TW201043620A - Isoxazolines as inhibitors of fatty acid amide hydrolase - Google Patents

Isoxazolines as inhibitors of fatty acid amide hydrolase Download PDF

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Publication number
TW201043620A
TW201043620A TW099115796A TW99115796A TW201043620A TW 201043620 A TW201043620 A TW 201043620A TW 099115796 A TW099115796 A TW 099115796A TW 99115796 A TW99115796 A TW 99115796A TW 201043620 A TW201043620 A TW 201043620A
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Taiwan
Prior art keywords
alkyl
group
aryl
several embodiments
compound
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TW099115796A
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English (en)
Chinese (zh)
Inventor
Alfredo C Castro
Lawrence K Chan
Mark L Behnke
Catherine A Evans
Louis Grenier
Michael J Grogan
Yves Leblanc
Tao Liu
Stephane Peluso
Daniel A Snyder
Thomas T Tibbitts
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Infinity Pharmaceuticals Inc
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Publication of TW201043620A publication Critical patent/TW201043620A/zh

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
TW099115796A 2009-05-18 2010-05-18 Isoxazolines as inhibitors of fatty acid amide hydrolase TW201043620A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17928309P 2009-05-18 2009-05-18
US17928509P 2009-05-18 2009-05-18
US17928009P 2009-05-18 2009-05-18

Publications (1)

Publication Number Publication Date
TW201043620A true TW201043620A (en) 2010-12-16

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW099115796A TW201043620A (en) 2009-05-18 2010-05-18 Isoxazolines as inhibitors of fatty acid amide hydrolase

Country Status (16)

Country Link
EP (1) EP2432771A4 (fr)
JP (1) JP2012527467A (fr)
KR (1) KR20120042766A (fr)
CN (1) CN102459202B (fr)
AR (1) AR076687A1 (fr)
AU (1) AU2010249674A1 (fr)
BR (1) BRPI1011049A2 (fr)
CA (1) CA2762527A1 (fr)
IL (1) IL216420A0 (fr)
MX (1) MX2011012263A (fr)
NZ (2) NZ596585A (fr)
RU (1) RU2539595C2 (fr)
SG (2) SG10201402443PA (fr)
TW (1) TW201043620A (fr)
WO (1) WO2010135360A1 (fr)
ZA (1) ZA201108657B (fr)

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US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
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JP2014510065A (ja) 2011-03-02 2014-04-24 バイオノミックス リミテッド 治療薬としての新規な小分子
JP6055817B2 (ja) 2011-05-12 2016-12-27 バイオノミックス リミテッド ナフチリジンの調製方法
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BR112020002519A2 (pt) 2017-08-10 2020-08-04 Taisho Pharmaceutical Co., Ltd. composto de piridina substituído por azol
EP3866798A4 (fr) * 2018-10-15 2022-07-13 Dana-Farber Cancer Institute, Inc. Inhibiteurs du facteur de transcription à domaine associé transcriptionnel amélioré (tead) et leurs utilisations
CN110016142B (zh) * 2019-04-30 2021-08-03 合肥工业大学 一种含嘧啶硼酸结构的硅油及其制备方法
WO2020243423A1 (fr) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
CN114466839A (zh) 2019-05-31 2022-05-10 医肯纳肿瘤学公司 Tead抑制剂和其用途
BR112023016031A2 (pt) 2021-02-11 2023-12-05 Basf Se Compostos de fórmula i, composições agrícolas, métodos para combater ou controlar pragas invertebradas, para proteger plantas em crescimento e para tratar ou proteger um animal e semente
EP4043444A1 (fr) 2021-02-11 2022-08-17 Basf Se Dérivés substitués d'isoxazoline
KR20240111312A (ko) 2021-10-25 2024-07-16 카이메라 쎄라퓨틱스 인코포레이티드 Tyk2 분해제 및 이의 용도
EP4238971A1 (fr) 2022-03-02 2023-09-06 Basf Se Dérivés substitués d'isoxazoline
WO2023165854A1 (fr) 2022-03-02 2023-09-07 Basf Se Dérivés d'isoxazoline substitués
WO2024061665A1 (fr) 2022-09-20 2024-03-28 Basf Se Dérivés de n-(3-(aminométhyl)-phényl)-5-(4-phényl)-5-(trifluorométhyl)-4,5-dihydroisoxazol-3-amine et composés similaires utilisés comme pesticides
EP4342885A1 (fr) 2022-09-20 2024-03-27 Basf Se Dérivés de n-(3-(aminométhyl)-phényl)-5-(4-phényl)-5-(trifluorométhyl)-4,5-dihydroisoxazol-3-amine et composés similaires en tant que pesticides

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JP2012527467A (ja) 2012-11-08
BRPI1011049A2 (pt) 2019-09-24
EP2432771A1 (fr) 2012-03-28
MX2011012263A (es) 2012-01-30
RU2539595C2 (ru) 2015-01-20
AR076687A1 (es) 2011-06-29
KR20120042766A (ko) 2012-05-03
AU2010249674A1 (en) 2011-12-15
SG176168A1 (en) 2011-12-29
NZ619076A (en) 2015-07-31
RU2011151635A (ru) 2013-06-27
WO2010135360A1 (fr) 2010-11-25
EP2432771A4 (fr) 2013-06-05
SG10201402443PA (en) 2014-10-30
CN102459202A (zh) 2012-05-16
NZ596585A (en) 2014-01-31
IL216420A0 (en) 2012-03-01
CA2762527A1 (fr) 2010-11-25
ZA201108657B (en) 2013-01-30

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