TW200416044A - Humanized anti-lymphotoxin β receptor antibodies - Google Patents
Humanized anti-lymphotoxin β receptor antibodies Download PDFInfo
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- TW200416044A TW200416044A TW092117964A TW92117964A TW200416044A TW 200416044 A TW200416044 A TW 200416044A TW 092117964 A TW092117964 A TW 092117964A TW 92117964 A TW92117964 A TW 92117964A TW 200416044 A TW200416044 A TW 200416044A
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- antibody
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US39299302P | 2002-07-01 | 2002-07-01 | |
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| TW200416044A true TW200416044A (en) | 2004-09-01 |
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| TW092117964A TW200416044A (en) | 2002-07-01 | 2003-07-01 | Humanized anti-lymphotoxin β receptor antibodies |
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| NZ (1) | NZ537965A (enExample) |
| TW (1) | TW200416044A (enExample) |
| WO (1) | WO2004002431A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6312691B1 (en) * | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
| US5925351A (en) | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| ATE329618T1 (de) * | 1998-10-09 | 2006-07-15 | Biogen Idec Inc | Umkehr des viral-induzierten systemischen schocks und des atemnotsyndroms durch blockierung des lymphotoxin-beta- aktivierungsweges |
| EE200300179A (et) * | 2000-10-13 | 2003-08-15 | Biogen, Inc. | Humaniseeritud LT-ß-R-i vastased antikehad |
| CN100473664C (zh) * | 2002-12-20 | 2009-04-01 | 拜奥根Idec马萨诸塞公司 | 多价淋巴毒素β受体激动剂及其治疗用途 |
| CN1753692A (zh) * | 2002-12-20 | 2006-03-29 | 比奥根艾迪克Ma公司 | 淋巴毒素β受体药剂与化疗剂的联合用药 |
| AU2004252170B2 (en) * | 2003-06-27 | 2011-01-27 | Biogen Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
| JP2005241389A (ja) * | 2004-02-25 | 2005-09-08 | Ochiyanomizu Jiyoshi Univ | 蛍光標識糖鎖の特異的固定化試薬および固定化方法 |
| JP2007530588A (ja) | 2004-03-23 | 2007-11-01 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | レセプターカップリング剤およびその治療用途 |
| WO2006074399A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
| EP2067041A2 (en) | 2006-10-03 | 2009-06-10 | Biogen Idec MA, Inc. | Biomarkers and assays for the treatment of cancer |
| CL2007002926A1 (es) | 2006-10-12 | 2008-05-16 | Genentech Inc | Anticuerpo antilinfotoxina alfa (lt-alfa); composicion con el anticuerpo; hibridoma pta-7538; acido nucleico codificante del anticuerpo; vector y celula huesped que comprenden el acido nucleico; metodo para inhibir la proliferacion celular activada p |
| US8338376B2 (en) * | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| SG178002A1 (en) * | 2006-10-20 | 2012-02-28 | Biogen Idec Inc | Treatment of demyelinating disorders |
| KR101573086B1 (ko) | 2007-06-25 | 2015-11-30 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 항체를 변형시키는 방법, 및 기능적 특성이 개선된 변형된 항체 |
| EP2382238A1 (en) * | 2008-12-31 | 2011-11-02 | Biogen Idec MA Inc. | Anti-lymphotoxin antibodies |
| CA2800311A1 (en) * | 2010-05-11 | 2011-11-17 | Aveo Pharmaceuticals, Inc. | Anti-fgfr2 antibodies |
| TWI897855B (zh) * | 2018-10-26 | 2025-09-21 | 美商免疫遺傳股份有限公司 | E p C A M 抗體、可活化抗體及免疫偶聯物以及其用途 |
| WO2021116337A1 (en) | 2019-12-11 | 2021-06-17 | Cilag Gmbh International | Multispecific binding molecules comprising ltbr and edb binding domains and uses thereof |
| JP2024500847A (ja) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | 適合可能な受容体特異性を有するキメラ抗原受容体システム |
