CN114225024B - 一种用于治疗疾病的益生菌药物 - Google Patents
一种用于治疗疾病的益生菌药物 Download PDFInfo
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Abstract
Description
组别 | n | DAI评分 |
正常组 | 10 | 0.00±0.00 |
模型组 | 10 | 6.89±2.05 |
阴性对照组 | 10 | 6.87±1.88 |
单抗组 | 10 | 2.30±0.79 |
益生菌组 | 10 | 3.88±0.81 |
益生菌联合单抗处理组 | 10 | 1.25±0.26 |
组别 | n | 组织学评分 |
正常组 | 10 | 0.00±0.00 |
模型组 | 10 | 10.58±1.79 |
阴性对照组 | 10 | 10.45±1.57 |
单抗组 | 10 | 5.02±0.68 |
益生菌组 | 10 | 6.91±0.45 |
益生菌联合单抗处理组 | 10 | 1.91±0.19 |
Claims (5)
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103002901A (zh) * | 2010-06-18 | 2013-03-27 | 雀巢产品技术援助有限公司 | 约汉逊氏乳杆菌La1,长双歧杆菌NCC2705和免疫疾病 |
CN104224851A (zh) * | 2014-08-15 | 2014-12-24 | 任发政 | 动物双歧杆菌乳酸亚种CGMCC No.9273的应用 |
CN108157973A (zh) * | 2017-12-14 | 2018-06-15 | 上海交通大学医学院附属瑞金医院 | 一种有益糖脂代谢功能的益生菌组合物及其制剂和应用 |
CN110101722A (zh) * | 2019-06-10 | 2019-08-09 | 北京科拓恒通生物技术股份有限公司 | 一种复合益生菌菌剂用于制备治疗溃疡性结肠炎产品的用途 |
CN113430133A (zh) * | 2021-06-24 | 2021-09-24 | 微康益生菌(苏州)股份有限公司 | 一种能够缓解溃疡性结肠炎的复合益生菌、制备方法及其应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2785658C (en) * | 2009-12-31 | 2017-10-24 | Ira Milton Trachtman | Compositions and method for treatment and prophylaxis of inflammatory bowel disease |
EP3710023A1 (en) * | 2017-11-14 | 2020-09-23 | Evelo Biosciences, Inc. | Compositions and methods for treating disease using a blautia strain |
WO2019152667A1 (en) * | 2018-01-31 | 2019-08-08 | Evelo Biosciences, Inc. | Compositions and methods for treating immune disorders using lachnospiraceae bacteria |
-
2021
- 2021-12-29 CN CN202111636163.5A patent/CN114225024B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103002901A (zh) * | 2010-06-18 | 2013-03-27 | 雀巢产品技术援助有限公司 | 约汉逊氏乳杆菌La1,长双歧杆菌NCC2705和免疫疾病 |
CN104224851A (zh) * | 2014-08-15 | 2014-12-24 | 任发政 | 动物双歧杆菌乳酸亚种CGMCC No.9273的应用 |
CN108157973A (zh) * | 2017-12-14 | 2018-06-15 | 上海交通大学医学院附属瑞金医院 | 一种有益糖脂代谢功能的益生菌组合物及其制剂和应用 |
CN110101722A (zh) * | 2019-06-10 | 2019-08-09 | 北京科拓恒通生物技术股份有限公司 | 一种复合益生菌菌剂用于制备治疗溃疡性结肠炎产品的用途 |
CN113430133A (zh) * | 2021-06-24 | 2021-09-24 | 微康益生菌(苏州)股份有限公司 | 一种能够缓解溃疡性结肠炎的复合益生菌、制备方法及其应用 |
Non-Patent Citations (3)
Title |
---|
Amelioration of Murine Experimental Colitis by Inhibition of Mucosal Addressin Cell Adhesion Molecule-1;SHINGO KATO et al.;《THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》;20001031;第295卷(第1期);摘要、第184页左栏第2段-第189页左栏第1段 * |
Bio-ecological control of acute pancreatitis: the role of enteral nutrition, pro and synbiotics;Stig Bengmark;《Nutrition and the gastrointestinal tract》;20051231;第8卷;第557-561页 * |
曲美布汀和奥美拉唑及双歧杆菌三联活菌胶囊在胃食管反流病患者中的应用;卢仁隆;《医疗装备》;20210830;第34卷(第16期);第106-107页 * |
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