WO2020262159A1

WO2020262159A1 - Composition for skin wiping

Info

Publication number: WO2020262159A1
Application number: PCT/JP2020/023787
Authority: WO
Inventors: 航平山本
Original assignee: 小林製薬株式会社
Priority date: 2019-06-26
Filing date: 2020-06-17
Publication date: 2020-12-30
Also published as: JP2021004205A; CN112449598A

Abstract

[Problem] The purpose of the present invention is to provide a composition for skin wiping, which has excellent cleansing power, while being suppressed in skin irritancy and lack of moisture retainability and being still suppressed in stickiness. [Solution] A composition for skin wiping, which contains (A) a naturally derived surfactant and/or an amino acid surfactant and (B) an amphiphilic ester, wherein the content of component (A) is from 0.025% by weight to 2% by weight. This composition for skin wiping is comprehensively excellent in terms of reduction of skin irritancy, suppression of the lack of moisture retainability, suppression of stickiness and cleansing power. Consequently, a composition for skin wiping according to the present invention is suitable for use by a person who has refrained from taking a bath and/or a shower for a plurality of days.

Description

Skin cleaning composition

The present invention relates to a composition for skin cleaning which is excellent in skin irritation reducing property, moisturizing property, stickiness suppressing property, and detergency.

Various sheets impregnated with liquid have been created as products aimed at keeping the skin comfortable by wiping the skin. For example, in Patent Document 1, a skin cleaning agent containing a polyhydric alcohol, a polyphenol-based deodorant, water, a predetermined amount of polypropylene glycol ethylene oxide adduct, and a predetermined amount of polyoxyethylene sorbitan ester is used as a low wiping agent. It is stated that dirt substances can be easily removed by rubbing and foul odors can be reduced. Patent Document 2 describes a liquid composition containing a predetermined amount of a specific nonionic surfactant, a predetermined amount of powder, a predetermined amount of another predetermined nonionic surfactant, and water. The sheet-like cosmetics impregnated into the sheet-like base material give an appropriate refreshing feeling and a smooth feeling without dryness to the skin, suppress stickiness, have excellent sustainability of the smooth feeling, and after sweating. It is described that it has excellent durability of the smooth feeling of the skin. Patent Document 3 describes a predetermined amount of citrus essential oil, a predetermined amount of a specific polyoxyethylene alkyl ether or a specific polyoxyethylene alkenyl ether, and a predetermined amount of a nonionic surfactant having a specific glyceryl group. The sheet-like cosmetics obtained by impregnating a sheet-like base material with a liquid composition containing a predetermined amount of liquid higher alcohol, a predetermined amount of water-soluble polymer, and water does not dry too much and the skin. It is described that a firm ability to remove the stratum corneum and a cleansing property can be obtained while maintaining the moisture of the substance.

JP-A-2010-184896 Japanese Unexamined Patent Publication No. 2013-116868 Japanese Unexamined Patent Publication No. 2016-084318

While conventional skin cleansing agents have obtained a certain level of cleansing property by using a nonionic surfactant, they have properties that are essentially contrary to the cleansing property, such as low irritation to the skin and moisturizing. There is no choice but to sacrifice sex. It is considered that this is stimulated by the nonionic surfactant that remains and concentrates on the skin after wiping. Considering the current situation where the demand for gentleness to the skin is increasing year by year, it cannot be said that the conventional skin cleansing agents that cause such irritation and lack of moisturizing are at a satisfactory level.

In addition, there are many people whose bathing and showering are restricted for a long time due to long working hours, ongoing aging, frequent disasters, etc. For such people, cleaning the skin by cleaning is a bathing or showering. It is the only means of comforting the skin during times of restriction. However, conventional skin cleansing agents are subject to such restrictions because they accumulate nonionic surfactants that remain and concentrate on the skin after cleaning and give the skin even stronger irritation due to repeated cleaning. Even for some people, it is not at a satisfactory level.

In order to reduce skin irritation, the present inventor used a naturally-derived surfactant or an amino acid-based surfactant as a surfactant, and set the blending amount to an extremely small amount of 0.025 to 2% by weight. .. However, with such a skin-cleaning composition containing only a very small amount of surfactant, the detergency cannot be obtained satisfactorily, and on the contrary, the irritation to the skin and the decrease in moisturizing cannot be effectively suppressed. In some cases, I faced the problem of feeling sticky.

