CN112449590A

CN112449590A - Spray for cleaning skin

Info

Publication number: CN112449590A
Application number: CN202080003386.5A
Authority: CN
Inventors: 山本航平; 伊庭翔子
Original assignee: Kobayashi Pharmaceutical Co Ltd
Current assignee: Kobayashi Pharmaceutical Co Ltd
Priority date: 2019-06-26
Filing date: 2020-06-17
Publication date: 2021-03-05
Also published as: WO2020262152A1; JP2021004198A

Abstract

The purpose of the present invention is to provide a skin cleanser composition used in a method different from the conventional method. A skin cleansing spray which contains (A) a surfactant, (B) an amphipathic ester and (C) a refreshing component and which is stored in a spray container, and which can exhibit excellent cleansing power while reducing skin irritation of a skin cleanser composition, and therefore can provide a new use for applying a skin cleanser composition by spraying it directly onto the skin, which is different from the conventional use for applying it to the skin by foaming it in advance.

Description

Spray for cleaning skin

Technical Field

The present invention relates to a spray for skin cleansing which is used by spraying directly on the skin.

Background

Various skin cleansing compositions such as facial cleanser, body soap, and shampoo are provided as products for the purpose of cleansing the skin and keeping the skin clean. In the mechanism of skin cleansing by the skin cleanser composition, the surfactant adsorbs to the dirt to reduce the surface tension between the dirt and water, and mechanical force due to friction also interacts with each other to float the dirt in water. In order to effectively exert such a cleaning mechanism, it is necessary to incorporate a surfactant at a critical micelle concentration or higher.

On the other hand, the cleansing power by the surfactant is too strong and causes skin irritation, and as a result, there is a current situation in which a skin problem typified by dry skin is caused. Therefore, various formulations for studying combinations of cleansing components, blending amounts, and the like have been proposed for the purpose of moderating the action on the skin. Among them, it is common knowledge that a formulation for improving the quality of foam such as foaming power and foam retention is excellent as a formulation for moderating the action on the skin because the foam formed during washing can reduce the friction caused by direct contact between the skin and fingers.

Therefore, in recent years, various pump foamer type skin cleansers have been proposed, which not only can easily obtain good quality foam, but also attract attention to the softness of the skin. Specifically, patent document 1 discloses a liquid skin cleansing composition comprising a foam container (Japanese original: フォーマー container) and a liquid skin cleansing composition filled in the foam container, wherein the liquid skin cleansing composition comprises (A) 3 to 10% by mass of a specific fatty acid salt having a linear or branched monovalent hydrocarbon group having 7 to 21 carbon atoms, (B) a copolymer of a specific dimethyldiallylammonium chloride and acrylic acid and/or acrylamide, and (C) a sugar alcohol, and the mass ratio (A)/(B) of the content of component (A) to the content of component (B) is 20 to 250. Patent document 2 discloses a skin cleansing composition comprising a cleansing agent filled in a foam container, wherein the cleansing agent comprises 2 to 9 mass% of a fatty acid salt (a), 0.5 to 4 mass% of lauryl dimethyl glycine betaine (b), and 1 to 10 mass% of one or more glycols (c), wherein the sum of the amounts (mass%) of a component (a) and a component (b) is 3 to 10 mass%, and the ratio (b)/(a) is 0.1 to 0.5. Further, patent document 3 discloses a detergent composition containing 4 to 15 mass% of a higher fatty acid soap (a) composed of lauryl dimethyl glycine betaine and (b) a fatty acid having 5 to 25 carbon atoms and having a specific composition, and being discharged from a foamer container.

On the other hand, the skin after sunburn causes inflammation, which is also called a burned state, and the barrier function and the moisture retention ability are reduced compared to normal skin. As a general treatment of the skin after sunburn, cooling of an affected part with water or ice, application of an anti-inflammatory agent, or the like is performed. Patent document 4 describes the use of a composition containing a cooling agent dissolved in a solvent containing (R) -1, 2-propanediol for the treatment of skin after sunburn, and patent document 5 describes the use of a specific hydrated hemitartrate benzimidazol-2-yl pyrimidine compound for the treatment of skin after sunburn.

Documents of the prior art

Patent document

Patent document 1: international publication No. 2014/003114

Patent document 2: japanese patent laid-open publication No. 2016-098182

Patent document 3: international publication No. 2017/081897

Patent document 4: japanese Kokai publication No. 2014-508740

Patent document 5: japanese patent laid-open publication No. 2016-510752

Disclosure of Invention

Problems to be solved by the invention

In view of the fact that the amount of the surfactant to be added is relatively small, the pump-foamer type skin cleanser composition tends to cause less irritation to the skin than the solid or semisolid skin cleanser composition. On the other hand, since it is a big premise that the pump foamer type skin cleanser composition is discharged in a state of foam, it is inevitable to add a minimum amount of surfactant necessary for exerting foaming power to the composition.

In addition to skin cleansing materials intended for cleansing (cleansing), various skin cleansing materials intended for removing body fluids such as sebum and sweat, dirt, and the like have been created, but it is common knowledge that any skin cleansing material is not exceptional, and foaming is performed before application to the skin, and further, foaming is preferably performed well before cleansing from the viewpoint of moderating friction against the skin. Although the foam can alleviate physical friction by being interposed between the skin and the hand, the foam itself generates physical friction by rubbing against the skin, and causes irritation to the skin, which is not changed. In particular, there is still a possibility that irritation may occur to an allergic skin such as a skin after sunburn in which barrier function and moisture retention ability are reduced by inflammation.

In this way, in the same use method as in the conventional art, the reduction of the burden on the skin by the skin cleansing material is limited. Therefore, in order to be applied to sensitive skin after sunburn or the like, it is considered that the skin cleansing composition needs to further reduce irritation to the skin than ever before. Furthermore, it is required not only to keep skin clean by washing but also to suppress hot flashes (hot flashes) caused by inflammation in skin causing inflammation.

Accordingly, an object of the present invention is to provide a skin cleanser composition which is used in a method different from the conventional method and can impart a pleasant cool feeling.

Means for solving the problems

The present inventors have conceived a novel use in which a skin cleansing composition is directly sprayed on the skin without causing a preliminary lathering when applied to the skin in order to further reduce the irritation to the skin. Further, it has been found that by allowing an amphiphilic ester to coexist with a surfactant, a cleansing power can be effectively obtained without foaming in advance, and a comfortable refreshing feeling can be imparted by further compounding a refreshing feeling component. The present invention has been completed through further repeated studies based on this finding.

