JP2018501189A - 骨欠損を治療するための体性幹細胞 - Google Patents

骨欠損を治療するための体性幹細胞 Download PDF

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Publication number
JP2018501189A
JP2018501189A JP2017504036A JP2017504036A JP2018501189A JP 2018501189 A JP2018501189 A JP 2018501189A JP 2017504036 A JP2017504036 A JP 2017504036A JP 2017504036 A JP2017504036 A JP 2017504036A JP 2018501189 A JP2018501189 A JP 2018501189A
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cells
sample
somatic stem
subject
lgr5
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JP2018501189A5 (enExample
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ジェイムズ ワン
ジェイムズ ワン
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Stembios Technologies Inc
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Stembios Technologies Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
JP2017504036A 2014-11-19 2015-11-18 骨欠損を治療するための体性幹細胞 Pending JP2018501189A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462081880P 2014-11-19 2014-11-19
US62/081,880 2014-11-19
PCT/US2015/061257 WO2016081553A1 (en) 2014-11-19 2015-11-18 Somatic stem cells for treating bone defects

Publications (2)

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JP2018501189A true JP2018501189A (ja) 2018-01-18
JP2018501189A5 JP2018501189A5 (enExample) 2018-11-29

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Family Applications (1)

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JP2017504036A Pending JP2018501189A (ja) 2014-11-19 2015-11-18 骨欠損を治療するための体性幹細胞

Country Status (7)

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US (3) US20160136203A1 (enExample)
EP (1) EP3220929A4 (enExample)
JP (1) JP2018501189A (enExample)
CN (2) CN106573018A (enExample)
HK (1) HK1232131A1 (enExample)
TW (2) TW201625280A (enExample)
WO (1) WO2016081553A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201819623A (zh) * 2016-10-18 2018-06-01 美商幹細胞生物科技股份有限公司 用於降低膽紅素位準之組成物及方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038231A1 (en) * 2006-06-15 2008-02-14 Rodgerson Denis O Processing procedure for peripheral blood stem cells
JP2010507392A (ja) * 2006-10-23 2010-03-11 アントフロゲネシス コーポレーション 胎盤細胞集団で骨欠損を治療するための方法及び組成物
JP2013535215A (ja) * 2010-08-04 2013-09-12 ステムバイオス テクノロジーズ，インコーポレイテッド 体性幹細胞
US20140161774A1 (en) * 2012-12-06 2014-06-12 StemBios Technologies, Inc. Lgr5+ SOMATIC STEM CELLS
US20140219952A1 (en) * 2010-03-23 2014-08-07 The Johns Hopkins University Methods of treatment using stem cell mobilizers

