MXPA04011466A - Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro. - Google Patents

Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro.

Info

Publication number
MXPA04011466A
MXPA04011466A MXPA04011466A MXPA04011466A MXPA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A MX PA04011466 A MXPA04011466 A MX PA04011466A
Authority
MX
Mexico
Prior art keywords
protease inhibitors
hiv protease
broadspectrum
substituted benzisoxazole
sulfonamide hiv
Prior art date
Application number
MXPA04011466A
Other languages
English (en)
Inventor
Bernhard Joanna Bern Vergouwen
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of MXPA04011466A publication Critical patent/MXPA04011466A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

La presente invencion se refiere a los compuestos que tiene la formula (I)(ver formula I)N-oxidos, sales, formas estereoisomericas, mezclas racemicas, esteres profarmacos y metabolitos de los mismos; ademas se refiere a su uso como inhibidores de la proteasa de HIV de amplio espectro, procedimiento para su preparacion, asi como composiciones farmaceuticas y equipos de diagnostico que los comprenden; tambien se refiere a combinaciones de los mismos con otro agente anti-retroviral y su uso en ensayos como compuestos d referencia o como reactivos.
MXPA04011466A 2002-05-17 2003-05-16 Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro. MXPA04011466A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076957 2002-05-17
PCT/EP2003/050173 WO2003097616A1 (en) 2002-05-17 2003-05-16 Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors

Publications (1)

Publication Number Publication Date
MXPA04011466A true MXPA04011466A (es) 2005-02-14

Family

ID=29433159

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04011466A MXPA04011466A (es) 2002-05-17 2003-05-16 Inhibidores de la proteasa de hiv de benzisoxazol sulfonamida sustituida de amplio espectro.

Country Status (29)

Country Link
US (1) US7462636B2 (es)
EP (1) EP1517899B1 (es)
JP (2) JP4674084B2 (es)
KR (2) KR101019648B1 (es)
CN (1) CN100582097C (es)
AP (1) AP2004003190A0 (es)
AR (1) AR039887A1 (es)
AT (1) ATE371652T1 (es)
AU (1) AU2003238074B2 (es)
BR (1) BR0310089A (es)
CA (1) CA2485903C (es)
CY (1) CY1107040T1 (es)
DE (1) DE60315984T2 (es)
DK (1) DK1517899T3 (es)
EA (1) EA010908B1 (es)
ES (1) ES2292976T3 (es)
HK (1) HK1076099A1 (es)
HR (1) HRP20050607B1 (es)
IL (1) IL165043A0 (es)
MX (1) MXPA04011466A (es)
MY (1) MY135226A (es)
NO (1) NO330184B1 (es)
NZ (1) NZ536496A (es)
PL (1) PL373425A1 (es)
PT (1) PT1517899E (es)
SI (1) SI1517899T1 (es)
TW (1) TWI356700B (es)
WO (1) WO2003097616A1 (es)
ZA (1) ZA200410156B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003238074B2 (en) * 2002-05-17 2009-04-30 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors
AU2005222435B2 (en) * 2004-03-11 2012-03-15 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
EP1750696B1 (en) * 2004-05-07 2013-06-26 Sequoia Pharmaceuticals Inc RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
ES2331257T3 (es) 2005-02-25 2009-12-28 Tibotec Pharmaceuticals Sintesis de precursores de inhibidores de proteasas.
EP2139883A4 (en) * 2007-03-23 2011-06-22 Univ Massachusetts INHIBITORS OF HIV-1 PROTEASE
ES2382618T3 (es) * 2008-03-25 2012-06-11 Formac Pharmaceuticals N.V. Método de preparación para dispersiones sólidas
WO2011061590A1 (en) 2009-11-17 2011-05-26 Hetero Research Foundation Novel carboxamide derivatives as hiv inhibitors
DE102010004957A1 (de) * 2010-01-14 2011-07-21 Universitätsklinikum Jena, 07743 Biologisch wirksame Moleküle zur Beeinflussung von Virus-, Bakterien-, Parasiten-infizierten Zellen und/oder Tumorzellen und Verfahren zu deren Anwendung
WO2014067962A1 (de) 2012-10-31 2014-05-08 Bayer Cropscience Ag Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
KR101661952B1 (ko) * 2013-03-07 2016-10-04 다우 글로벌 테크놀로지스 엘엘씨 극저점도의 신규한 에스테르화된 셀룰로스 에테르

