TW200510404A - Novel 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors - Google Patents
Novel 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitorsInfo
- Publication number
- TW200510404A TW200510404A TW093117906A TW93117906A TW200510404A TW 200510404 A TW200510404 A TW 200510404A TW 093117906 A TW093117906 A TW 093117906A TW 93117906 A TW93117906 A TW 93117906A TW 200510404 A TW200510404 A TW 200510404A
- Authority
- TW
- Taiwan
- Prior art keywords
- aza
- bicyclo
- novel
- uptake inhibitors
- monoamine neurotransmitter
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300939 | 2003-06-24 | ||
DKPA200301487 | 2003-10-09 | ||
DKPA200400228 | 2004-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200510404A true TW200510404A (en) | 2005-03-16 |
Family
ID=36754881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW093117906A TW200510404A (en) | 2003-06-24 | 2004-06-21 | Novel 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
Country Status (18)
Country | Link |
---|---|
US (3) | US7407970B2 (zh) |
EP (1) | EP1638965A1 (zh) |
JP (1) | JP2009513491A (zh) |
KR (1) | KR20060030482A (zh) |
CN (1) | CN100368409C (zh) |
AR (1) | AR044883A1 (zh) |
AU (1) | AU2004249441B2 (zh) |
BR (1) | BRPI0411608A (zh) |
CA (1) | CA2530023A1 (zh) |
CO (1) | CO5630004A2 (zh) |
HK (1) | HK1089157A1 (zh) |
IL (1) | IL171990A0 (zh) |
IS (1) | IS8212A (zh) |
NO (1) | NO20060360L (zh) |
RU (1) | RU2344136C2 (zh) |
TW (1) | TW200510404A (zh) |
UA (1) | UA82517C2 (zh) |
WO (1) | WO2004113334A1 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100368409C (zh) * | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
US20050171079A1 (en) * | 2004-02-04 | 2005-08-04 | Schrimpf Michael R. | Amino-substituted tricyclic derivatives and methods of use |
US7365193B2 (en) | 2004-02-04 | 2008-04-29 | Abbott Laboratories | Amino-substituted tricyclic derivatives and methods of use |
CN1960985A (zh) * | 2004-06-18 | 2007-05-09 | 神经研究公司 | 作为单胺神经递质再摄取抑制剂的新颖烷基取代的哌啶衍生物 |
US7713990B2 (en) | 2005-01-13 | 2010-05-11 | Neurosearch A/S | 3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors |
MX2007015488A (es) * | 2005-06-08 | 2008-03-04 | Neurosearch As | Derivados de 3-arilox-8-aza-biciclo[3.2.1]oct-6-eno y su uso como inhibidores de la reabsorcion del neurotransmisor monoamina. |
TW200716627A (en) | 2005-06-08 | 2007-05-01 | Neurosearch As | Novel compounds |
TW200745101A (en) | 2005-09-30 | 2007-12-16 | Organon Nv | 9-Azabicyclo[3.3.1]nonane derivatives |
US7868017B2 (en) | 2005-09-30 | 2011-01-11 | N.V. Organon | 9-azabicyclo[3.3.1]nonane derivatives |
EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
TW200804367A (en) | 2005-11-11 | 2008-01-16 | Neurosearch As | Novel compounds |
TW200806662A (en) * | 2005-12-01 | 2008-02-01 | Organon Nv | 8-azabicyclo[3.2.1]octane derivatives |
US7605170B2 (en) | 2005-12-01 | 2009-10-20 | N.V. Organon | 8-azabicyclo[3.2.1]octane derivatives |
CN102516241B (zh) | 2006-05-19 | 2015-07-29 | 艾伯维巴哈马有限公司 | Cns活性的稠合的双环杂环取代的氮杂双环烷烃衍生物 |
TW200904815A (en) * | 2007-05-09 | 2009-02-01 | Neurosearch As | Novel compounds |
