TW201936203A - 使用布勞特氏(blautia)菌株治療疾病之組合物及方法 - Google Patents

使用布勞特氏(blautia)菌株治療疾病之組合物及方法 Download PDF

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TW201936203A
TW201936203A TW107140449A TW107140449A TW201936203A TW 201936203 A TW201936203 A TW 201936203A TW 107140449 A TW107140449 A TW 107140449A TW 107140449 A TW107140449 A TW 107140449A TW 201936203 A TW201936203 A TW 201936203A
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cancer
protein
carcinoma
cell
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TW107140449A
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布萊恩 古德曼
霍莉 波尼奇特拉
安德烈 義塔諾
泰勒 Ａ 柯麥克
瑪麗亞 席偌瓦
維利瑞亞 奎維茲
艾可特莉娜 蓋瑞旭
賈格雷科 卡洛萊納 貝茲
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美商艾弗洛生物科技股份有限公司
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Publication of TW201936203A publication Critical patent/TW201936203A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
TW107140449A 2017-11-14 2018-11-14 使用布勞特氏(blautia)菌株治療疾病之組合物及方法 TW201936203A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762585782P 2017-11-14 2017-11-14
US62/585,782 2017-11-14

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TW201936203A true TW201936203A (zh) 2019-09-16

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TW107140449A TW201936203A (zh) 2017-11-14 2018-11-14 使用布勞特氏(blautia)菌株治療疾病之組合物及方法

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US (2) US10493113B2 (enExample)
EP (1) EP3710023A1 (enExample)
JP (1) JP2021502964A (enExample)
CN (1) CN111601610A (enExample)
AR (1) AR113881A1 (enExample)
TW (1) TW201936203A (enExample)
WO (1) WO2019099482A1 (enExample)

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US11241461B2 (en) * 2017-08-29 2022-02-08 Evelo Biosciences, Inc. Treating cancer using a blautia strain
US10493113B2 (en) 2017-11-14 2019-12-03 Evelo Biosciences, Inc. Compositions and methods for treating disease using a Blautia strain
EP3746121A1 (en) * 2018-01-31 2020-12-09 Evelo Biosciences, Inc. Compositions and methods for treating immune disorders using lachnospiraceae bacteria
JP7340591B2 (ja) * 2018-07-11 2023-09-07 アクティム・セラピューティクス・インコーポレイテッド 遺伝子操作された免疫刺激性細菌菌株およびその使用
CA3120709A1 (en) 2018-11-21 2020-05-28 Board Of Regents, The University Of Texas System Methods and compositions for treating cancer
US20220080001A1 (en) * 2019-01-16 2022-03-17 Board Of Regents, The University Of Texas System Methods and compositions for treating immune checkpoint inhibitor associated colitis
MX2021013776A (es) * 2019-05-10 2021-12-10 4D Pharma Res Limited Composiciones que comprenden cepas bacterianas.
WO2020252144A1 (en) * 2019-06-11 2020-12-17 Evelo Biosciences, Inc. Secreted microbial extracellular vesicles
CN112442455B (zh) * 2019-09-03 2022-04-01 北京量化健康科技有限公司 具有防治高血脂症功能的布劳特氏菌以及产品组合物及其制备方法和应用
CN111304120B (zh) * 2020-02-24 2021-07-23 浙江大学 Blautia sp B2132菌在预防和/或治疗炎症性肠病中的应用
AU2021280299B2 (en) 2020-05-28 2025-08-21 Trench Therapeutics, Inc. Airway medicaments
AR122610A1 (es) * 2020-06-11 2022-09-21 Evelo Biosciences Inc Composiciones y métodos para el tratamiento de enfermedades y trastornos usando vesículas extracelulares microbianas de oscillospiraceae
WO2021252861A1 (en) * 2020-06-11 2021-12-16 Evelo Biosciences, Inc. Compositions and methods for treating diseases and disorders using megasphaera sp
CN115768448A (zh) * 2020-06-11 2023-03-07 伊夫罗生物科学公司 使用马西里福涅拉氏菌治疗疾病和障碍的组合物和方法
CN113842497B (zh) * 2021-09-28 2022-05-17 太原理工大学 一种具有光控抗菌和自愈合功能的CuS@Cur杂化水凝胶敷料的制备方法
CN114225024B (zh) * 2021-12-29 2022-08-19 山东健袖生态科技有限公司 一种用于治疗疾病的益生菌药物
EP4494484A4 (en) 2022-03-18 2026-03-18 Meiji Co Ltd COMPOSITION FOR CONTROLLING THE PROLIFERATION OF COLLINSELLA BACTERIA AND ITS USE
WO2023192360A1 (en) * 2022-03-31 2023-10-05 Incelldx, Inc. Methods of treating a subject for post-treatment lyme disease (ptld) and compositions for use in the same
US20250235433A1 (en) * 2022-04-19 2025-07-24 Cedars-Sinai Medical Center Methods of treating and diagnosing fatty liver disease
CN114806979A (zh) * 2022-06-29 2022-07-29 杭州师范大学附属医院(杭州市第二人民医院) 一种治疗非酒精性脂肪性肝病的益生菌复合物及其应用
CN116254198B (zh) * 2023-01-05 2024-03-26 中国科学院微生物研究所 一种布劳特氏菌及其应用
CN116549465B (zh) * 2023-04-26 2025-02-11 复旦大学附属中山医院 Aldh2小分子激动剂在制备治疗心血管疾病及其代谢性疾病的药物中的应用
JP7706190B2 (ja) * 2023-09-25 2025-07-11 オルト株式会社 ブラウティア属細菌
WO2025070280A1 (ja) * 2023-09-25 2025-04-03 オルト株式会社 ブラウティア属細菌
WO2025070283A1 (ja) * 2023-09-25 2025-04-03 オルト株式会社 ブラウティア属細菌を用いた免疫賦活剤
JP7706191B2 (ja) * 2023-09-25 2025-07-11 オルト株式会社 ブラウティア属細菌を用いた免疫賦活剤
CN117617181B (zh) * 2023-12-27 2025-10-28 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) 一种系统性红斑狼疮小鼠模型的构建方法和应用
CN119709558B (zh) * 2025-02-26 2025-05-30 昆明医科大学第一附属医院(云南省皮肤病医院) 布劳特氏菌emf75-02b1b及其用途

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CN107083339B (zh) * 2017-03-01 2020-02-14 华中农业大学 防治仔猪腹泻的复合益生菌制剂及其制备方法和应用
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JP2021502964A (ja) 2021-02-04
AR113881A1 (es) 2020-06-24
US20190216862A1 (en) 2019-07-18
EP3710023A1 (en) 2020-09-23
CN111601610A8 (zh) 2023-07-21
WO2019099482A1 (en) 2019-05-23
US10493113B2 (en) 2019-12-03
US10702561B2 (en) 2020-07-07
CN111601610A (zh) 2020-08-28
US20200030389A1 (en) 2020-01-30

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