TW201625280A - 用於治療骨骼缺損之體幹細胞 - Google Patents
用於治療骨骼缺損之體幹細胞 Download PDFInfo
- Publication number
- TW201625280A TW201625280A TW104138263A TW104138263A TW201625280A TW 201625280 A TW201625280 A TW 201625280A TW 104138263 A TW104138263 A TW 104138263A TW 104138263 A TW104138263 A TW 104138263A TW 201625280 A TW201625280 A TW 201625280A
- Authority
- TW
- Taiwan
- Prior art keywords
- cells
- sample
- stem cell
- individual
- lgr5
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 23
- 230000007547 defect Effects 0.000 title claims abstract description 20
- 210000001988 somatic stem cell Anatomy 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 28
- 101150017554 LGR5 gene Proteins 0.000 claims abstract description 21
- 210000004027 cell Anatomy 0.000 claims description 105
- 210000000130 stem cell Anatomy 0.000 claims description 24
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- 210000001185 bone marrow Anatomy 0.000 claims description 7
- 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 claims description 5
- 102100032999 Integrin beta-3 Human genes 0.000 claims description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 229920000669 heparin Polymers 0.000 claims description 4
- 229960002897 heparin Drugs 0.000 claims description 4
- 229920000855 Fucoidan Polymers 0.000 claims description 3
- 230000004936 stimulating effect Effects 0.000 claims description 2
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000523 sample Substances 0.000 description 15
- 230000004069 differentiation Effects 0.000 description 8
- 239000002243 precursor Substances 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 5
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000011712 cell development Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 210000003014 totipotent stem cell Anatomy 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 210000004504 adult stem cell Anatomy 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 230000032823 cell division Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000000515 collagen sponge Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 210000003981 ectoderm Anatomy 0.000 description 2
- 210000001900 endoderm Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 210000001654 germ layer Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 210000003716 mesoderm Anatomy 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 210000003130 muscle precursor cell Anatomy 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000001537 neural effect Effects 0.000 description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 210000002027 skeletal muscle Anatomy 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 208000027205 Congenital disease Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 1
- 238000011579 SCID mouse model Methods 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 210000002805 bone matrix Anatomy 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 239000002458 cell surface marker Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940045110 chitosan Drugs 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000001671 embryonic stem cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 229940027278 hetastarch Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010603 microCT Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000003098 myoblast Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 231100001055 skeletal defect Toxicity 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462081880P | 2014-11-19 | 2014-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201625280A true TW201625280A (zh) | 2016-07-16 |
Family
ID=55960744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104138263A TW201625280A (zh) | 2014-11-19 | 2015-11-19 | 用於治療骨骼缺損之體幹細胞 |
| TW110135166A TW202224691A (zh) | 2014-11-19 | 2015-11-19 | 用於治療骨骼缺損之體幹細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110135166A TW202224691A (zh) | 2014-11-19 | 2015-11-19 | 用於治療骨骼缺損之體幹細胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20160136203A1 (enExample) |
| EP (1) | EP3220929A4 (enExample) |
| JP (1) | JP2018501189A (enExample) |
| CN (2) | CN106573018A (enExample) |
| HK (1) | HK1232131A1 (enExample) |
| TW (2) | TW201625280A (enExample) |
| WO (1) | WO2016081553A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201819623A (zh) * | 2016-10-18 | 2018-06-01 | 美商幹細胞生物科技股份有限公司 | 用於降低膽紅素位準之組成物及方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2936171B2 (ja) * | 1989-09-01 | 1999-08-23 | 東ソー株式会社 | 血清アルブミンの製造方法 |
