KR20210095143A - Hbv의 치료를 위한 5원 헤테로아릴 카르복스아미드 화합물 - Google Patents

Hbv의 치료를 위한 5원 헤테로아릴 카르복스아미드 화합물 Download PDF

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KR20210095143A
KR20210095143A KR1020217015135A KR20217015135A KR20210095143A KR 20210095143 A KR20210095143 A KR 20210095143A KR 1020217015135 A KR1020217015135 A KR 1020217015135A KR 20217015135 A KR20217015135 A KR 20217015135A KR 20210095143 A KR20210095143 A KR 20210095143A
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methyl
mmol
amino
chloro
alkyl
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사이먼 니콜라스 헤이더
레핑 리
마크 쥐. 버스
루파 레이
린 반넨
미카엘 월커
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어셈블리 바이오사이언시스, 인크.
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020217015135A 2018-10-22 2019-10-22 Hbv의 치료를 위한 5원 헤테로아릴 카르복스아미드 화합물 Withdrawn KR20210095143A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862748906P 2018-10-22 2018-10-22
US62/748,906 2018-10-22
US201962858790P 2019-06-07 2019-06-07
US62/858,790 2019-06-07
PCT/US2019/057362 WO2020086533A1 (en) 2018-10-22 2019-10-22 5-membered heteroaryl carboxamide compounds for treatment of hbv

Publications (1)

Publication Number Publication Date
KR20210095143A true KR20210095143A (ko) 2021-07-30

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KR1020217015135A Withdrawn KR20210095143A (ko) 2018-10-22 2019-10-22 Hbv의 치료를 위한 5원 헤테로아릴 카르복스아미드 화합물

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US (2) US11560370B1 (https=)
EP (1) EP3870296A1 (https=)
JP (1) JP2022508953A (https=)
KR (1) KR20210095143A (https=)
CN (1) CN113195055A (https=)
AU (1) AU2019364352A1 (https=)
BR (1) BR112021007602A2 (https=)
CA (1) CA3117449A1 (https=)
IL (1) IL282433A (https=)
MA (1) MA53983A (https=)
MX (1) MX2021004580A (https=)
PH (1) PH12021550887A1 (https=)
SG (1) SG11202104086PA (https=)
TW (1) TW202028190A (https=)
WO (1) WO2020086533A1 (https=)

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CA3180706A1 (en) * 2020-04-22 2021-10-28 Assembly Biosciences, Inc. 5-membered heteroaryl carboxamide compounds for treatment of hbv
JP2023551474A (ja) * 2020-11-25 2023-12-08 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の処置および予防のための芳香族架橋環アミド誘導体
WO2023069547A1 (en) * 2021-10-20 2023-04-27 Assembly Biosciences, Inc. 5-membered heteroaryl carboxamide compounds for treatment of hbv
CN118339163A (zh) * 2021-10-20 2024-07-12 组装生物科学股份有限公司 新的晶型
WO2023105481A1 (en) * 2021-12-10 2023-06-15 Assembly Biosciences, Inc. Pharmaceutical compositions for the treatment of hbv
EP4665330A1 (en) * 2023-02-17 2025-12-24 Merck Sharp & Dohme LLC Plasma kallikrein inhibitors
KR102827002B1 (ko) * 2023-06-28 2025-06-30 국립순천대학교산학협력단 신규한 마리노바자난 화합물 및 이를 포함하는 암 전이 및 침윤 억제, 또는 암 치료용 조성물
WO2025029961A1 (en) * 2023-07-31 2025-02-06 Makscientific, Llc Pharmaceutical compositions, and preparation and methods of use thereof
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US12030869B2 (en) 2024-07-09
EP3870296A1 (en) 2021-09-01
BR112021007602A2 (pt) 2021-07-27
WO2020086533A1 (en) 2020-04-30
SG11202104086PA (en) 2021-05-28
US20240150324A1 (en) 2024-05-09
CN113195055A (zh) 2021-07-30
JP2022508953A (ja) 2022-01-19
MA53983A (fr) 2021-12-15
PH12021550887A1 (en) 2022-02-21
MX2021004580A (es) 2021-09-08
CA3117449A1 (en) 2020-04-30
IL282433A (en) 2021-06-30
TW202028190A (zh) 2020-08-01
US11560370B1 (en) 2023-01-24

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