Therefore, an object of the present invention is to provide a composition for skin cleaning, which suppresses skin irritation and lack of moisturizing, suppresses stickiness, and has excellent cleansing power.

As a result of diligent studies, the present inventor has found that skin irritation and lack of moisturizing are caused by the coexistence of amphipathic esters in a small amount of naturally occurring surfactants and / or amino acid-based surfactants in a skin cleaning composition. It has been found that the sticky feeling is suppressed and excellent detergency can be exhibited while being reduced. The present invention has been completed by further studies based on this finding.

That is, the present invention provides the inventions of the following aspects.
Item 1. A skin bath containing (A) a naturally occurring surfactant and / or an amino acid-based surfactant and (B) an amphipathic ester, and the content of the component (A) is 0.025 to 2% by weight. Wiping composition.
Item 2. Item 2. The item (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. Composition for cleaning the skin.
Item 3. Item 2. The composition for skin cleaning according to Item 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
Item 4. Item 2. The composition for skin cleaning according to any one of Items 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins, and lipopeptides.
Item 5. Item 4. The composition for skin cleaning according to Item 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin.
Item 6. Item 4. The composition for skin cleaning according to Item 4, wherein the lipopeptide is selected from the group consisting of surfactins and salts thereof.
Item 7. Item 2. The skin cleaning composition according to any one of Items 1 to 6, which is applied to a person whose bathing and / or shower is restricted for multiple days.

According to the present invention, there is provided a composition for skin cleaning which is excellent in skin irritation reduction property, moisturizing deficiency suppression property, stickiness suppression property, and detergency. Therefore, the skin-cleaning composition of the present invention can be suitably used for a person whose bathing and / or shower is restricted for a plurality of days.

The composition for skin cleaning of the present invention contains (A) a naturally occurring surfactant and / or an amino acid-based surfactant (hereinafter, may be referred to as (A) component) in a predetermined amount and (B) amphipathic medium. It contains a sex ester (hereinafter, may be referred to as a component (B)) and is characterized by being used for skin cleaning. Hereinafter, the skin cleaning composition of the present invention will be described in detail.

(A) Naturally-Derived Surfactant and / or Amino Acid-based Surfactant The skin-cleaning composition of the present invention contains a naturally-derived surfactant and / or amino acid-based surfactant as the component (A). As the component (A), either one of a naturally-derived surfactant and an amino acid-based surfactant may be used, or both may be used in combination.

Naturally-derived surfactants are substances that originate from living organisms and have a surfactant action. The naturally occurring surfactant used in the present invention is not particularly limited, and is a natural product extracted and purified from an animal, a plant or a microorganism; these natural products are microbiologically cultured and synthesized, and genetically engineered. Examples include those that have been subjected to treatments such as hydrogenation treatment, hydroxylation treatment, and hydrolysis treatment.

Examples of the naturally occurring surfactant used in the present invention include phospholipids, saponins, lipopeptides, cholesterol, bile acids and the like. One of these naturally-derived surfactants may be used alone, or two or more thereof may be used in combination. Among these naturally-derived surfactants, phospholipids, saponins, and lipopeptides are mentioned from the viewpoints of comprehensively excellent skin irritation reducing property, moisturizing property, stickiness suppressing property, and detergency. Among these naturally-derived surfactants, phospholipids and lipopeptides are mentioned from the viewpoint of obtaining more preferable detergency, and lipopeptides are mentioned from the viewpoint of obtaining a more preferable refreshing feeling by continuous use. Phospholipids can be mentioned from the viewpoint of more preferably suppressing stickiness, reducing skin irritation, and suppressing lack of moisturizing.

Examples of phospholipids include glycerophospholipids and sphingolipids. Glycerophospholipid is a substance having a glycerophosphate skeleton, and has a fatty acid ester, a long-chain alkyl ether, a vinyl ether and the like as a parent oil group. Specific examples of glycerophospholipids include phosphatidylcholine (lecithin), phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, phosphatidylinositol polyphosphate, diphosphatidylglycerol (cardiolipin), phosphatidylic acid, and hydrolyzed products and hydroxylation treatments thereof. Examples include products and hydrolyzed products. Sphingolipids are phosphoric acid or phosphonic acid derivatives of long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine. Specific examples of sphingolipids include ceramide 1-phosphoric acid derivatives (sphingomyelin and the like) and ceramide 1-phosphonic acid derivatives (ceramide aminoethyl phosphonic acid and the like). One of these phospholipids may be used alone, or two or more thereof may be used in combination.