That is, the present invention provides the inventions of the embodiments disclosed below.

Item 1. a spray for skin cleansing, which contains (a) a surfactant, (B) an amphiphilic ester and (C) a cooling sensation component,

the spray for skin cleansing is contained in a spray container.

The spray for skin cleansing according to item 1, wherein the spray container is a pump spray container.

The spray according to item 1, item 3, wherein the spray container is an aerosol spray container.

Item 4 the spray for skin cleansing according to any one of items 1 to 3, wherein the component (B) is selected from the group consisting of bis (polyoxyalkylene alkyl ether) dicarboxylate, dialkoxyalkyl dicarboxylate, and polyglycerol-10 eicosadipate/tetradecadipate.

The spray for skin cleansing according to any one of claims 1 to 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate.

The spray for skin cleansing according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.

The spray for skin cleansing according to any one of claims 1 to 6, wherein the content of the component (A) is 0.025 to 0.9% by weight.

The spray for skin cleansing according to any one of claims 1 to 7, wherein the component (C) is menthol and/or menthyl succinate.

The spray for skin cleansing according to any one of claims 1 to 8, wherein the content of the component (C) is 0.001 to 0.5% by weight.

The spray for skin cleansing according to any one of claims 1 to 9, wherein the spray for skin cleansing is applied to the skin after sunburn.

Effects of the invention

According to the present invention, since the skin cleanser composition can exhibit excellent cleansing power while reducing skin irritation, a new use can be provided in which the skin cleanser composition is directly sprayed on the skin, unlike a conventional use in which the skin cleanser composition is previously foamed when applied to the skin. Since the cleansing can be performed without foaming in advance, the amount of the surfactant to be added to the liquid composition for cleansing skin can be significantly reduced as compared with the amount to be added to a conventional liquid composition for cleansing skin, and thus the skin irritation can be further reduced. Further, since a comfortable cool feeling can be imparted while reducing skin irritation, it can be suitably used for washing of skin which is allergic and causes hot flashes due to a reduction in barrier function and moisture retention ability due to inflammation, such as skin after sunburn.

Detailed Description

The spray for skin cleansing of the present invention contains (a) a surfactant (hereinafter, sometimes referred to as component (a)), an amphiphilic ester (hereinafter, sometimes referred to as component (B)), and (C) a refreshing feeling component (hereinafter, sometimes referred to as component (C)), and is stored in a spray container. The skin cleansing spray of the present invention will be described in detail below.

(A) Surface active agent

The spray for skin cleansing of the present invention contains a surfactant as the component (a). The surfactant is not particularly limited, and from the viewpoint of suppressing irritation to the skin, preferable examples thereof include anionic surfactants, nonionic surfactants, amphoteric surfactants, natural surfactants, and the like. As the surfactant, one of an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, and a natural surfactant may be used alone, and two or more kinds may be used in any combination.

Examples of the anionic surfactant used in the present invention include carboxylic acid type, sulfonic acid type, sulfate type, and phosphate type surfactants.

Specific examples of the carboxylic acid type surfactant include saturated or unsaturated fatty acids having 6 to 22 carbon atoms such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and the like; and an N-acylamino acid (carboxylic acid type amino acid type anionic surfactant) having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyl group, a lauroyl group, a myristoyl group, a palmitoyl group, and a cocoyl group. Examples of the N-acylamino acid in the carboxylic acid type amino acid type anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, lauroylmethyl-beta-alanine and the like. More specific examples of the carboxylic acid type amino acid anionic surfactant include N-lauroyl sarcosine, N-lauroyl aspartic acid, cocoyl glutamic acid, and sodium lauroyl methyl- β -alaninate.

Specific examples of the sulfonic acid type surfactant include esters of fatty acids having 6 to 22 carbon atoms such as cocoyl isethionic acid and isethionic acid; alkyl sulfonic acids having 6 to 22 carbon atoms such as hexane sulfonic acid, octane sulfonic acid, decane sulfonic acid, dodecane sulfonic acid and the like; alkyl benzene sulfonic acid having an alkyl group having 10 to 16 carbon atoms such as alkyl benzene sulfonic acid; N-acyl-N-methyltaurine (sulfonic acid-type amino acid-based anionic surfactant) having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as octanoyl group, decanoyl group, lauroyl group, myristoyl group, palmitoyl group, and cocoyl group. More specific examples of the sulfonic acid-type amino acid-based anionic surfactant include N-myristoyl-N-methyltaurine, N-lauroyl methyltaurine, and cocoyl methyltaurine.

Specific examples of the sulfate-type surfactant include esters of sulfuric acid with saturated or unsaturated fatty acids having 10 to 22 carbon atoms such as lauryl sulfate and myristyl sulfate. Specific examples of the phosphate ester type surfactant include esters of phosphoric acid with saturated or unsaturated fatty acids having 8 to 24 carbon atoms such as lauryl phosphate.

These anionic surfactants may be in the form of salts, and for example, alkali metal salts such as sodium salts and potassium salts; triethanolamine (TEA) salts; ammonium salts, and the like.

Among these anionic surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferable examples thereof include carboxylic acid type surfactants and sulfonic acid type surfactants, more preferable examples thereof include lauric acid, N-lauroyl aspartic acid, cocoyl glutamic acid, cocoyl methyl taurine and salts thereof, and further preferable examples thereof include sodium laurate, sodium N-lauroyl aspartate, cocoyl glutamic acid triethanolamine and sodium cocoyl methyl taurate. Further, among these, from the viewpoint of more favorably obtaining the skin irritation reducing property, N-acyl glutamic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms, fatty acid amide sulfonic acid having 8 to 22 carbon atoms, and salts thereof are preferably mentioned, cocoyl glutamic acid, cocoyl methyltaurine, and salts thereof are more preferably mentioned, cocoyl glutamic acid triethanolamine, and cocoyl methyltaurate are further preferably mentioned, and from the viewpoint of more favorably obtaining the cleansing power, N-acyl aspartic acid having a saturated or unsaturated acyl group having 8 to 24 carbon atoms is further preferably mentioned, N-lauroyl aspartic acid is further preferably mentioned, and sodium N-lauroyl aspartic acid is further preferably mentioned.

