TW201636033A - 使用臍帶血細胞的腦損傷治療 - Google Patents
使用臍帶血細胞的腦損傷治療 Download PDFInfo
- Publication number
- TW201636033A TW201636033A TW105122319A TW105122319A TW201636033A TW 201636033 A TW201636033 A TW 201636033A TW 105122319 A TW105122319 A TW 105122319A TW 105122319 A TW105122319 A TW 105122319A TW 201636033 A TW201636033 A TW 201636033A
- Authority
- TW
- Taiwan
- Prior art keywords
- stroke
- cells
- brain
- cord blood
- administered
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title claims abstract description 143
- 210000004700 fetal blood Anatomy 0.000 title claims abstract description 43
- 238000011282 treatment Methods 0.000 title abstract description 25
- 208000029028 brain injury Diseases 0.000 title description 10
- 230000006931 brain damage Effects 0.000 title description 9
- 231100000874 brain damage Toxicity 0.000 title description 9
- 208000006011 Stroke Diseases 0.000 claims abstract description 85
- 230000001684 chronic effect Effects 0.000 claims abstract description 21
- 208000030886 Traumatic Brain injury Diseases 0.000 claims abstract description 9
- 230000009529 traumatic brain injury Effects 0.000 claims abstract description 9
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 52
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 52
- 210000004556 brain Anatomy 0.000 claims description 37
- 210000005013 brain tissue Anatomy 0.000 claims description 22
- 230000000451 tissue damage Effects 0.000 claims description 13
- 231100000827 tissue damage Toxicity 0.000 claims description 13
- 210000002804 pyramidal tract Anatomy 0.000 claims description 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 229940127557 pharmaceutical product Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229940126601 medicinal product Drugs 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract description 7
- 238000000034 method Methods 0.000 description 28
- 241000700159 Rattus Species 0.000 description 24
- 210000001616 monocyte Anatomy 0.000 description 12
- 230000000302 ischemic effect Effects 0.000 description 8
- 230000003902 lesion Effects 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 206010061216 Infarction Diseases 0.000 description 7
- 230000007574 infarction Effects 0.000 description 7
- 239000008194 pharmaceutical composition Substances 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 230000007850 degeneration Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 5
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 5
- 239000011324 bead Substances 0.000 description 5
- 206010008118 cerebral infarction Diseases 0.000 description 5
- 230000001054 cortical effect Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 210000003657 middle cerebral artery Anatomy 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- 108010047303 von Willebrand Factor Proteins 0.000 description 5
- 102100036537 von Willebrand factor Human genes 0.000 description 5
- 206010008120 Cerebral ischaemia Diseases 0.000 description 4
- 206010012289 Dementia Diseases 0.000 description 4
- 201000011240 Frontotemporal dementia Diseases 0.000 description 4
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 4
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 4
- -1 HLA-J and HLA-X Proteins 0.000 description 4
- 108090000192 Methionyl aminopeptidases Proteins 0.000 description 4
- 102100021118 Microtubule-associated protein 2 Human genes 0.000 description 4
- 208000001089 Multiple system atrophy Diseases 0.000 description 4
- 230000003542 behavioural effect Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 4
- 230000007658 neurological function Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000024827 Alzheimer disease Diseases 0.000 description 3
- 201000006474 Brain Ischemia Diseases 0.000 description 3
- 208000005189 Embolism Diseases 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 208000018737 Parkinson disease Diseases 0.000 description 3
- 208000032109 Transient ischaemic attack Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000036770 blood supply Effects 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 210000001168 carotid artery common Anatomy 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000002059 diagnostic imaging Methods 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 230000001815 facial effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000003394 haemopoietic effect Effects 0.000 description 3
- 238000003125 immunofluorescent labeling Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002595 magnetic resonance imaging Methods 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 210000004498 neuroglial cell Anatomy 0.000 description 3
- 238000007665 sagging Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000008925 spontaneous activity Effects 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 201000010875 transient cerebral ischemia Diseases 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 210000003954 umbilical cord Anatomy 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- ZAUYNCUCMJDAHW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;hydrogen peroxide;molecular iodine Chemical compound OO.II.C=CN1CCCC1=O ZAUYNCUCMJDAHW-UHFFFAOYSA-N 0.000 description 2
