TW201943420A - Hair growing and nourishing agent and manufacturing method thereof applicable to patients suffering from hereditary hair loss or sudden hair loss to rebuild a healthy scalp environment - Google Patents

Abstract

A hair growing and nourishing agent provided by the present invention is made from natural plant extracts, capable of effectively promote hair follicle cell activation, and applicable to patients suffering from hereditary hair loss or sudden hair loss to rebuild a healthy scalp environment suitable for the growth of hair follicle cells. Meanwhile, with safe extraction method and natural ingredients, the present invention can avoid the harmful effects, such as generation of estrogen, on human body, and can be used for a long period of time.

Description

Nourishing hair nourishing nutrient and manufacturing method thereof

The present invention relates to a technology related to promoting hair growth, and in particular, to a hair-growing nutritional nourishing agent and a manufacturing method thereof.

The metabolism of hair follicle cells and tissues allows us to lose some hair every day, and also to grow some new hair. However, if there is abnormal hair loss; if there are too many severe hair loss per day (over 100), when the hair follicles are damaged or the hair follicle cells are slow to grow, or even the hair follicle cells no longer grow, the hair will gradually become thinner and cause baldness.

The causes of hair loss can be roughly divided into hereditary chronic hair loss and sudden hair loss of endocrine disorders such as poor scalp blood circulation and bacterial growth. Sudden hair loss, in addition to timely adjustment of pressure to return to normal, but also must rely on hair care nutrients to allow normal hair growth. The cause of hereditary chronic hair loss is mainly due to the testosterone hormone secreted by the gonads, which stimulates sebum hyperplasia in the scalp and causes seborrheic hair loss. Male baldness is more common and difficult to cure in hereditary baldness. . Male bald, most of the scalp appears greasy. That's because 5-alpha reductase in the sebaceous glands turns testosterone into active dehydrotestosterone (DHT), which stimulates excessive secretion of sebum, blocks hair follicles, affects the absorption of hair root nutrients, and causes hair loss. It is often necessary to normalize oil secretion by regulating androgen secretion. However, for many years, anti-hair loss or hair hyperplasia products have mostly used estrogen or western medicine ingredients as additives. If used for a long time, it may cause sexual dysfunction and cause cancer and sexual Concerns about precocity are currently banned in Taiwan from adding estrogen to cosmetics.

In response to the urgent need for abnormal hair loss, it is necessary to first suppress severe hair loss, and timely supplement the hair growth and nutrition to activate the hair follicles to prevent scalp health and prevent hair loss and promote hair growth. However, there is no technical content that has both safety and effectiveness.

Therefore, the main purpose of the present invention is to provide a nourishing hair nourishing nutrient, which is through the active ingredients of natural plants, to activate hair follicle cells to strengthen hair quality, and to quickly remove scalp hyperplasia lipids to prevent Hair loss, which in turn promotes blood circulation to the scalp, improves the physiological environment of the hair, and allows the hair to grow naturally.

Another object of the present invention is to provide a method for manufacturing a nourishing hair nourishing nutrient, which can ensure that when a natural plant component is used as an additive to the hair nutrient by means of extraction, fermentation, re-extraction and concentration. Its safety and effectiveness without causing harm to the human body.

The reason is that, in order to achieve the above-mentioned purpose, the present invention provides the developmental hair nourishing nutrition agent, which includes: a first composition and a second composition, these compositions are natural plant extracts or Fermenters; wherein, the first composition is a mixture of Puer tea leaves, mulberry leaves, Polygonum multiflorum, orange peel (Central peel), and mangosteen extract after further fermentation and concentration, and the second composition is ginger , Mandarin duck, Polygonum multiflorum, Equisetum, ginkgo, nettle, rosemary, willow bark and orange peel.

