TW202031684A - Fn14抗體及其用途 - Google Patents

Fn14抗體及其用途 Download PDF

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Publication number
TW202031684A
TW202031684A TW108146550A TW108146550A TW202031684A TW 202031684 A TW202031684 A TW 202031684A TW 108146550 A TW108146550 A TW 108146550A TW 108146550 A TW108146550 A TW 108146550A TW 202031684 A TW202031684 A TW 202031684A
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TW
Taiwan
Prior art keywords
seq
cdr
amino acid
acid sequence
antibody
Prior art date
Application number
TW108146550A
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English (en)
Chinese (zh)
Inventor
宋愛華
安德魯 約翰 麥肯奈特
瑞吉兒 索洛夫 納金特
約翰 洛卡 勞登斯拉格
約瑟佩 德斯蒂托
薩拉 薩瑞斯 貝克
小川進也
山崎雄司
大衛 米爾斯
阿魯納 碧然得
德克 邁克爾 扎伊翁茨
Original Assignee
日商協和麒麟股份有限公司
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Application filed by 日商協和麒麟股份有限公司 filed Critical 日商協和麒麟股份有限公司
Publication of TW202031684A publication Critical patent/TW202031684A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108146550A 2018-12-20 2019-12-19 Fn14抗體及其用途 TW202031684A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862782912P 2018-12-20 2018-12-20
US62/782,912 2018-12-20

Publications (1)

Publication Number Publication Date
TW202031684A true TW202031684A (zh) 2020-09-01

Family

ID=69159866

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108146550A TW202031684A (zh) 2018-12-20 2019-12-19 Fn14抗體及其用途

Country Status (7)

Country Link
US (1) US12234292B2 (https=)
EP (1) EP3898687A1 (https=)
JP (1) JP7548907B2 (https=)
AU (1) AU2019402163A1 (https=)
CA (1) CA3124356A1 (https=)
TW (1) TW202031684A (https=)
WO (1) WO2020128927A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240092916A1 (en) * 2021-01-13 2024-03-21 Astellas Pharma Inc. MULTISPECIFIC ANTIBODY BINDING TO ActRIIA, ActRIIB, AND Fn14
WO2022155705A1 (en) * 2021-01-20 2022-07-28 La Trobe University Humanized fn14-binding proteins and uses thereof

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Also Published As

Publication number Publication date
US20220289857A1 (en) 2022-09-15
AU2019402163A1 (en) 2021-07-08
JP7548907B2 (ja) 2024-09-10
JP2022514903A (ja) 2022-02-16
CA3124356A1 (en) 2020-06-25
US12234292B2 (en) 2025-02-25
WO2020128927A1 (en) 2020-06-25
EP3898687A1 (en) 2021-10-27

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