Among these phospholipids, glycerophospholipids are preferable, lecithin (soy lecithin, egg yolk lecithin), hydrogenated lecithin, hydroxylated lecithin, and lysolecithin are more preferable, and lecithin (soy lecithin, soybean lecithin,) is more preferable. Egg yolk lecithin etc.), hydrogenated lecithin, lysolecithin and the like. In addition, lysolecithin is more preferable from the viewpoint of more preferably detergency, skin irritation reduction property, moisturizing reduction suppression property, and stickiness suppression property.

Saponin is a glycoside composed of sapogenin and sugar, and specific examples thereof include triterpene glycosides and steroid glycosides. Specific examples of the saponin include Kiraya saponin, soybean saponin, yukka saponin, enju saponin, beet saponin, azukisaponin, carrot saponin, tea species saponin, hechimasaponin, and tsubokusaponin. One of these saponins may be used alone, or two or more of them may be used in combination.

The lipopeptide is a lipidized peptide, and specific examples thereof include surfactin, arslovactin, itulin, and salts thereof. One of these lipopeptides may be used alone, or two or more thereof may be used in combination.

Among these lipopeptides, surfactin and a salt thereof are preferably mentioned, and more preferably a salt of surfactin is mentioned. The salt of surfactin is a compound represented by the following formula (I).

In the formula (I), X is leucine, the amino acid residue selected from isoleucine and valine, R represents C ₉ - ₁₈ represent an alkyl group, M ⁺ represents an alkali metal ion or a quaternary ammonium ion. The alkali metal ion is not particularly limited, and examples thereof include lithium ion, sodium ion, potassium ion and the like, and sodium ion is preferable. Examples of the substituent of the quaternary ammonium ion include an alkyl group such as a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group and a tert-butyl group; a benzyl group, a methylbenzyl group and a phenylethyl group. Aralkyl groups such as groups; organic groups such as aryl groups such as phenyl group, toluyl group and xsilyl group can be mentioned. One of these surfactins or a salt thereof may be used alone, or two or more thereof may be used in combination.

The content of the component (A) in the skin cleaning composition of the present invention is 0.025 to 2% by weight. In the present invention, since excellent detergency can be exhibited by coexisting with the component (B), it is effective even with a small amount of surfactant that originally cannot exhibit effective detergency. It is possible to exert detergency.

Amino acid-based surfactants include amino acid-based anionic surfactants and amino acid-based amphoteric surfactants. As the amino acid-based surfactant, either one of the amino acid-based anionic surfactant and the amino acid-based amphoteric surfactant may be used, or both may be used in combination. Among these amino acid surfactants, amino acid-based anionic surfactants are mentioned from the viewpoint of more preferably smoothness and moisturizing feeling, and amino acid-based amphoteric surfactants are preferably used from the viewpoint of preferably obtaining softness. ..

Examples of the amino acid-based anionic surfactant used in the present invention include a carboxylic acid-type amino acid-based anionic surfactant and a sulfonic acid-type amino acid-based anionic surfactant.

Examples of the carboxylic acid-type amino acid-based anionic surfactant include N having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyyl group, a lauroyl group, a myritoyl group, a palmitoyl group, and a cocoyl group. -Acyl amino acids can be mentioned. Examples of the N-acyl amino acid in the carboxylic acid type amino acid-based anionic surfactant include N-acylsarcosine, N-acylaspartic acid, N-acylglutamic acid, N-acyl-N-methyl-β-alanine and the like. More specific carboxylic acid-type amino acid-based anionic surfactants include N-lauroyl sarcosine, cocoyl sarcosine, N-lauroyl aspartic acid, cocoyl aspartic acid, N-lauroyl glutamic acid, cocoyl glutamic acid, and N-lauroyl-N-methyl. -Β-alanine, cocoylmethylalanine and the like can be mentioned.

Examples of the sulfonic acid-type amino acid-based anionic surfactant include N having a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as an octanoyl group, a decanoyyl group, a lauroyl group, a myritoyl group, a palmitoyl group, and a cocoyl group. -Acyl-N-methyltaurine can be mentioned. More specific sulfonic acid-type amino acid-based anionic surfactants include N-myristoyl-N-methyltaurine, N-lauroyl-N-methyltaurine, cocoylmethyltaurine and the like.