| AU1705599A (en) * | 1997-11-26 | 1999-06-15 | Allegheny University Of The Health Sciences | Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood |
| US6175420B1 (en) * | 1998-05-20 | 2001-01-16 | Zymequest, Inc. | Optical sensors for cell processing systems |
| JP3553858B2 (ja) * | 1999-08-25 | 2004-08-11 | 東洋紡績株式会社 | 血管網類似構造体を有する細胞培養用モジュール |
| US7011761B2 (en) * | 1999-09-03 | 2006-03-14 | Baxter International Inc. | Red blood cell processing systems and methods which control red blood cell hematocrit |
| US20020020680A1 (en) * | 2000-06-20 | 2002-02-21 | Glen Jorgensen | Blood component preparation (BCP) device and method of use thereof |
| US6610002B2 (en) * | 2001-04-09 | 2003-08-26 | Medtronic, Inc. | Method for handling blood sample to ensure blood components are isolated |
| US6790371B2 (en) * | 2001-04-09 | 2004-09-14 | Medtronic, Inc. | System and method for automated separation of blood components |
| US6890291B2 (en) * | 2001-06-25 | 2005-05-10 | Mission Medical, Inc. | Integrated automatic blood collection and processing unit |
| JP2005523128A (ja) * | 2002-04-24 | 2005-08-04 | インターポア・オルソペディックス | 血液分離及び濃縮システム |
| JP2004123716A (ja) * | 2002-08-06 | 2004-04-22 | Mitsubishi Pharma Corp | 化学物質に起因する肝障害の予防及び/又は治療のための医薬 |
| JP2004099560A (ja) * | 2002-09-11 | 2004-04-02 | Hiroshi Makino | 薬剤性腎障害の予防及び/又は治療のための医薬 |
| ES2265199B1 (es) * | 2003-06-12 | 2008-02-01 | Cellerix, S.L. | Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones. |
| EP1789540B9 (en) * | 2004-09-03 | 2012-02-22 | Moraga Biotechnology Inc. | Non-embryonic totipotent blastomer-like stem cells and methods therefor |
| WO2006070370A2 (en) * | 2004-12-29 | 2006-07-06 | Hadasit Medical Research Services & Development Limited | Stem cells culture systems |
| JP4722508B2 (ja) * | 2005-02-23 | 2011-07-13 | 日本メナード化粧品株式会社 | 多能性幹細胞の同定及び分離培養方法 |
| EP1962719A4 (en) * | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| WO2009059032A2 (en) * | 2007-10-30 | 2009-05-07 | University Of Louisville Research Foundation, Inc. | Uses and isolation of very small embryonic-like (vsel) stem cells |
| US7939057B2 (en) * | 2006-01-25 | 2011-05-10 | Mount Sinai School Of Medicine | Methods and compositions for modulating the mobilization of stem cells |
| EP1991666A4 (en) * | 2006-02-27 | 2009-06-10 | Moraga Biotech Corp | NON-EMBRYONIC TOTIPOTENT STEM CELLS OF BLASTOMERIC TYPE AND METHODS |
| EP2489728A1 (en) * | 2006-06-15 | 2012-08-22 | Neostem, Inc | Processing procedure for peripheral blood stem cells |
| CA2850793A1 (en) * | 2006-10-23 | 2008-05-02 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
| CN101688177A (zh) * | 2007-02-12 | 2010-03-31 | 人类起源公司 | 来自贴壁胎盘干细胞的肝细胞和软骨细胞;以及cd34+、cd45-胎盘干细胞富集的细胞群 |
| US20090053182A1 (en) * | 2007-05-25 | 2009-02-26 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
| US7737175B2 (en) * | 2007-06-01 | 2010-06-15 | Duke University | Methods and compositions for regulating HDAC4 activity |
| WO2009012357A2 (en) * | 2007-07-17 | 2009-01-22 | The General Hospital Corporation | Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof |
| EP2022848A1 (en) * | 2007-08-10 | 2009-02-11 | Hubrecht Institut | A method for identifying, expanding, and removing adult stem cells and cancer stem cells |
| WO2009061024A1 (en) * | 2007-11-09 | 2009-05-14 | Rnl Bio Co., Ltd | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
| WO2009136283A2 (en) * | 2008-05-08 | 2009-11-12 | Coretherapix Slu | Multipotent adult stem cell population |
| US20120021482A1 (en) * | 2008-09-30 | 2012-01-26 | Zuba-Surma Ewa K | Methods for isolating very small embryonic-like (vsel) stem cells |
| US20110305673A1 (en) * | 2008-11-12 | 2011-12-15 | The University Of Vermont And State Agriculture College | Compositions and methods for tissue repair |
| CN101748096B (zh) * | 2008-12-17 | 2013-03-13 | 北京汉氏联合生物技术有限公司 | 亚全能干细胞、其制备方法及其用途 |
| WO2010083203A2 (en) * | 2009-01-13 | 2010-07-22 | StemBios Technologies, Inc. | Non-embryonic stem cells and uses thereof |
| CN102421467B (zh) * | 2009-03-13 | 2015-04-22 | 梅约医学教育与研究基金会 | 生物人工肝 |
| EP2549992B1 (en) * | 2010-03-23 | 2019-08-14 | The Johns Hopkins University | Methods of treatment using stem cell mobilizers |
| CA2835313A1 (en) * | 2010-05-07 | 2011-11-10 | Institut De Recherches Cliniques De Montreal | Gfi1b modulation and uses thereof |
