JP3781308B2 - アルギニンアミド類を含有する医薬製剤 - Google Patents

アルギニンアミド類を含有する医薬製剤 Download PDF

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Publication number
JP3781308B2
JP3781308B2 JP2005503766A JP2005503766A JP3781308B2 JP 3781308 B2 JP3781308 B2 JP 3781308B2 JP 2005503766 A JP2005503766 A JP 2005503766A JP 2005503766 A JP2005503766 A JP 2005503766A JP 3781308 B2 JP3781308 B2 JP 3781308B2
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JP
Japan
Prior art keywords
solution
group
pharmaceutical composition
argatroban
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2005503766A
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English (en)
Japanese (ja)
Other versions
JPWO2004083201A1 (ja
Inventor
和彦 尾崎
真奈美 平宮
勝芳 吉澤
孝志 山田
毅 広川
浩一 菅原
克典 来栖
昇 山田
健一 梶原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Towa Pharmaceutical Co Ltd
Original Assignee
Mitsubishi Pharma Corp
Towa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33027937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3781308(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Pharma Corp, Towa Pharmaceutical Co Ltd filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of JP3781308B2 publication Critical patent/JP3781308B2/ja
Publication of JPWO2004083201A1 publication Critical patent/JPWO2004083201A1/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2005503766A 2003-03-20 2004-03-19 アルギニンアミド類を含有する医薬製剤 Expired - Lifetime JP3781308B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003077125 2003-03-20
JP2003077125 2003-03-20
PCT/JP2004/003768 WO2004083201A1 (ja) 2003-03-20 2004-03-19 アルギニンアミド類を含有する医薬製剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005208135A Division JP2006008696A (ja) 2003-03-20 2005-07-19 アルギニンアミド類を含有する医薬製剤

Publications (2)

Publication Number Publication Date
JP3781308B2 true JP3781308B2 (ja) 2006-05-31
JPWO2004083201A1 JPWO2004083201A1 (ja) 2006-06-22

Family

ID=33027937

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2005503766A Expired - Lifetime JP3781308B2 (ja) 2003-03-20 2004-03-19 アルギニンアミド類を含有する医薬製剤

Country Status (5)

Country Link
JP (1) JP3781308B2 (enExample)
KR (1) KR101010547B1 (enExample)
CN (1) CN100344624C (enExample)
TW (1) TW200505422A (enExample)
WO (1) WO2004083201A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE514416T1 (de) * 2005-09-01 2011-07-15 Baxter Internat Inc A Delaware Corp Argatrobanformulierung mit einer säure als lösungsvermittler
JP5438999B2 (ja) * 2009-03-19 2014-03-12 テルモ株式会社 アルガトロバン注射液製剤
CN102120026A (zh) * 2011-03-03 2011-07-13 天津市炜杰科技有限公司 以醇作为增溶剂的21(s)阿加曲班静脉注射液
CN102228426A (zh) * 2011-06-17 2011-11-02 天津市炜杰科技有限公司 以醇作为增溶剂的21(r)阿加曲班静脉注射液
CN104098647B (zh) * 2014-06-24 2017-12-08 安徽省逸欣铭医药科技有限公司 阿加曲班类似物及其制备方法和医药用途
CN114689768A (zh) * 2020-12-31 2022-07-01 汉寿康运医药科技有限公司 一种阿加曲班一水合物中杂质含量的分离检测方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6431727A (en) * 1987-07-28 1989-02-02 Mitsubishi Chem Ind Dissolution of argininamide and drug composition containing argininamides
US5214052A (en) * 1987-07-28 1993-05-25 Mitsubishi Kasei Corporation Method for dissolving arginineamides and pharmaceutical compositions containing them
JP3530542B2 (ja) * 1992-03-18 2004-05-24 三菱化学株式会社 眼科用アルガトロバン製剤
FR2715566B1 (fr) * 1994-02-03 1996-03-08 Synthelabo Solutions aqueuses concentrées d'argatroban.
JP2002241284A (ja) * 2001-02-16 2002-08-28 Towa Yakuhin Kk 全身投与用アルガトロバン注射液

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006008696A (ja) * 2003-03-20 2006-01-12 Mitsubishi Pharma Corp アルギニンアミド類を含有する医薬製剤

Also Published As

Publication number Publication date
TW200505422A (en) 2005-02-16
JPWO2004083201A1 (ja) 2006-06-22
KR101010547B1 (ko) 2011-01-24
KR20060002825A (ko) 2006-01-09
CN100344624C (zh) 2007-10-24
CN1761661A (zh) 2006-04-19
WO2004083201A1 (ja) 2004-09-30
TWI327910B (enExample) 2010-08-01

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