These anionic surfactants may be used alone or in combination of two or more.

Examples of the nonionic surfactant used in the present invention include ester-type, ether-type, ester/ether-type, alkanolamide-type, alkyl glycoside-type, and alcohol-type surfactants.

Specific examples of the ester-type surfactant include monoesters or diesters of saturated or unsaturated fatty acids having 8 to 20 carbon atoms such as ethylene glycol dilaurate, ethylene glycol monostearate, ethylene glycol distearate, glycerol monolaurate, glycerol dilaurate, glycerol monostearate, and glycerol distearate with glycerol; sorbitan fatty acid esters; sucrose fatty acid esters, and the like.

Specific examples of the ether-type surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, and polyoxyethylene polyoxypropylene glycol.

Examples of the ester/ether type surfactant include polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hexitol anhydride fatty acid ester, sorbitan fatty acid ester polyethylene glycol, and the like.

Specific examples of the alkanolamide type surfactant include cocamide DEA (coconut fatty acid diethanolamide), lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide, and the like.

Specific examples of the alkyl glycoside type surfactant include octyl glucoside, decyl glucoside, and lauryl glucoside.

Examples of the alcohol-type surfactant include cetyl alcohol, stearyl alcohol, and oleyl alcohol.

Among these nonionic surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are ester-ether type surfactants and alkanolamide type surfactants, more preferred are polyoxyethylene hydrogenated castor oil and cocamide DEA, and still more preferred is polyoxyethylene hydrogenated castor oil.

These nonionic surfactants may be used singly or in combination of two or more.

Examples of the amphoteric surfactant used in the present invention include alkyl betaine type surfactants, fatty acid amide propyl betaine type surfactants, amine oxide type surfactants, and the like.

Specific examples of the alkyl betaine type surfactant include lauryl dimethyl glycine betaine, stearyl dimethyl glycine betaine, and stearyl amino methyl dimethyl sulfopropyl betaine.

Specific examples of the fatty acid amide propyl betaine amphoteric surfactant include an amide betaine (amino acid amphoteric surfactant) such as cocamidopropyl betaine, and a sulfobetaine such as cocamidopropyl hydroxysulfobetaine.

Specific examples of the amine oxide type amphoteric surfactant include lauryl dimethyl amine oxide and oleyl dimethyl amine oxide.

In addition, these amphoteric surfactants may be in the form of salts, and for example, alkali metal salts such as sodium salts and potassium salts; triethanolamine (TEA) salts; ammonium salts, and the like.

Among these amphoteric surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, a fatty acid amide propyl betaine type surfactant is preferably included, an amido betaine (amino acid type amphoteric surfactant) such as cocamidopropyl betaine is more preferably included, and cocamidopropyl betaine is further preferably included.

These amphoteric surfactants may be used singly or in combination of two or more.

Examples of the natural surfactant used in the present invention include lecithin and lysolecithin; saponins such as Quillaja Saponaria Molina saponin, soyasaponin, yucca saponin, Sophora Japonica Saponin, beet saponin, semen Phaseoli saponin, ginsenoside, tea saponin, fructus Luffae saponin, and asiaticoside.

Lecithin is a mixture of phospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol and components such as triglycerides, fatty acids, and carbohydrates derived from vegetable oils, and is a known component in pharmaceuticals, quasi drugs, and cosmetics.

The lecithin may be natural lecithin derived from animals and plants (e.g., soybean lecithin, egg yolk lecithin, etc.), or a chemically treated product of natural lecithin, or a purified product of natural lecithin. Examples of the chemically treated product of natural lecithin include hydrogenated lecithin obtained by hydrogenation (e.g., fully hydrogenated lecithin and partially hydrogenated lecithin), and hydroxylated lecithin obtained by hydroxylation. The purified product of natural lecithin may be lecithin in which the content of phosphatidylcholine has been increased by a solvent such as acetone.

Examples of the lysolecithin include lysosomes of the above-mentioned lecithins (natural lecithins, chemically treated products of natural lecithins, purified products of natural lecithins). Lysolecithin has a structure in which a fatty acid at the 2-position of phosphatidylcholine is removed by hydrolysis (dissolution) of lecithin with an enzyme such as phospholipase a 2.

Among these natural surfactants, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are lecithin, lysolecithin and saponin, more preferred are lecithin and lysolecithin, and still more preferred is lysolecithin.

These natural surfactants may be used alone or in combination of two or more.

The content of the component (a) in the skin cleansing spray of the present invention is not particularly limited, and can be appropriately determined according to the cleansing power to be imparted. Since the spray for skin cleansing of the present invention can cleanse the skin without physically rubbing the skin, the amount of surfactant to be added in the spray for skin cleansing can be significantly reduced from that contained in a conventional liquid composition for skin cleansing, and even a small amount of surfactant that cannot exert an effective cleansing power originally can exert an effective cleansing power effectively. From such a viewpoint, the content of the component (a) in the skin cleansing spray of the present invention is preferably 0.025 to 2 wt%. Further, from the viewpoint of further suppressing the feeling of tightness due to skin irritation and insufficient moisture retention, the upper limit of the range of the content of the component (a) is 1.5% by weight or less, preferably 1% by weight or less, more preferably 0.9% by weight or less, further preferably 0.6% by weight or less, and still further preferably 0.2% by weight or less. On the other hand, from the viewpoint of obtaining more excellent detergency, the lower limit of the range of the content of the component (a) is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, further preferably 1.5% by weight or more, and particularly preferably 1.8% by weight or more.

(B) Amphiphilic esters

The spray for skin cleansing of the present invention contains an amphiphilic ester as the component (B). (B) The component (A) does not exhibit a cleansing action when used alone, and can improve the cleansing power of the spray for cleansing the skin while maintaining low irritation by allowing the component (A) to coexist.

In the present invention, the amphiphilic ester is dissolved in ion-exchanged water having an electric conductivity adjusted to 70 to 110 μ s/m at room temperature by 2 mass% or more, and also dissolved in isotridecyl isononanoate (SALACOS 913, manufactured by riqing oitici corporation) as an oil agent at room temperature (25 ℃) by 10 mass% or more, and does not include an ester-based surfactant, in the measurement according to the method defined in the general test method of japanese pharmacopoeia.

