TW200512184A - 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure - Google Patents
10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressureInfo
- Publication number
- TW200512184A TW200512184A TW093103178A TW93103178A TW200512184A TW 200512184 A TW200512184 A TW 200512184A TW 093103178 A TW093103178 A TW 093103178A TW 93103178 A TW93103178 A TW 93103178A TW 200512184 A TW200512184 A TW 200512184A
- Authority
- TW
- Taiwan
- Prior art keywords
- hydrogen
- halogen
- alkyl
- carbon
- heteroaryloxy
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000004410 intraocular pressure Effects 0.000 title 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052736 halogen Chemical class 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 208000010412 Glaucoma Diseases 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 206010030043 Ocular hypertension Diseases 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 150000002430 hydrocarbons Chemical class 0.000 abstract 2
- -1 or CO2R Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical class [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/365,369 US6875787B2 (en) | 2003-02-11 | 2003-02-11 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200512184A true TW200512184A (en) | 2005-04-01 |
| TWI329631B TWI329631B (en) | 2010-09-01 |
Family
ID=32824631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093103178A TWI329631B (en) | 2003-02-11 | 2004-02-11 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure and method for making the derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6875787B2 (zh) |
| EP (2) | EP2263674B1 (zh) |
| CN (3) | CN102050811A (zh) |
| AR (1) | AR043138A1 (zh) |
| CY (1) | CY1113138T1 (zh) |
| DK (2) | DK2263674T3 (zh) |
| ES (2) | ES2391393T3 (zh) |
| HK (1) | HK1086191A1 (zh) |
| IL (1) | IL170052A (zh) |
| PT (1) | PT1608309E (zh) |
| SI (1) | SI1608309T1 (zh) |
| TW (1) | TWI329631B (zh) |
| ZA (1) | ZA200505728B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI386208B (zh) * | 2005-04-18 | 2013-02-21 | Allergan Inc | 治療性的經取代環戊酮 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7855226B2 (en) | 2003-02-11 | 2010-12-21 | Allergan, Inc. | Treatment of inflammatory bowel disease |
| US7169807B2 (en) * | 2004-04-09 | 2007-01-30 | Allergan, Inc. | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists |
| EP1805139A2 (en) * | 2004-10-26 | 2007-07-11 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| US7101906B2 (en) * | 2004-11-16 | 2006-09-05 | Allergan, Inc. | 2,3,4-substituted cyclopentanones as therapeutic agents |
| US7893107B2 (en) * | 2005-11-30 | 2011-02-22 | Allergan, Inc. | Therapeutic methods using prostaglandin EP4 agonist components |
| US20070232660A1 (en) * | 2006-04-04 | 2007-10-04 | Allergan, Inc. | Therapeutic and delivery methods of prostaglandin ep4 agonists |
| US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| ES2414879T4 (es) | 2009-04-20 | 2013-10-30 | Allergan, Inc. | Hidrogeles de fibroína de seda y usos de éstos |
| US20110052695A1 (en) * | 2009-04-20 | 2011-03-03 | Allergan, Inc. | Drug delivery platforms comprising silk fibroin hydrogels and uses thereof |
| US20110111031A1 (en) * | 2009-04-20 | 2011-05-12 | Guang-Liang Jiang | Drug Delivery Platforms Comprising Silk Fibroin Hydrogels and Uses Thereof |
| SG187653A1 (en) * | 2010-07-30 | 2013-03-28 | Allergan Inc | Compounds and methods for skin repair |
| BR112013003600A2 (pt) * | 2010-08-17 | 2016-08-16 | Allergan Inc | agonistas ep2 ou ep4 para o tratamento de névoa da córnea |
| US8697056B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8741281B2 (en) * | 2010-08-19 | 2014-06-03 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8697057B2 (en) * | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US20120142684A1 (en) * | 2010-12-02 | 2012-06-07 | Allergan, Inc. | Compounds and methods for skin repair |
| CA2827615A1 (en) | 2011-02-17 | 2012-08-23 | Dennis E. Van Epps | Compositions and improved soft tissue replacement methods |
| EP2678022A2 (en) | 2011-02-23 | 2014-01-01 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| US20120259413A1 (en) | 2011-04-07 | 2012-10-11 | Allergan, Inc. | Devices, compositions and methods utilizing ep4 and ep2 receptor agonists for preventing, reducing or treating capsular contracture |
