CN104800894A - Formula and preparation method of human lubricant - Google Patents
Formula and preparation method of human lubricant Download PDFInfo
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- CN104800894A CN104800894A CN201510214935.4A CN201510214935A CN104800894A CN 104800894 A CN104800894 A CN 104800894A CN 201510214935 A CN201510214935 A CN 201510214935A CN 104800894 A CN104800894 A CN 104800894A
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Abstract
The invention belongs to the field of human lubricants, and relates to a formula and a preparation method of a human lubricant. The formula comprises the following components in parts by mass: 0.05-0.5 parts of tremella polysaccharide and 0.1-1.5 parts of preservative. The preparation method of the vaginal lubricant comprises the steps that polyacrylamide resin, glycerol, propylene glycol and 1,3-butanediol are sufficiently mixed; an aqueous medium is uniformly mixed; the preservative is added; and the human lubricant is obtained. Compounded agents used by the natural antibacterial lubricant are good in lubrication, mild in property, colorless and odorless, have no adverse effect on a human, have antibacterial and anti-inflammatory action, can be dissolved in water, are convenient to clean, and cannot remain on the surface of human skin, so that the lubricant is safe and effective.
Description
Technical field
The invention belongs to human body lubricants field, relate to a kind of formula and preparation method of human body lubricants.
Background technology
Cumulative along with the age, each organ of human body is old and feeble gradually, particularly the arrival of Woman climacteric, women is transitioned into the old stage from the childbearing age, and ovarian function is faded, decrease in estrogen, human secretory decline, thus has a strong impact on the quality that man and wife asks sexual life.Separately there is some young woman to suffer from colpoxerosis, bring many difficulties to life.Enter in the process of tract at medical apparatus and instruments (diagnostor such as endoscope, colposcope, cervical clamps, medical catheter), often need to be coated with appropriate lubricant at medical apparatus surface, to reduce the damage of apparatus to tissue.The human body lubricants Main Ingredients and Appearance gone on the market has glycerol, mineral oil, paraffin oil, vaseline, estrogen etc., and what these compositions had only has viscosity, the lubricity do not had, and the not sliding sense of tool, as glycerol; Though what have has certain lubricity, there is side effect to human body, also not easy-clear, as vaseline and derivant thereof; And paraffin oil, mineral oil have certain zest to human body skin, be difficult to cleaning after using, often can remain in skin surface.In addition, some composition in these lubricants is also harmful, and frequent use easily produces ill symptoms, and causes inflammation and easy mould growth.Be badly in need of wanting a kind of safe and effective lubricant to be replaced.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of compositions of lubricating vagina or male genital organ, said composition is simulated humanbody secretions, has lubricious sense.
For achieving the above object, technical scheme of the present invention is:
For lubricating the compositions of vagina, comprise following component according to mass parts meter: tremella polysaccharide 0.05 ~ 0.5 part, antiseptic 0.1 ~ 1.5 part.Tremella polysaccharide moistening effect in this programme is good, and its moisture-keeping function principle forms hydrogen bond by numerous terminal hydroxyl and water molecules, thus in conjunction with a large amount of water, forms a spongiform structure of molecule in space.Such moisturizing principle has also been fitted the popular trend of current state-of-the art water absorption wetting agent.By 0.2g tremella polysaccharide powder dispersion in 100g distilled water, swelling is after 2 hours, and aqueous solution is through No. 2 filter paper filterings, and natural filtration 10 minutes, weighs to the gel section on filter paper.Result shows, and most water is all firmly held by tremella polysaccharide, and the water holding capacity of tremella polysaccharide is close to 500 times.In addition, its film property is good, and we test confirmation, is placed in evaporating dish by the aqueous solution of tremella polysaccharide and hyaluronate sodium and carries out drying, form the film of 15mm x15mm.Then be placed on (temperature 25 DEG C, relative humidity 87%) on the plate of politef, keep after 24 hours, condition changes temperature 25 DEG C, relative humidity 15% into, keeps 8 hours.Measure the change of membrane