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 2
- 208000011990 Corticobasal Degeneration Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 208000004929 Facial Paralysis Diseases 0.000 description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 2
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 2
- 108010075704 HLA-A Antigens Proteins 0.000 description 2
- 108010058607 HLA-B Antigens Proteins 0.000 description 2
- 108010052199 HLA-C Antigens Proteins 0.000 description 2
- 108010010378 HLA-DP Antigens Proteins 0.000 description 2
- 102000015789 HLA-DP Antigens Human genes 0.000 description 2
- 108010062347 HLA-DQ Antigens Proteins 0.000 description 2
- 108010058597 HLA-DR Antigens Proteins 0.000 description 2
- 102000006354 HLA-DR Antigens Human genes 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010019345 Heat stroke Diseases 0.000 description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 2
- 208000023105 Huntington disease Diseases 0.000 description 2
- 208000004044 Hypesthesia Diseases 0.000 description 2
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 2
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 2
- 208000010428 Muscle Weakness Diseases 0.000 description 2
- 206010028372 Muscular weakness Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 108010004729 Phycoerythrin Proteins 0.000 description 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 208000003443 Unconsciousness Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000037444 atrophy Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 210000000744 eyelid Anatomy 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000005021 gait Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000020658 intracerebral hemorrhage Diseases 0.000 description 2
- DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 201000006417 multiple sclerosis Diseases 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000001898 pallidal effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 201000002212 progressive supranuclear palsy Diseases 0.000 description 2
- 229960003351 prussian blue Drugs 0.000 description 2
- 239000013225 prussian blue Substances 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- ZCXUVYAZINUVJD-AHXZWLDOSA-N 2-deoxy-2-((18)F)fluoro-alpha-D-glucose Chemical compound OC[C@H]1O[C@H](O)[C@H]([18F])[C@@H](O)[C@@H]1O ZCXUVYAZINUVJD-AHXZWLDOSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000035657 Abasia Diseases 0.000 description 1
- 101800000263 Acidic protein Proteins 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010003062 Apraxia Diseases 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 102000007371 Ataxin-3 Human genes 0.000 description 1
- 206010008027 Cerebellar atrophy Diseases 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 208000000532 Chronic Brain Injury Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010073681 Epidural haemorrhage Diseases 0.000 description 1
- 102000003951 Erythropoietin Human genes 0.000 description 1
- 108090000394 Erythropoietin Proteins 0.000 description 1
- 206010051267 Facial paresis Diseases 0.000 description 1
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
- 102100028970 HLA class I histocompatibility antigen, alpha chain E Human genes 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 108010024164 HLA-G Antigens Proteins 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000016988 Hemorrhagic Stroke Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000986085 Homo sapiens HLA class I histocompatibility antigen, alpha chain E Proteins 0.000 description 1
- 101000993059 Homo sapiens Hereditary hemochromatosis protein Proteins 0.000 description 1
- 101000866971 Homo sapiens Putative HLA class I histocompatibility antigen, alpha chain H Proteins 0.000 description 1
- 206010058558 Hypoperfusion Diseases 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- 208000006264 Korsakoff syndrome Diseases 0.000 description 1
- 208000009829 Lewy Body Disease Diseases 0.000 description 1
- 201000002832 Lewy body dementia Diseases 0.000 description 1
- 208000002569 Machado-Joseph Disease Diseases 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 208000034819 Mobility Limitation Diseases 0.000 description 1
- 208000016285 Movement disease Diseases 0.000 description 1
- 208000005314 Multi-Infarct Dementia Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102000008730 Nestin Human genes 0.000 description 1
- 108010088225 Nestin Proteins 0.000 description 1
- 102000019040 Nuclear Antigens Human genes 0.000 description 1
- 108010051791 Nuclear Antigens Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102100031498 Putative HLA class I histocompatibility antigen, alpha chain H Human genes 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000009106 Shy-Drager Syndrome Diseases 0.000 description 1