In addition, these amino acid-based anionic surfactants may be in the form of salts, for example, alkali metal salts such as sodium salt and potassium salt; triethanolamine (TEA) salt; ammonium salt and the like. be able to.

Among these amino acid-based anionic surfactants, N-lauroyl aspartic acid, cocoyl glutamic acid, and N are preferable from the viewpoint of preferably obtaining detergency, skin irritation reduction property, moisturizing deficiency suppression property, and / or stickiness suppression property. -Lauroyl-N-methyl-β-alanine, cocoylmethylalanine, cocoylmethyltaurine are mentioned, and more preferably, sodium N-lauroyl aspartate, triethanolamine cocoylglutamate, N-lauroyl-N-methyl-β-alanine. Examples thereof include sodium, cocoyl methylalanine sodium, and cocoyl methyl taurine sodium. From the viewpoint of further preferable detergency, sodium cocoylmethyl taurine, sodium N-lauroyl-N-methyl-β-alanine, and sodium N-lauroyl aspartate are more preferable. From the viewpoint of further preferably reducing skin irritation and suppressing lack of moisturization, triethanolamine cocoyl glutamate, sodium cocoyl methyl taurine, sodium N-lauroyl-N-methyl-β-alanine, and N-lauroyl aspartic acid are more preferable. Examples include sodium and cocoyl methylalanine sodium.

As the amino acid-based anionic surfactant, one of the above-mentioned carboxylic acid-type amino acid-based anionic surfactant and sulfonic acid-type amino acid-based anionic surfactant may be used alone, or two types may be used. The above may be used in combination.

These amino acid-based anionic surfactants may be used alone or in combination of two or more.

Examples of the amino acid-based amphoteric tenside agent used in the present invention include an amide betaine-type amphoteric tenside agent and an alkyl betaine-type amphoteric tenside agent. Examples of the amino acid-based amphoteric tenside agent include an amide betaine-type amphoteric tenside agent from the viewpoint of further preferably reducing skin irritation, suppressing insufficient moisturization, suppressing stickiness, and / or detergency.

Amido betaine type amphoteric surfactants have the general formula ^{_{R 1 CO-NH- (CH 2}} ) n -N + (CH 3) 2 CH 2 CO 2 - ( wherein, R ¹ CO- groups, octanoyl group, decanoyl A compound represented by a saturated or unsaturated N-acyl group having 8 to 24 carbon atoms such as a group, a lauroyl group, a myristyl group, a palmitoyl group, and a cocoyl group, and n representing an integer of 2 to 8). From the viewpoint of preferably providing detergency, reducing skin irritation, moisturizing feeling and / or softness, cocamidopropyl betaine, lauric acid amide propyl betaine and the like are preferable, and cocamidopropyl betaine is more preferable. Can be mentioned.

Alkyl betaine type amphoteric surfactant has the general formula ^{^{_{R 2 -N + (CH 3)}}} 2 CH 2 CO 2 - ( wherein, R ² groups are octyl, decyl, lauryl group, myristyl group, palmityl group, It is a compound represented by a saturated or unsaturated alkyl group having 8 to 24 carbon atoms such as a coconut oil fatty acid alkyl group), and has a viewpoint of preferably obtaining detergency, reducing skin irritation, moisturizing feeling and / or softness. Therefore, preferably, lauryldimethylacetate betaine, tetradeceldimethylaminoacetate betaine and the like can be mentioned.

These amino acid-based amphoteric surfactants may be used alone or in combination of two or more.

The preferable content of the component (A) is, for example, 0.1 to 2% by weight, more preferably 0.2 to 2% by weight, still more preferably, from the viewpoint of obtaining even more excellent detergency and stickiness suppressing property. 0.3 to 2% by weight is mentioned, and 0.3 to 1% by weight, more preferably 0.3 to 0.5% by weight, from the viewpoint of obtaining even more excellent skin irritation reduction property and moisturizing deficiency suppression property. %.

(B) Amphiphile Ester The composition for skin cleaning of the present invention contains an amphipathic ester as a component (B). The component (B) does not show a cleansing effect by itself, but by coexisting with the component (A) of 0.025 to 2% by weight, the skin irritation reducing property and the moisturizing insufficient suppressing property of the skin cleaning composition are improved. However, the sticky feeling can be suppressed and the detergency can be improved.

