TW202028190A - 用於治療hbv之5員雜芳甲醯胺化合物 - Google Patents

用於治療hbv之5員雜芳甲醯胺化合物 Download PDF

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TW202028190A
TW202028190A TW108138129A TW108138129A TW202028190A TW 202028190 A TW202028190 A TW 202028190A TW 108138129 A TW108138129 A TW 108138129A TW 108138129 A TW108138129 A TW 108138129A TW 202028190 A TW202028190 A TW 202028190A
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alkyl
methyl
aia
amino
chloro
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TW108138129A
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Chinese (zh)
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賽門 尼可拉斯 海德
立平 李
馬克 Ｇ 布爾斯
魯派 瑞伊
林恩 班尼
麥可 沃克
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美商艾森伯利生物科學公司
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/20—Antivirals for DNA viruses
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW108138129A 2018-10-22 2019-10-22 用於治療hbv之5員雜芳甲醯胺化合物 TW202028190A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862748906P 2018-10-22 2018-10-22
US62/748,906 2018-10-22
US201962858790P 2019-06-07 2019-06-07
US62/858,790 2019-06-07

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TW202028190A true TW202028190A (zh) 2020-08-01

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US (2) US11560370B1 (https=)
EP (1) EP3870296A1 (https=)
JP (1) JP2022508953A (https=)
KR (1) KR20210095143A (https=)
CN (1) CN113195055A (https=)
AU (1) AU2019364352A1 (https=)
BR (1) BR112021007602A2 (https=)
CA (1) CA3117449A1 (https=)
IL (1) IL282433A (https=)
MA (1) MA53983A (https=)
MX (1) MX2021004580A (https=)
PH (1) PH12021550887A1 (https=)
SG (1) SG11202104086PA (https=)
TW (1) TW202028190A (https=)
WO (1) WO2020086533A1 (https=)

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US20230295096A1 (en) * 2020-04-22 2023-09-21 Assembly Biosciences, Inc. Pyrazole carboxamide compounds for treatment of hbv
CA3180706A1 (en) * 2020-04-22 2021-10-28 Assembly Biosciences, Inc. 5-membered heteroaryl carboxamide compounds for treatment of hbv
JP2023551474A (ja) * 2020-11-25 2023-12-08 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の処置および予防のための芳香族架橋環アミド誘導体
WO2023069547A1 (en) * 2021-10-20 2023-04-27 Assembly Biosciences, Inc. 5-membered heteroaryl carboxamide compounds for treatment of hbv
CN118339163A (zh) * 2021-10-20 2024-07-12 组装生物科学股份有限公司 新的晶型
WO2023105481A1 (en) * 2021-12-10 2023-06-15 Assembly Biosciences, Inc. Pharmaceutical compositions for the treatment of hbv
EP4665330A1 (en) * 2023-02-17 2025-12-24 Merck Sharp & Dohme LLC Plasma kallikrein inhibitors
KR102827002B1 (ko) * 2023-06-28 2025-06-30 국립순천대학교산학협력단 신규한 마리노바자난 화합물 및 이를 포함하는 암 전이 및 침윤 억제, 또는 암 치료용 조성물
WO2025029961A1 (en) * 2023-07-31 2025-02-06 Makscientific, Llc Pharmaceutical compositions, and preparation and methods of use thereof
CN117603089A (zh) * 2023-11-29 2024-02-27 南通瑞合达医药科技有限公司 一种环戊腈的合成方法

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AU2019364352A1 (en) 2021-06-03
US12030869B2 (en) 2024-07-09
KR20210095143A (ko) 2021-07-30
EP3870296A1 (en) 2021-09-01
BR112021007602A2 (pt) 2021-07-27
WO2020086533A1 (en) 2020-04-30
SG11202104086PA (en) 2021-05-28
US20240150324A1 (en) 2024-05-09
CN113195055A (zh) 2021-07-30
JP2022508953A (ja) 2022-01-19
MA53983A (fr) 2021-12-15
PH12021550887A1 (en) 2022-02-21
MX2021004580A (es) 2021-09-08
CA3117449A1 (en) 2020-04-30
IL282433A (en) 2021-06-30
US11560370B1 (en) 2023-01-24

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