TW200824693A - Pharmaceutical compositions of clonazepam and methods of use thereof - Google Patents
Pharmaceutical compositions of clonazepam and methods of use thereof Download PDFInfo
- Publication number
- TW200824693A TW200824693A TW096130010A TW96130010A TW200824693A TW 200824693 A TW200824693 A TW 200824693A TW 096130010 A TW096130010 A TW 096130010A TW 96130010 A TW96130010 A TW 96130010A TW 200824693 A TW200824693 A TW 200824693A
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- Prior art keywords
- clonazepam
- solvent
- composition
- administration
- dose
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- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical group C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 title claims abstract description 337
- 229960003120 clonazepam Drugs 0.000 title claims abstract description 330
- 238000000034 method Methods 0.000 title claims description 43
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 105
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 104
- 239000000243 solution Substances 0.000 claims description 54
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- 229940075557 diethylene glycol monoethyl ether Drugs 0.000 claims description 23
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 claims description 23
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- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 7
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- KJONHKAYOJNZEC-UHFFFAOYSA-N nitrazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1 KJONHKAYOJNZEC-UHFFFAOYSA-N 0.000 claims description 6
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| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11839597B2 (en) | 2016-07-22 | 2023-12-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
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| EP3150230A1 (en) * | 2007-01-19 | 2017-04-05 | Hananja Ehf | Methods and compositions for the delivery of a therapeutic agent |
| US20080275030A1 (en) | 2007-01-19 | 2008-11-06 | Sveinbjorn Gizurarson | Methods and Compositions for the Delivery of a Therapeutic Agent |
| US8946208B2 (en) | 2007-08-31 | 2015-02-03 | Archimedes Development Limited | Non-aqueous pharmaceutical composition |
| GB0716907D0 (en) * | 2007-08-31 | 2007-10-10 | Archimedes Dev Ltd | Pharmaceutical powder compositions |
| WO2009121039A2 (en) * | 2008-03-28 | 2009-10-01 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
| KR101517415B1 (ko) * | 2008-05-14 | 2015-05-07 | 에스케이바이오팜 주식회사 | 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물 |
| WO2010126970A1 (en) * | 2009-04-28 | 2010-11-04 | Optmed, Inc. | Methods for treating and preventing erectile dysfunction |
| EP2424540B1 (en) * | 2009-04-28 | 2014-04-23 | Optmed, Inc. | Compositions and methods for treating and preventing overactive bladder and conditions associated therewith |
| GB2481407B (en) * | 2010-06-22 | 2012-05-23 | Special Products Ltd | A rapid onset liquid midazolam composition for buccal administration |
| AU2012236334B2 (en) * | 2011-03-31 | 2017-02-16 | Sk Biopharmaceuticals Co., Ltd. | Intranasal benzodiazepine pharmaceutical compositions |
| ES2683902T3 (es) | 2011-06-14 | 2018-09-28 | Hale Biopharma Ventures, Llc | Administración de benzodiacepina |
| SG10201604653TA (en) * | 2011-12-11 | 2016-07-28 | Recro Pharma Inc | Intranasal dexmedetomidine compositions and methods of use thereof |
| US9125805B2 (en) * | 2012-06-27 | 2015-09-08 | Xeris Pharmaceuticals, Inc. | Stable formulations for parenteral injection of small molecule drugs |
| US8999393B1 (en) * | 2013-01-09 | 2015-04-07 | Edgemont Pharmaceuticals Llc | Sustained release formulations of lorazepam |
| US20160000702A1 (en) * | 2013-02-22 | 2016-01-07 | Eastgate Pharmaceuticals Inc. | Pharmaceutical composition for enhanced transmucosal adminstration of benzodiazepines |
