CN110678467B - 治疗化合物和组合物及其使用方法 - Google Patents

治疗化合物和组合物及其使用方法 Download PDF

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Publication number
CN110678467B
CN110678467B CN201880033713.4A CN201880033713A CN110678467B CN 110678467 B CN110678467 B CN 110678467B CN 201880033713 A CN201880033713 A CN 201880033713A CN 110678467 B CN110678467 B CN 110678467B
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compounds
compound
group
pharmaceutically acceptable
alkyl
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English (en)
Chinese (zh)
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CN110678467A (zh
Inventor
M·扎克
F·A·罗梅罗
Y-X·成
李伟
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201880033713.4A 2017-05-22 2018-05-21 治疗化合物和组合物及其使用方法 Expired - Fee Related CN110678467B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2017085277 2017-05-22
CNPCT/CN2017/085277 2017-05-22
US201862644784P 2018-03-19 2018-03-19
US62/644,784 2018-03-19
PCT/EP2018/063263 WO2018215390A1 (en) 2017-05-22 2018-05-21 Therapeutic compounds and compositions, and methods of use thereof

Publications (2)

Publication Number Publication Date
CN110678467A CN110678467A (zh) 2020-01-10
CN110678467B true CN110678467B (zh) 2023-06-13

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CN201880033713.4A Expired - Fee Related CN110678467B (zh) 2017-05-22 2018-05-21 治疗化合物和组合物及其使用方法

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US (3) US20180334465A1 (https=)
EP (1) EP3630767A1 (https=)
JP (1) JP7228318B6 (https=)
CN (1) CN110678467B (https=)
TW (1) TW201900648A (https=)
WO (1) WO2018215390A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201720828A (zh) * 2015-11-23 2017-06-16 赫孚孟拉羅股份公司 治療性化合物及組合物以及其使用方法
MX387969B (es) 2017-05-22 2025-03-19 Hoffmann La Roche Composiciones y compuestos terapéuticos, y métodos para su uso.
JP2022519696A (ja) * 2019-02-07 2022-03-24 ベンティックス バイオサイエンシーズ，インク． Ｔｙｋ２偽キナーゼリガンド
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
TW202115069A (zh) 2019-06-18 2021-04-16 瑞士商赫孚孟拉羅股份公司 Ｊａｋ激酶之經四唑取代之吡唑并嘧啶抑制劑及其用途
PH12021552998A1 (en) * 2019-06-18 2023-08-14 Hoffmann La Roche Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
EP4178950A1 (en) 2020-07-07 2023-05-17 Universitat Rovira I Virgili Reagents for the polyfluoroalkylthiolation of organic compounds and method for production thereof

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN108368116A (zh) * 2015-11-23 2018-08-03 豪夫迈·罗氏有限公司 Janus激酶抑制剂、其组合物及用途

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US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
DE60214428T2 (de) 2001-12-20 2007-09-20 Bayer Healthcare Ag 1, 4-dihydro-1, 4-diphenylpyridin-derivate
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
GB0502258D0 (en) 2005-02-03 2005-03-09 Argenta Discovery Ltd Compounds and their use
CN102131389A (zh) 2008-06-20 2011-07-20 健泰科生物技术公司 三唑并吡啶jak抑制剂化合物和方法
EP2348860B1 (en) 2008-10-31 2015-05-27 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
UA110324C2 (en) * 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
US8575336B2 (en) 2011-07-27 2013-11-05 Pfizer Limited Indazoles
AP2015008433A0 (en) 2012-11-09 2015-05-31 Jacobus Pahrmaceutical Company Inc Heteroaryl derivatives and uses thereof
JP2017516850A (ja) 2014-05-23 2017-06-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｊａｋ阻害剤である５−クロロ−２−ジフルオロメトキシフェニルピラゾロピリミジン化合物
JP6936236B2 (ja) * 2016-02-18 2021-09-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 治療化合物、組成物及びその方法の使用

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CN108368116A (zh) * 2015-11-23 2018-08-03 豪夫迈·罗氏有限公司 Janus激酶抑制剂、其组合物及用途

Also Published As

Publication number Publication date
TW201900648A (zh) 2019-01-01
JP7228318B2 (ja) 2023-02-24
US20220024945A1 (en) 2022-01-27
EP3630767A1 (en) 2020-04-08
WO2018215390A1 (en) 2018-11-29
US20180334465A1 (en) 2018-11-22
US20200062779A1 (en) 2020-02-27
JP7228318B6 (ja) 2023-03-10
JP2020520957A (ja) 2020-07-16
CN110678467A (zh) 2020-01-10

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