TW200908987A - RNA antagonist compounds for the modulation of HER3 - Google Patents
RNA antagonist compounds for the modulation of HER3 Download PDFInfo
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Applications Claiming Priority (2)
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|---|---|---|---|
| US91739207P | 2007-05-11 | 2007-05-11 | |
| US2325008P | 2008-01-24 | 2008-01-24 |
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| TW200908987A true TW200908987A (en) | 2009-03-01 |
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| TW097117351A TW200908987A (en) | 2007-05-11 | 2008-05-09 | RNA antagonist compounds for the modulation of HER3 |
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| US (2) | US8268793B2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SG178789A1 (en) | 2007-02-16 | 2012-03-29 | Merrimack Pharmaceuticals Inc | Antibodies against erbb3 and uses thereof |
| NZ581201A (en) | 2007-05-11 | 2012-05-25 | Enzon Pharmaceuticals Inc | Rna antagonist compounds for the modulation of her3 |
| BRPI0921407A2 (pt) * | 2008-11-07 | 2019-09-24 | Enzo Pharmaceuticals Inc | terapia de combinação seletiva de erbb-3 (her3) |
| AR076053A1 (es) * | 2009-04-14 | 2011-05-18 | Schering Corp | Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor |
| KR101798679B1 (ko) | 2010-03-11 | 2017-11-16 | 메리맥 파마슈티컬즈, 인크. | ３중 음성 및 기저형 유방암 치료 시의 ｅｒｂｂ３ 저해제의 용도 |
| AU2011325956B2 (en) | 2010-11-12 | 2016-07-14 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| BR112013022882A2 (pt) | 2011-03-11 | 2016-12-20 | Merrimack Pharmaceuticals Inc | uso de inibidores de receptores da família egfr no tratamento de cânceres de mama hormônio-refratários |
| JP2014509593A (ja) | 2011-03-15 | 2014-04-21 | メリマック ファーマシューティカルズ インコーポレーティッド | ＥｒｂＢ経路阻害剤に対する耐性の克服 |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| CN104583398A (zh) | 2012-05-16 | 2015-04-29 | Rana医疗有限公司 | 用于调节基因表达的组合物和方法 |
| CA2908096C (en) | 2013-03-27 | 2022-05-03 | Isarna Therapeutics Gmbh | Modified tgf-beta oligonucleotides |
| EP3087394A2 (en) | 2013-12-27 | 2016-11-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| US10858650B2 (en) | 2014-10-30 | 2020-12-08 | The General Hospital Corporation | Methods for modulating ATRX-dependent gene repression |
| WO2016149455A2 (en) | 2015-03-17 | 2016-09-22 | The General Hospital Corporation | The rna interactome of polycomb repressive complex 1 (prc1) |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| CN116492365A (zh) * | 2022-01-19 | 2023-07-28 | 圣诺生物医药技术(广州)有限公司 | 抑制HER2和HER3的siRNA药物组合物 |
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| US4962029A (en) | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| EP1042504A2 (en) * | 1997-12-29 | 2000-10-11 | Genena Ltd. | A method for identifying and characterizing cells and tissues |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| US6277640B1 (en) * | 2000-07-31 | 2001-08-21 | Isis Pharmaceuticals, Inc. | Antisense modulation of Her-3 expression |
| US20050176024A1 (en) * | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA) |
| ES2280826T5 (es) * | 2002-08-05 | 2017-08-03 | Silence Therapeutics Gmbh | Nuevas formas adicionales de moléculas de ARN de interferencia |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US9045518B2 (en) | 2002-11-18 | 2015-06-02 | Santaris Pharma A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
| US20050266409A1 (en) * | 2003-02-04 | 2005-12-01 | Wyeth | Compositions and methods for diagnosing, preventing, and treating cancers |
| US8653252B2 (en) * | 2003-03-21 | 2014-02-18 | Santaris Pharma A/S | Short interfering RNA (siRNA) analogues |
| MXPA05011022A (es) | 2003-04-13 | 2006-04-27 | Enzon Pharmaceuticals Inc | Profarmacos oligonucleotidos polimericos. |
| AU2004291709C1 (en) | 2003-05-30 | 2010-03-11 | Astrazeneca Uk Limited | Process |
| EP3611273A1 (en) * | 2004-03-31 | 2020-02-19 | The General Hospital Corporation | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| DK2021472T3 (da) | 2006-05-05 | 2011-09-19 | Isis Pharmaceuticals Inc | Forbindelser og fremgangsmåder til modulering af genekspression |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| MX2009002856A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Conjugados polimericos que contienen porciones cargadas positivamente. |
| US9398493B2 (en) | 2006-10-30 | 2016-07-19 | Nokia Technologies Oy | Method, apparatus, and system providing operator controlled mobility for user equipment |
| US20100112687A1 (en) | 2007-03-02 | 2010-05-06 | Mdrna, Inc. | Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof |
| WO2008112903A2 (en) * | 2007-03-13 | 2008-09-18 | The Children's Hospital Of Philadelphia | Genetic alterations on chromosome 16 and methods of use thereof for the diagnosis and treatment of type 1 diabetes |
| NZ581201A (en) | 2007-05-11 | 2012-05-25 | Enzon Pharmaceuticals Inc | Rna antagonist compounds for the modulation of her3 |
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2008
- 2008-05-09 NZ NZ581201A patent/NZ581201A/en not_active IP Right Cessation
- 2008-05-09 MX MX2009012271A patent/MX2009012271A/es active IP Right Grant
- 2008-05-09 KR KR1020097025807A patent/KR20100024410A/ko not_active Ceased
- 2008-05-09 TW TW097117351A patent/TW200908987A/zh unknown
- 2008-05-09 WO PCT/EP2008/055779 patent/WO2008138904A2/en not_active Ceased
- 2008-05-09 JP JP2010506953A patent/JP2010526797A/ja active Pending
- 2008-05-09 AU AU2008250033A patent/AU2008250033A1/en not_active Abandoned
- 2008-05-09 EA EA200971049A patent/EA200971049A1/ru unknown
- 2008-05-09 CN CN200880024089A patent/CN101849007A/zh active Pending
- 2008-05-09 BR BRPI0811156A patent/BRPI0811156A2/pt not_active IP Right Cessation
- 2008-05-09 EP EP08759503A patent/EP2155877A2/en not_active Withdrawn
- 2008-05-09 US US12/118,271 patent/US8268793B2/en not_active Expired - Fee Related
- 2008-05-09 CA CA002686908A patent/CA2686908A1/en not_active Abandoned
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2009
- 2009-11-10 IL IL202038A patent/IL202038A0/en unknown
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2012
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Also Published As
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|---|---|
| WO2008138904A3 (en) | 2009-04-09 |
| IL202038A0 (en) | 2011-08-01 |
| AU2008250033A1 (en) | 2008-11-20 |
| BRPI0811156A2 (pt) | 2019-09-24 |
| US20120295955A1 (en) | 2012-11-22 |
| CA2686908A1 (en) | 2008-11-20 |
| WO2008138904A2 (en) | 2008-11-20 |
| EP2155877A2 (en) | 2010-02-24 |
| NZ581201A (en) | 2012-05-25 |
| US8268793B2 (en) | 2012-09-18 |
| JP2010526797A (ja) | 2010-08-05 |
| MX2009012271A (es) | 2010-02-04 |
| EA200971049A1 (ru) | 2010-04-30 |
| CN101849007A (zh) | 2010-09-29 |
| KR20100024410A (ko) | 2010-03-05 |
| US20080318894A1 (en) | 2008-12-25 |
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