TW200930704A - Kinesin inhibitors as cancer therapeutics - Google Patents

Kinesin inhibitors as cancer therapeutics Download PDF

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Publication number
TW200930704A
TW200930704A TW097148535A TW97148535A TW200930704A TW 200930704 A TW200930704 A TW 200930704A TW 097148535 A TW097148535 A TW 097148535A TW 97148535 A TW97148535 A TW 97148535A TW 200930704 A TW200930704 A TW 200930704A
Authority
TW
Taiwan
Prior art keywords
group
cancer
substituted
compound
tumor
Prior art date
Application number
TW097148535A
Other languages
English (en)
Chinese (zh)
Inventor
Tinya Abrams
Paul Barsanti
David Duhl
Michel Faure
Paul A Renhowe
Annette Olga Walter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40328566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200930704(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW200930704A publication Critical patent/TW200930704A/zh

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW097148535A 2007-12-14 2008-12-12 Kinesin inhibitors as cancer therapeutics TW200930704A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1396607P 2007-12-14 2007-12-14

Publications (1)

Publication Number Publication Date
TW200930704A true TW200930704A (en) 2009-07-16

Family

ID=40328566

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097148535A TW200930704A (en) 2007-12-14 2008-12-12 Kinesin inhibitors as cancer therapeutics

Country Status (30)

Country Link
US (2) US8252832B2 (https=)
EP (1) EP2229170B1 (https=)
JP (1) JP5501976B2 (https=)
KR (1) KR20100098394A (https=)
CN (1) CN101939005B (https=)
AR (1) AR069676A1 (https=)
AU (1) AU2008337570B2 (https=)
BR (1) BRPI0821248A2 (https=)
CA (1) CA2708822A1 (https=)
CL (1) CL2008003707A1 (https=)
CO (1) CO6290651A2 (https=)
CR (1) CR11412A (https=)
DO (1) DOP2010000175A (https=)
EA (1) EA018014B1 (https=)
EC (1) ECSP10010248A (https=)
ES (1) ES2459442T3 (https=)
GE (1) GEP20125647B (https=)
GT (1) GT201000172A (https=)
IL (1) IL205831A0 (https=)
MA (1) MA31872B1 (https=)
MY (1) MY150214A (https=)
NI (1) NI201000091A (https=)
NZ (1) NZ585142A (https=)
PA (1) PA8807801A1 (https=)
PE (1) PE20091451A1 (https=)
SM (1) SMP201000095B (https=)
TN (1) TN2010000204A1 (https=)
TW (1) TW200930704A (https=)
UY (1) UY31532A1 (https=)
WO (1) WO2009077448A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
EP2558452A2 (en) 2010-04-15 2013-02-20 Novartis AG Oxazole and thiazole compounds as ksp inhibitors
US9498540B2 (en) 2013-03-15 2016-11-22 Novartis Ag Cell proliferation inhibitors and conjugates thereof
EP2968591A1 (en) * 2013-03-15 2016-01-20 Novartis AG Cell proliferation inhibitors and conjugates thereof
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
RU2751512C2 (ru) 2015-06-22 2021-07-14 Байер Фарма Акциенгезельшафт Конъюгаты антитела и лекарственного средства (adc) и конъюгаты антитела и пролекарства (apdc), содержащие ферментативно расщепляемые группы
CN105418527A (zh) * 2015-12-28 2016-03-23 青岛友诚高新技术有限公司 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途
CN105646361B (zh) * 2016-02-17 2017-12-01 吉首大学 一种2,4,5‑三芳基咪唑型化合物及其制法和用途
JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート(adc)
CN106668863B (zh) * 2017-02-21 2019-04-23 南方医科大学 靶向ktn1治疗皮肤鳞状细胞癌的药物
GB201706162D0 (en) * 2017-04-19 2017-05-31 Nat Univ Singapore Compounds
WO2019196111A1 (zh) * 2018-04-13 2019-10-17 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物
CN109646679A (zh) * 2019-01-28 2019-04-19 中国科学院长春应用化学研究所 铁离子螯合剂及其可药用盐的用途
CN111529526B (zh) * 2020-04-14 2021-04-23 广州领晟医疗科技有限公司 一种化合物在制备治疗急性胰腺炎的药物中的用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101170925B1 (ko) * 2004-06-18 2012-08-07 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 암 치료용 키네신 방추 단백질 (ksp) 억제제로서의n-(1-(1-벤질-4-페닐-1h-이미다졸-2-일)-2,2-디메틸프로필)벤자미드 유도체 및 관련 화합물
US7271271B2 (en) 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
TW200800951A (en) 2005-08-09 2008-01-01 Novartis Ag Substituted imidazole compounds as KSP inhibitors
AU2008205169B2 (en) 2007-01-05 2012-02-02 Novartis Ag Imidazole derivatives as kinesin spindle protein inhibitors (Eg-5)

Also Published As

Publication number Publication date
CL2008003707A1 (es) 2009-06-05
AU2008337570B2 (en) 2012-04-05
IL205831A0 (en) 2010-11-30
CN101939005B (zh) 2015-12-16
AU2008337570A1 (en) 2009-06-25
JP2011506402A (ja) 2011-03-03
MY150214A (en) 2013-12-13
EA201000900A1 (ru) 2011-02-28
JP5501976B2 (ja) 2014-05-28
BRPI0821248A2 (pt) 2015-06-16
GEP20125647B (en) 2012-09-25
WO2009077448A1 (en) 2009-06-25
US8252832B2 (en) 2012-08-28
MA31872B1 (fr) 2010-11-01
UY31532A1 (es) 2009-08-03
CO6290651A2 (es) 2011-06-20
EP2229170B1 (en) 2014-01-22
PE20091451A1 (es) 2009-10-19
US20130012560A1 (en) 2013-01-10
US8664256B2 (en) 2014-03-04
ECSP10010248A (es) 2010-07-30
DOP2010000175A (es) 2010-06-30
SMAP201000095A (it) 2010-09-10
CR11412A (es) 2010-06-30
NZ585142A (en) 2012-03-30
KR20100098394A (ko) 2010-09-06
GT201000172A (es) 2012-04-30
AR069676A1 (es) 2010-02-10
EP2229170A1 (en) 2010-09-22
US20090239922A1 (en) 2009-09-24
NI201000091A (es) 2011-03-15
ES2459442T3 (es) 2014-05-09
EA018014B1 (ru) 2013-04-30
CA2708822A1 (en) 2009-06-25
SMP201000095B (it) 2011-09-09
TN2010000204A1 (en) 2011-11-11
CN101939005A (zh) 2011-01-05
PA8807801A1 (es) 2009-07-23

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