The amphiphilic ester is not particularly limited, and is preferably an amphiphilic ester selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate, from the viewpoint of more satisfactory skin irritation reducing property and detergency. As the amphiphilic ester, any of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipate/tetradecadipate may be used alone, or two or more thereof may be used in combination. Among these amphiphilic esters, dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters are more preferable from the viewpoint of more satisfactory skin irritation reducing properties and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound such as the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether.

Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, preferred are diester compounds of cyclohexane-1, 4-dicarboxylic acid and diethylene glycol monoethyl ether, specifically under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331): the compounds known as BIS-diethoxydibycol CYCLOHEXANE 1,4-DICARBOXYLATE and the diester compounds of succinic acid and diethylene glycol monoethyl ether described by BIS-ETHOXYDIGLYCOL cyclonexane 1,4-DICARBOXYLATE, in particular under the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13 th edition, volume 1, CTFA, 2010, p.331-332): the compound called BIS-ETHOXYDIGLYCOL SUCCINATE described in BIS-ETHOXYDIGLYCOL SUCCINATE is more preferably BIS-diethoxydiol cyclohexane 1, 4-dicarboxylate.

In the present invention, specific examples of the bis-diethoxydiol cyclohexane 1,4-dicarboxylate include "neosolve-Aqulio (trade name)" manufactured by japan koku corporation. Specific examples of the bis-ethoxydiglycol succinate include "haiaqeosister DCS (trade name)" manufactured by higher alcohol industries.

These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used singly or in combination of two or more.

The dialkoxyalkyl dicarboxylate used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound such as dialkoxyalkyl dicarboxylate include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1, 4-dicarboxylic acid, and the like. Examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol and 2-ethoxyethanol.

Among these dialkoxyalkyl dicarboxylates, from the viewpoint of more satisfactory skin irritation reducing properties and detergency, a diester compound of succinic acid and 2-ethoxyethanol is preferable, and specifically diethoxyethyl succinate is preferable.

These dialkoxyalkyl dicarboxylates may be used singly or in combination of two or more.

The polyglycerol-10 eicosadioate/tetradecadioate used in the present invention is not particularly limited, and examples thereof include "neosolve-Aqua (trade name)" and "neosolve-Aqua (trade name)" manufactured by japan koku corporation.

The content of component (B) in the skin cleansing spray of the present invention is not particularly limited, and may be, for example, 0.1 wt% or more. From the viewpoint of more satisfactory detergency and/or from the viewpoint of further reducing a tight feeling due to insufficient moisture retention, the content of the component (B) is preferably 0.5% by weight or more, more preferably 1.5% by weight or more, and still more preferably 3% by weight or more. (B) The upper limit of the content range of the component is not particularly limited, and from the viewpoint of stability and the like such as suppression of deposition after high-temperature storage of the spray for skin cleansing, for example, 5% by weight or less, preferably 4% by weight or less, more preferably 2% by weight or less, still more preferably 1.2% by weight or less, and still more preferably 1% by weight or less may be mentioned.

The ratio of the component (a) to the component (B) in the skin cleansing spray of the present invention is not particularly limited, and is determined by the above-mentioned contents, and from the viewpoint of obtaining more favorable skin irritation reducing properties and cleansing power, the component (a) may be 1 part by weight and the component (B) may be, for example, 0.1 to 100 parts by weight. In addition, from the viewpoint of obtaining a more satisfactory detergency when the amount of the component (a) is as small as about 0.5 to 1.5% by weight, the component (B) is preferably 2 to 100 parts by weight, preferably 2.5 to 50 parts by weight, and more preferably 3 to 10 parts by weight, based on 1 part by weight of the component (a). Further, from the viewpoint of further reducing the feeling of tightness due to insufficient moisture retention, it is preferable that the component (B) is 2 to 100 parts by weight, more preferably 2.5 to 90 parts by weight, and still more preferably 3 to 80 parts by weight, based on 1 part by weight of the component (a).

(C) Component for refreshing feeling

The spray for skin cleansing of the present invention contains a cooling sensation component as the component (C). The refreshing component is not particularly limited as long as it imparts a cool feeling, and examples thereof include menthol, eucalyptol, menthanol, Menthyl lactate, Menthyl succinate, Menthyl glyceryl ether, Menthyl ethoxamide (Menthyl ethyl oxamide), menthol PCA ester, Menthyl succinate, Menthyl glutarate, menthanethylamine, menthanecarbonylglycine ethyl ester, menthone glycerol acetal, 2-sec-butylcyclohexanone, isophytol, mentholum, N,2, 3-trimethyl-2-isopropylbutanamide, thymol, eugenol, anethole, methyl salicylate, camphor, spilanthol, trimethylcyclohexanol, 3-menthoxy-2-methylpropane-1, 2-diol, and the like. These cooling sensation components may be used singly or in any combination of two or more.

Of these cooling sensation components, menthol and menthyl succinate are preferable from the viewpoint of more effectively obtaining a comfortable cooling sensation, and a combination of menthol and menthyl succinate is preferable from the viewpoint of more sustaining the cooling sensation.

The menthol may be any of d-isomer, l-isomer, and dl-isomer, preferably l-isomer and dl-isomer, and more preferably l-isomer. Further, as menthol, an essential oil containing menthol may also be used.

The monomenthyl succinate is an ester of succinic acid and menthol, and the menthol may be any of d-isomer, l-isomer, and dl-isomer, preferably l-isomer and dl-isomer, and more preferably l-isomer.

The content of the component (C) in the skin cleansing spray of the present invention is not particularly limited as long as it is appropriately determined in accordance with the cool feeling to be imparted, and is, for example, 0.001 to 0.5% by weight from the viewpoint of imparting a comfortable cool feeling and suppressing skin irritation due to the cool feeling component and from the viewpoint of suppressing stability such as odor after storage at high temperature. From the viewpoint of obtaining a more comfortable cool feeling, the content of the component (C) is preferably 0.01 to 0.5% by weight, more preferably 0.1 to 0.5% by weight, and from the viewpoint of further suppressing skin irritation due to the cool feeling component or obtaining more excellent stability after storage at high temperature, preferably 0.001 to 0.3% by weight, more preferably 0.001 to 0.2% by weight.