In order to stabilize the active ingredients of the first composition and the second composition, the manufacturing method of the lotion hair nourishing nutritional agent goes through the following steps:

a. The raw material ingredients of the first composition: Pu'er tea leaves, mulberry leaves, Polygonum multiflorum, orange peel (Central peel) and mandarin duck, respectively, are extracted by reflux water and wine extraction technology to obtain the raw material ingredients of the first composition respectively. Extracts.

b. Fermenting each of the extracts obtained in step a for 15 days.

c. Each of the extracts after the fermentation in step b is separately distilled under reduced pressure to obtain alcohol, so as to obtain its individual fermentation broth.

d. Distilling and concentrating each of the concentrated fermentation broths obtained in step c under reduced pressure.

e. Each of the reduced-pressure distillation-concentrated fermentation broths obtained in step d is concentrated and sub-extracted with propylene glycol and mixed with each other.

f. The raw material components of the second composition: ginger, mandarin duckweed, Polygonum multiflorum, Eucalyptus, ginkgo, nettle, rosemary, willow bark and orange peel are respectively extracted by reflux water wine extraction technology to obtain each Extraction of raw material ingredients of the second composition. Each of the extracts is separated and filtered to obtain its individual extract.

g. The extract liquid obtained in step f and the concentrated fermented material obtained in step e are mixed to form the lotion developing hair nourishing agent.

Among them, in steps a and f, the water-wine extraction technology uses a mixture of water and 95% alcohol in a ratio of 1: 1 as the extraction solvent.

In step e, each of the vacuum distillation solution and the propylene glycol is concentrated and extracted at a ratio of 2: 1.

Wherein, in step e, the mixing of the concentrated fermented extract of the raw material ingredients of the first composition is to make the propylene glycol re-extracting solution of Pu'er tea, mulberry leaves, Polygonum multiflorum, orange peel (Central peel) and human tincture into 6: 6 : 5: 2: 1 ratio.

The Rhodes hair development nutrient provided by the present invention is based on the extracts of natural plants, effectively promotes the activation of hair follicle cells, and is applied to help patients with hereditary or sudden hair loss to rebuild a healthy scalp suitable for the growth of hair follicle cells At the same time, with its safe extraction method and natural ingredients, it can avoid the harmful effects on the human body like estrogen, and can be used for a long time.

Specifically, the happy hair development nutritional supplement provided in the preferred embodiment of the present invention comprises a first composition and a second composition which is uniformly mixed with the first composition.

Wherein, the first composition is the fermented product of Pu'er tea, mulberry leaf, Polygonum multiflorum, tangerine peel (Central peel) and mandarin duck, and the second composition is ginger, mandarin duckweed, Polygonum multiflorum, Eucalyptus, Ginkgo , Nettle, rosemary, willow bark and orange peel extracts, and the respective components of the first composition and the second composition and each other are mixed with each other in an appropriate ratio.

Specifically, the composition ratio of the first composition, that is, the individual fermented products of Pu'er tea, mulberry leaves, Polygonum multiflorum, orange peel (Central peel) and mandarin duck, after extraction, is 6: 6: 5: 2: 1 .

In order to ensure that the user can safely use the Rhodes hair-growing nutritional supplement for a long time, the first composition is based on the original Pu'er tea, mulberry leaves, Polygonum multiflorum, orange peel (Central peel) and mandarin duck as raw materials. After the wine is mixed and extracted and fermented, the fermented product is obtained by distillation under reduced pressure and propylene glycol purification.

The second composition is made from ginger, mandarin duckweed, polygonum multiflorum, cuttlefish, ginkgo, nettle, rosemary, willow bark and orange peel as raw materials, and the extract is obtained by mixing and extracting with water and wine.

The first composition and the second composition are mixed in equal proportions to obtain the lotion-developing hair nourishing agent.

