TW202011932A - Anti-dandruff shampoo - Google Patents

Abstract

The present invention provides an anti-dandruff shampoo comprising the following components: Zinc Pyrithione, Climbazole, and wet-combing agents.

Description

Anti-dandruff shampoo

The invention relates to an anti-dandruff shampoo, in particular to a shampoo with dual anti-dandruff ingredients.

At present, anti-dandruff shampoos are mainly based on a single anti-dandruff ingredient, which cannot inhibit the reproduction of odor-causing microorganisms, and can not achieve the function of indeed long-term anti-dandruff. The anti-dandruff ingredients are usually powder particles, which are easy to clean during washing. Makes hair dry and rough. If you encounter high-damage hair, it will be more likely to be tangled.

Pyridinethione salt has a good anti-dandruff effect, so it has been adopted as a legal shampoo ingredient. However, shampoo-related products containing pyrithione salts tend to make the hair feel dry during shampooing and moisturizing. Since modern people are paying more and more attention to hair care, if there is dryness in shampooing and moisturizing Feelings, tangled hair during washing, or hair feels sticky and thick after drying, users will think that the hair has been damaged. Therefore, when using a shampoo composition containing pyrithione salt, how to reduce the feeling of dry hair is the key to consider when developing shampoo.

Therefore, it is quite necessary to develop a shampoo that has an excellent anti-dandruff effect, and that the hair no longer feels dry during shampooing and moisturizing, and is no longer sticky and hard after drying.

In view of this, the present invention provides a shampoo with dual anti-dandruff ingredients, so that the two anti-dandruff ingredients can be stably present in the shampoo base, effectively using the minimum inhibitory concentration to inhibit the activity of scalp microorganisms, which can effectively inhibit S.epidermis, C.minutissimum, S.haemolyticus, C.xerosis, M.luteus and other strains, and the addition of wet comb conditioning agent Plantasil ^® 4V to increase its wet combability, the fusion of hydrophilic formulations is improved.

The present invention provides an anti-dandruff shampoo, which contains the following ingredients: Zinc Pyrithione, Climbazole, Wet Comb Conditioner (Plantasil ^® 4V), wherein Wet Comb Conditioner (Plantasil ^® 4V) contains PEG-40 Hydrogenated Castor Oil (and) PEG-7 Glyceryl Cocoate (and) PEG/PPG-120/10 Trimethylolpropane Trioleate (and) Glycerin.

Preferably, the concentration of Zinc Pyrithione is 0.01wt% to 2wt%, the concentration of Climbazole is 1wt% to 5wt%, the wet comb conditioner (Plantasil ^® The concentration of 4V) is 0.5wt% to 4wt%.

Preferably, the aforementioned shampoo further includes menthol (Menthol), vitamin B5 (Panthenol), Myramaze ^® 9834, sodium hyaluronate (Sodium Hyaluronate), keratin hydrolysate KERA TEIN NPNF ^TM or dipotassium glycyrrhizinate (Dipotassium Glycyrrhizate).

In summary, the present invention solves the problem that the prior art cannot inhibit the reproduction of odorous microorganisms, and it is impossible to achieve indeed long-term anti-dandruff, and improves the product's anti-dandruff for only a short time, and solves the problem of hair tangles during the washing process , Especially to overcome the problem of tangled hair used in cold water washing.

Figure 1 is a graph of the water-soluble shampoo of the present invention; Figures 2A and 2B are photos of the water-soluble shampoo of the present invention; Figure 3 is a general hyaluronic acid of Example 1 of the present invention Compared with low-molecular-weight hyaluronic acid skin conductivity; Figures 4A and 4B are the anti-inflammatory effects of MYRAMAZE ^® LS 9834 on keratinocytes; Figure 5 is the shampoo and other ingredients of the present invention with fresh and fluffy effects The market survey results of the brand shampoos in terms of freshness and anti-dandruff; Figure 6 is the market survey results of the present invention shampoos with moisturizing and softening effect raw materials and other brand shampoos in terms of moisturizing and softening; 7 is the market survey results of the oil shampoo and other brand shampoos with oil control and antipruritic functions of the present invention in terms of oil control and antipruritic.