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 208000002667 Subdural Hematoma Diseases 0.000 description 1
- 206010042364 Subdural haemorrhage Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010043647 Thrombotic Stroke Diseases 0.000 description 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 1
- 201000004810 Vascular dementia Diseases 0.000 description 1
- 206010047555 Visual field defect Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 230000002567 autonomic effect Effects 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 208000025698 brain inflammatory disease Diseases 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 208000025434 cerebellar degeneration Diseases 0.000 description 1
- 210000003591 cerebellar nuclei Anatomy 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 230000036757 core body temperature Effects 0.000 description 1
- 230000002594 corticospinal effect Effects 0.000 description 1
- 238000007428 craniotomy Methods 0.000 description 1
- 210000001787 dendrite Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940105423 erythropoietin Drugs 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 210000001097 facial muscle Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000003619 fibrillary effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 210000004744 fore-foot Anatomy 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 210000001905 globus pallidus Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000002758 humerus Anatomy 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 208000013409 limited attention Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000002826 magnetic-activated cell sorting Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 230000004973 motor coordination Effects 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000005055 nestin Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 238000010984 neurological examination Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 206010029864 nystagmus Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 208000031237 olivopontocerebellar atrophy Diseases 0.000 description 1
- 238000004091 panning Methods 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 210000004976 peripheral blood cell Anatomy 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001179 pupillary effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000002637 putamen Anatomy 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 208000002320 spinal muscular atrophy Diseases 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 210000004500 stellate cell Anatomy 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000023516 stroke disease Diseases 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000003523 substantia nigra Anatomy 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- 229940029273 trichloroacetaldehyde Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000001644 umbilical artery Anatomy 0.000 description 1
- 210000003606 umbilical vein Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychology (AREA)
- Zoology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7217308P | 2008-03-28 | 2008-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201636033A true TW201636033A (zh) | 2016-10-16 |
Family
ID=41114539
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW105122319A TW201636033A (zh) | 2008-03-28 | 2009-03-27 | 使用臍帶血細胞的腦損傷治療 |
| TW098110103A TWI593417B (zh) | 2008-03-28 | 2009-03-27 | 使用臍帶血細胞的腦損傷治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098110103A TWI593417B (zh) | 2008-03-28 | 2009-03-27 | 使用臍帶血細胞的腦損傷治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11318170B2 (OSRAM) |
| EP (1) | EP2282748B1 (OSRAM) |
| JP (4) | JP2011515470A (OSRAM) |
| CN (1) | CN102036671A (OSRAM) |
| AU (1) | AU2009229153B2 (OSRAM) |
| CA (1) | CA2719740C (OSRAM) |
| IL (1) | IL208406A0 (OSRAM) |
| SG (1) | SG191701A1 (OSRAM) |
| TW (2) | TW201636033A (OSRAM) |
| WO (1) | WO2009120368A2 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9694038B2 (en) * | 2000-04-06 | 2017-07-04 | Wayne P. Franco | Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs |
| BR112014014560A8 (pt) * | 2011-12-14 | 2017-07-04 | Yeda Res & Dev | subpopulação de monócitos humanos para tratamento de lesões do sistema nervoso central |
| CN103599129A (zh) * | 2013-11-07 | 2014-02-26 | 唐明淇 | 一种人干细胞组合物在制备用于治疗阿尔茨海默症的药物中的用途 |
| WO2015174087A1 (ja) * | 2014-05-16 | 2015-11-19 | 公益財団法人先端医療振興財団 | 脳梗塞の予防及び／又は治療の為の医薬 |
| WO2017204231A1 (ja) * | 2016-05-24 | 2017-11-30 | 国立大学法人 東京大学 | 臍帯由来細胞を含む脳障害の治療剤 |
| CN108269615A (zh) * | 2018-03-14 | 2018-07-10 | 南宁市第人民医院 | 一种脐血pH值与婴幼儿脑损伤的关系评价方法 |
| AU2020332352A1 (en) * | 2019-08-20 | 2022-01-20 | Stemcyte Inc. | Treatment of cardiovascular diseases |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4714680B1 (en) | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US4965204A (en) | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US5087570A (en) | 1988-05-10 | 1992-02-11 | Weissman Irving L | Homogeneous mammalian hematopoietic stem cell composition |
