TW201124406A - Novel estrogen receptor ligands - Google Patents

Novel estrogen receptor ligands Download PDF

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Publication number
TW201124406A
TW201124406A TW099133976A TW99133976A TW201124406A TW 201124406 A TW201124406 A TW 201124406A TW 099133976 A TW099133976 A TW 099133976A TW 99133976 A TW99133976 A TW 99133976A TW 201124406 A TW201124406 A TW 201124406A
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TW
Taiwan
Prior art keywords
group
alkyl
hydroxyphenyl
hydroxy
pyrazole
Prior art date
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TW099133976A
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English (en)
Chinese (zh)
Inventor
Joakim Loefstedt
Xiong-Yu Wu
Lars Krueger
Original Assignee
Karobio Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0917576A external-priority patent/GB0917576D0/en
Priority claimed from GBGB1011859.4A external-priority patent/GB201011859D0/en
Application filed by Karobio Ab filed Critical Karobio Ab
Publication of TW201124406A publication Critical patent/TW201124406A/zh

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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
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TW099133976A 2009-10-07 2010-10-06 Novel estrogen receptor ligands TW201124406A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0917576A GB0917576D0 (en) 2009-10-07 2009-10-07 Novel estrogenreceptor ligands
GBGB1011859.4A GB201011859D0 (en) 2010-07-14 2010-07-14 Novel estrogen receptor ligands

Publications (1)

Publication Number Publication Date
TW201124406A true TW201124406A (en) 2011-07-16

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ID=43856389

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Application Number Title Priority Date Filing Date
TW099133976A TW201124406A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands
TW099133977A TW201124409A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands

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Application Number Title Priority Date Filing Date
TW099133977A TW201124409A (en) 2009-10-07 2010-10-06 Novel estrogen receptor ligands

Country Status (10)

Country Link
US (2) US8653112B2 (OSRAM)
EP (1) EP2486018B1 (OSRAM)
JP (1) JP5735518B2 (OSRAM)
CN (1) CN102648183B (OSRAM)
AR (2) AR078536A1 (OSRAM)
DK (1) DK2486018T3 (OSRAM)
ES (1) ES2737429T3 (OSRAM)
IN (1) IN2012DN02556A (OSRAM)
TW (2) TW201124406A (OSRAM)
WO (2) WO2011042477A1 (OSRAM)

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KR20160067981A (ko) 2008-04-16 2016-06-14 카로 바이오 아베 신규한 에스트로겐 수용체 리간드
GB0817221D0 (en) 2008-09-19 2008-10-29 Karobio Ab Novel estrogen receptor ligands

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