| CR20240246A (es) * | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| WO2023218320A1 (en) * | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Anti-lymphotoxin beta receptor antibodies and methods of use thereof |
| WO2025012620A1 (en) | 2023-07-07 | 2025-01-16 | Mestag Therapeutics Ltd | Binding constructs |
| EP4527851A1 (en) | 2023-09-22 | 2025-03-26 | Bayer Aktiengesellschaft | Bispecific antibodies binding ltbr and lrrc15 |
| WO2025172587A1 (en) | 2024-02-16 | 2025-08-21 | Mestag Therapeutics Ltd | Binding constructs |
| WO2025172588A1 (en) | 2024-02-16 | 2025-08-21 | Mestag Therapeutics Ltd | Bispecific constructs directed against fap and ltbr |
| WO2025221728A2 (en) | 2024-04-15 | 2025-10-23 | Janssen Biotech, Inc. | Ltbr binding molecules and uses thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| AU8228891A (en) | 1990-06-27 | 1992-01-23 | Biogen, Inc. | Surface complexed lymphotoxin |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| EP0672143B1 (en) | 1992-12-04 | 2008-06-04 | Biogen Idec MA Inc. | Lymphotoxin-beta, lymphotoxin-beta complexes, pharmaceutical preparations and therapeutic uses thereof |
| CA2211443A1 (en) * | 1995-01-26 | 1996-08-01 | Biogen, Inc. | Lymphotoxin-.alpha./.beta. complexes and anti-lymphotoxin-beta receptor antibodies as anti-tumor agents |
| US6312691B1 (en) | 1996-01-26 | 2001-11-06 | Jeffrey L. Browning | Lymphotoxin-α/β complexes and anti-lympotoxin-β receptor antibodies as anti-tumor agents |
| US5925351A (en) * | 1995-07-21 | 1999-07-20 | Biogen, Inc. | Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease |
| US7060667B1 (en) | 1998-01-30 | 2006-06-13 | Biogen Idec Ma, Inc. | Treatment of follicular lymphomas using inhibitors of the LT pathway |
| BR9908214A (pt) | 1998-01-30 | 2000-11-28 | Biogen Inc | Tratamento para linfomas foliculares utilizando inibidores da via da linfotoxina (lt) |
| GB9809839D0 (en) * | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
| EE200300179A (et) | 2000-10-13 | 2003-08-15 | Biogen, Inc. | Humaniseeritud LT-ß-R-i vastased antikehad |
| CN1753692A (zh) | 2002-12-20 | 2006-03-29 | 比奥根艾迪克Ma公司 | 淋巴毒素β受体药剂与化疗剂的联合用药 |
| CN100473664C (zh) | 2002-12-20 | 2009-04-01 | 拜奥根Idec马萨诸塞公司 | 多价淋巴毒素β受体激动剂及其治疗用途 |
| JP2007530588A (ja) | 2004-03-23 | 2007-11-01 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | レセプターカップリング剤およびその治療用途 |
-
2003
- 2003-07-01 TW TW092117964A patent/TW200416044A/zh unknown
- 2003-07-01 WO PCT/US2003/020762 patent/WO2004002431A2/en not_active Ceased
- 2003-07-01 NZ NZ537965A patent/NZ537965A/en unknown
- 2003-07-01 JP JP2004518186A patent/JP2005532051A/ja active Pending
- 2003-07-01 AR ARP030102391A patent/AR040367A1/es unknown
- 2003-07-01 CN CNA038207214A patent/CN1678625A/zh active Pending
- 2003-07-01 CA CA002491480A patent/CA2491480A1/en not_active Abandoned
- 2003-07-01 AU AU2003248782A patent/AU2003248782A1/en not_active Abandoned
- 2003-07-01 EP EP03762296A patent/EP1539793A4/en not_active Withdrawn
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2004
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| US7429645B2 (en) | 2008-09-30 |
| US20060222644A1 (en) | 2006-10-05 |
| EP1539793A2 (en) | 2005-06-15 |
| NZ537965A (en) | 2008-04-30 |
| CA2491480A1 (en) | 2004-01-08 |
| WO2004002431A2 (en) | 2004-01-08 |
| AU2003248782A1 (en) | 2004-01-19 |
| CN1678625A (zh) | 2005-10-05 |
| JP2005532051A (ja) | 2005-10-27 |
| WO2004002431A3 (en) | 2004-08-26 |
| AR040367A1 (es) | 2005-03-30 |
| EP1539793A4 (en) | 2006-02-01 |
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