Other ingredients

The spray for skin cleansing of the present invention may contain other base agents and additives necessary for formulation and the like, in addition to the above components, within a range not impairing the effects of the present invention. Such additives are not particularly limited as long as they are pharmaceutically acceptable, and examples thereof include water, aqueous base agents such as lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, and the like) and polyhydric alcohols (ethylene glycol, 1, 3-butanediol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, and glycerin); preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), perfuming agents (citral, citronellal, farnesol, etc.), colorants (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.), cacao pigments, chlorophyll, alumina, etc.), viscous agents (hydroxypropyl cellulose, hydroxyethyl cellulose, crosslinked acrylic acid polymer, carboxyvinyl polymer, hydroxypropyl methylcellulose, polyvinylpyrrolidone, sodium alginate, ethylcellulose, sodium carboxymethylcellulose, xanthan gum, carrageenan, etc.), pH regulators (phosphoric acid, hydrochloric acid, citric acid, sodium citrate (trisodium citrate), succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wetting agents (dl-pyrrolidone carboxylic acid sodium solution), D-sorbitol solution, polyethylene glycol (MACROGOL), etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium ethylenediaminetetraacetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, ultraviolet absorbers, chelating agents, binders, buffers, dissolution aids, solubilizers, preservatives, and other additives. These base materials and additives may be used singly or in combination of two or more. The contents of these base materials and additives may be appropriately set according to the form of the preparation.

The spray for skin cleansing of the present invention may contain other pharmacological components as needed, in addition to the above components, within a range not impairing the effects of the present invention. Examples of such pharmacological components include vitamins (e.g., vitamin a, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, nicotinic acid, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupivacaine, mepivacaine, chloroprocaine, proparacaine, mepivacaine or salts thereof, oxolocaine, oxicaine, oxypolyethoxydecane (oxyphenoxydecane) (japanese manuscript: オキシポリエントキシデカン), hyoscyamine, dibucaine powder (japanese manuscript: ペルカミンパーゼ), polyoxyethylene lauryl ether (japanese manuscript: テシットデシチン), anti-inflammatory agents (indomethacin, etc.) Felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protecting agents (collodion, castor oil, etc.), blood circulation promoting components (vanillylnonanoate amide, benzyl nicotinate, capsaicin, capsicum extract, etc.), mucopolysaccharides (chondroitin sulfate sodium, glucosamine, hyaluronic acid, cationized hyaluronic acid (dihydroxypropyltrimethylammonium chloride hyaluronic acid (japanese original: ヒアルロン acid ジヒドロキシプロピルトリモニウム), etc., and the like. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the kind of the pharmacological component to be used, the desired effect, and the like.

Form of the composition

The spray for skin cleansing according to the present invention is in the form of a liquid or gel at room temperature. The viscosity of the skin cleansing spray of the present invention is 10000mPa · s or less, preferably 5000mPa · s or less at 20 ℃. The viscosity was measured by using a BL viscometer (rotor No3, 6rpm, 20 ℃).

Container with a lid

The container for containing the spray for skin cleansing according to the present invention is not particularly limited as long as it is a spray type container. The aerosol container of the present invention is different from a pump foamer container that ejects a skin cleanser composition in a foam state by ejecting the contents in a mist state.

In the present invention, by housing the spray for skin cleansing in the spray container in this manner, the spray for skin cleansing can be directly applied to the skin by spraying without causing a bubble before being applied to the skin. Therefore, application to the skin is simple and physical friction by hands or the like at the time of application can be avoided. Examples of the spray container include a pump type spray container which is a non-aerosol type spray container, and an aerosol type spray container. Examples of the diameter (nozzle inner diameter) of the spray container include

Preference is given to

The amount of spray per 1-time pressing when the spray container is a pump spray container is, for example, 0.05 to 1.2g, preferably 0.1 to 0.3 g.

Use of

The spray for skin cleansing of the present invention is used for removing body fluids such as oil and fat, sweat, dirt, and the like from the skin, and is not used as a makeup remover (makeup remover cream). The spray for skin cleansing of the present invention is used by being applied directly to the skin without dilution with water or foaming. The amount of the surfactant used per 1 time depends on the concentration of the surfactant, the degree of dirt, and the like, and for example, in the case of washing face, the amount is 0.5 to 3g, preferably 1 to 2 g.

More specifically, the spray for skin cleansing can be applied directly to the site to be cleansed by spraying from the spray container without taking the spray for skin cleansing on the hand. As described above, by directly applying the skin cleansing spray to the site to be cleansed, it is possible to wash the skin by only the mechanical force of the liquid flow without applying any physical friction such as friction between the skin of the site to be cleansed and the hand and friction between the skin of the site to be cleansed and the air bubbles. Since the spray for skin cleansing of the present invention is a formulation having an excellent cleansing power, by cleansing with a mechanical force of a liquid flow without applying physical friction in this way, it is possible to realize an extremely excellent cleansing method capable of remarkably reducing the burden on the skin during cleansing. Such a non-foaming cleansing method enables rapid cleansing, and is also easy to feel that the skin is soft with a small amount of surfactant, and to obtain a satisfactory feeling for consumers who have high awareness of gently cleansing the skin. The spray for skin cleansing of the present invention is particularly suitable for a cleansing method in which physical friction is not applied to the skin as described above, but does not exclude a use method in which the spray for skin cleansing is applied to a site to be cleansed and then rubbed with the hand or the like.

The part to be cleaned with the spray for skin cleansing according to the present invention is not particularly limited since all body parts can be cleaned, and examples thereof include hands, hair, scalp, body, face, and the like. The spray for skin cleansing of the present invention is applied to the site to be cleansed by spraying, and therefore, is suitable for application to hair, scalp, and body from the viewpoint of ease of application. The spray for skin cleansing of the present invention can exhibit excellent cleansing power without foaming in advance, and is therefore suitable for use on a face sensitive to irritation. Furthermore, the spray for skin cleansing of the present invention is particularly suitable for skin in which the state of skin at the site to be cleansed is reduced in barrier function, skin in which the ability to retain moisture is reduced, and skin showing hot flashes. A preferred example of a skin exhibiting a reduction in barrier function, a reduction in moisture retention capacity, and hot flashes is a skin that has developed inflammation, and a more preferred example is a skin after sunburn.

After washing, the skin-washing spray can be rinsed with water. In the case of rinsing with water, it is sufficient to perform rinsing in the same manner as normal face washing, but from the viewpoint of reducing the burden on the skin, it is preferable to rinse with a mechanical force of a water flow so as not to apply friction by the hand.