In the present invention, the amphipathic ester is dissolved in ion-exchanged water adjusted to a conductivity of 70 to 110 μs / m in an amount of 2% by mass or more at room temperature by the method specified in the General Test Method of the Japanese Pharmacopoeia. , Isotridecyl isononanoate (manufactured by Nisshin Oillio Group, Saracos 913), which is an oil agent, also dissolves in 10% by mass or more at room temperature (25 ° C.), and ester-based surfactants are excluded.

The amphoteric ester is not particularly limited, but a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester or a dicarboxylic acid can be obtained from the viewpoint of reducing skin irritation, suppressing insufficient moisturization, suppressing stickiness, and obtaining better detergency. It is preferably selected from the group consisting of a dialkoxyalkyl ester and a (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10. As the amphoteric ester, any one of dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, dicarboxylic acid dialkoxyalkyl ester, and (eicosandioic acid / tetradecanedioic acid) polyglyceryl-10 is used alone. Also, two or more kinds may be used in combination. Among these amphoteric esters, dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is more preferable from the viewpoint of obtaining better skin irritation reducing property, moisturizing deficiency suppressing property, stickiness suppressing property, and detergency.

The dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester used in the present invention is a diester compound of a dicarboxylic acid and a polyoxyalkylene alkyl ether. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, and the like. Examples thereof include suberic acid, azelaic acid, sebacic acid, aspartic acid, glutamic acid, acetonedicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the polyoxyalkylene alkyl ether constituting the diester compound include polyoxyethylene monoalkyl ether, and more specifically, diethylene glycol monoethyl ether and triethylene glycol monoethyl ether. Be done.

Among these dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters, cyclohexane-1,4- is preferable from the viewpoint of obtaining better skin irritation reducing property, moisturizing deficiency suppressing property, stickiness suppressing property, and detergency. A diester compound of a dicarboxylic acid and a diethylene glycol monoethyl ether, specifically, an INCI name (International Cosmetic Ingredient Dictionary and Handbook, 13th edition, Volume 1, CTFA, 2010, p.331): BIS-ETHOXYDIGLYCOL , 4-DICARBOXYLATE, a compound called cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, and a diester compound of succinic acid and diethylene glycol monoethyl ether, specifically, INCI name ( International Cosmetic Ingredient Dictionary and Handbook, 13th Edition, Volume 1, CTFA, 2010, p.331-332): BIS-ETHOXYDIGLYCOL SUCCINATE, a compound called bisethoxydiglycol succinate. , More preferably, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.

Further, in the present invention, specific examples of the cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol include, for example, "Neosolue-Aqulio (trade name)" manufactured by Nippon Fine Chemical Co., Ltd. Further, specific examples of the bisethoxydiglycol succinate include "High Aquos Star DCS (trade name)" manufactured by Higher Alcohol Industry Co., Ltd.

These dicarboxylic acid bis (polyoxyalkylene alkyl ether) esters may be used alone or in combination of two or more.

The dicarboxylic acid dialkoxyalkyl ester used in the present invention is a diester compound of a dicarboxylic acid and an alkoxy alcohol. Specific examples of the dicarboxylic acid constituting the diester compound of the dicarboxylic acid dialkoxyalkyl include oxalic acid, malonic acid, succinic acid, tartaric acid, malic acid, glutaric acid, adipic acid, pemeric acid, suberic acid, and azelaic acid. Examples thereof include sebacic acid, aspartic acid, glutamic acid, acetone dicarboxylic acid, phthalic acid, cyclohexane-1,4-dicarboxylic acid and the like. Examples of the alkoxy alcohol constituting the diester compound include 2-methoxyethanol and 2-ethoxyethanol.

Among these dicarboxylic acid dialkoxyalkyl esters, a diester compound of succinic acid and 2-ethoxyethanol is preferable, and specifically, diethoxyethyl succinate is mentioned from the viewpoint of obtaining the effect of the present invention better. ..

These dicarboxylic acid dialkoxyalkyl esters may be used alone or in combination of two or more.

The polyglyceryl-10 (eicosanedioic acid / tetradecanedioic acid) used in the present invention is not particularly limited, but for example, "Neosolue-Aqua (trade name)" and "Neosolue-AquaS" manufactured by Nippon Seika Co., Ltd. Product name) ”and the like.