In order to ensure that the components of the first composition and the second composition do not degrade due to the mixed extraction, the manufacturing method of the lotion hair nourishing nutritional agent is made according to the following steps:

a. The raw material components of the first composition: Pu'er tea leaves, mulberry leaves, Polygonum multiflorum, orange peel (Central peel), and mandarin duck are extracted by using a solvent mixed with water and alcohol and other ratios to obtain the first Extraction solution of each raw material component of the composition.

b. Seal each of the extracts obtained in step a and allow them to naturally ferment for 15 days.

c. Each of the extracts after the fermentation in step b is separately distilled under reduced pressure to obtain alcohol, so as to obtain its individual fermentation broth.

d. Concentrating and trans-extracting each of the fermentation broth obtained in step c and propylene glycol respectively at a ratio of 2: 1 to obtain trans-extracted liquids of each raw material component.

e. Mix each of the trans-extracted liquids at a ratio of 6: 6: 5: 2: 1 to obtain the first composition.

f. The raw material ingredients of the second composition: ginger, mandarin duckweed, polygonum multiflorum, equisetum, ginkgo, nettle, rosemary, willow bark and orange peel are respectively carried out by using a solvent mixed with water and alcohol in a ratio Extraction to obtain extracts of its individual components.

g. Mix the extract obtained in step f into the second composition in equal proportions.

h. The first composition and the second composition are mixed uniformly in a ratio of 1: 1 to obtain the happy hair development nutritional agent.

The lota hair development nutritional agent manufactured through the above steps has a brown-green liquid appearance, a boiling point of about 100 ° C, a freezing point of about 0 ° C, a density of about 1.0g / ml, and a pH value of about 6.5. And stored under normal room temperature environment for 2 years.

In order to know whether the Rhodes hair development nutritional agent of the present invention has a proliferative effect on cells, the TF-1 cells were cultured in a 96-well plate, and the Rhodes hair development nutritional agent (code: A) and a commercially available promotion Hair growth products (codes: B and C), diluted 30, 60, 120, 240, 480, 960, and 1920 times with ultrapure water dilution sequence, filtered through a 0.22 μM filter membrane and co-cultured with TF-1 cells Four days later, XTT reagent was added for 16 hours, the absorbance was measured at a wavelength of 490 nm, and the test was repeated three times.

Please refer to the first figure. The control group without any product that promotes hair growth is 100%, and the average absorbance of the three groups A, B and C diluted 240 times is divided by the absorbance of the control group and then multiplied. Taking 100% as a graph, it can be found that the effect of the present developmental hair nourishing nutrient provided by the present invention to promote the proliferation of TF-1 cells is higher than that of B and C.

Except that in the foregoing preferred embodiment, the first composition and the second composition are mixed uniformly at a ratio of 1: 1 to obtain the happy hair development nutritional agent for use, the first composition and the second composition Individual components of the composition can also exist alone, whether mixed or individual, it can be used directly as a hair conditioner, and can also be used as an addition to general hair care products, and can be used as shampoo and hair care The added ingredients of milk have a wide range of uses.

In addition, 126 persons (65 males; 61 females) with hair loss problems were selected for trial and questionnaire satisfaction surveys. How to use: Use once a day for 6 weeks.

Table 1 Satisfaction Survey

Satisfaction analysis results: (1) 90% of the subjects are satisfied. After 3 weeks of use, the abnormal hair loss can be improved. (2) 65% of the subjects were satisfied. After 6 weeks of use, fine hair began to grow.

Please refer to Table 2 for the analysis of the ingredients of this hair development hair nourishing agent:

Table 2 Hydrolyzed Amino Acid Composition Unit: mg / 100g This ingredient is inspected by the Hsinchu Food Industry Development Institute.

Among them, the hydrolysable amino acid group of the Loto hair development nutritional agent is aspartic acid, glutamic acid, serine, glutamic acid, glycine, alanine, cystine, valine, Methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histamine, arginine and proline.

In addition, further analysis of the ingredients of the hair development hair nutrition nutrient can analyze: chlorophyll, ruegan, dendolin, gingerol, hesperidin, isodendrin, hesperidin, limonene, citral , Phellandrene, lupinol, etc.

The nutrient hair development nutritional agent provided by the present invention mainly achieves the functions of activating hair follicle cells and promoting hair proliferation through the following mechanisms:

1. Regulates the hormonal mechanism involved in hair fall: The nutritional hair development nutrient of the present invention is a potential inhibitor of 5α-reductase, which can inhibit the effect of 5α-reductase and control the androgen receptor To prevent testosterone from forming active Dihydrotestosterone (DHT), which leads to male baldness.