| WO2013123270A1 (en) | 2012-02-16 | 2013-08-22 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| EP2814526B1 (en) | 2012-02-16 | 2016-11-02 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| WO2013123272A1 (en) | 2012-02-16 | 2013-08-22 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| WO2013123275A1 (en) | 2012-02-16 | 2013-08-22 | Allergan, Inc. | Compositions and improved soft tissue replacement methods |
| CA2941648C (en) | 2014-03-07 | 2022-08-16 | Dynaenergetics Gmbh & Co. Kg | Device and method for positioning a detonator within a perforating gun assembly |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117014A (en) * | 1976-01-09 | 1978-09-26 | Abbott Laboratories | Prostaglandin derivatives |
| JPS59101458A (ja) * | 1982-12-01 | 1984-06-12 | Nippon Iyakuhin Kogyo Kk | 新規なチアプロスタグランジン誘導体及びその製法 |
| JPS632972A (ja) * | 1986-06-20 | 1988-01-07 | Nippon Iyakuhin Kogyo Kk | 新規プロスタグランジンｅ↓１誘導体及びその製法 |
| US6187813B1 (en) * | 1990-04-10 | 2001-02-13 | Pharmacia & Upjohn Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US4994274A (en) * | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| US5034413A (en) * | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| AU635294B2 (en) * | 1989-07-27 | 1993-03-18 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| CA2021316C (en) * | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| CA2020254A1 (en) * | 1989-07-27 | 1991-01-28 | Ming F. Chan | Intraocular pressure reducing 9, 15-diacyl prostaglandins |
| US6034413A (en) * | 1997-02-27 | 2000-03-07 | Texas Instruments Incorporated | High speed biCMOS gate power for power MOSFETs incorporating improved injection immunity |
| DE10057158C1 (de) * | 2000-11-16 | 2002-03-28 | Asglawo Gmbh Stoffe Zum Daemme | Lagerungsmatte für die Lagerung eines Abgaskatalysators |
| US6531504B2 (en) * | 2001-05-17 | 2003-03-11 | Allergan, Inc. | Prostanoic acid derivatives as agents for lowering intraocular pressure |
| WO2003040126A1 (en) * | 2001-11-05 | 2003-05-15 | Allergan, Inc. | φ-CYCLOALKYL 17-HETEROARYL PROSTAGLANDIN E2 ANALOGS AS EP2-RECEPTOR AGONISTS |
| US7175476B2 (en) * | 2005-01-11 | 2007-02-13 | Daeun Electronics Co., Ltd. | Crosstalk canceling pattern for high-speed communications and modular jack having the same |
-
2003
- 2003-02-11 US US10/365,369 patent/US6875787B2/en not_active Expired - Lifetime
-
2004
- 2004-02-04 US US10/772,720 patent/US20040235958A1/en not_active Abandoned
- 2004-02-06 PT PT04709028T patent/PT1608309E/pt unknown
- 2004-02-06 ES ES04709028T patent/ES2391393T3/es not_active Expired - Lifetime
- 2004-02-06 DK DK10178294.4T patent/DK2263674T3/da active
- 2004-02-06 CN CN2010105303996A patent/CN102050811A/zh active Pending
- 2004-02-06 EP EP10178294.4A patent/EP2263674B1/en not_active Expired - Lifetime
- 2004-02-06 SI SI200431931T patent/SI1608309T1/sl unknown
- 2004-02-06 EP EP14177792.0A patent/EP2803358B1/en not_active Expired - Lifetime
- 2004-02-06 ES ES10178294.4T patent/ES2515217T3/es not_active Expired - Lifetime
- 2004-02-06 DK DK04709028.7T patent/DK1608309T3/da active
- 2004-02-06 CN CN201010530469.8A patent/CN102050812B/zh not_active Expired - Fee Related
- 2004-02-06 CN CNA2004800026773A patent/CN1758915A/zh active Pending
- 2004-02-10 AR ARP040100405A patent/AR043138A1/es not_active Application Discontinuation
- 2004-02-11 TW TW093103178A patent/TWI329631B/zh not_active IP Right Cessation
-
2005
- 2005-07-18 ZA ZA200505728A patent/ZA200505728B/xx unknown
- 2005-08-02 IL IL170052A patent/IL170052A/en active IP Right Grant
-
2006
- 2006-06-02 HK HK06106364.9A patent/HK1086191A1/xx not_active IP Right Cessation
-
2012
- 2012-09-25 CY CY20121100873T patent/CY1113138T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI386208B (zh) * | 2005-04-18 | 2013-02-21 | Allergan Inc | 治療性的經取代環戊酮 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2515217T3 (es) | 2014-10-29 |
| CN1758915A (zh) | 2006-04-12 |
| DK2263674T3 (da) | 2014-10-27 |
| EP2803358B1 (en) | 2017-05-03 |
| SI1608309T1 (sl) | 2012-11-30 |
| US20040157901A1 (en) | 2004-08-12 |
| CN102050812B (zh) | 2015-02-18 |
| HK1086191A1 (en) | 2006-09-15 |
| EP2263674B1 (en) | 2014-07-23 |
| ZA200505728B (en) | 2006-04-26 |
| DK1608309T3 (da) | 2012-09-03 |
| US20040235958A1 (en) | 2004-11-25 |
| US6875787B2 (en) | 2005-04-05 |
| CY1113138T1 (el) | 2016-04-13 |
| ES2391393T3 (es) | 2012-11-23 |
| EP2263674A1 (en) | 2010-12-22 |
| IL170052A (en) | 2011-10-31 |
| TWI329631B (en) | 2010-09-01 |
| EP2803358A1 (en) | 2014-11-19 |
| PT1608309E (pt) | 2012-10-18 |
| CN102050811A (zh) | 2011-05-11 |
| AR043138A1 (es) | 2005-07-20 |
| CN102050812A (zh) | 2011-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Expiration of patent term of an invention patent |