JP2017155060A5

JP2017155060A5 -

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Publication number: JP2017155060A5
Authority: JP; Japan
Prior art keywords: hydrochloride; polyethylene glycol; glycol; therapeutic agent; methoxy
Prior art date: 2017-06-15
Legal status : Pending

Application number

JP2017117506A

Other languages

English (en)

Japanese (ja)

Other versions

JP2017155060A (ja

Filing date

2017-06-15

Publication date

2018-11-15

2017-06-15 Application filed filed Critical

2017-09-07 Publication of JP2017155060A publication Critical patent/JP2017155060A/ja

2018-11-15 Publication of JP2017155060A5 publication Critical patent/JP2017155060A5/ja

Status Pending legal-status Critical Current

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239000000203 mixture Substances 0.000 description 139
239000003814 drug Substances 0.000 description 105
229940124597 therapeutic agent Drugs 0.000 description 90
229920001223 polyethylene glycol Polymers 0.000 description 73
238000009472 formulation Methods 0.000 description 70
239000002202 Polyethylene glycol Substances 0.000 description 54
-1 polyoxyethylene Polymers 0.000 description 51
239000008194 pharmaceutical composition Substances 0.000 description 49
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 31
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 28
229960003793 midazolam Drugs 0.000 description 27
DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 description 27
239000000546 pharmaceutical excipient Substances 0.000 description 27
229920001427 mPEG Polymers 0.000 description 23
210000004877 mucosa Anatomy 0.000 description 22
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Substances OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 19
238000000034 method Methods 0.000 description 19
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
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DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 14
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
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KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
230000002209 hydrophobic effect Effects 0.000 description 9
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 9
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JP2017117506A 2007-01-19 2017-06-15 治療薬を送達するための方法および組成物 Pending JP2017155060A (ja)