TW201124406A - Novel estrogen receptor ligands - Google Patents

Novel estrogen receptor ligands Download PDF

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Publication number
TW201124406A
TW201124406A TW099133976A TW99133976A TW201124406A TW 201124406 A TW201124406 A TW 201124406A TW 099133976 A TW099133976 A TW 099133976A TW 99133976 A TW99133976 A TW 99133976A TW 201124406 A TW201124406 A TW 201124406A
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TW
Taiwan
Prior art keywords
group
alkyl
hydroxyphenyl
hydroxy
pyrazole
Prior art date
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TW099133976A
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English (en)
Chinese (zh)
Inventor
Joakim Loefstedt
Xiong-Yu Wu
Lars Krueger
Original Assignee
Karobio Ab
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Publication date
Priority claimed from GB0917576A external-priority patent/GB0917576D0/en
Priority claimed from GBGB1011859.4A external-priority patent/GB201011859D0/en
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of TW201124406A publication Critical patent/TW201124406A/zh

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
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  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
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TW099133976A 2009-10-07 2010-10-06 Novel estrogen receptor ligands TW201124406A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0917576A GB0917576D0 (en) 2009-10-07 2009-10-07 Novel estrogenreceptor ligands
GBGB1011859.4A GB201011859D0 (en) 2010-07-14 2010-07-14 Novel estrogen receptor ligands

Publications (1)

Publication Number Publication Date
TW201124406A true TW201124406A (en) 2011-07-16

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ID=43856389

Family Applications (2)

Application Number Title Priority Date Filing Date
TW099133976A TW201124406A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands
TW099133977A TW201124409A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands

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Application Number Title Priority Date Filing Date
TW099133977A TW201124409A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands

Country Status (10)

Country Link
US (2) US8653112B2 (enExample)
EP (1) EP2486018B1 (enExample)
JP (1) JP5735518B2 (enExample)
CN (1) CN102648183B (enExample)
AR (2) AR078538A1 (enExample)
DK (1) DK2486018T3 (enExample)
ES (1) ES2737429T3 (enExample)
IN (1) IN2012DN02556A (enExample)
TW (2) TW201124406A (enExample)
WO (2) WO2011042475A1 (enExample)

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JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
WO2015039073A1 (en) 2013-09-16 2015-03-19 Kellogg Glen E Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methds of use thereof
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EP3782616B1 (en) 2014-09-02 2023-11-01 The Regents of The University of California Estrogen receptor ligand treatment for neurodegenerative diseases
WO2016097036A1 (en) * 2014-12-17 2016-06-23 Karo Bio Ab Estrogen receptor ligand for use in treating melanoma
CN106397377B (zh) * 2016-09-05 2019-04-05 中南大学 一种富电子五元杂环酸及其衍生物脱羧上氟的方法
CA3062972C (en) 2017-05-09 2021-09-14 Kind Pharmaceutical Indolizine derivatives and their application in medicine
CN108610246A (zh) * 2018-06-01 2018-10-02 山东潍坊润丰化工股份有限公司 一种环丙唑醇中间体1-（4-氯苯基）-2-环丙基-1-丙酮的制备方法
WO2021057998A1 (zh) * 2019-09-29 2021-04-01 上海森辉医药有限公司 一种吡咯并氨基哒嗪酮化合物的制备方法

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CN102648183B (zh) 2015-12-02

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