area.Experimental result shows, the film shrinkage factor of tremella polysaccharide is only 10%, and the film shrinkage factor of hyaluronate sodium almost reaches half, proves that tremella polysaccharide film does not shrink with the change of humidity, so do not have tight sensation.Each for the solution of 1% 0.5g is coated in (30mm x 30mm square) on OHP thin slice respectively, same thickness, under the condition of temperature 25 DEG C, relative humidity 40% dry (in order to see, film having spilt TiO2 powder).Result forms a lot of slight crack on the film of hyaluronate sodium, but does not almost form slight crack on the film of tremella polysaccharide.Illustrate that the film of tremella polysaccharide has more elasticity than the film of hyaluronate sodium.In addition, its antioxidant effect is good, with HA unlike, tremella polysaccharide except there is fabulous water retention, can also the activity of inhibit activities oxygen, improve the activity of SOD enzyme in Skin Cell, play antioxidative effect.From the skin of rat, isolate horn cell and fibrocyte is cultivated, add tremella polysaccharide in the medium.Cultivate after 24 hours, at 37 DEG C, in the C02 of 5%, measure the activity of SOD.Prove by experiment, add the tremella polysaccharide of more than 0.1% at horn cell (Keratinocyte), the activity of SOD improves.Add the tremella polysaccharide of more than 0.05% at fibrocyte (Fibroblast), the activity of SOD improves.Therefore, tremella polysaccharide has high moistening effect and film property, is used in electrical conductivity skin can improving skin, and effectively prevent the evaporation of moisture and virus and air in toxic dust from skin pore, invade the harm caused human body.Tremella polysaccharide has excellent efficient skin care, shows antioxidative effect with the experiment in vitro that Skin Cell does.Tremella polysaccharide aqueous solution has very high viscosity, but the sensation of not adhering.The viscosity of aqueous solution has very high stability to acid, alkali and salt.Tremella polysaccharide has good affinity to skin, makes skin become moistening, smooth.
Two of object of the present invention is to provide a kind of human body lubricants, can Rapid Cleaning after this human body lubricants uses.
For achieving the above object, technical scheme of the present invention is:
Human body lubricants containing described compositions, composed of the following components according to mass parts meter: the glycerol of 0.1 ~ 10 part, the propylene glycol of 0.1 ~ 5 part, 0.1 ~ 10 part 1,3 butylene glycol, 0.05 ~ 0.5 part tremella polysaccharide, 0.1 ~ 1.8 part containing polyacrylamide resin, the xanthan gum of 0.1 ~ 0.8 part, the antiseptic and inhibiting bacteria function agent of 0.1 ~ 1.5 part and aqueous medium.Prove through our previous experiments, glycerol and tremella polysaccharide conjunctive use, synergism can be produced in lubrication sense.
Further, described human body lubricants, composed of the following components according to mass parts meter: the glycerol of 5 parts, the propylene glycol of 2.5 parts, 7 parts 1,3 butylene glycol, 0.3 part tremella polysaccharide, 1.2 parts containing polyacrylamide resin, the xanthan gum of 0.4 part, the antiseptic and inhibiting bacteria function agent of 0.8 part and aqueous medium.
Further, in described human body lubricants, the mass percentage concentration of described tremella polysaccharide is 0.05 ~ 0.5%.
Further, in described human body lubricants, described antiseptic be poly hexamethylene biguanide, Pericarpium Zanthoxyli extracting solution, Radix Pulsatillae root extracting solution, must one or more in Luo Song extracting solution.Poly hexamethylene biguanide belongs to environment-friendly type macromolecule polymer disinfection sanitizer, has broad-spectrum; Valid density is low; Speed of action is fast; Stable in properties; Premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Non-corrosiveness; Colourless, odorless; Nontoxic; Do not fire, not quick-fried, use safety; Moderate; Convenient transportation, can be described as best antibacterial.Pericarpium Zanthoxyli extract in component be obtain from Pericarpium Zanthoxyli refining in containing multiple unsaturated fatty acid, as Fructus Citri Limoniae oil 58%, citron 22%, Beta phellandrene 6.4%, the mixture of cineol 2.2% and terpinolene 1.4% etc.There are local fiber crops and antagonism escherichia coli, dysentery bacterium, corynebacterium, the effect of dermatophytes etc.Radix Pulsatillae extract in component is that a kind of deciduous perennial herb---Flos Pulsatillae extracts, and has antibacterial action by the soil block area grown in North America and meadow, Asia and pasture.