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2936171B2 (ja) * 1989-09-01 1999-08-23 東ソー株式会社 血清アルブミンの製造方法
AU1705599A (en) * 1997-11-26 1999-06-15 Allegheny University Of The Health Sciences Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
US6175420B1 (en) * 1998-05-20 2001-01-16 Zymequest, Inc. Optical sensors for cell processing systems
JP3553858B2 (ja) * 1999-08-25 2004-08-11 東洋紡績株式会社 血管網類似構造体を有する細胞培養用モジュール
US7011761B2 (en) * 1999-09-03 2006-03-14 Baxter International Inc. Red blood cell processing systems and methods which control red blood cell hematocrit
US20020020680A1 (en) * 2000-06-20 2002-02-21 Glen Jorgensen Blood component preparation (BCP) device and method of use thereof
US6610002B2 (en) * 2001-04-09 2003-08-26 Medtronic, Inc. Method for handling blood sample to ensure blood components are isolated
US6790371B2 (en) * 2001-04-09 2004-09-14 Medtronic, Inc. System and method for automated separation of blood components
US6890291B2 (en) * 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
JP2005523128A (ja) * 2002-04-24 2005-08-04 インターポア・オルソペディックス 血液分離及び濃縮システム
JP2004123716A (ja) * 2002-08-06 2004-04-22 Mitsubishi Pharma Corp 化学物質に起因する肝障害の予防及び／又は治療のための医薬
JP2004099560A (ja) * 2002-09-11 2004-04-02 Hiroshi Makino 薬剤性腎障害の予防及び／又は治療のための医薬
ES2265199B1 (es) * 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
EP1789540B9 (en) * 2004-09-03 2012-02-22 Moraga Biotechnology Inc. Non-embryonic totipotent blastomer-like stem cells and methods therefor
WO2006070370A2 (en) * 2004-12-29 2006-07-06 Hadasit Medical Research Services & Development Limited Stem cells culture systems
JP4722508B2 (ja) * 2005-02-23 2011-07-13 日本メナード化粧品株式会社 多能性幹細胞の同定及び分離培養方法
EP1962719A4 (en) * 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd MEDIA FOR BREEDING STEM CELLS
WO2009059032A2 (en) * 2007-10-30 2009-05-07 University Of Louisville Research Foundation, Inc. Uses and isolation of very small embryonic-like (vsel) stem cells
US7939057B2 (en) * 2006-01-25 2011-05-10 Mount Sinai School Of Medicine Methods and compositions for modulating the mobilization of stem cells
EP1991666A4 (en) * 2006-02-27 2009-06-10 Moraga Biotech Corp NON-EMBRYONIC TOTIPOTENT STEM CELLS OF BLASTOMERIC TYPE AND METHODS
CN101688177A (zh) * 2007-02-12 2010-03-31 人类起源公司 来自贴壁胎盘干细胞的肝细胞和软骨细胞；以及cd34+、cd45-胎盘干细胞富集的细胞群
US20090053182A1 (en) * 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
US7737175B2 (en) * 2007-06-01 2010-06-15 Duke University Methods and compositions for regulating HDAC4 activity
WO2009012357A2 (en) * 2007-07-17 2009-01-22 The General Hospital Corporation Methods to identify and enrich for populations of ovarian cancer stem cells and somatic ovarian stem cells and uses thereof
EP2022848A1 (en) * 2007-08-10 2009-02-11 Hubrecht Institut A method for identifying, expanding, and removing adult stem cells and cancer stem cells
WO2009061024A1 (en) * 2007-11-09 2009-05-14 Rnl Bio Co., Ltd Method for isolating and culturing adult stem cells derived from human amniotic epithelium
WO2009136283A2 (en) * 2008-05-08 2009-11-12 Coretherapix Slu Multipotent adult stem cell population
US20120021482A1 (en) * 2008-09-30 2012-01-26 Zuba-Surma Ewa K Methods for isolating very small embryonic-like (vsel) stem cells
US20110305673A1 (en) * 2008-11-12 2011-12-15 The University Of Vermont And State Agriculture College Compositions and methods for tissue repair
CN101748096B (zh) * 2008-12-17 2013-03-13 北京汉氏联合生物技术有限公司 亚全能干细胞、其制备方法及其用途
WO2010083203A2 (en) * 2009-01-13 2010-07-22 StemBios Technologies, Inc. Non-embryonic stem cells and uses thereof
CN102421467B (zh) * 2009-03-13 2015-04-22 梅约医学教育与研究基金会 生物人工肝
CA2835313A1 (en) * 2010-05-07 2011-11-10 Institut De Recherches Cliniques De Montreal Gfi1b modulation and uses thereof
SG10201913920PA (en) * 2010-05-12 2020-03-30 Abt Holding Co Modulation of splenocytes in cell therapy
CN102008650B (zh) * 2010-12-16 2017-02-15 天津市医药科学研究所 一种治疗肿瘤的复方中药制剂及其制备方法
WO2012139131A1 (en) * 2011-04-08 2012-10-11 The Regents Of The University Of Michigan Autologous human adult pluripotent very small embryonic-like (hvsel) stem cell regeneration of bone and cartilage
US9289375B2 (en) * 2011-08-05 2016-03-22 Stemtech International Inc. Skin care compositions containing combinations of natural ingredients
TWI614340B (zh) * 2011-09-28 2018-02-11 幹細胞生物科技股份有限公司 體幹細胞及其製備方法
EP2818544A1 (en) * 2013-06-24 2014-12-31 Stembios Technologies, Inc. Method for counting number of stem cells in human or animal samples
CN105687245A (zh) * 2014-12-13 2016-06-22 干细胞生物科技公司 制备注射液的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080038231A1 (en) * 2006-06-15 2008-02-14 Rodgerson Denis O Processing procedure for peripheral blood stem cells
JP2010507392A (ja) * 2006-10-23 2010-03-11 アントフロゲネシス コーポレーション 胎盤細胞集団で骨欠損を治療するための方法及び組成物
US20140219952A1 (en) * 2010-03-23 2014-08-07 The Johns Hopkins University Methods of treatment using stem cell mobilizers
JP2013535215A (ja) * 2010-08-04 2013-09-12 ステムバイオス テクノロジーズ，インコーポレイテッド 体性幹細胞
US20140161774A1 (en) * 2012-12-06 2014-06-12 StemBios Technologies, Inc. Lgr5+ SOMATIC STEM CELLS

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIOMATERIALS, vol. 28, JPN6019032888, 2007, pages 5477 - 5486, ISSN: 0004473431 *
CELL, vol. 124, JPN6019032890, 2006, pages 407 - 421, ISSN: 0004473430 *
日本輸血学会雑誌, vol. 44, no. 3, JPN6020027790, 1998, pages 418 - 420, ISSN: 0004315164 *
旭川医科大学研究フォーラム, vol. 12, JPN6019032889, 2011, pages 2 - 11, ISSN: 0004473432 *
移植, vol. 43, no. 2, JPN6019032887, 2008, pages 113 - 118, ISSN: 0004473429 *
脳卒中, vol. 24, no. 2, JPN6020027789, 2002, pages 234 - 238, ISSN: 0004315163 *

Also Published As

Publication number Publication date
EP3220929A1 (en) 2017-09-27
US20210093676A1 (en) 2021-04-01
CN113521107A (zh) 2021-10-22
WO2016081553A1 (en) 2016-05-26
EP3220929A4 (en) 2018-06-27
TW201625280A (zh) 2016-07-16
CN106573018A (zh) 2017-04-19
TW202224691A (zh) 2022-07-01
HK1232131A1 (zh) 2018-01-05
US20160136203A1 (en) 2016-05-19
US20190105353A1 (en) 2019-04-11

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