| SG10201913920PA (en) * | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
| CN103097519B (zh) * | 2010-08-04 | 2016-08-03 | 干细胞生物科技公司 | 体干细胞 |
| CN102008650B (zh) * | 2010-12-16 | 2017-02-15 | 天津市医药科学研究所 | 一种治疗肿瘤的复方中药制剂及其制备方法 |
| WO2012139131A1 (en) * | 2011-04-08 | 2012-10-11 | The Regents Of The University Of Michigan | Autologous human adult pluripotent very small embryonic-like (hvsel) stem cell regeneration of bone and cartilage |
| US9289375B2 (en) * | 2011-08-05 | 2016-03-22 | Stemtech International Inc. | Skin care compositions containing combinations of natural ingredients |
| TWI614340B (zh) * | 2011-09-28 | 2018-02-11 | 幹細胞生物科技股份有限公司 | 體幹細胞及其製備方法 |
| CN104822827B (zh) * | 2012-12-06 | 2020-01-21 | 干细胞生物科技公司 | Lgr5+体干细胞 |
| EP2818544A1 (en) * | 2013-06-24 | 2014-12-31 | Stembios Technologies, Inc. | Method for counting number of stem cells in human or animal samples |
| CN105687245A (zh) * | 2014-12-13 | 2016-06-22 | 干细胞生物科技公司 | 制备注射液的方法 |
-
2015
- 2015-11-18 JP JP2017504036A patent/JP2018501189A/ja active Pending
- 2015-11-18 WO PCT/US2015/061257 patent/WO2016081553A1/en not_active Ceased
- 2015-11-18 CN CN201580043614.0A patent/CN106573018A/zh active Pending
- 2015-11-18 US US14/945,012 patent/US20160136203A1/en not_active Abandoned
- 2015-11-18 EP EP15860413.2A patent/EP3220929A4/en not_active Withdrawn
- 2015-11-18 HK HK17105713.6A patent/HK1232131A1/zh unknown
- 2015-11-18 CN CN202110799982.5A patent/CN113521107A/zh active Pending
- 2015-11-19 TW TW104138263A patent/TW201625280A/zh unknown
- 2015-11-19 TW TW110135166A patent/TW202224691A/zh unknown
-
2018
- 2018-11-02 US US16/179,522 patent/US20190105353A1/en not_active Abandoned
-
2020
- 2020-10-08 US US17/066,163 patent/US20210093676A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3220929A1 (en) | 2017-09-27 |
| US20210093676A1 (en) | 2021-04-01 |
| CN113521107A (zh) | 2021-10-22 |
| WO2016081553A1 (en) | 2016-05-26 |
| EP3220929A4 (en) | 2018-06-27 |
| CN106573018A (zh) | 2017-04-19 |
| TW202224691A (zh) | 2022-07-01 |
| JP2018501189A (ja) | 2018-01-18 |
| HK1232131A1 (zh) | 2018-01-05 |
| US20160136203A1 (en) | 2016-05-19 |
| US20190105353A1 (en) | 2019-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7134317B2 (ja) | 生体組織から単離できる多能性幹細胞 | |
| Stocum | Stem cells in regenerative biology and medicine | |
| US7560280B2 (en) | Human cord blood derived unrestricted somatic stem cells (USSC) | |
| JP4862046B2 (ja) | ヒト脂肪組織由来の多能性幹細胞及びそれを含む細胞治療剤 | |
| Rinaldi et al. | Stem cells for skeletal muscle regeneration: therapeutic potential and roadblocks | |
| Moretti et al. | Mesenchymal stromal cells derived from human umbilical cord tissues: primitive cells with potential for clinical and tissue engineering applications | |
| KR100871984B1 (ko) | 태반 조직 유래 다능성 줄기세포 및 이를 함유하는세포치료제 | |
| Azari et al. | Effects of transplanted mesenchymal stem cells isolated from Wharton’s jelly of caprine umbilical cord on cutaneous wound healing; histopathological evaluation | |
| US20070243172A1 (en) | Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same | |
| JP6486948B2 (ja) | 純粋栄養膜層から由来した幹細胞及びそれを含む細胞治療剤 | |
| AU2002229533A1 (en) | Human cord blood derived unrestricted somatic stem cells (ussc) | |
| JP2016509863A5 (enExample) | ||
| JP2016509863A (ja) | 細胞、臍帯血収集のための方法及び装置、並びに細胞の単離のための方法及び装置 | |
| Mohammadi-Sangcheshmeh et al. | Isolation, characterization, and mesodermic differentiation of stem cells from adipose tissue of camel (Camelus dromedarius) | |
| Nakatsuka et al. | Identification and characterization of lineage− CD45− Sca-1+ VSEL phenotypic cells residing in adult mouse bone tissue | |
| US20210093676A1 (en) | Somatic stem cells for treating bone defects | |
| Oh et al. | Murine Sca1+ Lin− bone marrow contains an endodermal precursor population that differentiates into hepatocytes | |
| CA3029505A1 (en) | Prophylactic or therapeutic agent for organ fibrosis | |
| Bhattacharya et al. | Regenerative medicine using pregnancy-specific biological substances | |
| Pavlović et al. | Animal and plant stem cells | |
| Smith | The Therapeutic Potential of CD271+ Sorted Adipose-Derived Stem Cells in Adipose Tissue Engineering | |
| Bianco et al. | Cell source | |
| JP2008069183A (ja) | 唾液腺腺管上皮由来幹細胞及びその用途 | |
| Weiss et al. | Mesenchymal Stromal Cells Derived from Wharton's Jelly | |
| Yang et al. | Identification of mesenchymal stem cells in aorta-gonad-mesonephros and |