Poly hexamethylene biguanide in component can have been bought from market; Pericarpium Zanthoxyli extracting solution and Radix Pulsatillae extract extract with reference to method in patent CN102379317A or this area conventional practices, the manufacture method of Pericarpium Zanthoxyli extract: Pericarpium Zanthoxyli is cleaned and dries, after oven dry, add 70% (V/V) alcohol reflux three times, each 5 hours, cooling, filters with Whatman#5 filter paper.The extracting solution filtered, lower than after 50 DEG C of concentrating under reduced pressure, obtains product by lyophilization; The manufacture method of Radix Pulsatillae extract: cleaned by the Radix Pulsatillae and dry, after oven dry, adds 70% (V/V) alcohol reflux three times, each 5 hours, and cooling, filters with Whatman#5 filter paper.The extracting solution filtered, lower than after 50 DEG C of concentrating under reduced pressure, obtains product by lyophilization.The manufacture method of palpus Luo Song extract: must clean and dry by Luo Song, after oven dry, adding 70% (V/V) alcohol reflux three times, each 5 hours, cooling, filters with Whatman#5 filter paper.The extracting solution filtered, lower than after 50 DEG C of concentrating under reduced pressure, obtains product by lyophilization.
Further, in described human body lubricants, described antiseptic is composed of the following components by weight: poly hexamethylene biguanide 0.1 ~ 95 part, Pericarpium Zanthoxyli extracting solution 0.1 ~ 5 part, Radix Pulsatillae root extracting solution 0.1 ~ 5 part, must Luo Song extracting solution 0.1 ~ 5 part.
Further, in described human body lubricants, described antiseptic is composed of the following components by weight: poly hexamethylene biguanide 45 parts, Pericarpium Zanthoxyli extracting solution 3 parts, Radix Pulsatillae root extracting solution 2.5 parts, must Luo Song extracting solution 3 parts.
Three of object of the present invention is the new opplication providing tremella polysaccharide, and this is applied as sexual love process raising enjoyment and provides new solution.
For achieving the above object, technical scheme of the present invention is:
The application of tremella polysaccharide in the medicine for the preparation for the treatment of vagina drying.
Four of object of the present invention is the new method providing a kind of human body lubricants, human body lubricants prepared by this method, and ductility is good.
For achieving the above object, technical scheme of the present invention is:
The method of the human body lubricants described in preparation, specifically comprises the following steps:
Mixing homogeneously with aqueous medium after polyacrylamide resin is fully mixed with glycerol, propylene glycol, 1,3 butylene glycol, and adding antiseptic, obtaining human body lubricants.
Further, in described method, the temperature of described aqueous medium is 90 DEG C ± 5 DEG C.
Natural antibacterial lubricant of the present invention has following good effect: 1, all colourless odorlessness of ingredients that uses of natural antibacterial lubricant of the present invention, and character is gentle, has no adverse reaction, also have antibacterial, antiinflammatory action simultaneously to human body; 2, the ingredients that natural antibacterial lubricant of the present invention uses has superior slip; 3, all ingredients that natural antibacterial lubricant of the present invention uses all can be water-soluble, is convenient to cleaning; Human skin can not be remained in.
Detailed description of the invention
In order to make the object, technical solutions and advantages of the present invention clearly, below the preferred embodiments of the present invention are described in detail.
Embodiment 1
The component of the present invention program 1-6 and content (mass percent) thereof see the following form:
| Scheme 1 | Scheme 2 | Scheme 3 | Scheme 4 | Scheme 5 | Scheme 6 | Remarks | |
| Glycerol | 5 | 10 | 3 | 2 | 4 | 3 | |
| Propylene glycol | 3 | 0 | 2 | 1 | 2 | 2 | |
| 1,3 butylene glycol | 2 | 0 | 3 | 3 | 3 | 5 | |
| Tremella polysaccharide | 0 | 0 | 0.05 | 0.15 | 0.08 | 0.05 | |
| Polyacrylamide resin | 1.1 | 1.12 | 1.0 | 1.05 | 1.1 | 1.15 | |
| Xanthan gum | 0 | 0 | 0.1 | 0.2 | 0.25 | 0.18 | |
| Antiseptic and inhibiting bacteria function agent | 0.5 | 0.3 | 0.4 | 0.5 | 0.6 | 0.35 | |
| Pure water | 88.4 | 88.58 | 90.35 | 92.1 | 88.97 | 88.27 |
A kind of preparation method realizing human body lubricants:
By purified water, be heated to 90 DEG C, obtain component A; Take the glycerol of formula ratio, propylene glycol, 1,3-butanediol, evenly joins polyacrylamide resin in the mixed solution of glycerol, propylene glycol, 1,3 butylene glycol under stirring, continue to stir until polyacrylamide resin disperses completely, obtain B component; B component is added component A under stirring, stirs insulation 30 minutes, natural cooling; Thing temperature to be mixed drops to about about 50 DEG C, and add the mixture of antiseptic and inhibiting bacteria function agent, low rate mixing is cooled to room temperature, obtains natural antibacterial human body lubricants.
