinate ("HAIAQUEOSTER DCS (trade name)" manufactured by higher alcohol industries Co., Ltd.)

< evaluation of detergency >

For the prepared spray for skin cleansing, 10 panelists were subjected to detergency evaluation. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by spraying 1.5g directly onto the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was sucked, the skin was evaluated for sensory evaluation of the sensation of dirt falling based on the following indices, and the evaluation was performed.

And 5, dividing: feel that the dirt is completely fallen off

And 4, dividing: feeling of soil falling

And 3, dividing: it cannot be said whether or not the soil is sensed to fall off

And 2, dividing: hardly any peeling of the soil was sensed

1 minute: no dirt was sensed to fall off

The scores of 10 panelists were summed up, and the degree of detergency was evaluated according to the following classification. The results are shown in tables 1 to 4.

Very good: over 45 minutes

O: 40 minutes or more and less than 45 minutes

And (delta): 35 minutes or more and less than 40 minutes

X: less than 35 minutes

< evaluation of tightening feeling >

For the prepared spray for skin cleansing, 10 panelists were subjected to the evaluation of the feeling of tightness. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by spraying 1.5g directly onto the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was sucked, the tightness immediately after washing was evaluated organoleptically based on the following criteria, and thereby the score was obtained. The stronger the tightness, the less sufficient the moisture retention.

And 5, dividing: completely does not feel tight

And 4, dividing: hardly felt a tight feeling

And 3, dividing: feeling only slight tightness

And 2, dividing: feeling of tightness

1 minute: strongly feel the sense of tightness

The scores of 10 panelists were summed up, and the degree of tightness was evaluated according to the following classification. The results are shown in tables 3 to 4.

Very good: over 45 minutes

O: 40 minutes or more and less than 45 minutes

And (delta): 35 minutes or more and less than 40 minutes

X: less than 35 minutes

< test for stimulating skin by cultured epidermis (in vitro evaluation of skin irritation) >

The cultured epidermal skin irritation test was performed on the prepared spray for skin cleansing as follows.

1. Preparation of culture epidermal MODEL LabCyte EPI-MODEL24

The test medium was heated and 0.5mL of each was added to a 24-well test plate.The culture epidermis MODEL LabCyte EPI-MODEL24 (batch No.: LCE24-180226-A) was transferred to a 24-well test plate supplemented with test medium. After confirming that no air bubbles are present on the bottom surface of the culture cup, adding CO₂The incubator is allowed to stand for more than 1 hour until exposed to the test substance.

2. Application and cleaning of test objects

12 of 24 epidermal models were used (the remainder was kept pre-cultured until the official test). Test plates from 24 wells were removed from CO₂Taking out the culture box. The test medium was heated and 1.0mL of each was added to row 3 of the 24-well assay plate. Without using a pump spray container, 25. mu.L of the test substance (each spray for skin washing) was dropped onto the culture epidermis of the culture cup, and the entire surface was exposed. After the exposure, the test substance was removed by aspiration at 1 minute, 5 minutes, and 10 minutes, and the culture epidermis model in the cup was washed with Phosphate Buffered Saline (PBS) and transferred to the 24-well test plate, line 3.

MTT assay

The MTT assay is the following: the viable cell rate is measured by extracting formazan pigment produced by reduction of MTT [3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide ] taken into cells by a mitochondrial dehydrogenase located in the cells with an organic solvent and measuring the absorbance at 570 nm.

10mL of MTT medium was prepared at a final concentration of 0.5 mg/mL. MTT medium was heated and 0.5mL of each was added to row 4 of the 24-well assay plate. Transfer the cultured epidermis model to 24-well assay plate, line 4, and place CO₂In the incubator, MTT reaction was performed for 3 hours. After the MTT reaction was completed, the cultured skin was grasped with forceps and removed, and transferred to a 1.5mL microtube. The culture epidermis model was completely immersed in 300. mu.L of isopropyl alcohol in a microtube. After that, the mixture was allowed to stand for 2 hours, and a vortex was applied to the microtube to extract the pigment. The extract (200mL) was placed in each well of a 96-well plate. In addition, as a blank (negative control), 200. mu.L of isopropanol was added to A1. The absorbance at 570nm and 650nm was measured with a microplate reader. The living cell rate of the specimen was calculated from the following formula, using the value obtained by subtracting the absorbance at 570nm from the absorbance at 650nm as the measured value.

[ number 1 ]

The living cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in tables 3 to 4.

Very good: over 90 percent

O: more than 75 percent and less than 90 percent

And (delta): more than 65% and less than 75%

X: more than 50 percent and less than 65 percent

X: less than 50 percent

As shown in tables 1 to 4, the skin cleansing sprays containing the surfactant alone at a concentration of 0.025 to 2 wt% (reference comparative examples 1 to 10) showed no cleansing power. On the other hand, the skin cleansing spray (reference examples 1 to 20) containing the amphiphilic ester (reference examples 11 to 15) which does not exhibit cleansing power when used alone and 0.025 to 2 wt% of the surfactant was applied directly to the skin from the spray container by spraying only, and excellent cleansing power was obtained by using only the mechanical force of the liquid flow without any physical friction. That is, it was shown that the skin can be gently washed.