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
US5004751A (en) * 1987-08-28 1991-04-02 Mochida Pharmaceutical Co., Ltd. Hydantoin derivatives
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
KR100336699B1 (ko) * 1992-08-25 2002-05-13 윌리암스 로저 에이 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
DE69415326T2 (de) 1993-08-24 1999-06-02 Searle & Co Hydroxyaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
SK283569B6 (sk) 1993-10-01 2003-09-11 Astra Aktiebolag Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom
DE69637380T2 (de) * 1995-01-20 2009-09-17 G.D. Searle Llc, Chicago Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1996028465A1 (en) 1995-03-10 1996-09-19 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997018205A1 (en) 1995-11-15 1997-05-22 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
IL124935A (en) 1996-05-20 2001-06-14 Janssen Pharmaceutica Nv Dissolvable fungicidal preparations contain itraconazole with improved bioavailability
SI0969821T1 (en) 1997-03-26 2003-10-31 Janssen Pharmaceutica N.V. Pellets having a core coated with an antifungal and a polymer
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2092599A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
ATE500823T1 (de) * 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
WO1999067254A2 (en) 1998-06-23 1999-12-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Multi-drug resistant retroviral protease inhibitors and use thereof
SK287153B6 (sk) 1999-10-06 2010-01-07 Tibotec Pharmaceuticals Ltd. Hexahydrofuro[2,3-b]furan-3-yl-N-{3-[(1,3-benzodioxol-5- ylsulfonyl)(izobutyl)amino]1-benzyl-2-hydroxypropyl}karbamát, jeho použitie a farmaceutický prípravok s jeho obsahom
SK288232B6 (sk) * 2001-04-09 2014-11-04 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie
AU2003238074B2 (en) * 2002-05-17 2009-04-30 Tibotec Pharmaceuticals Ltd. Broadspectrum substituted benzisoxazole sulfonamide HIV protease inhibitors

Also Published As

Publication number Publication date
DE60315984D1 (de) 2007-10-11
PL373425A1 (en) 2005-08-22
TW200404538A (en) 2004-04-01
NO20045444L (no) 2005-02-16
AU2003238074B2 (en) 2009-04-30
CN1668605A (zh) 2005-09-14
US20050171173A1 (en) 2005-08-04
KR101019648B1 (ko) 2011-03-07
CN100582097C (zh) 2010-01-20
EA010908B1 (ru) 2008-12-30
EP1517899B1 (en) 2007-08-29
CA2485903A1 (en) 2003-11-27
NO330184B1 (no) 2011-02-28
DE60315984T2 (de) 2008-05-29
KR20100130234A (ko) 2010-12-10
ZA200410156B (en) 2005-11-30
HRP20050607B1 (hr) 2014-07-04
US7462636B2 (en) 2008-12-09
HRP20050607A2 (en) 2006-02-28
NZ536496A (en) 2006-06-30
JP2005527607A (ja) 2005-09-15
AR039887A1 (es) 2005-03-09
HK1076099A1 (en) 2006-01-06
JP2011051999A (ja) 2011-03-17
PT1517899E (pt) 2007-11-16
BR0310089A (pt) 2005-02-15
ES2292976T3 (es) 2008-03-16
KR20050013549A (ko) 2005-02-04
AU2003238074A1 (en) 2003-12-02
EA200401524A1 (ru) 2005-06-30
SI1517899T1 (sl) 2008-02-29
AP2004003190A0 (en) 2004-12-31
CA2485903C (en) 2011-08-16
JP4674084B2 (ja) 2011-04-20
IL165043A0 (en) 2005-12-18
CY1107040T1 (el) 2012-09-26
EP1517899A1 (en) 2005-03-30
ATE371652T1 (de) 2007-09-15
MY135226A (en) 2008-02-29
WO2003097616A1 (en) 2003-11-27
DK1517899T3 (da) 2007-12-03
TWI356700B (en) 2012-01-21

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