The content of the component (B) in the skin cleaning composition of the present invention is not particularly limited, and examples thereof include 0.1% by weight or more. From the viewpoint of obtaining skin irritation reduction property, moisturizing deficiency suppression property, stickiness suppression property, and / or detergency even better, the content of the component (B) is preferably 0.5% by weight or more. The upper limit of the content of the component (B) is not particularly limited, but from the viewpoint of the stability of the skin cleaning composition, for example, 5% by weight or less, preferably 4% by weight or less, more preferably 3% by weight. Hereinafter, it is more preferably 2% by weight or less, and particularly preferably 1% by weight or less.

In the skin-cleaning composition of the present invention, the ratio of the component (A) to the component (B) is not particularly limited and is determined by each of the above-mentioned contents, but it reduces skin irritation, suppresses insufficient moisturization, and suppresses stickiness. From the viewpoint of obtaining better properties and / or detergency, the component (B) is, for example, 0.1 to 100 parts by weight, preferably 0.1 to 20 parts by weight, based on 1 part by weight of the component (A). It is preferably 0.1 to 10 parts by weight, more preferably 0.1 to 5 parts by weight, and particularly preferably 0.1 to 3 parts by weight.

Other Ingredients In addition to the above ingredients, the composition for skin cleaning of the present invention contains other bases and additives required for formulation and the like as long as the effects of the present invention are not impaired. You may. Such additives are not particularly limited as long as they are pharmaceutically acceptable, but for example, water, lower alcohols having 1 to 5 carbon atoms (ethanol, isopropanol, etc.), and polyhydric alcohols (ethylene glycol, Aqueous bases such as 1,3-butylene glycol (1,3-BG), propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, glycerin, etc.; preservatives (phenoxyethanol, methylparaben, propylparaben, benzoic acid, etc.) , Sodium citrate, sorbic acid, etc.), flavoring agents (citral, 1,8-cyonel, citroneral, farnesol, etc.), colorants (tar pigments (brown 201, blue 201, yellow 4, yellow 403, etc.) ), Cacao pigment, chlorophyll, aluminum oxide, etc.), viscous agent (hydroxypropyl cellulose, hydroxyethyl cellulose, crosslinked acrylic acid polymer, carboxyvinyl polymer, hypromerose, polyvinylpyrrolidone, sodium alginate, ethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, Caraginan, etc.), pH adjusters (phosphate, hydrochloric acid, citric acid, sodium citrate (trisodium citrate), succinic acid, tartaric acid, sodium hydroxide, potassium hydroxide, triethanolamine, triisopropanolamine, etc.), wet Agents (dl-sodium pyrrolidone carboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-asparanic acid, DL -Alanin, glycine, sodium erythorbinate, propyl citrate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, UV absorbers, chelating agents, adhesives, buffers, dissolution aids Additives such as agents, solubilizers, preservatives and the like can be mentioned. These substrates and additives may be used alone or in combination of two or more. The contents of these base materials and additives can be appropriately set according to the formulation form and the like.

In addition to the above-mentioned components, the composition for skin cleaning of the present invention may contain other pharmacological components as necessary, as long as the effects of the present invention are not impaired. Examples of such pharmacological components include vitamins (vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin K, niacin). Kind, folic acid, biotin, lycopene, etc.), antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procine, tetrakine, bupivakine, mepivacaine, chloroprocine, proparakine, meprilcaine or salts thereof, orthokine, oxesazein, oxypolyentoxy Decane, funnel extract, percamine pase, tesitdecitin, etc.), anti-inflammatory agents (indomethasin, fervinac, diclofenac sodium, loxoprofen sodium, etc.), skin protectants (corodione, sunflower oil, etc.) , Capsaicin, capsicum extract, etc.), refreshing agents (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, hyaluronic acid, cationized hyaluronic acid (dihydroxypropyltrimonium hyaluronate) Etc.) etc.) etc. These pharmacological components may be used alone or in combination of two or more. When these pharmacological components are contained, the content thereof may be appropriately set according to the type of the pharmacological component used, the expected effect, and the like.

Form The form of the skin-cleaning composition of the present invention is not particularly limited, and examples thereof include liquid, cream, and gel, but the composition is preferably liquid or gel at room temperature. When the skin cleaning composition of the present invention is in the form of a liquid or gel, the viscosity at 20 ° C. is 10,000 mPa · s or less, preferably 5000 mPa · s or less. The viscosity is a value measured by a BL viscometer (rotor No. 3, 6 rpm, 20 ° C.).

