TW200526547A - Amino-substituted ethylamino β2 adrenergic receptor agonists - Google Patents

Amino-substituted ethylamino β2 adrenergic receptor agonists Download PDF

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Publication number
TW200526547A
TW200526547A TW093128456A TW93128456A TW200526547A TW 200526547 A TW200526547 A TW 200526547A TW 093128456 A TW093128456 A TW 093128456A TW 93128456 A TW93128456 A TW 93128456A TW 200526547 A TW200526547 A TW 200526547A
Authority
TW
Taiwan
Prior art keywords
group
compound
phenyl
amino
doc
Prior art date
Application number
TW093128456A
Other languages
English (en)
Chinese (zh)
Inventor
Martin S Linsell
John R Jacobsen
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of TW200526547A publication Critical patent/TW200526547A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
TW093128456A 2003-09-22 2004-09-20 Amino-substituted ethylamino β2 adrenergic receptor agonists TW200526547A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50568503P 2003-09-22 2003-09-22

Publications (1)

Publication Number Publication Date
TW200526547A true TW200526547A (en) 2005-08-16

Family

ID=34393055

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093128456A TW200526547A (en) 2003-09-22 2004-09-20 Amino-substituted ethylamino β2 adrenergic receptor agonists

Country Status (27)

Country Link
US (2) US7399863B2 (OSRAM)
EP (1) EP1687257B1 (OSRAM)
JP (1) JP2007505931A (OSRAM)
KR (1) KR20070015496A (OSRAM)
CN (1) CN100465158C (OSRAM)
AR (1) AR046085A1 (OSRAM)
AT (1) ATE428685T1 (OSRAM)
AU (1) AU2004276254A1 (OSRAM)
BR (1) BRPI0414634A (OSRAM)
CA (1) CA2538037A1 (OSRAM)
CO (1) CO5680412A2 (OSRAM)
DE (1) DE602004020655D1 (OSRAM)
DK (1) DK1687257T3 (OSRAM)
ES (1) ES2326172T3 (OSRAM)
IL (1) IL174026A0 (OSRAM)
IS (1) IS8346A (OSRAM)
MA (1) MA28089A1 (OSRAM)
MX (1) MXPA06003093A (OSRAM)
NO (1) NO20061737L (OSRAM)
NZ (1) NZ545764A (OSRAM)
PL (1) PL1687257T3 (OSRAM)
PT (1) PT1687257E (OSRAM)
RU (1) RU2385317C2 (OSRAM)
SI (1) SI1687257T1 (OSRAM)
TW (1) TW200526547A (OSRAM)
WO (1) WO2005030678A2 (OSRAM)
ZA (1) ZA200602308B (OSRAM)

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JP2008501705A (ja) * 2004-06-03 2008-01-24 セラヴァンス， インコーポレーテッド ジアミンβ２アドレナリン作用性レセプターアゴニスト
JP2008507532A (ja) * 2004-07-21 2008-03-13 セラヴァンス， インコーポレーテッド ジアリールエーテルβ２アドレナリン作用性レセプターアゴニスト
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EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN112645875A (zh) * 2020-12-09 2021-04-13 深圳海王医药科技研究院有限公司 一种盐酸丙卡特罗杂质的制备方法

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Also Published As

Publication number Publication date
EP1687257A2 (en) 2006-08-09
KR20070015496A (ko) 2007-02-05
NZ545764A (en) 2009-12-24
MXPA06003093A (es) 2006-06-20
SI1687257T1 (sl) 2009-10-31
NO20061737L (no) 2006-05-31
JP2007505931A (ja) 2007-03-15
CN1856465A (zh) 2006-11-01
ATE428685T1 (de) 2009-05-15
PL1687257T3 (pl) 2009-09-30
IL174026A0 (en) 2006-08-01
AU2004276254A1 (en) 2005-04-07
US7399863B2 (en) 2008-07-15
CO5680412A2 (es) 2006-09-29
PT1687257E (pt) 2009-05-28
EP1687257B1 (en) 2009-04-15
HK1093486A1 (en) 2007-03-02
ES2326172T3 (es) 2009-10-02
ZA200602308B (en) 2007-07-25
RU2006113700A (ru) 2006-09-10
MA28089A1 (fr) 2006-08-01
BRPI0414634A (pt) 2006-11-07
IS8346A (is) 2006-03-09
US20090111850A1 (en) 2009-04-30
DK1687257T3 (da) 2009-07-20
AR046085A1 (es) 2005-11-23
CA2538037A1 (en) 2005-04-07
US7964730B2 (en) 2011-06-21
DE602004020655D1 (de) 2009-05-28
US20050113411A1 (en) 2005-05-26
WO2005030678A3 (en) 2005-05-26
CN100465158C (zh) 2009-03-04
WO2005030678A2 (en) 2005-04-07
RU2385317C2 (ru) 2010-03-27

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