| KR101635635B1 (ko) * | 2014-12-04 | 2016-07-01 | 주식회사 엘지생활건강 | 디팔미토일 하이드록시프롤린과 갈릭산 에스터 유도체를 함유하는 화장료 조성물 |
| WO2016191413A1 (en) | 2015-05-25 | 2016-12-01 | Iso Therapeutics Group, Llc | Dotmp kit formulations for radioisotopes |
| LT3551189T (lt) * | 2016-12-09 | 2024-02-12 | Alexza Pharmaceuticals, Inc. | Alprazolamas, skirtas vartoti gydant epilepsiją |
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| WO2022261400A1 (en) * | 2021-06-10 | 2022-12-15 | Neurelis, Inc. | Methods and compositions for treating seizure disorders in pediatric patients |
| CN115707451A (zh) * | 2021-08-19 | 2023-02-21 | 北京万全德众医药生物技术有限公司 | 氯硝西泮口服溶液 |
| CN118812444A (zh) * | 2022-03-02 | 2024-10-22 | 济南同路医药科技发展有限公司 | 一种喹唑啉类化合物及其制备方法和应用 |
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| ITRM20020357A1 (it) | 2002-07-03 | 2004-01-05 | Foscama Biomed Chim Farma | Composizione liquida per la somministrazione orale di lorazepam. |
| NZ541167A (en) | 2003-01-31 | 2008-07-31 | Orexo Ab | A rapid-acting pharmaceutical composition comprising e.g. fentanyl and particles insoluble in water |
| WO2004110403A1 (en) | 2003-06-17 | 2004-12-23 | Sk Corporation | Transnasal microemulsions containing diazepam |
| WO2006075123A1 (en) * | 2005-01-14 | 2006-07-20 | Camurus Ab | Topical bioadhesive formulations |
| US20070021411A1 (en) | 2005-05-11 | 2007-01-25 | Cloyd James C | Supersaturated benzodiazepine solutions and their delivery |
| TW200824693A (en) | 2006-08-28 | 2008-06-16 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of clonazepam and methods of use thereof |
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| US12138239B2 (en) | 2016-07-22 | 2024-11-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12144793B2 (en) | 2016-07-22 | 2024-11-19 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12257223B2 (en) | 2016-07-22 | 2025-03-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12239625B2 (en) | 2016-07-22 | 2025-03-04 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186298B2 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12226389B2 (en) | 2016-07-22 | 2025-02-18 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12226388B2 (en) | 2016-07-22 | 2025-02-18 | Flamel Ireland Limited | Modified release gamma- hydroxybutyrate formulations having improved pharmacokinetics |
| US12226377B2 (en) | 2019-03-01 | 2025-02-18 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US12167992B2 (en) | 2019-03-01 | 2024-12-17 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US12167991B2 (en) | 2019-03-01 | 2024-12-17 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US12303478B2 (en) | 2019-03-01 | 2025-05-20 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12295926B1 (en) | 2022-02-07 | 2025-05-13 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007290589B2 (en) | 2012-04-05 |
| AU2007290589A1 (en) | 2008-03-06 |
| CA2662197A1 (en) | 2008-03-06 |
| NZ575744A (en) | 2011-10-28 |
| WO2008027357A2 (en) | 2008-03-06 |
| WO2008027395A2 (en) | 2008-03-06 |
| IL197275A0 (en) | 2009-12-24 |
| CN101528261B (zh) | 2012-07-18 |
| BRPI0714907A2 (pt) | 2014-08-19 |
| EP2056877A2 (en) | 2009-05-13 |
| WO2008027357A9 (en) | 2009-04-30 |
| NZ595388A (en) | 2011-12-22 |
| WO2008027357A3 (en) | 2008-04-17 |
| US8609651B2 (en) | 2013-12-17 |
| UY30561A1 (es) | 2008-03-31 |
| US20080076761A1 (en) | 2008-03-27 |
| EP2068933A2 (en) | 2009-06-17 |
| KR20090043603A (ko) | 2009-05-06 |
| CN101528261A (zh) | 2009-09-09 |
| NO20091211L (no) | 2009-05-27 |
| WO2008027395A3 (en) | 2008-04-17 |
| US20080070904A1 (en) | 2008-03-20 |
| AR062556A1 (es) | 2008-11-19 |
| PE20081361A1 (es) | 2008-11-06 |
| US8716279B2 (en) | 2014-05-06 |
| MX2009002310A (es) | 2009-09-21 |
| JP2010502614A (ja) | 2010-01-28 |
| JP2010502612A (ja) | 2010-01-28 |
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