The invention provides a shampoo with dual anti-dandruff ingredients, and allows the two anti-dandruff ingredients to be stably present in the shampoo base. Effectively inhibit microbial activity, use the minimum inhibitory concentration to achieve antibacterial effect, can effectively inhibit microorganisms such as S.epidermis, C.minutissimum, S.haemolyticus, C.xerosis, M.luteus, and add Plantasil ^® 4V to increase its wet combability. The fusion degree of hydrophilic formula is improved.

The present invention provides an anti-dandruff shampoo, which contains the following components: zinc zinc pyrithione (Zinc Pyrithione), clomiprazole (Climbazole) and wet comb conditioning agent (Plantasil ^® 4V), wherein the wet comb conditioning agent (Plantasil ^® 4V) contains PEG-40 Hydrogenated Castor Oil (and) PEG-7 Glyceryl Cocoate (and) PEG/PPG-120/10 Trimethylolpropane Trioleate (and) Glycerin.

In the preferred embodiment, the zinc pyrithione (Zinc Pyrithione) the concentration of 0.01wt% based to 2wt%, the climbazole (the climbazole) the concentration of 1wt% to based 5wt%, of the Plantasil ^® 4V The concentration ranges from 0.5wt% to 4wt%.

In a preferred embodiment, the aforementioned shampoo further includes menthol (Menthol), vitamin B5 (Panthenol), Myramaze ^® 9834, sodium hyaluronate, sodium keratin hydrolysate KERA TEIN NPNF ^TM or glycyrrhizin di Potassium (Dipotassium Glycyrrhizate).

Zinc Pyrithione is a legally effective anti-dandruff ingredient; Climbazole: a legally effective anti-dandruff ingredient; ANTI-DANDRUFF: anti-dandruff; Plantasil ^® 4V: Wet comb conditioning agent; MYRAMAZE LS 9834: Propolis extract, anti-inflammatory; Dipotassium Glycyrrhizate: Anti-allergic ingredient; KERA TEIN NPNF ^TM : Hydrolyzed keratin, which can repair damaged hair.

Example 1. The main ingredients of anti-dandruff shampoo

Please refer to Table 1 and Table 2. Table 1 shows the typical minimum bacteriostatic concentration of Climbazole and Zinc Pyrithione on the skin surface. Table 2 shows the main ingredients of the anti-dandruff shampoo of the present invention. Zinc Pyrithione, Climbazole and Plantasil ^® 4V are added percentage.

The addition of Plantasil ^® 4V in the present invention can improve the solubility of shampoo. For its solubility, refer to Figure 1. Compare the intensity of light scattered by a water sample and a standard reference turbidity suspension to a specific light source to determine the turbidity and scattering of the water sample. The greater the light intensity, the greater the turbidity. It can be found in the figure that the shampoo stabilizer and the addition of Plantasil ^® 4V have the ability to reduce the turbidity, but it can be seen from the figure that the addition of Plantasil ^® 4V is in the scattered light The intensity is significantly lower, indicating that the liquid is easier to penetrate and the clarity is higher. The photos of its dissolution in water are shown in Figures 2A and 2B. The picture on the left of 2A is the formula for adding 4V, and the picture on the right of 2A is the addition of stabilizer for general shampoo. Picture 2B shows that at the same X700 magnification from a high-magnification microscope, 2B left 4V significantly improves the turbidity and dilution at dilution "Cohesive" volume improves the clarity of the overall formula.

