TW201900648A - 治療性化合物及組成物以及其使用方法 - Google Patents

治療性化合物及組成物以及其使用方法 Download PDF

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Publication number
TW201900648A
TW201900648A TW107117164A TW107117164A TW201900648A TW 201900648 A TW201900648 A TW 201900648A TW 107117164 A TW107117164 A TW 107117164A TW 107117164 A TW107117164 A TW 107117164A TW 201900648 A TW201900648 A TW 201900648A
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TW
Taiwan
Prior art keywords
group
alkyl
pharmaceutically acceptable
acceptable salt
compound
Prior art date
Application number
TW107117164A
Other languages
English (en)
Chinese (zh)
Inventor
馬克 亞克
F 安東尼 羅蜜羅
韻欣 鄭
李巍
Original Assignee
瑞士商赫孚孟拉羅股份公司
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Application filed by 瑞士商赫孚孟拉羅股份公司 filed Critical 瑞士商赫孚孟拉羅股份公司
Publication of TW201900648A publication Critical patent/TW201900648A/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW107117164A 2017-05-22 2018-05-21 治療性化合物及組成物以及其使用方法 TW201900648A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2017085277 2017-05-22
??PCT/CN2017/085277 2017-05-22
US201862644784P 2018-03-19 2018-03-19
US62/644,784 2018-03-19

Publications (1)

Publication Number Publication Date
TW201900648A true TW201900648A (zh) 2019-01-01

Family

ID=62486555

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107117164A TW201900648A (zh) 2017-05-22 2018-05-21 治療性化合物及組成物以及其使用方法

Country Status (6)

Country Link
US (3) US20180334465A1 (https=)
EP (1) EP3630767A1 (https=)
JP (1) JP7228318B6 (https=)
CN (1) CN110678467B (https=)
TW (1) TW201900648A (https=)
WO (1) WO2018215390A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201720828A (zh) * 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
MX387969B (es) 2017-05-22 2025-03-19 Hoffmann La Roche Composiciones y compuestos terapéuticos, y métodos para su uso.
JP2022519696A (ja) * 2019-02-07 2022-03-24 ベンティックス バイオサイエンシーズ,インク. Tyk2偽キナーゼリガンド
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
TW202115069A (zh) 2019-06-18 2021-04-16 瑞士商赫孚孟拉羅股份公司 Jak激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途
PH12021552998A1 (en) * 2019-06-18 2023-08-14 Hoffmann La Roche Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4178950A1 (en) 2020-07-07 2023-05-17 Universitat Rovira I Virgili Reagents for the polyfluoroalkylthiolation of organic compounds and method for production thereof

Family Cites Families (18)

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
DE60214428T2 (de) 2001-12-20 2007-09-20 Bayer Healthcare Ag 1, 4-dihydro-1, 4-diphenylpyridin-derivate
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
CN102131389A (zh) 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
EP2348860B1 (en) 2008-10-31 2015-05-27 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
AP2015008433A0 (en) 2012-11-09 2015-05-31 Jacobus Pahrmaceutical Company Inc Heteroaryl derivatives and uses thereof
JP2017516850A (ja) 2014-05-23 2017-06-22 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Jak阻害剤である5−クロロ−2−ジフルオロメトキシフェニルピラゾロピリミジン化合物
TW201720828A (zh) * 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
JP6936236B2 (ja) * 2016-02-18 2021-09-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 治療化合物、組成物及びその方法の使用

Also Published As

Publication number Publication date
JP7228318B2 (ja) 2023-02-24
US20220024945A1 (en) 2022-01-27
EP3630767A1 (en) 2020-04-08
WO2018215390A1 (en) 2018-11-29
US20180334465A1 (en) 2018-11-22
US20200062779A1 (en) 2020-02-27
JP7228318B6 (ja) 2023-03-10
JP2020520957A (ja) 2020-07-16
CN110678467B (zh) 2023-06-13
CN110678467A (zh) 2020-01-10

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