Another kind realizes the preparation method of human body lubricants:
By purified water, be heated to 90 DEG C, obtain component A; Take glycerol, polyacrylamide resin is evenly joined in glycerite under stirring, continue to stir until polyacrylamide resin disperses completely, obtain B component; B component is added component A under stirring, stirs insulation 30 minutes, natural cooling; Wait upon mixture temperature and drop to about about 50 DEG C, add the mixture of antiseptic and inhibiting bacteria function agent, low rate mixing is cooled to room temperature, obtains natural antibacterial human body lubricants.
Another preparation method is:
By purified water, be heated to 90 DEG C, obtain component A; Take glycerol, propylene glycol, 1,3 butylene glycol, polyacrylamide resin, tremella polysaccharide, xanthan gum are evenly joined in the mixed solution of glycerol, propylene glycol, 1,3 butylene glycol under stirring, continue to stir until disperse completely, obtain B component; B component is added component A under stirring, stirs insulation 30 minutes, natural cooling; Wait upon mixture temperature and drop to about about 50 DEG C, add the mixture of antiseptic and inhibiting bacteria function agent, low rate mixing is cooled to room temperature, obtains natural antibacterial human body lubricants.
Embodiment 2 effect is tested and assessed
The present invention program 1-6 is estimated, nasil, water white transparency thick liquid, without precipitation: abnormal smells from the patient without exception and foreign body.
One sense organ and physical and chemical index
Sense organ, physical and chemical index
Two microbiological indicators
Three extensive experiments
Medical assistance instrumental examination: the 40 routine patients meeting inclusion criteria use lubricant of the present invention before medical apparatus and instruments checks, result lubricity effect is without significant difference, lubricant effect when all significantly increasing medical apparatus and instruments insertion intracavity alleviates friction injury during insertion, and untoward reaction does not occur.
Sexual life lubricates: the 100 routine patients meeting inclusion criteria, and MethodsThe cases enrolled is between 35 ~ 60 years old, and informed consent this test of voluntary participation is also signed Informed Consent Form and at least meets one of following condition: the sexual life caused because of gynecilogical operation inserts difficulty; The few caused sexual life of the dry and astringent vaginal secretions of the pudendum that climacteric causes inserts difficulty; The insertion difficulty using condom to cause; The sexual life that other unknown causes cause inserts difficulty.Effect shows lubricant of the present invention to be had obvious lubricant effect and can improve the not enough symptom of vaginal lubrication that women causes because of a variety of causes, couple's sexual life satisfaction 100%, and does not find untoward reaction; Clinical confirmation lubricant of the present invention also has antibacterial, antiinflammatory, reparation maintenance effect simultaneously, pathogenic microorganism can be suppressed to grow improve vagina physiological environment to alleviate the symptoms such as the leucorrhoea grow in quantity abnormal flavour pruritus of vagina caused by slight vaginitis; And all ingredients used all can be water-soluble, be convenient to cleaning, can not remain in human skin, be a kind of safe and effective lubricant.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1. for lubricating the compositions of vagina, it is characterized in that, comprising following component according to mass parts meter: tremella polysaccharide 0.05 ~ 0.5 part, antiseptic 0.1 ~ 1.5 part.
2. the human body lubricants containing compositions according to claim 1, it is characterized in that: composed of the following components according to mass parts meter: the glycerol of 0.1 ~ 10 part, the propylene glycol of 0.1 ~ 5 part, 0.1 ~ 10 part 1,3 butylene glycol, 0.05 ~ 0.5 part tremella polysaccharide, 0.1 ~ 1.8 part containing polyacrylamide resin, the xanthan gum of 0.1 ~ 0.8 part, the antiseptic and inhibiting bacteria function agent of 0.1 ~ 1.5 part and aqueous medium.