As shown in reference examples 1 to 3, the skin cleansing spray containing the surfactant in an amount of more than 2% by weight alone also provides excellent cleansing power by directly applying the spray to the skin only by spraying. On the other hand, considering the skin irritation caused by the surfactant concentrations shown in reference examples 1 to 3, when the surfactant concentration was set to 2% by weight or less as shown in reference examples 9 to 20, not only the cleansing power but also the excellent low irritation property were achieved. That is, it is shown that by setting the surfactant concentration of the skin cleansing spray applied directly to the skin by spraying to 0.025 to 2 wt%, it is possible to cleanse the skin gently both physically and chemically.

[ TABLE 1 ]

In the table, the unit of the numerical value indicating the blending amount of each component is% by weight.

[ TABLE 2 ]

In the table, the unit of the numerical value indicating the blending amount of each component is% by weight. In addition, the numerical values in parentheses represent the converted amounts of the components.

[ TABLE 3 ]

[ TABLE 4 ]

[ test examples ]

Skin cleansing sprays having compositions shown in tables 5 to 6 were prepared. The details of each component shown in tables 5 to 6 are shown in the reference test examples. The skin cleansing sprays shown in tables 5 to 6 were liquid, and had viscosities at 20 ℃ (measured at 6rpm in spindle No3 of BL viscometer (B type viscometer manufactured by Brookfield corporation)) of 5000mPa · s or less.

< determination of pH >

The pH of the skin cleansing composition thus prepared was measured at 25 ℃ using a benchtop pH meter (F-72) manufactured by HORIBA corporation.

< evaluation of detergency >

The degree of cleaning power of the skin cleanser composition prepared was evaluated in the same manner as in the reference test example. The results are shown in tables 5 to 6.

< evaluation of irritation feeling >

For the skin cleanser composition prepared, 10 cosmetic evaluation panelists were subjected to irritation sensation evaluation. Specifically, each skin cleansing composition was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo Container Co., Ltd., and the spray amount per 1 press was 0.15g), and 1.5g of the composition was directly sprayed onto the whole body for application. Left to stand for about 5 seconds, and then rinsed with water so that the hands do not touch the skin. After pressing the skin with a towel and absorbing water, sensory evaluation was performed on the sensation of irritation based on the following indices, and thereby scoring was performed.

And 5, dividing: no irritation feeling was felt at all

And 4, dividing: hardly felt the irritating feeling

And 3, dividing: with only slight sensation of stimulation

And 2, dividing: sense the stimulus

1 minute: feeling strong stimulation

The scores of 10 panelists were summed up, and the degree of irritation was evaluated according to the following classification. The results are shown in tables 5 to 6.

Very good: over 45 minutes

O: 40 minutes or more and less than 45 minutes

And (delta): 35 minutes or more and less than 40 minutes

X: less than 35 minutes

< evaluation of tightening feeling >

The degree of the tightening feeling was evaluated in the same manner as in the reference test example except that the tightening feeling was evaluated also after 5 minutes of washing and after 10 minutes of washing, except immediately after washing. The results are shown in tables 5 to 6.

As shown in tables 5 to 6, it was found that in the skin cleansing sprays (examples 1 to 15) in which the surfactant was 2 wt% and the amphiphilic ester was blended and the pH was adjusted to 3 to 8, even though the concentration of the surfactant was low, the skin was directly applied from the spray container by spraying, and excellent cleansing power was obtained by only the mechanical force of the liquid flow without giving any physical friction at all. Even when the amphiphilic ester was added to the skin cleansing spray at a pH of less than 3 (comparative examples 1 to 5) in which the surfactant was 2 wt%, the irritativeness was increased, the cleansing power decreased depending on the type of the surfactant, and the tightening feeling due to insufficient moisture retention was increased, while the tightening feeling due to insufficient moisture retention was increased in the skin cleansing spray at a pH of more than 8 (comparative examples 6 to 10), and the irritativeness and cleansing power decreased depending on the type of the surfactant.

[ TABLE 5 ]

[ TABLE 6 ]

Claims

1. A spray for skin cleansing which comprises (A) a surfactant and (B) an amphiphilic ester,

the pH value of the spray for cleaning the skin is 3-8,

the spray for skin cleansing is contained in a spray container.

2. The spray for skin cleansing according to claim 1, wherein the spray container is a pump spray container.

3. The spray for skin cleansing according to claim 1, wherein the spray container is an aerosol spray container.

4. The spray for skin cleansing according to any one of claims 1 to 3, wherein the component (B) is selected from the group consisting of bis (polyoxyalkylene alkyl ether) dicarboxylate, dialkoxyalkyl dicarboxylate, and polyglycerol-10 eicosadipate/tetradecadipate.

5. The spray for skin cleansing according to claim 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate.

6. The spray for skin cleansing according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.

7. The spray for skin cleansing according to any one of claims 1 to 6, wherein the spray for skin cleansing is applied to sensitive skin.