BRPI0509384A - processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo - Google Patents

processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo

Info

Publication number
BRPI0509384A
BRPI0509384A BRPI0509384-8A BRPI0509384A BRPI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A BR PI0509384 A BRPI0509384 A BR PI0509384A
Authority
BR
Brazil
Prior art keywords
salt
compound
preparation
hydrogenation process
asymmetric hydrogenation
Prior art date
Application number
BRPI0509384-8A
Other languages
English (en)
Inventor
David M Tellers
Guy R Humphrey
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of BRPI0509384A publication Critical patent/BRPI0509384A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO DE HIDROGENAçãO ASSIMéTRICA PARA A PREPARAçãO DE UM COMPOSTO OU UM SAL DO MESMO, E, COMPOSTO OU UM SAL DO MESMO" A presente invenção fornece um processo de hidrogenação assimétrica para a preparação de antagonistas do receptor DP do cicloalcanoindol quiral de fórmula 1, em elevado excesso enantiomérico.
BRPI0509384-8A 2004-04-02 2005-03-29 processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo BRPI0509384A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55897204P 2004-04-02 2004-04-02
PCT/US2005/010501 WO2005097745A1 (en) 2004-04-02 2005-03-29 Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives

Publications (1)

Publication Number Publication Date
BRPI0509384A true BRPI0509384A (pt) 2007-09-18

Family

ID=34964828

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509384-8A BRPI0509384A (pt) 2004-04-02 2005-03-29 processo de hidrogenação assimétrica para a preparação de um composto ou um sal do mesmo, e, composto ou um sal do mesmo

Country Status (19)

Country Link
US (1) US7576118B2 (pt)
EP (1) EP1737820B1 (pt)
JP (1) JP5239071B2 (pt)
CN (1) CN1942440B (pt)
AR (1) AR048459A1 (pt)
AT (1) ATE384046T1 (pt)
AU (1) AU2005230897B2 (pt)
BR (1) BRPI0509384A (pt)
CA (1) CA2561632A1 (pt)
CY (1) CY1107223T1 (pt)
DE (1) DE602005004393T2 (pt)
DK (1) DK1737820T3 (pt)
ES (1) ES2297695T3 (pt)
HR (1) HRP20080145T3 (pt)
PL (1) PL1737820T3 (pt)
PT (1) PT1737820E (pt)
SI (1) SI1737820T1 (pt)
TW (1) TWI344954B (pt)
WO (1) WO2005097745A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190004843A (ko) 2008-07-23 2019-01-14 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[ｂ]인돌-3-일)아세트산 유도체
ES2583630T3 (es) 2008-08-27 2016-09-21 Arena Pharmaceuticals, Inc. Derivados de ácido tricíclico sustituido como agonistas del receptor S1P1 útiles en el tratamiento de trastornos autoinmunes e inflamatorios
CN103221391B (zh) * 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
CN105503882B (zh) 2010-03-03 2019-07-05 艾尼纳制药公司 制备s1p1受体调节剂及其晶体形式的方法
CN102659664B (zh) * 2012-03-28 2015-01-21 中国计量学院 合成分离拉洛皮兰及其类似物的方法
MX2021011472A (es) 2015-01-06 2022-08-17 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
MX2019009841A (es) 2017-02-16 2020-01-30 Arena Pharm Inc Compuestos y metodos para el tratamiento de la colangitis biliar primaria.
MA47503A (fr) 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
WO2020051378A1 (en) 2018-09-06 2020-03-12 Arena Pharmaceuticals, Inc. Compounds useful in the treatment of autoimmune and inflammatory disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3778857D1 (de) 1986-11-14 1992-06-11 Takasago Perfumery Co Ltd Katalytische produktion von optisch aktiven carbonsaeuren.
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
US20080153817A1 (en) * 2003-08-07 2008-06-26 Dirk Beher Treatment for Alzheimer's Disease and Related Conditions

Also Published As

Publication number Publication date
PL1737820T3 (pl) 2008-05-30
CA2561632A1 (en) 2005-10-20
PT1737820E (pt) 2008-03-17
EP1737820A1 (en) 2007-01-03
JP2007532488A (ja) 2007-11-15
CN1942440B (zh) 2011-09-14
SI1737820T1 (sl) 2008-04-30
DE602005004393T2 (de) 2009-01-08
ES2297695T3 (es) 2008-05-01
JP5239071B2 (ja) 2013-07-17
EP1737820B1 (en) 2008-01-16
CY1107223T1 (el) 2012-11-21
AR048459A1 (es) 2006-04-26
DE602005004393D1 (de) 2008-03-06
US7576118B2 (en) 2009-08-18
TW200606145A (en) 2006-02-16
HRP20080145T3 (en) 2008-04-30
US20050222428A1 (en) 2005-10-06
ATE384046T1 (de) 2008-02-15
DK1737820T3 (da) 2008-04-28
CN1942440A (zh) 2007-04-04
AU2005230897B2 (en) 2011-03-03
AU2005230897A1 (en) 2005-10-20
WO2005097745A1 (en) 2005-10-20
TWI344954B (en) 2011-07-11

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

Free format text: ALTERADO DE: MERCK AND CO., INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: SCHERING CORPORATION, (US)

B25D Requested change of name of applicant approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B25G Requested change of headquarter approved

Owner name: MERCK SHARP AND DOHME CORP. (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.