TW200640469A - 9-Substituted tetracyclines - Google Patents
9-Substituted tetracyclinesInfo
- Publication number
- TW200640469A TW200640469A TW095104895A TW95104895A TW200640469A TW 200640469 A TW200640469 A TW 200640469A TW 095104895 A TW095104895 A TW 095104895A TW 95104895 A TW95104895 A TW 95104895A TW 200640469 A TW200640469 A TW 200640469A
- Authority
- TW
- Taiwan
- Prior art keywords
- carbon atoms
- optionally substituted
- atoms optionally
- alkyl
- alkynyl
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title 1
- 235000019364 tetracycline Nutrition 0.000 title 1
- 150000003522 tetracyclines Chemical class 0.000 title 1
- 229940040944 tetracyclines Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 -NR6 R7 Chemical group 0.000 abstract 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65326905P | 2005-02-15 | 2005-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200640469A true TW200640469A (en) | 2006-12-01 |
Family
ID=36676182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095104895A TW200640469A (en) | 2005-02-15 | 2006-02-14 | 9-Substituted tetracyclines |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7812008B2 (enExample) |
| EP (1) | EP1848686A2 (enExample) |
| JP (1) | JP2008530106A (enExample) |
| CN (1) | CN101119964A (enExample) |
| AR (1) | AR053131A1 (enExample) |
| AU (1) | AU2006214543A1 (enExample) |
| BR (1) | BRPI0607353A2 (enExample) |
| CA (1) | CA2597870A1 (enExample) |
| GT (1) | GT200600063A (enExample) |
| MX (1) | MX2007009863A (enExample) |
| TW (1) | TW200640469A (enExample) |
| WO (1) | WO2006088720A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2649221A1 (en) * | 2006-04-17 | 2007-10-25 | Evgeny Tsiperman | Isolation of tetracycline derivatives |
| US8198470B2 (en) * | 2006-04-24 | 2012-06-12 | Teva Pharmaceutical Industries Ltd. | Crystalline form II of tigecycline and processes for preparation thereof |
| DE202007019460U1 (de) * | 2006-04-24 | 2012-10-24 | Teva Pharmaceutical Industries Ltd. | Kristalline Tigecyclin-Formen |
| WO2008066935A2 (en) * | 2006-11-29 | 2008-06-05 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of tigecycline and processes for preparation thereof |
| WO2008066908A1 (en) * | 2006-11-30 | 2008-06-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
| EP2114865A1 (en) * | 2007-03-01 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
| US7939513B2 (en) | 2007-09-07 | 2011-05-10 | Dr. Reddy's Laboratories Limited | Tetracycline derivatives as antibacterial agents |
| ES2655911T3 (es) * | 2008-08-08 | 2018-02-22 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina sustituidos con C7-fluoro |
| ES2627772T3 (es) | 2009-05-08 | 2017-07-31 | Tetraphase Pharmaceuticals, Inc. | Compuestos de tetraciclina |
| JP5944825B2 (ja) * | 2009-08-28 | 2016-07-05 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物 |
| CN101955443B (zh) * | 2010-09-30 | 2012-05-23 | 浙江大学 | 一种替加环素中间体及其盐的制备方法 |
| WO2013013504A1 (zh) * | 2011-07-26 | 2013-01-31 | 山东亨利医药科技有限责任公司 | 替加环素衍生物 |
| BR112015004523B1 (pt) | 2012-08-31 | 2020-08-04 | Tetraphase Pharmaceuticals, Inc | Compostos de tetraciclina, composições farmacêuticas e seus usos |
| CN107759503A (zh) * | 2016-08-16 | 2018-03-06 | 四川科伦博泰生物医药股份有限公司 | 一种四环素衍生物及其用途 |
| ES2978198T3 (es) | 2016-10-19 | 2024-09-06 | Tetraphase Pharmaceuticals Inc | Formas cristalinas de eravaciclina |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2482055A (en) | 1948-02-11 | 1949-09-13 | American Cyanamid Co | Aureomycin and preparation of same |
| US3007965A (en) | 1959-02-13 | 1961-11-07 | American Cyanamid Co | New tetracyclines produced by streptomyces aureofaciens |
| US3043875A (en) | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| FR1430859A (enExample) | 1960-05-23 | 1966-05-25 | ||
| US3338963A (en) | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| US3148212A (en) | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
| US3360557A (en) | 1963-05-10 | 1967-12-26 | American Cyanamid Co | 9-hydroxytetracyclines and a process of preparing same |
| USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3341585A (en) | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
| US3360561A (en) | 1967-06-19 | 1967-12-26 | American Cyanamid Co | Nitration of tetracyclines |
| US3518306A (en) | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
| US4806529A (en) | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5328902A (en) * | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5420272A (en) * | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
| US5834450A (en) * | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| DE60144375D1 (de) * | 2000-07-07 | 2011-05-19 | Trustees Of Tufts College Medford | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| EP2298732A1 (en) * | 2001-03-13 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | 7,9-Substituted tetracycline compounds |
| WO2004064728A2 (en) * | 2003-01-16 | 2004-08-05 | Paratek Pharmaceuticals, Inc. | Use of specific tetracycline compounds in therapy |
-
2006
- 2006-02-09 MX MX2007009863A patent/MX2007009863A/es active IP Right Grant
- 2006-02-09 JP JP2007555215A patent/JP2008530106A/ja active Pending
- 2006-02-09 CA CA002597870A patent/CA2597870A1/en not_active Abandoned
- 2006-02-09 CN CNA2006800049045A patent/CN101119964A/zh active Pending
- 2006-02-09 AU AU2006214543A patent/AU2006214543A1/en not_active Abandoned
- 2006-02-09 BR BRPI0607353-0A patent/BRPI0607353A2/pt not_active IP Right Cessation
- 2006-02-09 EP EP06720553A patent/EP1848686A2/en not_active Withdrawn
- 2006-02-09 WO PCT/US2006/004562 patent/WO2006088720A2/en not_active Ceased
- 2006-02-14 GT GT200600063A patent/GT200600063A/es unknown
- 2006-02-14 TW TW095104895A patent/TW200640469A/zh unknown
- 2006-02-14 AR ARP060100514A patent/AR053131A1/es not_active Application Discontinuation
- 2006-02-14 US US11/354,306 patent/US7812008B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0607353A2 (pt) | 2009-09-01 |
| WO2006088720A2 (en) | 2006-08-24 |
| JP2008530106A (ja) | 2008-08-07 |
| MX2007009863A (es) | 2007-09-04 |
| GT200600063A (es) | 2006-11-09 |
| AR053131A1 (es) | 2007-04-25 |
| US20060183720A1 (en) | 2006-08-17 |
| WO2006088720A3 (en) | 2007-01-11 |
| EP1848686A2 (en) | 2007-10-31 |
| CA2597870A1 (en) | 2006-08-24 |
| CN101119964A (zh) | 2008-02-06 |
| US7812008B2 (en) | 2010-10-12 |
| AU2006214543A1 (en) | 2006-08-24 |
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