In addition, since the skin cleansing spray of the present invention can reduce the surfactant concentration to a very low level, in this case, rinsing after cleansing may not be necessary. Therefore, the spray for skin cleansing of the present invention is also suitable for wiping applications in hospitals, skin cleansing applications such as face washing in beauty salons and beauty parlors, disaster supplies, and the like. When the washing is not performed, the skin cleansing spray remaining on the cleansing area may be sucked and removed by using a water-absorbent base material such as a towel or a paper towel.

Manufacturing method

The spray for skin cleansing of the present invention is produced by mixing the above-described components (a), (B), and (C), and other components and the like which are blended as necessary, preparing a predetermined form, and storing the form in a spray container. When the aerosol spray container is stored as a spray container, the aerosol spray container is stored together with an aerosol such as a gas and manufactured.

[ examples ] A method for producing a compound

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

[ reference test example ]

Skin cleansing sprays having compositions shown in tables 1 to 4 were prepared. The details of each component shown in tables 1 to 4 are as follows. The skin cleansing sprays shown in tables 1 to 4 were liquid, and had viscosities at 20 ℃ (measured with a BL viscometer (B type viscometer manufactured by Brookfield) spindle nos. 3, 6 rpm) of 5000mPa · s or less.

Sodium laurate (Nonsoul LN-1 (trade name) manufactured by Nichii oil Co., Ltd.)

Cocoylglutamic acid TEA (product name of Aomoto Co., Ltd. "Amisoft CT-12S")

Sodium cocoyl methyl taurate ("DIAPON K-SF (trade name)" manufactured by Nichikoku Co., Ltd.)

N-sodium lauroyl aspartate solution (20% by weight) ("Amino former FLDS-L (trade name)" manufactured by Asahi Kasei chemical Co., Ltd.)

Polyoxyethylene lauryl ether acetic acid ("KAOAKYPO RLM-45 (trade name)" made by Kao corporation)

Cocoamide DEA ("AMISOL CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)

PEG-60 hydrogenated Castor oil (polyoxyethylene hydrogenated Castor oil; Nikkol HCO-60 (trade name) available from Nikko Chemicals Co., Ltd.)

Polyoxyethylene sorbitan monostearate (RHEODOL TW-S120V manufactured by Kao corporation)

Glycerol mono-2-ethylhexyl ether ("sendivaSC 50JP (trade name)" manufactured by SEPPIC Co.)

Cocoamidopropyl betaine (product name of "SOFTAZOLINE CPB" manufactured by Kawaken Fine Chemicals)

Lauryl hydroxysulfobetaine solution (30% by weight) ("AMPHITOL 20HD (trade name)" manufactured by Kao corporation)

Lysolecithin ("Lysolecithin KYOWA (Pyraca, Co., Ltd.) (trade name)", product of Kyowa fermentation Co., Ltd.)

Quillaja bark extract (bark extract BG, manufactured by Wanshan pharmaceuticals Co., Ltd., saponin content 5 wt%)

Bis-diethoxydiol cyclohexane 1,4-dicarboxylate ("Neosolve-Aqulio (trade name)" made by Nippon Kogyo Co., Ltd.)

Bisethoxydiglycol succinate ("HAIAQUEOSTER DCS (trade name)" manufactured by higher alcohol industries Co., Ltd.)

< evaluation of detergency >

For the prepared spray for skin cleansing, 10 panelists were subjected to detergency evaluation. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by spraying 1.5g directly onto the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was sucked, the skin was evaluated for sensory evaluation of the sensation of dirt falling based on the following indices, and the evaluation was performed.

And 5, dividing: feel that the dirt is completely fallen off

And 4, dividing: feeling of soil falling

And 3, dividing: it cannot be said whether or not the soil is sensed to fall off

And 2, dividing: hardly any peeling of the soil was sensed

1 minute: no dirt was sensed to fall off

The scores of 10 panelists were summed up, and the degree of detergency was evaluated according to the following classification. The results are shown in tables 1 to 4.

Very good: over 45 minutes

O: 40 minutes or more and less than 45 minutes

And (delta): 35 minutes or more and less than 40 minutes

X: less than 35 minutes

< evaluation of tightening feeling >

For the prepared spray for skin cleansing, 10 panelists were subjected to the evaluation of the feeling of tightness. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1 press was 0.15g), and applied by spraying 1.5g directly onto the face. Left for about 5 seconds, and thereafter, rinsed with water without touching the face with hands. After the face was pressed with a towel and water was absorbed, the tightness was evaluated organoleptically based on the following criteria, and thereby the score was obtained. The stronger the tightness, the less sufficient the moisture retention.

And 5, dividing: completely does not feel tight

And 4, dividing: hardly felt a tight feeling

And 3, dividing: feeling only slight tightness

And 2, dividing: feeling of tightness

1 minute: strongly feel the sense of tightness

The scores of 10 panelists were summed up, and the degree of tightness was evaluated according to the following classification. The results are shown in tables 3 to 4.

Very good: over 45 minutes

O: 40 minutes or more and less than 45 minutes

And (delta): 35 minutes or more and less than 40 minutes

X: less than 35 minutes

< evaluation of Cool feeling >

The prepared spray for skin cleansing was evaluated for cooling feeling by 10 people who spent outdoors and had hot flashes due to sunburn without using sunscreen cream during the daytime in a period of intense ultraviolet rays. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1-push was 0.15g), and 5g of the spray was directly sprayed on the entire body to apply the spray. Left to stand for about 5 seconds, and then rinsed with water so that the hands do not touch the skin. After pressing the skin with a towel and absorbing water, the skin was evaluated for cooling based on the following criteria.

And 3, dividing: feeling a particularly pleasant cooling sensation

And 2, dividing: feeling a comfortable cool feeling

1 minute: a cooling sensation was slightly felt

0 minute: no cool feeling and discomfort

The scores of 10 persons in total were averaged, and the degree of coolness was evaluated according to the following classification. The results are shown in tables 1 to 4.

Very good: 2.5 min or more

O: 1.5 min or more and less than 2.5 min

And (delta): 0.5 min or more and less than 1.5 min

X: less than 0.5 min

< test for stimulating skin by cultured epidermis (in vitro evaluation of skin irritation) >

The cultured epidermal skin irritation test was performed on the prepared spray for skin cleansing as follows.

