JP2010502614A - ベンゾジアゼピンの薬学的組成物およびその使用方法 - Google Patents

ベンゾジアゼピンの薬学的組成物およびその使用方法 Download PDF

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Publication number
JP2010502614A
JP2010502614A JP2009526683A JP2009526683A JP2010502614A JP 2010502614 A JP2010502614 A JP 2010502614A JP 2009526683 A JP2009526683 A JP 2009526683A JP 2009526683 A JP2009526683 A JP 2009526683A JP 2010502614 A JP2010502614 A JP 2010502614A
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Prior art keywords
benzodiazepine
composition
clonazepam
solvent
administration
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Ceased
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JP2009526683A
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English (en)
Japanese (ja)
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JP2010502614A5 (enExample
Inventor
ジーン ジャミーソン,
ジャーディン, マイケル デス
クラーク オールフィン,
シグリデュール オラフスドティール,
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Jazz Pharmaceuticals Inc
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Jazz Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38819711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010502614(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jazz Pharmaceuticals Inc filed Critical Jazz Pharmaceuticals Inc
Publication of JP2010502614A publication Critical patent/JP2010502614A/ja
Publication of JP2010502614A5 publication Critical patent/JP2010502614A5/ja
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009526683A 2006-08-28 2007-08-27 ベンゾジアゼピンの薬学的組成物およびその使用方法 Ceased JP2010502614A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84056806P 2006-08-28 2006-08-28
PCT/US2007/018942 WO2008027395A2 (en) 2006-08-28 2007-08-27 Pharmaceutical compositions of benzodiazepines and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2010502614A true JP2010502614A (ja) 2010-01-28
JP2010502614A5 JP2010502614A5 (enExample) 2011-08-25

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ID=38819711

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JP2009526683A Ceased JP2010502614A (ja) 2006-08-28 2007-08-27 ベンゾジアゼピンの薬学的組成物およびその使用方法
JP2009526675A Ceased JP2010502612A (ja) 2006-08-28 2007-08-27 クロナゼパムの薬学的組成物およびその使用方法

Family Applications After (1)

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JP2009526675A Ceased JP2010502612A (ja) 2006-08-28 2007-08-27 クロナゼパムの薬学的組成物およびその使用方法

Country Status (17)

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US (2) US8716279B2 (enExample)
EP (2) EP2068933A2 (enExample)
JP (2) JP2010502614A (enExample)
KR (1) KR20090043603A (enExample)
CN (1) CN101528261B (enExample)
AR (1) AR062556A1 (enExample)
AU (1) AU2007290589B2 (enExample)
BR (1) BRPI0714907A2 (enExample)
CA (1) CA2662197A1 (enExample)
IL (1) IL197275A0 (enExample)
MX (1) MX2009002310A (enExample)
NO (1) NO20091211L (enExample)
NZ (2) NZ575744A (enExample)
PE (1) PE20081361A1 (enExample)
TW (1) TW200824693A (enExample)
UY (1) UY30561A1 (enExample)
WO (2) WO2008027395A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013231089A (ja) * 2007-01-19 2013-11-14 Hananja Ehf 治療薬を送達するための方法および組成物
JP2014509655A (ja) * 2011-03-31 2014-04-21 アコルダ セラピュティクス インコーポレーテッド 鼻腔内ベンゾジアゼピン薬剤学的組成物
US9289432B2 (en) 2007-01-19 2016-03-22 HANANJA EHF and UNIVERSITY OF ICELAND Methods and compositions for the delivery of a therapeutic agent