2. Regulate androgen secretion: The plant extracts of the nourishing hair nourishing nutrient according to the present invention can inhibit the synthesis of oil and fat increased by dehydro testosterone and shrink the oil glands, thereby normalizing oil secretion.

3. Clean the scalp: In normal scalp environment, dandruff spores account for 45% -50% of the microbiota, and the happy hair development nutritional agent of the present invention contains alcohol and natural plant essential oils, which can clean the scalp and prevent the formation of free radicals. In order to maintain the normal scalp environment, Bacillus dandruff does not grow due to strong secretion of scalp oil.

4. Stimulate the microvascular circulation near the hair follicle cells: The active hair nourishing nutrient of the present invention can stimulate the blood circulation of the scalp, thereby helping other active ingredients to enter the hair follicle to function and improve the subcutaneous blood circulation.

5. Promote hair follicle activation and hair growth: The active hair growth nutrition agent of the present invention can help hair follicles absorb effective nutrients to promote hair growth ability. At the same time, the hair nutrition agent can help hair follicle activation to promote hair protein formation.

6. Can be used for a long period of time: The dermatological hair nourishing nutrient of the present invention does not contain carcinogenic additives such as estrogen and western medicine ingredients, so it can be used safely for a long time.

The first figure is a comparison chart of the active hair nourishing nutrient of the present invention and a commercially available product that promotes the proliferation of hair follicle cells.

Claims (9)

A nourishing hair development and nutrition nutrition agent comprises: a first composition, which is an extract or fermented material of Pu'er tea, mulberry leaves, Polygonum multiflorum, orange peel (Central peel), and mandarin duck. A lotion for hair development and nutrition contains: a second composition, which is an extract of ginger, mandarin duckweed, Polygonum multiflorum, Eucalyptus, ginkgo, nettle, rosemary, willow bark and orange peel. A happy hair development and nourishing nutrient, comprising: a first composition according to claim 1; and a second composition according to claim 2. As described in claim 3, the developmental hair nourishing nutritional agent has a mixing ratio of the first composition to the second composition of 1: 1. As described in claim 3, the nourishing hair nourishing hair nourishing agent, wherein the first composition and the second composition are separately extracted by mixing water and wine, and the mixing ratio of water and wine is 1: 1. A method for manufacturing a nourishing hair nourishing nutrient, which comprises the following steps: a. The raw materials of a first composition: Pu'er tea, mulberry leaves, Polygonum multiflorum, orange peel and mandarin duck are separately extracted with water and wine, water The mixing ratio with wine is 1: 1; b. Sealing and immersing each of the extracts after extraction for 15 days to perform fermentation; c. Distilling each of the extracts after fermentation under reduced pressure; d . Purify a vacuum distillation solution separately; e. Concentrate each vacuum distillation solution through a propylene glycol, and then uniformly mix to obtain the first composition; f. The raw material of a second composition: ginger, The mandarin duck, Polygonum multiflorum, Equisetum, ginkgo, nettle, rosemary, willow bark and orange peel are separately extracted with water and wine. The ratio of water to wine is 1: 1, and then mixed evenly to obtain the second combination. G. Uniformly mixing the first composition with the second composition. According to the method of claim 6, wherein, in the step e, each of the vacuum distillation solution and the propylene glycol is concentrated and extracted at a ratio of 2: 1. The method for manufacturing a nourishing hair nourishing nutrient as described in claim 6, wherein Pu'er tea leaves, mulberry leaves, Polygonum multiflorum, orange peel (Central peel), or mandarin duck are processed in steps a to e, respectively, at 6: 6: The ratio of 5: 2: 1 is mixed uniformly to obtain the first composition. According to the method for manufacturing a nourishing hair nourishing nutrient according to claim 6, wherein the mixing ratio of the first composition and the second composition described in step g is 1: 1.