TW200606145A - Asymmetric hydrogenation process - Google Patents

Asymmetric hydrogenation process

Info

Publication number
TW200606145A
TW200606145A TW094109815A TW94109815A TW200606145A TW 200606145 A TW200606145 A TW 200606145A TW 094109815 A TW094109815 A TW 094109815A TW 94109815 A TW94109815 A TW 94109815A TW 200606145 A TW200606145 A TW 200606145A
Authority
TW
Taiwan
Prior art keywords
hydrogenation process
asymmetric hydrogenation
cycloalkanoindole
chiral
provides
Prior art date
Application number
TW094109815A
Other languages
English (en)
Other versions
TWI344954B (en
Inventor
David M Tellers
Guy R Humphrey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of TW200606145A publication Critical patent/TW200606145A/zh
Application granted granted Critical
Publication of TWI344954B publication Critical patent/TWI344954B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
TW094109815A 2004-04-02 2005-03-29 Asymmetric hydrogenation process TWI344954B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55897204P 2004-04-02 2004-04-02

Publications (2)

Publication Number Publication Date
TW200606145A true TW200606145A (en) 2006-02-16
TWI344954B TWI344954B (en) 2011-07-11

Family

ID=34964828

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094109815A TWI344954B (en) 2004-04-02 2005-03-29 Asymmetric hydrogenation process

Country Status (19)

Country Link
US (1) US7576118B2 (zh)
EP (1) EP1737820B1 (zh)
JP (1) JP5239071B2 (zh)
CN (1) CN1942440B (zh)
AR (1) AR048459A1 (zh)
AT (1) ATE384046T1 (zh)
AU (1) AU2005230897B2 (zh)
BR (1) BRPI0509384A (zh)
CA (1) CA2561632A1 (zh)
CY (1) CY1107223T1 (zh)
DE (1) DE602005004393T2 (zh)
DK (1) DK1737820T3 (zh)
ES (1) ES2297695T3 (zh)
HR (1) HRP20080145T3 (zh)
PL (1) PL1737820T3 (zh)
PT (1) PT1737820E (zh)
SI (1) SI1737820T1 (zh)
TW (1) TWI344954B (zh)
WO (1) WO2005097745A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190004843A (ko) 2008-07-23 2019-01-14 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[ｂ]인돌-3-일)아세트산 유도체
US8415484B2 (en) 2008-08-27 2013-04-09 Arena Pharmaceuticals, Inc. Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders
EP4148045A1 (en) * 2010-01-27 2023-03-15 Arena Pharmaceuticals, Inc. Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof
CA2789480A1 (en) 2010-03-03 2011-09-09 Arena Pharmaceuticals, Inc. Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN102659664B (zh) * 2012-03-28 2015-01-21 中国计量学院 合成分离拉洛皮兰及其类似物的方法
MX2021011472A (es) 2015-01-06 2022-08-17 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
PL3310760T3 (pl) 2015-06-22 2023-03-06 Arena Pharmaceuticals, Inc. Krystaliczna sól L-argininy kwasu (R)-2-(7-(4-cyklopentylo-3-(trifluorometylo)benzyloksy)- 1,2,3,4-tetrahydrocyklo-penta[b]indol-3-ilo)octowego do zastosowania w zaburzeniach związanych z receptorem S1P1
CN110545848A (zh) 2017-02-16 2019-12-06 艾尼纳制药公司 用于治疗具有肠外表现的炎症性肠病的化合物和方法
CN110520124A (zh) 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
WO2020051378A1 (en) 2018-09-06 2020-03-12 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272787B1 (en) 1986-11-14 1992-05-06 Takasago International Corporation Catalytic production of optically active carboxylic acid
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
US20080153817A1 (en) * 2003-08-07 2008-06-26 Dirk Beher Treatment for Alzheimer's Disease and Related Conditions

Also Published As

Publication number Publication date
EP1737820A1 (en) 2007-01-03
DE602005004393T2 (de) 2009-01-08
ES2297695T3 (es) 2008-05-01
CN1942440B (zh) 2011-09-14
DK1737820T3 (da) 2008-04-28
US7576118B2 (en) 2009-08-18
AU2005230897B2 (en) 2011-03-03
EP1737820B1 (en) 2008-01-16
CY1107223T1 (el) 2012-11-21
JP2007532488A (ja) 2007-11-15
SI1737820T1 (sl) 2008-04-30
TWI344954B (en) 2011-07-11
CN1942440A (zh) 2007-04-04
HRP20080145T3 (en) 2008-04-30
PT1737820E (pt) 2008-03-17
AU2005230897A1 (en) 2005-10-20
ATE384046T1 (de) 2008-02-15
US20050222428A1 (en) 2005-10-06
AR048459A1 (es) 2006-04-26
DE602005004393D1 (de) 2008-03-06
CA2561632A1 (en) 2005-10-20
JP5239071B2 (ja) 2013-07-17
BRPI0509384A (pt) 2007-09-18
PL1737820T3 (pl) 2008-05-30
WO2005097745A1 (en) 2005-10-20

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees