TW201107345A - Immunoglobulins - Google Patents

Info

Publication number

TW201107345A

TW201107345A TW099116859A TW99116859A TW201107345A TW 201107345 A TW201107345 A TW 201107345A TW 099116859 A TW099116859 A TW 099116859A TW 99116859 A TW99116859 A TW 99116859A TW 201107345 A TW201107345 A TW 201107345A

Authority

TW

Taiwan

Prior art keywords

seq

antigen binding

heavy chain

binding protein

antibody

Prior art date

2009-05-28

Links

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• 108060003951 Immunoglobulin Proteins 0.000 title claims description 48
• 102000018358 immunoglobulin Human genes 0.000 title claims description 48
• 229940072221 immunoglobulins Drugs 0.000 title description 3
• 102000025171 antigen binding proteins Human genes 0.000 claims abstract description 148
• 108091000831 antigen binding proteins Proteins 0.000 claims abstract description 148
• 208000006673 asthma Diseases 0.000 claims abstract description 73
• 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 claims abstract description 36
• 102000019207 human interleukin-13 Human genes 0.000 claims abstract description 36
• 238000011282 treatment Methods 0.000 claims abstract description 19
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
• 230000027455 binding Effects 0.000 claims description 212
• 210000004027 cell Anatomy 0.000 claims description 92
• 241000282414 Homo sapiens Species 0.000 claims description 78
• 108090000978 Interleukin-4 Proteins 0.000 claims description 51
• 150000001413 amino acids Chemical class 0.000 claims description 44
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 42
• 238000000034 method Methods 0.000 claims description 40
• 235000001014 amino acid Nutrition 0.000 claims description 32
• 229940024606 amino acid Drugs 0.000 claims description 32
• 150000003431 steroids Chemical class 0.000 claims description 23
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 22
• 239000013598 vector Substances 0.000 claims description 22
• 201000010099 disease Diseases 0.000 claims description 19
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims description 18
• 108010002616 Interleukin-5 Proteins 0.000 claims description 17
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• 239000002253 acid Substances 0.000 claims description 14
• 230000002776 aggregation Effects 0.000 claims description 14
• 238000004220 aggregation Methods 0.000 claims description 14
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 108091033319 polynucleotide Proteins 0.000 claims description 11
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• 239000002157 polynucleotide Substances 0.000 claims description 11
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• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 8
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• 235000013922 glutamic acid Nutrition 0.000 claims description 5
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• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 4
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 4
• 201000009594 Systemic Scleroderma Diseases 0.000 claims description 4
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• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
• 235000004279 alanine Nutrition 0.000 claims description 4
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• 101001138132 Homo sapiens Immunoglobulin kappa variable 1-6 Proteins 0.000 claims description 3
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• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 3
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 3
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• COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
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• 101001008327 Homo sapiens Immunoglobulin kappa variable 2D-30 Proteins 0.000 claims description 2
• 101001009876 Homo sapiens Probable non-functional immunoglobulin kappa variable 1D-42 Proteins 0.000 claims description 2
• 102100020945 Immunoglobulin kappa variable 1-17 Human genes 0.000 claims description 2
• 102100027457 Immunoglobulin kappa variable 1D-17 Human genes 0.000 claims description 2
• 102100027465 Immunoglobulin kappa variable 2D-30 Human genes 0.000 claims description 2
• 102100030884 Probable non-functional immunoglobulin kappa variable 1D-42 Human genes 0.000 claims description 2
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 2
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 5
• VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical group NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 claims 1
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• 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
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• 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
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