Example 2: Shampoo formula providing freshness and fluffiness

Please refer to Table 3, which shows that the present invention further provides shampoos with raw materials for cooling and fluffy effects. In the composition disclosed in Example 1, the addition of menthol (Menthol) can provide a cooling effect, in addition to vitamin B5 (Panthenol). Hair conditioner moisturizing and softening agent, can gradually enter the hair stalk, and within one to two days after rinsing, the sebum becomes soft, to moisturize the hair for a long time, avoid dry and split.

Conduct market research on shampoos with raw materials with cool and fluffy effect and other brand shampoos, and compare the user experience after use. The results are shown in the fifth figure. Among them, ZP395 is a commercially available other brand competing product, and ZP831 is The shampoo and ZP542 disclosed in the second embodiment are competing products from other brands on the market. Users generally believe that the shampoo ZP831 of the present invention has better feedback after cooling than other brands of shampoo, good cooling preference, good rinsing and non-stickiness, dryness and bulkiness, and overall satisfaction.

Example 3: A shampoo formula that provides moisturizing and supple effects

Please refer to Table 4 to show that the present invention further provides shampoos with moisturizing and softening ingredients. In the composition disclosed in Example 1, ultra-low molecular hyaluronic acid (sodium hyaluronate) is added to penetrate deeply into the hair to make hyaluronic acid A uniform film is formed on the surface of the hair, and then keratin (KERA TEIN NPNF ^TM ) is used to moisturize and smooth the hair. Unlike other proteins, keratin is rich in cysteine (sulfur-containing amino acids) and covalently cross-linked into disulfide bonds. Gives keratin unique strength and protective properties, which can be used to repair damage on hair. KERA TEIN NPNF ^TM has a protective colloid effect, which can reduce the irritation caused by lotions and other harsh products, making the shampoo of the present invention Good moisture binding ability, can restore damaged hair to luster.

Generally, the electrical conductivity of hyaluronic acid and low-molecular-weight hyaluronic acid are compared. The results are shown in Figure 3. Using the principle of high dielectric constant, the dielectric constant of water and other substances changes considerably. , The higher the dielectric constant, so the higher the dielectric constant, the better the water retention.

Attach the gauze soaked in 1% hyaluronic acid liquid to the human skin for 24 hours, then pick up the gauze, test the conductivity value, and continue to measure 1 to 3 days after separation. The larger the value, the more the skin moisture content. high. From the results revealed in Figure 3, it can be found that the 1% low-molecular-weight hyaluronic acid maintains its conductivity value at about 8 μs with the increase of days, and the general hyaluronic acid can be seen on the third day. A sharp drop, showing that the general hyaluronic acid is less capable of maintaining moisture than the ultra-low molecular hyaluronic acid. It can be seen from the skin conductivity value through the three-day experiment that the effect of low molecular hyaluronic acid is better than that of general hyaluronic acid.

Conduct market research on shampoos with moisturizing and softening ingredients and shampoos of other brands, and compare the user's experience after use. The results are shown in the sixth figure, in which QP428 is a commercially available brand-name competitive product and QP953 is a commercially available product. The brand competing products and QP319 are shampoos shown in the third embodiment. Users generally believe that the shampoo QP319 of the present invention has better odor preference, inner consistency, inner color and overall satisfaction feedback response than other brands of shampoo.

Embodiment 4 A shampoo formula that provides oil control and antipruritic effects

Please refer to Table 5 to show that the present invention further provides a shampoo with raw materials for controlling oil and itching. In the composition disclosed in Example 1, the addition of propolis extract (MYRAMAZE ^® LS 9834) can balance the secretion of scalp oil, and at the same time can prevent inflammation Dipotassium Glycyrrhizate is added. Glycyrrhizic acid contains glycyrrhetinic acid and glucuronic acid. Its anti-allergic and anti-itch function is the most important pharmacological effect of glycyrrhizic acid. Glycyrrhizin can inhibit the synthesis and release of prostaglandins (PGs) by phospholipids required for the hydrolysis of amino acids.