3. human body lubricants according to claim 3, it is characterized in that: composed of the following components according to mass parts meter: the glycerol of 5 parts, the propylene glycol of 2.5 parts, 7 parts 1,3 butylene glycol, 0.3 part tremella polysaccharide, 1.2 parts containing polyacrylamide resin, the xanthan gum of 0.4 part, the antiseptic and inhibiting bacteria function agent of 0.8 part and aqueous medium.
4. human body lubricants according to claim 3, is characterized in that: the mass percentage concentration of described tremella polysaccharide is 0.05 ~ 0.5%.
5. human body lubricants according to claim 3, is characterized in that: described antiseptic be poly hexamethylene biguanide, Pericarpium Zanthoxyli extracting solution, Radix Pulsatillae root extracting solution, must one or more in Luo Song extracting solution.
6. human body lubricants according to claim 6, it is characterized in that: described antiseptic is composed of the following components by weight: poly hexamethylene biguanide 0.1 ~ 95 part, Pericarpium Zanthoxyli extracting solution 0.1 ~ 5 part, Radix Pulsatillae root extracting solution 0.1 ~ 5 part, must Luo Song extracting solution 0.1 ~ 5 part.
7. human body lubricants according to claim 7, is characterized in that: described antiseptic is composed of the following components by weight: poly hexamethylene biguanide 45 parts, Pericarpium Zanthoxyli extracting solution 3 parts, Radix Pulsatillae root extracting solution 2.5 parts, must Luo Song extracting solution 3 parts.
8. the application of tremella polysaccharide in the medicine for the preparation of alleviation vagina drying.
9. prepare the method for human body lubricants according to claim 2, it is characterized in that, specifically comprise the following steps:
Mixing homogeneously with aqueous medium after polyacrylamide resin is fully mixed with glycerol, propylene glycol, 1,3 butylene glycol, and adding antiseptic, obtaining human body lubricants.
10. method according to claim 9, is characterized in that, the temperature of described aqueous medium is 90 DEG C ± 5 DEG C.
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| CN201510214935.4A CN104800894A (en) | 2015-04-30 | 2015-04-30 | Formula and preparation method of human lubricant |
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| CN201510214935.4A CN104800894A (en) | 2015-04-30 | 2015-04-30 | Formula and preparation method of human lubricant |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581780A (en) * | 2016-10-26 | 2017-04-26 | 成都清科生物科技有限公司 | Lubricating agent, and preparation method and application thereof |
| CN107028825A (en) * | 2017-03-21 | 2017-08-11 | 陕西万维健康咨询服务有限公司 | A kind of new food preservative and application for skin care item |
| CN108653823A (en) * | 2018-05-30 | 2018-10-16 | 安徽省银锂子生物科技发展有限公司 | A kind of water-soluble human body lubricating fluid of long-acting bactericidal |
| CN109674671A (en) * | 2019-01-07 | 2019-04-26 | 广州市拓瑞科技有限公司 | The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid |
| CN111282026A (en) * | 2018-12-07 | 2020-06-16 | 重庆海洁雅润日化用品有限公司 | Sexual lubricant capable of quickly killing various venereal disease pathogens |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106581780A (en) * | 2016-10-26 | 2017-04-26 | 成都清科生物科技有限公司 | Lubricating agent, and preparation method and application thereof |
| CN107028825A (en) * | 2017-03-21 | 2017-08-11 | 陕西万维健康咨询服务有限公司 | A kind of new food preservative and application for skin care item |
| CN108653823A (en) * | 2018-05-30 | 2018-10-16 | 安徽省银锂子生物科技发展有限公司 | A kind of water-soluble human body lubricating fluid of long-acting bactericidal |
| CN108653823B (en) * | 2018-05-30 | 2021-03-23 | 安徽省银锂子生物科技发展有限公司 | Long-acting bactericidal water-soluble human body lubricating liquid |
| CN111282026A (en) * | 2018-12-07 | 2020-06-16 | 重庆海洁雅润日化用品有限公司 | Sexual lubricant capable of quickly killing various venereal disease pathogens |
| CN109674671A (en) * | 2019-01-07 | 2019-04-26 | 广州市拓瑞科技有限公司 | The preparation method of vaginal care composition object and its application and the women secret conditioning liquid comprising it and women secret conditioning liquid |
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