The skin cleaning composition of the present invention may be in the form of a cleaning tool impregnated with the skin cleaning composition. The cleaning tool is not particularly limited as long as it is an absorbent base material that can be impregnated with the skin cleaning composition of the present invention. Specific examples include a fiber base material. The fiber base material may be either a woven fabric or a non-woven fabric.

Examples of the material of the fiber base material include natural fibers and chemical fibers derived from plants or animals. Examples of plant-derived natural fibers include cotton and pulp, and examples of animal-derived natural fibers include silk, chitin and collagen fibers. Examples of the chemical fiber include rayon, cupra, polyester, polyamide, polypropylene, and polyacrylic nitrile. One of these fibers may be used alone, or two or more of these fibers may be used in combination. Further, the material of these fiber base materials may be reinforced with a thermoplastic resin (for example, polyethylene, polypropylene, polyethylene terephthalate, etc.).

When the skin cleaning composition of the present invention is impregnated in a cleaning tool, the cleaning tool impregnated with the skin cleaning composition of the present invention is contained in a suitable container. The container is not particularly limited, and examples thereof include a packaging bag and a box-shaped container.

Applications The skin cleaning composition of the present invention is used for removing (wiping) stains such as oils and fats on the skin and body fluids such as sweat by wiping, and is not used as a makeup remover (cleansing). Absent. Since the skin cleaning composition of the present invention has excellent detergency, the skin can be kept comfortable by cleaning the skin instead of bathing or showering. Further, since the skin cleaning composition of the present invention is specialized for cleaning applications, it inevitably remains on the skin after cleaning, but it is also excellent in suppressing stickiness, which makes the skin even more comfortable. Can be kept in.

Furthermore, since the composition for skin cleaning of the present invention is also excellent in reducing skin irritation and suppressing insufficient moisturizing, it is applied to people with sensitive skin even though it remains on the skin after cleaning. However, it is possible to keep the skin comfortable while suppressing the burden on the skin. In addition, even if the amount of skin-cleaning composition remaining on the skin is increased by wiping multiple times while bathing or showering is restricted, the stickiness is still suppressed and skin irritation is reduced. It is possible to suppress the lack of moisturizing. Therefore, it can be used instead of bathing or showering for a person whose bathing and / or shower is restricted for a plurality of days (for example, 2 to 10 days, preferably 2 to 7 days). Those who are restricted from bathing and / or showering for multiple days include those who work long hours, inpatients, the elderly, and evacuees in the event of a disaster.

Since the skin cleaning composition of the present invention enables cleaning of any body part, the application part thereof is not particularly limited, and examples thereof include hands, hair, scalp, body, and face.

Production Method The composition for skin cleaning of the present invention is prepared into a predetermined form by mixing the above-mentioned components (A) and (B), and other components to be blended as necessary. Manufactured. If necessary, it can be manufactured by impregnating it with a cleaning tool and housing it in a container.

The present invention will be described in more detail with reference to Examples below, but the present invention is not limited thereto.

The composition for skin cleaning having the composition shown in Tables 1 and 2 was prepared. Details of each component shown in Tables 1 and 2 are as follows. The skin cleaning compositions shown in Tables 1 and 2 are liquid, and their viscosities at 20 ° C. (measured by BL viscometer (Brookfield B-type viscometer) rotor No. 3 and 6 rpm) are all liquid. It was in the range of 5000 mPa · s or less.
(A) Naturally-derived surfactant, amino acid-based surfactant, lysolecithin ("Resolecithin Kyowa (trade name)" manufactured by Kyowa Hakko Bio Co., Ltd.)
・ Lecithin (“Basis LP-20 (trade name)” manufactured by Nisshin Oillio Co., Ltd.)
・ Hydrogenated lecithin (“Basis LP-20H (trade name)” manufactured by Nisshin Oillio Co., Ltd.)
・ Kiraya extract (“Kiraya extract BG” manufactured by Maruzen Pharmaceuticals Co., Ltd., saponin content 5% by weight)
・ Soap nut extract powder (“Soap nut extract powder (trade name)” manufactured by Ichimaru Falcos, saponin content 20% by weight)
・ Sodium surfactin (Kaneka's "Kaneka Surfactin (trade name)")
・ Cocamidopropyl betaine ("Softazoline CPB (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)
・ Cocoyl glutamic acid TEA (Ajinomoto Co., Inc. "Amisoft CT-12S (trade name)")
・ Cocoyl methyl taurine Na (“Diapon K-SF (trade name)” manufactured by NOF CORPORATION)
-N-lauroyl-N-methyl-β-alanine sodium (NOF CORPORATION "Softilt AS-L (trade name)")
-N-Lauroyl aspartate sodium solution (20% by weight) ("Aminoformer FLDS-L (trade name)" manufactured by Asahi Kasei Fine Chemicals Co., Ltd.)
(A) Other surfactants ・ PEG-60 hydrogenated castor oil (polyoxyethylene hydrogenated castor oil; Nikko Chemicals Co., Ltd. “NIKKOL HCO-60 (trade name)”)
・ Sodium laurate (NOF CORPORATION "Non-Sal LN-1 (trade name)"
・ Cocamide DEA ("Amisol CDE-G (trade name)" manufactured by Kawaken Fine Chemicals Co., Ltd.)

