TW200801015A - Substituted aminophenylsulfonamide compounds as HIV protease inhibitor - Google Patents

Substituted aminophenylsulfonamide compounds as HIV protease inhibitor

Info

Publication number
TW200801015A
TW200801015A TW095143659A TW95143659A TW200801015A TW 200801015 A TW200801015 A TW 200801015A TW 095143659 A TW095143659 A TW 095143659A TW 95143659 A TW95143659 A TW 95143659A TW 200801015 A TW200801015 A TW 200801015A
Authority
TW
Taiwan
Prior art keywords
compounds
hiv protease
protease inhibitor
present
substituted
Prior art date
Application number
TW095143659A
Other languages
English (en)
Other versions
TWI385173B (zh
Inventor
Kock Herman Augustinus De
Tim Hugo Maria Jonckers
Stefaan Julien Last
Paul Jozef Gabriel Maria Boonants
Dominique Louis Nestor Ghislain Surleraux
Piet Tom Bert Paul Wigerinck
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36217947&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200801015(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of TW200801015A publication Critical patent/TW200801015A/zh
Application granted granted Critical
Publication of TWI385173B publication Critical patent/TWI385173B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
TW095143659A 2005-11-28 2006-11-27 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 TWI385173B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111394 2005-11-28

Publications (2)

Publication Number Publication Date
TW200801015A true TW200801015A (en) 2008-01-01
TWI385173B TWI385173B (zh) 2013-02-11

Family

ID=36217947

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095143659A TWI385173B (zh) 2005-11-28 2006-11-27 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物

Country Status (12)

Country Link
US (1) US8084494B2 (zh)
EP (1) EP1960404B1 (zh)
JP (1) JP5279503B2 (zh)
CN (1) CN101316850A (zh)
AR (1) AR057182A1 (zh)
AU (1) AU2006316403B2 (zh)
BR (1) BRPI0619011A2 (zh)
CA (1) CA2628542A1 (zh)
EA (1) EA017138B1 (zh)
TW (1) TWI385173B (zh)
WO (1) WO2007060253A1 (zh)
ZA (1) ZA200804607B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
US20110313035A1 (en) 2009-12-16 2011-12-22 Hetero Research Foundation Polymorphs of darunavir
WO2011092687A1 (en) 2010-01-28 2011-08-04 Mapi Pharma Hk Limited Process for the preparation of darunavir and darunavir intermediates
CA2799762C (en) 2010-05-20 2018-03-06 Hetero Research Foundation Crystalline hydrochloride salt of darunavir
CN102617586B (zh) * 2011-01-26 2016-04-06 浙江九洲药业股份有限公司 地瑞那韦中间体的制备方法
HUE053006T2 (hu) * 2016-11-17 2021-06-28 Janssen Sciences Ireland Unlimited Co Egyszerûsített eljárás darunavir elõállítására

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
US5831117A (en) 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (en) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
EP1042280A2 (en) 1997-12-24 2000-10-11 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
WO1999065870A2 (en) * 1998-06-19 1999-12-23 Vertex Pharmaceuticals Incorporated Sulfonamide inhibitors of aspartyl protease
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
TWI286476B (en) * 2001-12-12 2007-09-11 Tibotec Pharm Ltd Combination of cytochrome P450 dependent protease inhibitors
US7157489B2 (en) * 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
EA200401437A1 (ru) 2002-04-26 2005-04-28 Джилид Сайэнс, Инк. Ненуклеозидные ингибиторы обратной транскриптазы для лечения вич инфекции, способ их получения (варианты), способ увеличения периода полупревращения ненуклеозидного соединения, обладающего активностью против ретровирусов, и способ получения фармацевтической композиции, обладающей специфичностью к лейкоцитам

Also Published As

Publication number Publication date
TWI385173B (zh) 2013-02-11
AR057182A1 (es) 2007-11-21
EA017138B1 (ru) 2012-10-30
AU2006316403B2 (en) 2012-09-06
ZA200804607B (en) 2009-10-28
AU2006316403A1 (en) 2007-05-31
WO2007060253A1 (en) 2007-05-31
US20080269322A1 (en) 2008-10-30
EP1960404A1 (en) 2008-08-27
JP5279503B2 (ja) 2013-09-04
BRPI0619011A2 (pt) 2013-04-02
EA200801476A1 (ru) 2009-02-27
JP2009517371A (ja) 2009-04-30
CA2628542A1 (en) 2007-05-31
CN101316850A (zh) 2008-12-03
US8084494B2 (en) 2011-12-27
EP1960404B1 (en) 2015-06-17

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees