TW200505422A - Pharmaceutical preparations containing arginine amides - Google Patents
Pharmaceutical preparations containing arginine amidesInfo
- Publication number
- TW200505422A TW200505422A TW093107492A TW93107492A TW200505422A TW 200505422 A TW200505422 A TW 200505422A TW 093107492 A TW093107492 A TW 093107492A TW 93107492 A TW93107492 A TW 93107492A TW 200505422 A TW200505422 A TW 200505422A
- Authority
- TW
- Taiwan
- Prior art keywords
- residue
- general formula
- pharmaceutical preparations
- solution
- benzene ring
- Prior art date
Links
- -1 arginine amides Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- VCZKTIKPEDMZNW-UHFFFAOYSA-N O=S(=O)=S Chemical group O=S(=O)=S VCZKTIKPEDMZNW-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003077125 | 2003-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200505422A true TW200505422A (en) | 2005-02-16 |
| TWI327910B TWI327910B (enExample) | 2010-08-01 |
Family
ID=33027937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW093107492A TW200505422A (en) | 2003-03-20 | 2004-03-19 | Pharmaceutical preparations containing arginine amides |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP3781308B2 (enExample) |
| KR (1) | KR101010547B1 (enExample) |
| CN (1) | CN100344624C (enExample) |
| TW (1) | TW200505422A (enExample) |
| WO (1) | WO2004083201A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006008696A (ja) * | 2003-03-20 | 2006-01-12 | Mitsubishi Pharma Corp | アルギニンアミド類を含有する医薬製剤 |
| CN101257890B (zh) * | 2005-09-01 | 2012-10-31 | 巴克斯特国际公司 | 含有酸作为增溶剂的阿加曲班制剂 |
| JP5438999B2 (ja) * | 2009-03-19 | 2014-03-12 | テルモ株式会社 | アルガトロバン注射液製剤 |
| CN102120026A (zh) * | 2011-03-03 | 2011-07-13 | 天津市炜杰科技有限公司 | 以醇作为增溶剂的21(s)阿加曲班静脉注射液 |
| CN102228426A (zh) * | 2011-06-17 | 2011-11-02 | 天津市炜杰科技有限公司 | 以醇作为增溶剂的21(r)阿加曲班静脉注射液 |
| CN104098647B (zh) * | 2014-06-24 | 2017-12-08 | 安徽省逸欣铭医药科技有限公司 | 阿加曲班类似物及其制备方法和医药用途 |
| CN114689768A (zh) * | 2020-12-31 | 2022-07-01 | 汉寿康运医药科技有限公司 | 一种阿加曲班一水合物中杂质含量的分离检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214052A (en) * | 1987-07-28 | 1993-05-25 | Mitsubishi Kasei Corporation | Method for dissolving arginineamides and pharmaceutical compositions containing them |
| JPS6431727A (en) * | 1987-07-28 | 1989-02-02 | Mitsubishi Chem Ind | Dissolution of argininamide and drug composition containing argininamides |
| JP3530542B2 (ja) * | 1992-03-18 | 2004-05-24 | 三菱化学株式会社 | 眼科用アルガトロバン製剤 |
| FR2715566B1 (fr) * | 1994-02-03 | 1996-03-08 | Synthelabo | Solutions aqueuses concentrées d'argatroban. |
| JP2002241284A (ja) * | 2001-02-16 | 2002-08-28 | Towa Yakuhin Kk | 全身投与用アルガトロバン注射液 |
-
2004
- 2004-03-19 WO PCT/JP2004/003768 patent/WO2004083201A1/ja not_active Ceased
- 2004-03-19 KR KR1020057017410A patent/KR101010547B1/ko not_active Expired - Lifetime
- 2004-03-19 CN CNB2004800076128A patent/CN100344624C/zh not_active Ceased
- 2004-03-19 JP JP2005503766A patent/JP3781308B2/ja not_active Expired - Lifetime
- 2004-03-19 TW TW093107492A patent/TW200505422A/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100344624C (zh) | 2007-10-24 |
| JPWO2004083201A1 (ja) | 2006-06-22 |
| TWI327910B (enExample) | 2010-08-01 |
| CN1761661A (zh) | 2006-04-19 |
| WO2004083201A1 (ja) | 2004-09-30 |
| JP3781308B2 (ja) | 2006-05-31 |
| KR20060002825A (ko) | 2006-01-09 |
| KR101010547B1 (ko) | 2011-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |