AR053131A1 - Tetraciclinas 9-sustituidas - Google Patents

Tetraciclinas 9-sustituidas

Info

Publication number
AR053131A1
AR053131A1 ARP060100514A ARP060100514A AR053131A1 AR 053131 A1 AR053131 A1 AR 053131A1 AR P060100514 A ARP060100514 A AR P060100514A AR P060100514 A ARP060100514 A AR P060100514A AR 053131 A1 AR053131 A1 AR 053131A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
alkynyl
alkenyl
halogen
Prior art date
Application number
ARP060100514A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR053131A1 publication Critical patent/AR053131A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen compuestos de formula (1) donde R1 es un residuo seleccionado del grupo de formulas (2) y (3), n es un entero de 1 o 2; R2 se selecciona de H, amino, -NR6R7, alquilo C1-12, opcionalmente sustituido, arilo de 6,10 o 14 átomos de C opcionalmente sustituido, alquenilo C2-12 opcionalmente sustituido, alquinilo C2-12 opcionalmente sustituido, halogeno, y un anillo heteroarilo de 5 a 10 miembros opcionalmente sustituido que posee 1 a 4 heteroátomos independientemente seleccionados de N, O y S; R3 se selecciona de H, alquilo C1-12, opcionalmente sustituido, arilo de 6,10 o 14 átomos de C opcionalmente sustituido, alquenilo C2-12 opcionalmente sustituido, vinilo, alquinilo C2-12 opcionalmente sustituido, y halogeno; R4 es H, alquilo C1-12 opcionalmente sustituido,, cicloalquilo C3-8, bicicloalquilo C5-10 o aralquilo opcionalmente sustituido; R5 es OH o -OR8; R6 y R7 son cada uno independientemente H o alquilo C1-12 o cuando son opcionalmente tomados conjuntamente con el átomo de N al cual cada uno está unido forman un anillo heterociclilo saturado de 3 a 8 miembros; R8 es alquilo C1-12 alquilo opcionalmente sustituido, o un tautomero o sales farmacéuticamente aceptables de los mismos.
ARP060100514A 2005-02-15 2006-02-14 Tetraciclinas 9-sustituidas AR053131A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65326905P 2005-02-15 2005-02-15

Publications (1)

Publication Number Publication Date
AR053131A1 true AR053131A1 (es) 2007-04-25

Family

ID=36676182

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060100514A AR053131A1 (es) 2005-02-15 2006-02-14 Tetraciclinas 9-sustituidas

Country Status (12)

Country Link
US (1) US7812008B2 (es)
EP (1) EP1848686A2 (es)
JP (1) JP2008530106A (es)
CN (1) CN101119964A (es)
AR (1) AR053131A1 (es)
AU (1) AU2006214543A1 (es)
BR (1) BRPI0607353A2 (es)
CA (1) CA2597870A1 (es)
GT (1) GT200600063A (es)
MX (1) MX2007009863A (es)
TW (1) TW200640469A (es)
WO (1) WO2006088720A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2528202T3 (es) * 2006-04-24 2015-02-05 Teva Pharmaceutical Industries Ltd. Una forma cristalina de tigeciclina y procesos para su preparación
US8198469B2 (en) * 2006-11-29 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
EP2114865A1 (en) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
WO2009073056A1 (en) * 2007-09-07 2009-06-11 Dr. Reddy's Laboratories Ltd. Novel tetracycline derivatives as antibacterial agents
HUE026562T2 (hu) * 2008-08-08 2016-06-28 Tetraphase Pharmaceuticals Inc C7-fluor-helyettesített tetraciklin vegyületek
DK2427425T3 (en) 2009-05-08 2017-06-12 Tetraphase Pharmaceuticals Inc tetracycline
US9624166B2 (en) * 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
CN101955443B (zh) * 2010-09-30 2012-05-23 浙江大学 一种替加环素中间体及其盐的制备方法
CN103635456B (zh) * 2011-07-26 2016-03-09 山东亨利医药科技有限责任公司 替加环素衍生物
LT2890673T (lt) 2012-08-31 2019-04-10 Tetraphase Pharmaceuticals, Inc. Tetraciklino junginiai
CN107759503A (zh) * 2016-08-16 2018-03-06 四川科伦博泰生物医药股份有限公司 一种四环素衍生物及其用途
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2482055A (en) 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US3007965A (en) 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) 1960-05-23 1966-05-25
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3360557A (en) 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3341585A (en) 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en) 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
JP2784847B2 (ja) * 1994-02-17 1998-08-06 ファイザー インク． ９−（置換アミノ）−アルファ−６−デオキシ−５−オキシテトラサイクリン誘導体、それらの製造及び、抗生物質としてのそれらの使用
JP4963771B2 (ja) * 2000-07-07 2012-06-27 トラスティーズ・オブ・タフツ・カレッジ ７、８および９−置換テトラサイクリン化合物
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
WO2004064728A2 (en) * 2003-01-16 2004-08-05 Paratek Pharmaceuticals, Inc. Use of specific tetracycline compounds in therapy

Also Published As

Publication number Publication date
EP1848686A2 (en) 2007-10-31
BRPI0607353A2 (pt) 2009-09-01
US20060183720A1 (en) 2006-08-17
US7812008B2 (en) 2010-10-12
WO2006088720A3 (en) 2007-01-11
AU2006214543A1 (en) 2006-08-24
GT200600063A (es) 2006-11-09
WO2006088720A2 (en) 2006-08-24
JP2008530106A (ja) 2008-08-07
CA2597870A1 (en) 2006-08-24
CN101119964A (zh) 2008-02-06
MX2007009863A (es) 2007-09-04
TW200640469A (en) 2006-12-01

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