| US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| WO2001066698A1 (en) | 2000-03-09 | 2001-09-13 | Cryo-Cell International, Inc. | Human cord blood as a source of neural tissue for repair of the brain and spinal cord |
| WO2001075094A1 (en) * | 2000-04-04 | 2001-10-11 | Thomas Jefferson University | Application of myeloid-origin cells to the nervous system |
| US8062837B2 (en) | 2002-02-14 | 2011-11-22 | Stemcyte, Inc. | Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| DE10330216A1 (de) * | 2003-07-03 | 2005-01-20 | Jensen, Arne Wilhelm Oluf, Prof. Dr. | Verwendung von Stammzellen aus Nabelschnurblut zur Verhinderung von Hirnschäden infolge Sauerstoffmangel und zur Neuroprotektion |
| BRPI0511287A (pt) * | 2004-05-17 | 2007-12-04 | Univ Minnesota | uso de células-tronco do sangue do cordão umbilical para tratar evento isquêmico |
| US20060264365A1 (en) | 2005-05-18 | 2006-11-23 | Hung Li | Treatment of brain tissue damage |
| US7569545B2 (en) | 2005-05-20 | 2009-08-04 | Academia Sinica | Methods of increasing neurotrophic factor expression |
| DK1926813T4 (da) | 2005-09-23 | 2019-08-19 | Tigenix S A U | Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser |
| US7427597B2 (en) | 2005-11-21 | 2008-09-23 | Academia Sinica | Method of treating brain tissue damages |
| US8329166B2 (en) | 2005-12-16 | 2012-12-11 | Academia Sinica | Pluripotent olfactory stem cells |
| WO2010135610A2 (en) | 2009-05-21 | 2010-11-25 | Stemcyte Inc. | Cell therapy for brain tissue damage |
-
2009
- 2009-03-26 AU AU2009229153A patent/AU2009229153B2/en not_active Ceased
- 2009-03-26 CN CN2009801155168A patent/CN102036671A/zh active Pending
- 2009-03-26 CA CA2719740A patent/CA2719740C/en not_active Expired - Fee Related
- 2009-03-26 JP JP2011501820A patent/JP2011515470A/ja active Pending
- 2009-03-26 US US12/935,077 patent/US11318170B2/en active Active
- 2009-03-26 WO PCT/US2009/001915 patent/WO2009120368A2/en not_active Ceased
- 2009-03-26 EP EP09725197.9A patent/EP2282748B1/en not_active Not-in-force
- 2009-03-26 SG SG2013050984A patent/SG191701A1/en unknown
- 2009-03-27 TW TW105122319A patent/TW201636033A/zh unknown
- 2009-03-27 TW TW098110103A patent/TWI593417B/zh not_active IP Right Cessation
-
2010
- 2010-10-03 IL IL208406A patent/IL208406A0/en unknown
-
2014
- 2014-07-18 JP JP2014148317A patent/JP6138090B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-22 JP JP2016162002A patent/JP6401757B2/ja not_active Expired - Fee Related
-
2018
- 2018-05-16 JP JP2018094486A patent/JP6655123B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US11318170B2 (en) | 2022-05-03 |
| CN102036671A (zh) | 2011-04-27 |
| TWI593417B (zh) | 2017-08-01 |
| EP2282748A4 (en) | 2012-01-11 |
| JP2017031158A (ja) | 2017-02-09 |
| EP2282748A2 (en) | 2011-02-16 |
| EP2282748B1 (en) | 2016-11-09 |
| JP2018154634A (ja) | 2018-10-04 |
| WO2009120368A3 (en) | 2010-01-07 |
| JP2011515470A (ja) | 2011-05-19 |
| JP6401757B2 (ja) | 2018-10-10 |
| JP6655123B2 (ja) | 2020-02-26 |
| JP6138090B2 (ja) | 2017-05-31 |
| AU2009229153B2 (en) | 2015-06-11 |
| SG191701A1 (en) | 2013-07-31 |
| AU2009229153A1 (en) | 2009-10-01 |
| US20110256107A1 (en) | 2011-10-20 |
| CA2719740C (en) | 2018-11-20 |
| TW200948370A (en) | 2009-12-01 |
| IL208406A0 (en) | 2010-12-30 |
| JP2014237677A (ja) | 2014-12-18 |
| CA2719740A1 (en) | 2009-10-01 |
| WO2009120368A2 (en) | 2009-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6655123B2 (ja) | 臍帯血細胞を用いた脳損傷の処置 | |
| US20210213068A1 (en) | Pluripotent stem cell for treatment of cerebral infarction | |
| JP5649786B2 (ja) | ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法 | |
| Liao et al. | Exogenous neural stem cell transplantation for cerebral ischemia | |
| US20200030380A1 (en) | Stimulation of therapeutic angiogenesis by t regulatory cells | |
| WO2012156968A2 (en) | Use of mesenchymal stem cells for the improvement of affective and cognitive function | |
| JP6604492B2 (ja) | 脳梗塞治療のための多能性幹細胞 | |
| HK1153663A (en) | Treatment of brain damage using umbilical cord blood cells | |
| HK1153663B (en) | Treatment of brain damage using umbilical cord blood cells | |
| US20250144150A1 (en) | Preparation method of pharmaceutical composition for treating chronic stroke | |
| Bonab et al. | Mesenchymal stem cell therapy for multiple sclerosis | |
| US20230233613A1 (en) | Pharmaceutical composition for treating chronic stroke | |
| EP1180036B1 (en) | Cell therapy for chronic stroke | |
| England | Mobilisation of endogenous haematopoietic stem cells and their use as treatment for subacute stroke | |
| KR20130075027A (ko) | 초기 분화된 양수 줄기세포를 포함하는 요실금 치료제 | |
| Banfi et al. | A CASE OF CHRONIC IMMUNE SENSORY POLIRADICU-LOPATHY (CISP) RESPONSIVE TO IMMUNE MODULATING TREATMENT | |
| Zalewska | Investigation of corticosterone impact on the sub-acute stage of recovery after photothrombotic stroke induction | |
| Kim | The role of neural stem cells in stroke recovery |