1. Preparation of culture epidermal MODEL LabCyte EPI-MODEL24

The test medium was heated and 0.5mL of each was added to a 24-well test plate. The culture epidermis MODEL LabCyte EPI-MODEL24 (batch No.: LCE24-180226-A) was transferred to a 24-well test plate supplemented with test medium. After confirming that no air bubbles are present on the bottom surface of the culture cup, adding CO₂The incubator is allowed to stand for more than 1 hour until exposed to the test substance.

2. Application and cleaning of test objects

12 of 24 epidermal models were used (the remainder was kept pre-cultured until the official test). Test plates from 24 wells were removed from CO₂Taking out the culture box. The test medium was heated and 1.0mL of each was added to row 3 of the 24-well assay plate. Without using a pump spray container, 25. mu.L of the test substance (each spray for skin washing) was dropped onto the culture epidermis of the culture cup, and the entire surface was exposed. After the exposure, the test substance was removed by aspiration at 1 minute, 5 minutes, and 10 minutes, and the culture epidermis model in the cup was washed with Phosphate Buffered Saline (PBS) and transferred to the 24-well test plate, line 3.

MTT assay

The MTT assay is the following: the viable cell rate is measured by extracting formazan pigment produced by reduction of MTT [3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide ] taken into cells by a mitochondrial dehydrogenase located in the cells with an organic solvent and measuring the absorbance at 570 nm.

10mL of MTT medium was prepared at a final concentration of 0.5 mg/mL. MTT medium was heated and 0.5mL of each was added to row 4 of the 24-well assay plate. Transfer the cultured epidermis model to 24-well assay plate, line 4, and place CO₂In the incubator, MTT reaction was performed for 3 hours. After the MTT reaction is finished, useThe cultured skin was grasped with forceps and removed, and transferred to a 1.5mL microtube. The culture epidermis model was completely immersed in 300. mu.L of isopropyl alcohol in a microtube. After that, the mixture was allowed to stand for 2 hours, and a vortex was applied to the microtube to extract the pigment. The extract (200mL) was placed in each well of a 96-well plate. In addition, as a blank (negative control), 200. mu.L of isopropanol was added to A1. The absorbance at 570nm and 650nm was measured with a microplate reader. The living cell rate of the specimen was calculated from the following formula, using the value obtained by subtracting the absorbance at 570nm from the absorbance at 650nm as the measured value.

[ number 1 ]

The living cell rate was classified based on the following criteria, and skin irritation was evaluated. The results are shown in tables 3 to 4.

Very good: over 90 percent

O: more than 75 percent and less than 90 percent

And (delta): more than 65% and less than 75%

X: more than 50 percent and less than 65 percent

X: less than 50 percent

As shown in tables 1 to 4, the skin cleansing sprays containing the surfactant alone at a concentration of 0.025 to 2 wt% (reference comparative examples 1 to 10) showed no cleansing power. On the other hand, the skin cleansing spray (reference examples 1 to 20) containing the amphiphilic ester (reference examples 11 to 15) which does not exhibit cleansing power when used alone and 0.025 to 2 wt% of the surfactant was applied directly to the skin from the spray container by spraying only, and excellent cleansing power was obtained by using only the mechanical force of the liquid flow without any physical friction. That is, it was shown that the skin can be gently washed.

As shown in reference examples 1 to 3, the skin cleansing spray containing the surfactant in an amount of more than 2% by weight alone also provides excellent cleansing power by directly applying the spray to the skin only by spraying. On the other hand, considering the skin irritation caused by the surfactant concentrations shown in reference examples 1 to 3, when the surfactant concentration was set to 2% by weight or less as shown in reference examples 9 to 20, not only the cleansing power but also the excellent low irritation property were achieved. That is, it is shown that by setting the surfactant concentration of the skin cleansing spray applied directly to the skin by spraying to 0.025 to 2 wt%, it is possible to cleanse the skin gently both physically and chemically. On the other hand, none of the skin cleanser compositions of reference examples 1 to 20, reference comparative examples 1 to 15, and reference examples 1 to 3 gave comfort due to a cool feeling.

[ TABLE 1 ]

In the table, the unit of the numerical value indicating the blending amount of each component is% by weight.

[ TABLE 2 ]

In the table, the unit of the numerical value indicating the blending amount of each component is% by weight. In addition, the numerical values in parentheses represent the converted amounts of the components.

[ TABLE 3 ]

[ TABLE 4 ]

[ test examples ]

Skin cleansing sprays having compositions shown in tables 5 to 7 were prepared. The details of each component shown in tables 5 to 7 are shown in the reference test examples. Further, 1-menthol was used as menthol, and an ester of succinic acid with 1-menthol was used as menthyl succinate. The skin cleansing sprays shown in tables 5 to 7 were liquid, and had viscosities at 20 ℃ (measured at 6rpm in spindle No3 of BL viscometer (B type viscometer manufactured by Brookfield corporation)) of 5000mPa · s or less.

< evaluation of detergency >

The skin cleansing spray prepared was evaluated for cleansing ability by 10 people who spent outdoors and had hot flashes due to sunburn without using sunscreen cream during the daytime at a time of intense ultraviolet light. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1-push was 0.15g), and 5g of the spray was directly sprayed on the entire body to apply the spray. Left to stand for about 5 seconds, and then rinsed with water so that the hands do not touch the skin. After pressing the skin with a towel and absorbing water, the skin was evaluated for the sensation of dirt shedding based on the following indices, and the skin was scored.

And 3, dividing: feel that the dirt is completely fallen off

And 2, dividing: feeling of soil falling

1 minute: slight soil release was felt

0 minute: no dirt was sensed to fall off

The scores of 10 persons were averaged in total, and the degree of detergency was evaluated according to the following classification. The results are shown in tables 5 to 7.

Very good: 2.5 min or more

O: 1.5 min or more and less than 2.5 min

And (delta): 0.5 min or more and less than 1.5 min

X: less than 0.5 min

< evaluation of irritation feeling >

The skin cleansing spray prepared was evaluated for irritation by 10 people who spent outdoors and had hot flashes due to sunburn without using sunscreen cream during the daytime when the ultraviolet light was intense. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1-push was 0.15g), and 5g of the spray was directly sprayed on the entire body to apply the spray. Left to stand for about 5 seconds, and then rinsed with water so that the hands do not touch the skin. After pressing the skin with a towel and absorbing water, sensory evaluation was performed on the sensation of irritation based on the following indices, and thereby scoring was performed.