About the prepared skin cleaning composition, 15 subjects evaluated the detergency, the anti-stickiness property, the skin irritation reduction property, and the moisturizing deficiency suppression property. Specifically, each skin cleaning composition is impregnated into a disposable towel (nonwoven fabric), and the subject wipes the entire body once a day for 7 days, and after cleaning once (after use on the first day). ) And after 7 times of wiping (after 7 days of continuous use), the detergency (dirt removal feeling), the anti-sticky feeling of the skin after wiping, the skin irritation reduction property and the moisturizing deficiency suppression property. We got answers about "good" or "not good". The subjects did not bathe or shower the parts other than the hair, but only wiped with each skin cleaning composition. The number of "good" responses was classified based on the following criteria, and the characteristics of each were evaluated. The results are shown in Tables 1 and 2.

◎: 13 or more people answered good ○: 9 to 12 people answered good △: 6 to 8 people answered good ×: 3 to 5 people answered good × ×: 2 or less people answered that it is good

As shown in Tables 1 and 2, in the skin cleaning composition (Comparative Examples 2 to 5) containing a surfactant other than the naturally occurring surfactant and the amino acid-based surfactant at a concentration of 0.025 to 2% by weight. A composition for skin cleaning containing a naturally occurring surfactant and an amino acid-based surfactant at a concentration of 0.025 to 2% by weight, which is not sufficiently observed to reduce skin irritation and suppress insufficient moisturization (Comparative Examples 6 to 6). In 11), no detergency was observed, and in the skin cleaning composition of Comparative Example 10, a sticky feeling was also remarkable. On the other hand, 0.025 to 2% by weight of a naturally-derived surfactant containing an amphipathic ester (Comparative Example 1), which does not show detergency and stickiness-suppressing property alone, and does not have skin irritation reducing property and moisturizing deficiency suppressing property, In the skin cleaning compositions (Examples 1 to 18) containing the above-mentioned and amino acid-based surfactants, the detergency was improved, the skin irritation reduction property and the moisturizing deficiency suppression property were improved, and the stickiness suppression property was also good. It was.

Claims

A skin bath containing (A) a naturally occurring surfactant and / or an amino acid-based surfactant and (B) an amphipathic ester, and the content of the component (A) is 0.025 to 2% by weight. Wiping composition.
According to claim 1, the component (B) is selected from the group consisting of a dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester, a dicarboxylic acid dialkoxyalkyl ester, and a (icosane diic acid / tetradecane diic acid) polyglyceryl-10. The described skin cleaning composition.
The composition for skin cleaning according to claim 2, wherein the dicarboxylic acid bis (polyoxyalkylene alkyl ether) ester is cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol.
The skin cleaning composition according to any one of claims 1 to 3, wherein the component (A) is selected from the group consisting of glycerophospholipids, saponins, and lipopeptides.
The skin cleaning composition according to claim 4, wherein the glycerophospholipid is selected from the group consisting of lecithin, lysolecithin, and hydrogenated lecithin.
The composition for skin cleaning according to claim 4, wherein the lipopeptide is selected from the group consisting of surfactin and a salt thereof.
The skin-cleaning composition according to any one of claims 1 to 6, which is applied to a person whose bathing and / or shower is restricted for a plurality of days.