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WO2010126970A1 (en) * 2009-04-28 2010-11-04 Optmed, Inc. Methods for treating and preventing erectile dysfunction
WO2010126963A1 (en) * 2009-04-28 2010-11-04 Optmed, Inc. Compositions and methods for treating and preventing overactive bladder and conditions associated therewith
GB2481407B (en) * 2010-06-22 2012-05-23 Special Products Ltd A rapid onset liquid midazolam composition for buccal administration
EP3415139B8 (en) 2011-06-14 2022-05-18 Neurelis, Inc. Administration of benzodiazepine
BR112014019171A8 (pt) 2011-12-11 2017-07-11 Recro Pharma Inc Composições intranasais de dexdetomida e seus métodos de uso
US9125805B2 (en) * 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
US8999393B1 (en) * 2013-01-09 2015-04-07 Edgemont Pharmaceuticals Llc Sustained release formulations of lorazepam
EP2958594A4 (en) * 2013-02-22 2017-03-01 Eastgate Pharmaceuticals Inc. Pharmaceutical composition for enhanced transmucosal administration of benzodiazepines
KR101635635B1 (ko) * 2014-12-04 2016-07-01 주식회사 엘지생활건강 디팔미토일 하이드록시프롤린과 갈릭산 에스터 유도체를 함유하는 화장료 조성물
WO2016191413A1 (en) 2015-05-25 2016-12-01 Iso Therapeutics Group, Llc Dotmp kit formulations for radioisotopes
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
HUE064864T2 (hu) * 2016-12-09 2024-04-28 Alexza Pharmaceuticals Inc Az alprazolam alkalmazása epilepszia kezelésében
MX2020005169A (es) * 2017-11-17 2020-12-03 Neurana Pharmaceuticals Inc Métodos de administración de tolperisona.
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
US10896106B2 (en) 2018-05-10 2021-01-19 Teradyne, Inc. Bus synchronization system that aggregates status
EP3930702A1 (en) 2019-03-01 2022-01-05 Flamel Ireland Limited Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state
US20200338090A1 (en) * 2019-04-29 2020-10-29 Marsh and Wang Medical Systems, LLC Seizure control compositions and methods of using same
CN110420190B (zh) * 2019-08-29 2021-07-09 湖南洞庭药业股份有限公司 氯硝西泮片及其制备方法
EP4351586A4 (en) * 2021-06-10 2025-04-02 Neurelis, Inc. Methods and compositions for treating seizure disorders in pediatric patients
CN115707451A (zh) * 2021-08-19 2023-02-21 北京万全德众医药生物技术有限公司 氯硝西泮口服溶液
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal
CN114656410A (zh) * 2022-03-02 2022-06-24 济南同路医药科技发展有限公司 一种氯硝西泮杂质及其制备方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013231089A (ja) * 2007-01-19 2013-11-14 Hananja Ehf 治療薬を送達するための方法および組成物
US9289432B2 (en) 2007-01-19 2016-03-22 HANANJA EHF and UNIVERSITY OF ICELAND Methods and compositions for the delivery of a therapeutic agent
US9687495B2 (en) 2007-01-19 2017-06-27 Hananja Ehf Methods and systems for the delivery of a therapeutic agent
US10052333B2 (en) 2007-01-19 2018-08-21 University Of Iceland Methods and systems for the delivery of a therapeutic agent
JP2014509655A (ja) * 2011-03-31 2014-04-21 アコルダ セラピュティクス インコーポレーテッド 鼻腔内ベンゾジアゼピン薬剤学的組成物

Also Published As

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US20080070904A1 (en) 2008-03-20
US20080076761A1 (en) 2008-03-27
EP2068933A2 (en) 2009-06-17
WO2008027395A2 (en) 2008-03-06
AR062556A1 (es) 2008-11-19
WO2008027357A3 (en) 2008-04-17
TW200824693A (en) 2008-06-16
IL197275A0 (en) 2009-12-24
AU2007290589B2 (en) 2012-04-05
WO2008027357A2 (en) 2008-03-06
BRPI0714907A2 (pt) 2014-08-19
US8716279B2 (en) 2014-05-06
JP2010502612A (ja) 2010-01-28
MX2009002310A (es) 2009-09-21
WO2008027357A9 (en) 2009-04-30
NZ575744A (en) 2011-10-28
KR20090043603A (ko) 2009-05-06
PE20081361A1 (es) 2008-11-06
CN101528261A (zh) 2009-09-09
NZ595388A (en) 2011-12-22
AU2007290589A1 (en) 2008-03-06
US8609651B2 (en) 2013-12-17
WO2008027395A3 (en) 2008-04-17
CN101528261B (zh) 2012-07-18
NO20091211L (no) 2009-05-27
CA2662197A1 (en) 2008-03-06
UY30561A1 (es) 2008-03-31
EP2056877A2 (en) 2009-05-13

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