MX2010004493A (es) * | 2007-10-25 | 2010-06-11 | Exelixis Inc | Compuestos de tropano. |
MX2010009581A (es) * | 2008-03-05 | 2010-09-30 | Neurosearch As | Derivados novedosos de 4-bencidriloxi-tetraalquil-piperidina y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
WO2014005274A1 (zh) * | 2012-07-03 | 2014-01-09 | 海南卫康制药(潜山)有限公司 | 多取代的8-氮杂环【3.2.1】辛烷化合物 |
WO2014102590A1 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted piperidin-4-amino-type compounds and uses thereof |
Family Cites Families (30)
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US2640829A (en) * | 1950-11-10 | 1953-06-02 | Smith Kline French Lab | Isoquinolyl heterocyclic ethers |
GB969518A (en) * | 1961-04-27 | 1964-09-09 | Koninklijke Pharma Fab Nv | Tetrahydrodibenzocyclo-octene derivatives |
GB1008645A (en) | 1963-08-06 | 1965-11-03 | Koninklijke Pharma Fab Nv | Dibenzocycloheptane derivatives |
GB1164555A (en) * | 1966-09-20 | 1969-09-17 | Chinoin Gyogyszer Es Vegyeszet | New Tropine Derivatives |
US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
US3657253A (en) * | 1970-08-31 | 1972-04-18 | Robins Co Inc A H | 3-aryloxy-8-carbamoylnortropanes |
FR2476088A2 (fr) | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
IL61642A0 (en) * | 1979-12-20 | 1981-01-30 | Beecham Group Ltd | Aniline derivatives,their preparation and pharmalceutical compositions containing them |
EP0067615B1 (en) * | 1981-06-17 | 1986-01-08 | Beecham Group Plc | Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions |
JPS6070183A (ja) * | 1983-09-28 | 1985-04-20 | C Uyemura & Co Ltd | 化学銅めっき方法 |
ZA848275B (en) * | 1983-12-28 | 1985-08-28 | Degussa | New piridine-2-ethers or pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring |
GB8718445D0 (en) * | 1987-08-04 | 1987-09-09 | Wyeth John & Brother Ltd | Pyridyl-ethers |
CA1307790C (en) * | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
US4861889A (en) * | 1988-03-14 | 1989-08-29 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(2,3,4,5,6-pentafluorophenoxy)-8-azabicyclo[3.2.1]octanes |
JP3087763B2 (ja) * | 1990-11-30 | 2000-09-11 | 三井化学株式会社 | 新規な複素環式化合物およびそれを含有する医薬組成物 |
US5710168A (en) * | 1991-10-23 | 1998-01-20 | Pfizer Inc. | 2-piperidino-1-alkanol derivatives as neuroprotective agents |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
MX9701282A (es) * | 1994-08-18 | 1997-05-31 | Pfizer | Fenoles neuroprotectores. |
US5852037A (en) * | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
AU720358B2 (en) | 1996-02-22 | 2000-06-01 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
DE19629652A1 (de) * | 1996-03-06 | 1998-01-29 | Thomae Gmbh Dr K | 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
US6248752B1 (en) * | 1998-02-27 | 2001-06-19 | Charles Duane Smith | Azabicyclooctane compositions and methods for enhancing chemotherapy |
WO2000027790A1 (en) * | 1998-11-11 | 2000-05-18 | Smithkline Beecham P.L.C. | Mutilin compounds |
CA2374668A1 (en) * | 1999-05-21 | 2000-11-30 | Pfizer Products Inc. | New pharmaceutical combinations for nos inhibitors |