MYRAMAZE ^® LS 9834 anti-inflammatory test steps and results are shown in Figures 4A and 4B. MYRAMAZE ^® LS 9834 has a strong anti-inflammatory effect on keratinocytes.

As shown in Figure 4A, it is an experimental method for testing anti-inflammation. Inoculate human keratinocytes in standard culture medium and incubate at 37°C for 3 days, carbon dioxide = 5%, and irradiate the tested product with UVB light, (0, 30 millimeters per square centimeter) Joule, incubate at 37°C for 1 day, carbon dioxide = 5%), and finally measure the number of cells and the LDH released (an enzyme related to glucose metabolism, widely distributed in various organs of the body, LDH will be released when the body cells are injured ) And PGE2 (prostaglandin E2: is an important cell growth and regulation factor, the concentration will be significantly increased in inflamed tissues).

As shown in Figure 4B, the experiment first differentiated the keratinocytes. The Cell number group was the initial amount of cells. The cells were inflamed by UVB irradiation. Compare with the application of universal anti-inflammatory drugs (aspirin, indomethacin) and The anti-inflammatory effect of MELLIDYN® LS 9834, for reducing the amount of LDH and PGE2 released, it can be seen that the addition of 0.1% MELLIDYN® LS 9834 shows a strong anti-inflammatory effect on keratinocytes.

Conduct market research on the shampoos with oil control and anti-itching ingredients and other brands of shampoos, and compare the user experience after use. The results are shown in the seventh figure, in which XP328 is the shampoo disclosed in Example 4 and XP672 is It is a commercially available other brand competitive product, XP735 is a commercially available other brand competitive product. Users generally believe that the shampoo XP328 of the present invention has better odor preference, inner color, inner thickness, wet combability and overall satisfaction feedback response than other brands of shampoo.

All the features disclosed in the present invention should be implemented in any combination. Each feature disclosed in the present invention should be replaced by a substitute for the same, equal or similar purpose. Therefore, unless explicitly specified, each feature disclosed is merely an embodiment of a class of equivalents or similar features.

Claims (12)

An anti-dandruff shampoo comprising the following components: zinc pyrithione (Zinc Pyrithione), monochlorimazole (Climbazole) and a wet comb conditioning agent. The shampoo as described in item 1 of the patent application scope, wherein the wet comb conditioner comprises a PEG-40 Hydrogenated Castor Oil, a PEG-7 Glyceryl Cocoate, a PEG/PPG-120/10 Trimethylolpropane Trioleate and a Glycerin. The shampoo as described in item 1 of the patent application scope, wherein the concentration of the zinc pyrithione zinc (Zinc Pyrithione) is 0.01wt% to 2wt%, and the concentration of the clombrazole (Climbazole) is 1wt% to 5wt%, the concentration of the wet comb conditioning agent is 0.5wt% to 4wt%. The shampoo as described in item 1 of the patent application scope, wherein the shampoo contains a menthol or a vitamin B5. The shampoo as described in item 4 of the patent application scope, wherein the concentration of the menthol is 0.1 wt% to 3 wt%. The shampoo as described in item 4 of the patent application scope, wherein the concentration of the vitamin B5 is 0.01wt to 2wt%. The shampoo according to item 1 of the patent application scope, wherein the shampoo contains sodium hyaluronate or keratin. The shampoo according to item 7 of the patent application scope, wherein the concentration of the sodium hyaluronate is 0.1wt% to 3wt%. The shampoo as described in item 7 of the patent application scope, wherein the concentration of the keratin is 0.01wt to 2wt%. The shampoo as described in item 1 of the patent application scope, wherein the shampoo contains a propolis extract or dipotassium monoglycyrrhizinate. The shampoo according to item 10 of the patent application scope, wherein the concentration of the propolis extract is 0.01 wt% to 2 wt%. The shampoo as described in item 10 of the patent application scope, wherein the concentration of the dipotassium glycyrrhizinate is 0.01wt to 2wt%.

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