And 3, dividing: no irritation feeling was felt at all

And 2, dividing: only slight irritation was felt

1 minute: feeling of irritation

0 minute: strongly felt the irritation

The scores of 10 persons were averaged in total, and the degree of irritation was evaluated according to the following classification. The results are shown in tables 5 to 7.

Very good: 2.5 min or more

O: 1.5 min or more and less than 2.5 min

And (delta): 0.5 min or more and less than 1.5 min

X: less than 0.5 min

< evaluation of tightening feeling >

The skin cleansing spray prepared was evaluated for tightness by 10 people who spent outdoors and had hot flashes due to sunburn without using sunscreen cream during the daytime when the ultraviolet light was intense. Specifically, each of the skin cleansing sprays was stored in a pump spray container ("Z-155-C110 (trade name)" manufactured by bamboo container co., ltd., and the spray amount per 1-push was 0.15g), and 5g of the spray was directly sprayed on the entire body to apply the spray. Left to stand for about 5 seconds, and then rinsed with water so that the hands do not touch the skin. After pressing the skin with a towel and absorbing water, the skin was evaluated for tightness by sensory evaluation based on the following criteria. The stronger the tightness, the less sufficient the moisture retention.

And 3, dividing: completely no sense of tightness

And 2, dividing: feeling of tightness only slightly

1 minute: feeling of tightness

0 minute: strongly feel the sense of tightness

The scores of 10 persons were averaged in total, and the degree of tightness was evaluated according to the following classification. The results are shown in tables 5 to 7.

Very good: 2.5 min or more

O: 1.5 min or more and less than 2.5 min

And (delta): 0.5 min or more and less than 1.5 min

X: less than 0.5 min

< evaluation of Cool feeling >

The degree of coolness of the prepared spray for skin cleansing was evaluated in the same manner as in the reference test example. The results are shown in tables 5 to 7.

< evaluation of high temperature stability >

The prepared spray for cleaning skin is stored at room temperature or 50 deg.C for 1 week. After storage, the spray for skin cleansing stored at room temperature and the spray for skin cleansing stored at 50 ℃ were evaluated for high temperature stability by visual observation for differences in appearance and odor, and then scored according to the following criteria. The differences in appearance and odor were evaluated for the deposition in the skin cleansing spray stored at 50 ℃ (specifically, deposition of bis-diethoxydiol cyclohexane 1, 4-dicarboxylate) and odor (specifically, odor due to menthol and menthyl succinate).

And 3, dividing: no difference was observed at all

And 2, dividing: only slight differences were observed

1 minute: differences were observed

0 minute: a large difference was observed

The scores of 10 persons were averaged in total, and the degree of stability of the preparation was evaluated according to the following classification. The results are shown in tables 5 to 7.

Very good: 2.5 min or more

O: 1.5 min or more and less than 2.5 min

And (delta): 0.5 min or more and less than 1.5 min

X: at 0.5 min

As shown in tables 5 to 7, the skin cleansing spray containing the surfactant alone (comparative example 1) showed no cleansing power due to the low concentration of the surfactant. In addition, in the case of the spray for skin cleansing (comparative example 2) containing the amphiphilic ester (comparative example 3) which does not exhibit cleansing power when used alone and the surfactant, even if the concentration of the surfactant is low, the amphiphilic ester can be directly applied to the skin from the spray container by spraying only, and excellent cleansing power can be obtained by only the mechanical force of the liquid flow without giving any physical friction at all, but in terms of cooling sensation, the spray is not comfortable to the sunburned hot skin. On the other hand, in the skin cleansing sprays containing the surfactant and the amphipathic ester which does not exhibit cleansing power when used alone and further containing the refreshing feeling component (examples 1 to 20), even if the concentration of the surfactant is low, the skin can be gently cleansed in such a manner that the skin can be directly applied to the skin from the spray container only by spraying, and excellent cleansing power can be obtained only by the mechanical force of the liquid flow without giving any physical friction at all, and a comfortable refreshing feeling can be given to the sunburned and hot skin.

In addition, all of the skin cleansing sprays of examples and comparative examples were stable and no precipitates and off-flavors were observed at room temperature. On the other hand, regarding high temperature stability (formulation stability after storage at 50 ℃), precipitation of amphiphilic ester was observed in the spray for skin cleansing of example 21, while an odor of menthol was observed in the spray for skin cleansing of example 22, and the sprays for skin cleansing of examples 1 to 20 were also excellent in high temperature stability.

[ TABLE 5 ]

In the table, the unit of the numerical value indicating the blending amount of each component is% by weight. In addition, the numerical values in parentheses represent component equivalent values.

[ TABLE 6 ]

[ TABLE 7 ]

[ formulation examples ]

Liquid skin cleansing sprays having the formulations shown in table 8 were prepared. The spray for skin cleansing of any formulation has low skin irritation and excellent cleansing power, can impart a pleasant cool feeling, and is excellent in formulation stability at room temperature and high temperature.

[ TABLE 8 ]

Claims

1. A spray for cleaning skin comprises (A) a surfactant, (B) an amphiphilic ester and (C) a refreshing feeling component,

the spray for skin cleansing is contained in a spray container.

2. The spray for skin cleansing according to claim 1, wherein the spray container is a pump spray container.

3. The spray for skin cleansing according to claim 1, wherein the spray container is an aerosol spray container.

4. The spray for skin cleansing according to any one of claims 1 to 3, wherein,

the (B) component is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and polyglycerol-10 eicosadipates/tetradecadipates.

5. The spray for skin cleansing according to any one of claims 1 to 4, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate.

6. The spray for skin cleansing according to any one of claims 1 to 5, wherein the content of the component (A) is 0.025 to 2% by weight.

7. The spray for skin cleansing according to any one of claims 1 to 6, wherein the content of the component (A) is 0.025 to 0.9% by weight.

8. The spray for skin cleansing according to any one of claims 1 to 7, wherein the component (C) is menthol and/or menthyl succinate.

9. The spray for skin cleansing according to any one of claims 1 to 8, wherein the content of the component (C) is 0.001 to 0.5% by weight.

10. The spray for skin cleansing according to any one of claims 1 to 9, wherein the spray for skin cleansing is applied to the skin after sunburn.