TW200718730A - Methods of preparing polymers having terminal amine groups using protected amine salts - Google Patents
Methods of preparing polymers having terminal amine groups using protected amine saltsInfo
- Publication number
- TW200718730A TW200718730A TW095136519A TW95136519A TW200718730A TW 200718730 A TW200718730 A TW 200718730A TW 095136519 A TW095136519 A TW 095136519A TW 95136519 A TW95136519 A TW 95136519A TW 200718730 A TW200718730 A TW 200718730A
- Authority
- TW
- Taiwan
- Prior art keywords
- terminal
- methods
- protected amine
- amine
- polymer
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- -1 amine salts Chemical class 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 title 1
- 150000001412 amines Chemical group 0.000 abstract 4
- 229920000233 poly(alkylene oxides) Polymers 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 125000005490 tosylate group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
- C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
- C08G65/3348—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing nitrogen in addition to sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/242,656 US7601798B2 (en) | 2005-10-04 | 2005-10-04 | Methods of preparing polymers having terminal amine groups using protected amine salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200718730A true TW200718730A (en) | 2007-05-16 |
Family
ID=37902700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095136519A TW200718730A (en) | 2005-10-04 | 2006-10-02 | Methods of preparing polymers having terminal amine groups using protected amine salts |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7601798B2 (https=) |
| EP (1) | EP1931313A4 (https=) |
| JP (1) | JP2009510253A (https=) |
| KR (1) | KR20080056267A (https=) |
| CN (1) | CN101321516A (https=) |
| AU (1) | AU2006302585A1 (https=) |
| CA (1) | CA2623542A1 (https=) |
| IL (1) | IL190415A0 (https=) |
| TW (1) | TW200718730A (https=) |
| WO (1) | WO2007044319A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1913036B1 (en) * | 2005-07-20 | 2013-03-06 | Bridgestone Corporation | Amine functionalized polymers |
| US8133707B2 (en) * | 2006-01-17 | 2012-03-13 | Enzon Pharmaceuticals, Inc. | Methods of preparing activated polymers having alpha nitrogen groups |
| US20090156629A1 (en) * | 2006-06-09 | 2009-06-18 | Enzon Pharmaceuticals, Inc. | Indenoisoquinoline-releasable polymer conjugates |
| WO2008089185A2 (en) * | 2007-01-16 | 2008-07-24 | Enzon Pharmaceuticals, Inc. | Posaconazole polymer conjugates and methods of treatment using posaconazole and polymer conjugates thereof |
| HUE027603T2 (en) * | 2007-04-20 | 2016-10-28 | Sigma-Tau Rare Disease Ltd | Stable, recombinant adenosine deaminase |
| EP2147122B1 (en) * | 2007-04-20 | 2014-07-16 | Sigma-Tau Rare Diseases S.A. | Enzymatic anticancer therapy |
| TW200922624A (en) * | 2007-07-11 | 2009-06-01 | Enzon Pharmaceuticals Inc | Polymeric drug delivery system containing a multi-substituted aromatic moiety |
| ES2753391T3 (es) | 2014-10-14 | 2020-04-08 | Halozyme Inc | Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas |
| CN114080232A (zh) | 2019-03-21 | 2022-02-22 | 科迪亚克生物科学公司 | 用于疫苗递送的细胞外囊泡 |
| WO2020191369A1 (en) | 2019-03-21 | 2020-09-24 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| US20230366794A1 (en) | 2020-09-23 | 2023-11-16 | Codiak Biosciences, Inc. | Process for preparing extracellular vesicles |
| US20240241020A1 (en) | 2020-09-23 | 2024-07-18 | Lonza Sales Ag | Process for preparing extracellular vesicles |
| CN114409890A (zh) * | 2022-02-28 | 2022-04-29 | 中国科学院长春应用化学研究所 | 一种氨基功能化的聚乙二醇衍生物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US6448369B1 (en) | 1997-11-06 | 2002-09-10 | Shearwater Corporation | Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation |
| US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| KR20020022691A (ko) * | 1999-06-08 | 2002-03-27 | 와이즈먼 앤드루 | 아미노옥시기를 포함하는 원자가 플랫폼 분자 |
| US20030149307A1 (en) | 2001-10-24 | 2003-08-07 | Baxter International Inc. | Process for the preparation of polyethylene glycol bis amine |
| WO2004035657A1 (en) * | 2002-10-15 | 2004-04-29 | Baxter International Inc. | Process for the preparation of polyethylene glycol bis amine |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| KR100512483B1 (ko) | 2003-05-07 | 2005-09-05 | 선바이오(주) | 신규한 폴리에틸렌글리콜-말레이미드 유도체의 합성방법 |
| EP1688150A1 (en) * | 2005-02-08 | 2006-08-09 | Novo Nordisk A/S | Process for the preparation of alkoxyamine functionalised poly ethylene glycols |
-
2005
- 2005-10-04 US US11/242,656 patent/US7601798B2/en not_active Expired - Fee Related
-
2006
- 2006-09-29 WO PCT/US2006/038562 patent/WO2007044319A2/en not_active Ceased
- 2006-09-29 KR KR1020087010397A patent/KR20080056267A/ko not_active Withdrawn
- 2006-09-29 US US11/537,172 patent/US7569657B2/en not_active Expired - Fee Related
- 2006-09-29 JP JP2008534615A patent/JP2009510253A/ja active Pending
- 2006-09-29 AU AU2006302585A patent/AU2006302585A1/en not_active Abandoned
- 2006-09-29 CA CA002623542A patent/CA2623542A1/en not_active Abandoned
- 2006-09-29 EP EP06816091A patent/EP1931313A4/en not_active Withdrawn
- 2006-09-29 CN CNA2006800455829A patent/CN101321516A/zh active Pending
- 2006-10-02 TW TW095136519A patent/TW200718730A/zh unknown
-
2008
- 2008-03-25 IL IL190415A patent/IL190415A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2623542A1 (en) | 2007-04-19 |
| EP1931313A4 (en) | 2009-12-23 |
| US20070078219A1 (en) | 2007-04-05 |
| US7601798B2 (en) | 2009-10-13 |
| KR20080056267A (ko) | 2008-06-20 |
| CN101321516A (zh) | 2008-12-10 |
| WO2007044319A3 (en) | 2007-07-12 |
| AU2006302585A1 (en) | 2007-04-19 |
| WO2007044319A2 (en) | 2007-04-19 |
| JP2009510253A (ja) | 2009-03-12 |
| US7569657B2 (en) | 2009-08-04 |
| US20070078257A1 (en) | 2007-04-05 |
| IL190415A0 (en) | 2009-09-22 |
| EP1931313A2 (en) | 2008-06-18 |
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