AU2001249250A1 (en) * | 2000-03-29 | 2001-10-08 | Research Triangle Institute | Selective ligands for the delta opioid receptor |
CA2364178C (en) * | 2000-12-05 | 2006-01-10 | Yasuhiro Katsu | N-benzenesulfonyl l-proline compounds as bradykinin antagonists |
US20040106643A1 (en) * | 2001-05-23 | 2004-06-03 | Gouliaev Alex Haarh | Tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
EP1525201A1 (en) * | 2002-07-18 | 2005-04-27 | Pfizer Products Inc. | Bicyclic piperidine derivatives as antagonists of the ccr1 chemokine receptor |
CN100368409C (zh) * | 2003-06-24 | 2008-02-13 | 神经研究公司 | 8-氮杂双环[3.2.1]辛烷衍生物及其用于制备单胺神经递质再摄取抑制剂的用途 |
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2004
- 2004-06-18 CN CNB2004800155755A patent/CN100368409C/zh not_active Expired - Fee Related
- 2004-06-18 UA UAA200510857A patent/UA82517C2/uk unknown
- 2004-06-18 JP JP2006516168A patent/JP2009513491A/ja active Pending
- 2004-06-18 EP EP04741837A patent/EP1638965A1/en not_active Withdrawn
- 2004-06-18 WO PCT/EP2004/051167 patent/WO2004113334A1/en active Application Filing
- 2004-06-18 KR KR1020057024770A patent/KR20060030482A/ko not_active Application Discontinuation
- 2004-06-18 US US10/561,417 patent/US7407970B2/en active Active
- 2004-06-18 CA CA002530023A patent/CA2530023A1/en not_active Abandoned
- 2004-06-18 RU RU2005138591/04A patent/RU2344136C2/ru not_active IP Right Cessation
- 2004-06-18 AU AU2004249441A patent/AU2004249441B2/en not_active Ceased
- 2004-06-18 BR BRPI0411608-9A patent/BRPI0411608A/pt not_active IP Right Cessation
- 2004-06-21 TW TW093117906A patent/TW200510404A/zh unknown
- 2004-06-23 AR ARP040102198A patent/AR044883A1/es unknown
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2005
- 2005-11-16 IL IL171990A patent/IL171990A0/en unknown
- 2005-12-16 CO CO05126920A patent/CO5630004A2/es not_active Application Discontinuation
- 2005-12-30 IS IS8212A patent/IS8212A/is unknown
-
2006
- 2006-01-23 NO NO20060360A patent/NO20060360L/no not_active Application Discontinuation
- 2006-08-25 HK HK06109422A patent/HK1089157A1/xx not_active IP Right Cessation
-
2008
- 2008-07-01 US US12/216,213 patent/US7888358B2/en not_active Expired - Fee Related
-
2011
- 2011-01-14 US US13/007,172 patent/US20110112139A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080269229A1 (en) | 2008-10-30 |
US20060142331A1 (en) | 2006-06-29 |
AR044883A1 (es) | 2005-10-05 |
WO2004113334A1 (en) | 2004-12-29 |
CN100368409C (zh) | 2008-02-13 |
JP2009513491A (ja) | 2009-04-02 |
CN1798745A (zh) | 2006-07-05 |
EP1638965A1 (en) | 2006-03-29 |
US7888358B2 (en) | 2011-02-15 |
RU2344136C2 (ru) | 2009-01-20 |
RU2005138591A (ru) | 2006-07-27 |
AU2004249441A1 (en) | 2004-12-29 |
BRPI0411608A (pt) | 2006-08-08 |
US7407970B2 (en) | 2008-08-05 |
US20110112139A1 (en) | 2011-05-12 |
AU2004249441B2 (en) | 2009-11-12 |
CA2530023A1 (en) | 2004-12-29 |
CO5630004A2 (es) | 2006-04-28 |
UA82517C2 (uk) | 2008-04-25 |
KR20060030482A (ko) | 2006-04-10 |
NO20060360L (no) | 2006-03-24 |
IS8212A (is) | 2005-12-30 |
IL171990A0 (en) | 2011-08-01 |
HK1089157A1 (en) | 2006-11-24 |
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